Abstract:
INTRODUCTION:Patients with features of both asthma and chronic obstructive pulmonary disease (COPD) ('asthma-COPD overlap') experience greater symptom burden and higher risk of adverse health outcomes than those with asthma or COPD alone. However, virtually no pharmacotherapy studies have been performed in this overlap population, leading to confusion amongst clinicians regarding therapeutic approaches. Areas covered: A pragmatic approach is suggested to identify patients with typical asthma, typical COPD, and those with overlap features. Interim clinical guidance on the treatment of asthma-COPD overlap is provided, acknowledging that these recommendations are based on expert opinion given the paucity of available evidence. Expert commentary: There is an urgent need for new studies in patients with asthma-COPD overlap to evaluate the efficacy and safety of existing pharmacotherapeutic options. Multiple underlying mechanisms are likely to contribute to the development of asthma-COPD overlap and a greater understanding of these mechanisms may allow a personalised approach to therapy in the future.
journal_name
Expert Rev Clin Immunoljournal_title
Expert review of clinical immunologyauthors
Lau EMT,Roche NA,Reddel HKdoi
10.1080/1744666X.2017.1273109subject
Has Abstractpub_date
2017-05-01 00:00:00pages
449-455issue
5eissn
1744-666Xissn
1744-8409journal_volume
13pub_type
杂志文章,评审abstract:INTRODUCTION:The etiology of atopic dermatitis (AD) is multifactorial with interaction between genetics, immune and environmental factors. Areas covered: We review the role of prenatal exposures, irritants and pruritogens, pathogens, climate factors, including temperature, humidity, ultraviolet radiation, outdoor and i...
journal_title:Expert review of clinical immunology
pub_type: 杂志文章,评审
doi:10.1080/1744666X.2016.1212660
更新日期:2017-01-01 00:00:00
abstract::Introduction: While biologic agents that can be used for treating pemphigus vulgaris (PV) are increasing, themajority of the world's PV patients can afford only corticosteroids (CS) and some immunosuppressive agents (ISA). Areas covered: The spectrum of side effects encountered when PV patients receive high-dose, long...
journal_title:Expert review of clinical immunology
pub_type: 杂志文章,评审
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更新日期:2019-10-01 00:00:00
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journal_title:Expert review of clinical immunology
pub_type: 杂志文章
doi:10.1586/1744666X.2.4.519
更新日期:2006-07-01 00:00:00
abstract::Hematopoietic stem cell transplantation (HSCT), both allogeneic and autologous, has become one of the hottest topics in clinical immunology. One of the main autoimmune diseases in which HSCT has been extensively tried during the last decade is multiple sclerosis (MS). A few original papers and many anecdotal reports h...
journal_title:Expert review of clinical immunology
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journal_title:Expert review of clinical immunology
pub_type: 杂志文章,评审
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更新日期:2018-12-01 00:00:00
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journal_title:Expert review of clinical immunology
pub_type: 杂志文章,评审
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journal_title:Expert review of clinical immunology
pub_type: 杂志文章,评审
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更新日期:2011-01-01 00:00:00
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journal_title:Expert review of clinical immunology
pub_type: 杂志文章,评审
doi:10.1080/1744666X.2018.1531704
更新日期:2018-12-01 00:00:00
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journal_title:Expert review of clinical immunology
pub_type: 杂志文章,评审
doi:10.1080/1744666X.2019.1561281
更新日期:2019-02-01 00:00:00
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journal_title:Expert review of clinical immunology
pub_type: 杂志文章
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journal_title:Expert review of clinical immunology
pub_type: 杂志文章,评审
doi:10.1586/1744666X.2015.977260
更新日期:2015-01-01 00:00:00
abstract:INTRODUCTION:The survival of SLE patients has improved significantly over the past few decades placing them at increased risk of cardiovascular disease (CVD), malignancies, and osteoporosis, among other comorbidities. The aim of this review was to assess the incidence and prevalence of comorbidities in these patients a...
journal_title:Expert review of clinical immunology
pub_type: 杂志文章,评审
doi:10.1080/1744666X.2017.1327353
更新日期:2017-08-01 00:00:00
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journal_title:Expert review of clinical immunology
pub_type: 杂志文章,评审
doi:10.1586/1744666X.2015.993970
更新日期:2015-02-01 00:00:00
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journal_title:Expert review of clinical immunology
pub_type: 杂志文章
doi:10.1586/1744666X.2.2.309
更新日期:2006-03-01 00:00:00
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journal_title:Expert review of clinical immunology
pub_type: 杂志文章
doi:10.1586/1744666X.3.5.695
更新日期:2007-09-01 00:00:00
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journal_title:Expert review of clinical immunology
pub_type: 杂志文章,评审
doi:10.1586/eci.12.110
更新日期:2013-03-01 00:00:00
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journal_title:Expert review of clinical immunology
pub_type: 杂志文章,评审
doi:10.1080/1744666X.2018.1459188
更新日期:2018-04-01 00:00:00
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journal_title:Expert review of clinical immunology
pub_type: 杂志文章,评审
doi:10.1586/1744666X.2016.1147957
更新日期:2016-06-01 00:00:00
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journal_title:Expert review of clinical immunology
pub_type: 杂志文章,评审
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更新日期:2011-09-01 00:00:00
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journal_title:Expert review of clinical immunology
pub_type: 杂志文章,评审
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更新日期:2013-04-01 00:00:00
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journal_title:Expert review of clinical immunology
pub_type: 杂志文章,评审
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更新日期:2012-07-01 00:00:00
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journal_title:Expert review of clinical immunology
pub_type: 杂志文章,评审
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更新日期:2012-05-01 00:00:00
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journal_title:Expert review of clinical immunology
pub_type: 杂志文章,评审
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更新日期:2014-05-01 00:00:00
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journal_title:Expert review of clinical immunology
pub_type: 杂志文章,评审
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更新日期:2017-01-01 00:00:00
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journal_title:Expert review of clinical immunology
pub_type: 杂志文章,评审
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更新日期:2012-03-01 00:00:00
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journal_title:Expert review of clinical immunology
pub_type: 杂志文章,评审
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更新日期:2014-09-01 00:00:00
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journal_title:Expert review of clinical immunology
pub_type: 杂志文章,评审
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更新日期:2016-12-01 00:00:00
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journal_title:Expert review of clinical immunology
pub_type: 杂志文章,评审
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更新日期:2017-03-01 00:00:00
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journal_title:Expert review of clinical immunology
pub_type: 杂志文章,评审
doi:10.1586/1744666X.2014.966691
更新日期:2014-11-01 00:00:00
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journal_title:Expert review of clinical immunology
pub_type: 杂志文章,评审
doi:10.1080/1744666X.2016.1215245
更新日期:2017-02-01 00:00:00