Recent insights into CD4+ T-cell specificity and function in type 1 diabetes.

Abstract:

:Type 1 diabetes (T1D) is caused by T-cell-mediated destruction of the insulin-producing beta-cells in the pancreas. Genetic and immunological evidence from humans and mouse models indicates that CD4(+) T cells play a crucial role in the development and prevention of T1D. The dichotomy between CD4(+) T regulatory and effector T cells has encouraged research into the role of these cell subsets in T1D. New antigens and epitopes recognized by CD4(+) T cells in affected individuals have been identified. Growing knowledge of T-cell specificity and function is helping to develop new assays for analyzing islet antigen-specific CD4(+) T cells from human blood. Here we discuss, with particular reference to human studies, advances in our understanding of CD4(+) T-cell responses in T1D.

authors

Mannering SI,Brodnicki TC

doi

10.1586/1744666X.3.4.557

subject

Has Abstract

pub_date

2007-07-01 00:00:00

pages

557-64

issue

4

eissn

1744-666X

issn

1744-8409

journal_volume

3

pub_type

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