Adalimumab for the treatment of uveitis.

abstract：:Introduction: The metabolic syndrome (MetS) is now recognized as a chronic proinflammatory and prothrombotic state that aggravates insulin resistance, oxidative injury, and cardiovascular risk. MetS is more prevalent in patients with systemic lupus erythematosus (SLE), a prototype of systemic autoimmune disease associ...

journal_title：Expert review of clinical immunology

authors： Mok CC

更新日期：2019-07-01 00:00:00

abstract：INTRODUCTION:HAE is a very debilitating disease that causes significant distress for patients not only during an acute attack but also constant fear for a subsequent attack. It is important to address long-term prophylactic (LTP) therapy to prevent attacks, decrease morbidity and increase the quality of life. When disc...

journal_title：Expert review of clinical immunology

authors： Villavicencio MF,Craig T

更新日期：2020-05-01 00:00:00

abstract：OBJECTIVES:Methylation pattern of gene modification is essential for the differentiation of T regulatory cells (Tregs) and 5-Aza-2'-deoxycytidine is a common inhibitor of methylation. This study aimed to investigate the potential effects of Treg polarizing conditions and 5-Aza-2'-deoxycytidine treatment in the differen...

journal_title：Expert review of clinical immunology

authors： Fang Y,Yuan XD,Liu HH,Xiang L,Chen LM,Fan YC,Gao S,Wang K

更新日期：2021-01-13 00:00:00

abstract：:Data generated using high-throughput DNA microarrays are changing the way we think about systemic lupus erythematosus (SLE). The identification of an interferon gene-expression signature in the majority of patients with SLE, especially those with severe SLE, has stimulated substantial interest in targeting the interfe...

journal_title：Expert review of clinical immunology

authors： Gaffney PM,Moser KL,Baechler EC

更新日期：2007-11-01 00:00:00

abstract：:In the 1990s, elucidation of the primary amino acid sequence of several major allergens using molecular cloning techniques opened the door to T-cell epitope mapping studies. Such analyses underscored the complexity of the allergen-specific T-cell repertoire and the challenges to using allergen-derived peptides to iden...

journal_title：Expert review of clinical immunology

authors： Woodfolk JA

更新日期：2006-03-01 00:00:00

abstract：INTRODUCTION:Chronic rhinosinusitis (CRS) is a broad clinical syndrome linked by mucosal inflammation. Primary treatment modalities are corticosteroids and antibiotics with surgery an option for failures, but the level of supporting evidence is generally low. The primary reason is that CRS is a symptom complex and not ...

journal_title：Expert review of clinical immunology

authors： Ghogomu N,Kern R

更新日期：2017-03-01 00:00:00

abstract：INTRODUCTION:Secondary immunodeficiency is becoming a greater medical concern as the usage of immunosuppressive and biological treatments has increased. Individuals with certain medical conditions, such as hematological malignancies, can also have secondary immunodeficiency. Immunoglobulin replacement therapy (IGRT), w...

journal_title：Expert review of clinical immunology

authors： Patel V,Cowan J

更新日期：2020-07-01 00:00:00

abstract：:Respiratory diseases, such as asthma and chronic obstructive pulmonary disease (COPD), are a major health burden on society and current treatment modalities for these diseases have not significantly changed over the past 40 years. The only major pharmacological advancement for the treatment of these diseases has been ...

journal_title：Expert review of clinical immunology

authors： Venkatasamy R,Spina D

更新日期：2007-05-01 00:00:00

abstract：INTRODUCTION:Despite the emergence of newer immunomodulating agents for systemic lupus erythematosus (SLE), a substantial proportion of patients still do not respond optimally. While the mechanisms for the differential responses to drug therapy are unclear, variation in drug exposure with the same dosing protocol relat...

journal_title：Expert review of clinical immunology

authors： Mok CC

更新日期：2017-01-01 00:00:00

abstract：:Epidemiological and clinical studies have suggested that the pathogenesis of inflammatory bowel disease (IBD) is strongly influenced by genetic predisposition. Beyond the limitations of linkage analysis, multiple genome-wide association studies, their meta-analyses, and targeted genotyping array techniques have broade...

journal_title：Expert review of clinical immunology

authors： Ye BD,McGovern DP

更新日期：2016-10-01 00:00:00

abstract：:The 31st Annual Meeting of the American Society for Reproductive Immunology provided an excellent platform for basic and clinical scientists to brainstorm on current reproductive health issues such as repeated implantation and pregnancy failure, preterm birth, preeclampsia and genital tract infections such as HIV. The...

journal_title：Expert review of clinical immunology

authors： Joukhadar J,Nevers T,Kalkunte S

更新日期：2011-09-01 00:00:00

abstract：INTRODUCTION:The transcription factors signal transducer and activator of transcription (STAT) 1 and STAT3 fulfill fundamental functions in nonimmune and immune cells. The description and follow-up of patients with germline mutations that result in either loss-of-function or gain-of-function have contributed to our und...

journal_title：Expert review of clinical immunology

authors： Olbrich P,Freeman AF

更新日期：2018-12-01 00:00:00

abstract：:Recent epidemiological studies estimated that more than 30% of European suffer from allergic rhinitis or conjunctivitis, while up to 20% suffer from asthma and 15% from allergic skin conditions, while for many other regions the prevalence is increasing. Allergen immunotherapy represents the only available treatment th...

journal_title：Expert review of clinical immunology

authors： Pajno GB,Nadeau KC,Passalacqua G,Caminiti L,Hobson B,Jay DC,Arasi S,Chiera F,Salzano G

更新日期：2015-01-01 00:00:00

abstract：:Antiphospholipid syndrome is an autoimmune disease characterized by venous and/or arterial thrombosis and/or recurrent fetal loss and the presence of antiphospholid antibodies. Among the causes of death of antiphospholipid syndrome there are the myocardial infarction and stroke. Comorbidities could worsen the evolutio...

journal_title：Expert review of clinical immunology

authors： Muniz Caldas CA,Freire de Carvalho J

更新日期：2013-10-01 00:00:00

abstract：:Lung fibrosis is a devastating disease that involves a variable degree of inflammation, alveolar epithelial injury, fibroblast hyperplasia and the deposition of extracellular matrix. Standard therapies that consist of corticosteroids and immunosuppressive agents offer little benefit and most patients experience a prog...

journal_title：Expert review of clinical immunology

authors： Moore BB,Peters-Golden M

更新日期：2006-01-01 00:00:00

abstract：INTRODUCTION:Modern imaging may aid in the diagnosis, prognosis and monitoring of therapeutic response in psoriatic arthritis (PsA). Detection of osteitis and technical advances like whole body magnetic resonance imaging (MRI) exemplify the value of this technology. Areas covered: Ultrasound (US) provides a clinic-base...

journal_title：Expert review of clinical immunology

authors： Mathew AJ,Coates LC,Danda D,Conaghan PG

更新日期：2017-02-01 00:00:00

abstract：:Beclomethasone dipropionate is a corticosteroid with topical activity for inflammatory disorders at mucosal surfaces. Oral beclomethasone dipropionate (orBec) has demonstrated activity in gastrointestinal acute graft-versus-host disease (aGVHD) associated with hematopoietic cell transplantation. Since the GI tract is ...

journal_title：Expert review of clinical immunology

authors： Hockenbery DM

更新日期：2007-09-01 00:00:00

abstract：:Pathological similarities between sarcoidosis (SA) and tuberculosis (TB) suggest that mycobacterial antigen(s), in genetically different predisposed hosts, may be a cause of SA. The authors' work and other published comparative analyses of HLA and non-HLA alleles in patients with SA or TB from different ethnic groups ...

journal_title：Expert review of clinical immunology

authors： Dubaniewicz A,Zimmermann A,Dudziak M,Typiak M,Skotarczak M

更新日期：2013-04-01 00:00:00

abstract：:Inflammatory bowel disease includes ulcerative colitis and Crohn's disease, which are both inflammatory disorders of the gastrointestinal tract. Both types of inflammatory bowel disease have a complex etiology, resulting from a genetically determined susceptibility interacting with environmental factors, including the...

journal_title：Expert review of clinical immunology

authors： Ferguson LR

更新日期：2013-08-01 00:00:00

abstract：:Introduction: While biologic agents that can be used for treating pemphigus vulgaris (PV) are increasing, themajority of the world's PV patients can afford only corticosteroids (CS) and some immunosuppressive agents (ISA). Areas covered: The spectrum of side effects encountered when PV patients receive high-dose, long...

journal_title：Expert review of clinical immunology

authors： Yanovsky RL,McLeod M,Ahmed AR

更新日期：2019-10-01 00:00:00

abstract：:Epigenetic modifications of gene expression comprise modifications of DNA by DNA methylation and modifications of the histone proteins by acetylation, methylation, SUMOylation or phosphorylation. DNA methylation in the promoter region of genes represses gene transcription. Histone modifications influence the structure...

journal_title：Expert review of clinical immunology

authors： Jüngel A,Distler JH,Gay S,Distler O

更新日期：2011-07-01 00:00:00

abstract：:The measuring tools for disease activity of rheumatoid arthritis have long been adapted for assessing the disease activity of psoriatic arthritis (PsA), particularly as regards peripheral arthritis. However, because of the multifactorial aspects and multiple domains of PsA, such as axial and peripheral joints, skin an...

journal_title：Expert review of clinical immunology

authors： Her M,Kavanaugh A

更新日期：2014-09-01 00:00:00

abstract：:Hashimoto's thyroiditis (HT) is the most prevalent thyroid autoimmune disorder, characterized by the presence of specific thyroid autoantibodies (TAb). The development of autoimmunity, including TAb production and clinical presentation of HT, is determined by a complex interplay of genetic susceptibility and several e...

journal_title：Expert review of clinical immunology

authors： Zaletel K

更新日期：2007-03-01 00:00:00

abstract：:Type 1 diabetes (T1D) is caused by T-cell-mediated destruction of the insulin-producing beta-cells in the pancreas. Genetic and immunological evidence from humans and mouse models indicates that CD4(+) T cells play a crucial role in the development and prevention of T1D. The dichotomy between CD4(+) T regulatory and e...

journal_title：Expert review of clinical immunology

authors： Mannering SI,Brodnicki TC

更新日期：2007-07-01 00:00:00

abstract：INTRODUCTION:Rheumatoid arthritis (RA) is characterized by systemic synovitis causing joint destruction. With the development of biological disease-modifying anti-rheumatic drugs (bDMARDs) and combination of conventional DMARDs, clinical remission is perceived as an appropriate and realistic goal in many patients. Howe...

journal_title：Expert review of clinical immunology

authors： Kubo S,Nakayamada S,Tanaka Y

更新日期：2016-09-01 00:00:00

abstract：:Neonates have little immunological memory and a developing immune system, which increases their vulnerability to infectious agents. Recent advances in the understanding of neonatal immunity indicate that both innate and adaptive responses are dependent on precursor frequency of lymphocytes, antigenic dose and mode of ...

journal_title：Expert review of clinical immunology

authors： Basha S,Surendran N,Pichichero M

更新日期：2014-09-01 00:00:00

abstract：:Treatment of idiopathic membranous nephropathy (IMN) is controversial. However, two randomized controlled trials (RCTs) reported that treatment with steroids alternated with an alkylating agent achieved significantly more remissions and better renal survival at 10 years in comparison with untreated controls. Short-ter...

journal_title：Expert review of clinical immunology

authors： Ponticelli C

更新日期：2013-01-01 00:00:00

abstract：:Psoriatic arthritis (PsA) is a chronic inflammatory joint disease occurring in 6-39% of patients with psoriasis. Standard therapy of PsA includes nonsteroidal anti-inflammatory drugs, intra-articular steroids and disease-modifying antirheumatic drugs. Failure of standard therapy is an indication for anti-TNF-alpha the...

journal_title：Expert review of clinical immunology

authors： Poddubnyy DA,Rudwaleit M

更新日期：2009-11-01 00:00:00

abstract：:Graft-versus-host disease (GVHD) remains a significant complication that greatly enhances morbidity and mortality associated with hematopoietic stem cell transplantation. Key immunoregulatory molecules have been implicated in the pathogenesis of GVHD, but the mechanisms by which these molecules affect the incidence an...

journal_title：Expert review of clinical immunology

authors： Conway SE,Abdi R

更新日期：2009-09-01 00:00:00

abstract：:In cross-sectional studies, vitamin D deficiency is frequent in spondyloarthritic patients and associated with increased spondyloarthritis (SpA) activity and structural damage. Experimental studies also show that vitamin D interferes with molecular pathways critically involved in SpA, especially regarding entheseal in...

journal_title：Expert review of clinical immunology

authors： Guillot X,Prati C,Wendling D

更新日期：2014-12-01 00:00:00