Tuberculosis in the course of sarcoidosis treatment: is genotyping necessary for personalized therapy?

abstract：INTRODUCTION:Rheumatoid arthritis (RA) is a complex disease in which different mechanisms are involved. Studies suggest a key role for aberrant pathways of T-cell activation in the initiation and perpetuation of disease. Abatacept is a fusion protein composed of the Fc region of the immunoglobulin G1 (IgG1) fused to th...

journal_title：Expert review of clinical immunology

authors： Pombo-Suarez M,Gomez-Reino JJ

更新日期：2019-04-01 00:00:00

abstract：:Antiphospholipid syndrome is an autoimmune disease characterized by venous and/or arterial thrombosis and/or recurrent fetal loss and the presence of antiphospholid antibodies. Among the causes of death of antiphospholipid syndrome there are the myocardial infarction and stroke. Comorbidities could worsen the evolutio...

journal_title：Expert review of clinical immunology

authors： Muniz Caldas CA,Freire de Carvalho J

更新日期：2013-10-01 00:00:00

abstract：INTRODUCTION:Common variable immunodeficiency (CVID) comprises a large heterogeneous group of patients with primary antibody deficiency. Areas covered: The affected patients are characterized by increased susceptibility to infections and low levels of serum immunoglobulin. However, enteropathy, granulomatous organ infi...

journal_title：Expert review of clinical immunology

authors： Azizi G,Abolhassani H,Asgardoon MH,Alinia T,Yazdani R,Mohammadi J,Rezaei N,Ochs HD,Aghamohammadi A

更新日期：2017-02-01 00:00:00

abstract：INTRODUCTION:Despite the emergence of newer immunomodulating agents for systemic lupus erythematosus (SLE), a substantial proportion of patients still do not respond optimally. While the mechanisms for the differential responses to drug therapy are unclear, variation in drug exposure with the same dosing protocol relat...

journal_title：Expert review of clinical immunology

authors： Mok CC

更新日期：2017-01-01 00:00:00

abstract：:Ulcerative colitis is a chronic condition that requires long-term treatment. The first-line therapy remains 5-aminosalicylic acid, which is available in several different formulations and dosing schedules. Several studies have demonstrated that adherence rates to prescribed 5-aminosalicylic acid products are below tho...

journal_title：Expert review of clinical immunology

authors： Bernick SJ,Kane S

更新日期：2010-07-01 00:00:00

abstract：INTRODUCTION:CD40 ligand (CD40L) deficiency or X-linked Hyper-IgM syndrome is a severe primary immunodeficiency caused by mutations in the CD40L gene. Despite currently available treatments, CD40L-deficient patients remain susceptible to life-threatening infections and have poor long term survival. Areas covered: Here,...

journal_title：Expert review of clinical immunology

authors： França TT,Barreiros LA,Al-Ramadi BK,Ochs HD,Cabral-Marques O,Condino-Neto A

更新日期：2019-05-01 00:00:00

abstract：:Evaluation of: Chung CP, Avalos I, Oeser A et al. High prevalence of the metabolic syndrome in patients with systemic lupus erythematosus: association with disease characteristic and cardiovascular risk factors. Ann. Rheum. Dis. 66(2), 208-214 (2007). Systemic lupus erythematosus is associated with higher rates of car...

journal_title：Expert review of clinical immunology

authors： Jara LJ,Medina G,Vega-Hinojosa O

更新日期：2007-03-01 00:00:00

abstract：:In adulthood, new or recurrent asthma is caused by work in approximately 10% of cases. The term occupational asthma is reserved for those cases arising from respiratory hypersensitivity to a specific workplace agent; in others (work-exacerbated asthma) the mechanism is of nonspecific airway irritation on a background ...

journal_title：Expert review of clinical immunology

authors： Cullinan P

更新日期：2005-05-01 00:00:00

abstract：INTRODUCTION:Patients with features of both asthma and chronic obstructive pulmonary disease (COPD) ('asthma-COPD overlap') experience greater symptom burden and higher risk of adverse health outcomes than those with asthma or COPD alone. However, virtually no pharmacotherapy studies have been performed in this overlap...

journal_title：Expert review of clinical immunology

authors： Lau EMT,Roche NA,Reddel HK

更新日期：2017-05-01 00:00:00

abstract：INTRODUCTION:The incidence of inflammatory bowel disease (IBD) has increased over the last 50 years. It is now recognized that several genetic defects can express an IBD-like phenotype at very early onset (<6 years). AREAS COVERED:The aim of this review was to update knowledge concerning the specificity of IBD at onse...

journal_title：Expert review of clinical immunology

authors： Capriati T,Cardile S,Papadatou B,Romano C,Knafelz D,Bracci F,Diamanti A

更新日期：2016-09-01 00:00:00

abstract：:Although training and exercise have several benefits, overdoing it might not necessarily be a good thing. For instance, elite athletes have an increased risk for asthma and allergy. Several mechanisms can be implicated for this risk, which include the interplay between environmental training factors and athlete's pers...

journal_title：Expert review of clinical immunology

authors： Silva D,Moreira A

更新日期：2015-01-01 00:00:00

abstract：:The course of inflammatory bowel diseases is heterogeneous and varies over time. Therefore, the search for predictive factors has increasingly become the focus of research. Mucosal healing has emerged as an important objective, as evidence indicates that it is associated with improved disease outcome. Nevertheless, ma...

journal_title：Expert review of clinical immunology

authors： Miheller P,Mandel MD,Mullner K,Lakatos PL

更新日期：2013-09-01 00:00:00

abstract：:Thymic stromal lymphopoietin (TSLP) is an IL-7-related cytokine expressed predominantly by barrier epithelial cells. TSLP is a potent activator of several cell types, including myeloid-derived dendritic cells, monocytes/macrophages and mast cells. Recent studies have revealed an important role for TSLP in the initiati...

journal_title：Expert review of clinical immunology

authors： Miazgowicz MM,Headley MB,Larson RP,Ziegler SF

更新日期：2009-09-01 00:00:00

abstract：INTRODUCTION:Highly sensitized patients awaiting a kidney transplant accrue on the transplant waiting list. The breadth of HLA antibodies in this subpopulation of patients precludes receiving a compatible organ offer through regular allocation within an acceptable time-frame. Areas covered: Several alternative options ...

journal_title：Expert review of clinical immunology

authors： Heidt S,Claas FHJ

更新日期：2018-08-01 00:00:00

abstract：INTRODUCTION:Allergic conditions such as asthma and atopic dermatitis have a high prevalence but represent a heterogeneous group of diseases despite similar clinical presentation and underlying pathophysiology. A better understanding of the phenotypes and endotypes of these diseases has driven rapid development of biol...

journal_title：Expert review of clinical immunology

authors： Manka LA,Wechsler ME

更新日期：2018-04-01 00:00:00

abstract：:Eosinophilic esophagitis (EoE) represents a prevalent chronic esophageal disorder. Since the condition was first described, its pathophysiology has been known to have an immune-allergic origin, but the high response rate to dietary therapies based on feeding patients exclusively with amino acid-based elemental formula...

journal_title：Expert review of clinical immunology

authors： Arias A,Lucendo AJ

更新日期：2014-01-01 00:00:00

abstract：:Non-immediate drug reactions (NIR) are induced by specific immunological mechanisms and involve the recognition of hapten molecules by the immune system, with the participation of dendritic cells and other antigen-presenting cells. This process is followed by an effector response that can induce several clinical entit...

journal_title：Expert review of clinical immunology

authors： Perkins JR,Ariza A,Blanca M,Fernández TD

更新日期：2014-11-01 00:00:00

abstract：:The 31st Annual Meeting of the American Society for Reproductive Immunology provided an excellent platform for basic and clinical scientists to brainstorm on current reproductive health issues such as repeated implantation and pregnancy failure, preterm birth, preeclampsia and genital tract infections such as HIV. The...

journal_title：Expert review of clinical immunology

authors： Joukhadar J,Nevers T,Kalkunte S

更新日期：2011-09-01 00:00:00

abstract：:Some chemotherapeutic agents and all radiation therapy generates reactive oxygen species (ROS), which induce apoptosis in cancer cells. As ROS play a role in drug-induced apoptosis, one might suspect that antioxidants may inhibit ROS and prevent apoptosis of cancer cells. In order to find an answer to whether or not t...

journal_title：Expert review of clinical immunology

authors： Akbas HS,Timur M,Ozben T

更新日期：2006-11-01 00:00:00

abstract：:Dendritic cell (DC) immunotherapy is a clinical reality. Despite two decades of considerable data demonstrating the feasibility of using DCs to prolong transplant allograft survival and to prevent autoimmunity, only now are these cells entering clinical trials in humans. Type 1 diabetes is the first autoimmune disorde...

journal_title：Expert review of clinical immunology

authors： Phillips B,Giannoukakis N,Trucco M

更新日期：2009-05-01 00:00:00

abstract：:Atherosclerosis is the major cause of cardiovascular disease (CVD), which represents the major cause of death. During recent years, it has become clear that atherosclerosis is a chronic inflammatory condition where immunity could play an important role. Usually, it is when atherosclerotic plaques rupture that CVD foll...

journal_title：Expert review of clinical immunology

authors： Frostegård J

更新日期：2015-02-01 00:00:00

abstract：:Introduction: The majority of the patients with anti-neutrophil cytoplasmic autoantibody (ANCA) associated vasculitis (AAV) achieve remission with effective induction therapy. Therefore, prevention of relapses and avoiding long-term damage and treatment-related toxicity are major challenges.Areas covered: This review ...

journal_title：Expert review of clinical immunology

authors： Berti A,Specks U

更新日期：2019-12-01 00:00:00

abstract：:Metabolic syndrome is a highly atherogenic state in which hyperglycemia, dyslipidemia and hypertension cluster in one individual. Intra-abdominal visceral fat accumulation plays a key role in the development of these disorders and the occurrence of metabolic syndrome. We have investigated adipocyte functions intensive...

journal_title：Expert review of clinical immunology

authors： Matsuzawa Y

更新日期：2007-01-01 00:00:00

abstract：BACKGROUND:Allergic diseases are among the most common diseases in humans. Besides allergen avoidance, allergen-specific immunotherapy is the only causative treatment option. During recent years, many innovations of this therapy have emerged. METHODS:Selective literature research in Medline and PubMed, under the inclu...

journal_title：Expert review of clinical immunology

authors： Klimek L,Pfaar O

更新日期：2013-05-01 00:00:00

abstract：INTRODUCTION:Biologic drugs have revolutionized the treatment of moderate to severe psoriasis in recent years because of their high efficacy and low risk of toxicity. However, even within the group of biologic therapies, there are differences related to the different mechanisms of action. Areas covered: We review the m...

journal_title：Expert review of clinical immunology

authors： Carrascosa JM,Del-Alcazar E

更新日期：2018-04-01 00:00:00

abstract：:Background: The etiology of allergic rhinitis includes an increase in cytokine levels, including IL- 4, IL-13, IL-17, and reduction in B7 homologous 1 (B7-H1) or programmed cell death-1 ligand-1 (PD-L1), a new member of the CD28: B7 stimulant molecule family. The aim of this study was to determine the relationship bet...

journal_title：Expert review of clinical immunology

authors： Nasiri Kalmarzi R,Fakhimi R,Manouchehri F,Ataee P,Naleini N,Babaei E,Azadi N,Rabeti K,Kooti W

更新日期：2019-08-01 00:00:00

abstract：:Mounting evidence suggests insulin is an important and potentially initiating antigen in the pathogenesis of Type 1 diabetes. High-affinity insulin antibodies are found early in disease development and appear to predict progression. Insulin is the only Type 1 diabetes auto-antigen with exclusive pancreatic expression ...

journal_title：Expert review of clinical immunology

authors： Wicklow BA,Polychronakos C

更新日期：2009-01-01 00:00:00

abstract：:Inflammatory bowel disease includes ulcerative colitis and Crohn's disease, which are both inflammatory disorders of the gastrointestinal tract. Both types of inflammatory bowel disease have a complex etiology, resulting from a genetically determined susceptibility interacting with environmental factors, including the...

journal_title：Expert review of clinical immunology

authors： Ferguson LR

更新日期：2013-08-01 00:00:00

abstract：:In this review, recent changes in both treatments and outcomes of rheumatoid arthritis (RA) in Japan were analyzed by viewing the National Database of Rheumatic Diseases by iR-net, one of the largest clinical databases for RA patients in Japan. Regarding drug therapy, the use of methotrexate has been continuously incr...

journal_title：Expert review of clinical immunology

authors： Saeki Y,Matsui T,Saisho K,Tohma S

更新日期：2012-07-01 00:00:00

abstract：OBJECTIVES:Impairment in early B-cell development can cause a predominantly antibody deficiency with severe depletion of peripheral B-cells. Mutations in the gene encoding for Bruton's-tyrosine-kinase (BTK) and the components of the pre-B-cell receptor complex or downstream signaling molecules have been related to this...

journal_title：Expert review of clinical immunology

authors： Abolhassani H,Vitali M,Lougaris V,Giliani S,Parvaneh N,Parvaneh L,Mirminachi B,Cheraghi T,Khazaei H,Mahdaviani SA,Kiaei F,Tavakolinia N,Mohammadi J,Negahdari B,Rezaei N,Hammarstrom L,Plebani A,Aghamohammadi A

更新日期：2016-01-01 00:00:00