Transplantation in highly sensitized patients: challenges and recommendations.

Abstract:

INTRODUCTION:Highly sensitized patients awaiting a kidney transplant accrue on the transplant waiting list. The breadth of HLA antibodies in this subpopulation of patients precludes receiving a compatible organ offer through regular allocation within an acceptable time-frame. Areas covered: Several alternative options to receive a transplant exist for these patients, including additional priority in regular allocation, special programs based on allocation through acceptable antigens, kidney paired donation programs, desensitization protocols, or a combination of the latter two. In this review, these options and their outcomes are discussed as well as some possibilities to further enhance transplantation of this disadvantaged group of patients. Expert commentary: For highly sensitized patients, special attention is required, for which several strategies may apply. A step-wise approach may be the optimal strategy to facilitate successful transplantation of highly sensitized patients.

authors

Heidt S,Claas FHJ

doi

10.1080/1744666X.2018.1498335

subject

Has Abstract

pub_date

2018-08-01 00:00:00

pages

673-679

issue

8

eissn

1744-666X

issn

1744-8409

journal_volume

14

pub_type

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