Abstract：
:Sprague-Dawley rats were intoxicated with alcohol or morphine, by ingestion in a fluid diet. Alcohol or morphine preference was studied in two-bottle choice tests. Preference increased up to a certain level with increasing time of intoxication at one dose level. Some 10% of the animals had an extremely high preference already after a short ingestion period. Another 10% showed an extremely low drug preference even after long intoxication. When rats were consecutively intoxicated with morphine and alcohol, or vice versa, followed by choice tests with the respective drug, the statistical correlation between alcohol and morphine preference was weak in the individual rats. Approximately 20% of the high morphine preference rats also had a high alcohol preference. Early postnatal morphine intoxication slightly increased morphine, but not alcohol preference in the physically dependent male adult rats. Thus, there seem to be different and specific mechanisms underlying the alcohol and opiate preference in rats, although some overlapping probably exists.
journal_name
Drug Alcohol Dependjournal_title
Drug and alcohol dependenceauthors
Rönnbäck Ldoi
10.1016/0376-8716(88)90067-1subject
Has Abstractpub_date
1988-07-01 00:00:00pages
177-82issue
3eissn
0376-8716issn
1879-0046pii
0376-8716(88)90067-1journal_volume
21pub_type
杂志文章abstract：BACKGROUND:Previously reported comorbidity between schizophrenia and substance use may be explained by shared underlying risk factors, such as genetic background. The aim of the present longitudinal study was to investigate how a genetic predisposition to schizophrenia was associated with patterns of substance use (can...
journal_title：Drug and alcohol dependence
pub_type： 杂志文章
doi：10.1016/j.drugalcdep.2018.05.024
更新日期：2018-09-01 00:00:00
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journal_title：Drug and alcohol dependence
pub_type： 杂志文章
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更新日期：2021-02-01 00:00:00
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journal_title：Drug and alcohol dependence
pub_type： 杂志文章
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更新日期：2019-11-01 00:00:00
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journal_title：Drug and alcohol dependence
pub_type： 杂志文章
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更新日期：2011-12-01 00:00:00
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journal_title：Drug and alcohol dependence
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.drugalcdep.2011.08.001
更新日期：2012-01-01 00:00:00
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doi：10.1016/0376-8716(80)90144-1
更新日期：1980-06-01 00:00:00
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journal_title：Drug and alcohol dependence
pub_type： 临床试验,杂志文章,随机对照试验
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更新日期：2003-12-11 00:00:00
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journal_title：Drug and alcohol dependence
pub_type： 杂志文章
doi：10.1016/j.drugalcdep.2013.02.004
更新日期：2013-09-01 00:00:00
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journal_title：Drug and alcohol dependence
pub_type： 杂志文章,评审
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更新日期：2009-10-01 00:00:00
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journal_title：Drug and alcohol dependence
pub_type： 杂志文章
doi：10.1016/j.drugalcdep.2012.03.024
更新日期：2012-09-01 00:00:00
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journal_title：Drug and alcohol dependence
pub_type： 杂志文章
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更新日期：2001-04-01 00:00:00
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journal_title：Drug and alcohol dependence
pub_type：
doi：10.1016/s0376-8716(00)00171-x
更新日期：2001-05-01 00:00:00
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journal_title：Drug and alcohol dependence
pub_type： 杂志文章
doi：10.1016/0376-8716(85)90113-9
更新日期：1985-11-01 00:00:00
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journal_title：Drug and alcohol dependence
pub_type： 杂志文章
doi：10.1016/s0376-8716(00)00161-7
更新日期：2001-03-01 00:00:00
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pub_type： 杂志文章
doi：10.1016/j.drugalcdep.2020.108162
更新日期：2020-09-01 00:00:00
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journal_title：Drug and alcohol dependence
pub_type： 杂志文章
doi：10.1016/j.drugalcdep.2013.08.008
更新日期：2013-12-01 00:00:00
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journal_title：Drug and alcohol dependence
pub_type： 杂志文章
doi：10.1016/0376-8716(94)90115-5
更新日期：1994-04-01 00:00:00
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journal_title：Drug and alcohol dependence
pub_type： 杂志文章,meta分析
doi：10.1016/j.drugalcdep.2015.05.030
更新日期：2015-08-01 00:00:00
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journal_title：Drug and alcohol dependence
pub_type： 杂志文章
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journal_title：Drug and alcohol dependence
pub_type： 杂志文章
doi：10.1016/j.drugalcdep.2016.10.032
更新日期：2017-01-01 00:00:00
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journal_title：Drug and alcohol dependence
pub_type： 杂志文章
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更新日期：2001-05-01 00:00:00
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journal_title：Drug and alcohol dependence
pub_type： 杂志文章
doi：10.1016/j.drugalcdep.2019.05.019
更新日期：2019-10-01 00:00:00
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journal_title：Drug and alcohol dependence
pub_type： 杂志文章
doi：10.1016/0376-8716(79)90013-9
更新日期：1979-05-01 00:00:00
abstract：BACKGROUND:Despite harmful consequences of drug addiction, it is common for individuals with substance use disorders to deny having problems with drugs. Emerging evidence suggests that some drug users lack insight into their behavior due to neurocognitive dysfunction, but little research has examined potential neurocog...
journal_title：Drug and alcohol dependence
pub_type： 杂志文章
doi：10.1016/j.drugalcdep.2015.03.004
更新日期：2015-06-01 00:00:00
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journal_title：Drug and alcohol dependence
pub_type： 杂志文章
doi：10.1016/j.drugalcdep.2007.01.009
更新日期：2007-07-10 00:00:00
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journal_title：Drug and alcohol dependence
pub_type： 杂志文章
doi：10.1016/s0376-8716(02)00337-x
更新日期：2003-05-01 00:00:00
abstract：:This paper reports on the incidence of risk taking behaviours, and the relationship between risk perception and risk behaviours in a sample of 1245 Sydney injecting drug users (IDUs). Almost all respondents reported engaging in behaviours that placed them at risk of HIV infection: 32.9% through unsafe injecting, 84.4%...
journal_title：Drug and alcohol dependence
pub_type： 杂志文章
doi：10.1016/0376-8716(93)90035-o
更新日期：1993-06-01 00:00:00
abstract：BACKGROUND:The Russian Federation is experiencing a very high rate of HIV infection among people who inject drugs (PWID). However, few studies have explored characteristics of people with co-occurring opioid use disorders and HIV, including psychiatric symptom presentations and how these symptoms might relate to qualit...
journal_title：Drug and alcohol dependence
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.drugalcdep.2016.12.007
更新日期：2017-03-01 00:00:00
abstract：BACKGROUND:To describe all-cause and cause-specific mortality in a cohort of people who had ever injected drugs (PWID) with a low prevalence of HIV over 20-30 years. METHODS:Using a retrospective study design, identifying data from a cohort of PWID recruited between 1982 and 1993 through in-patient drug treatment serv...
journal_title：Drug and alcohol dependence
pub_type： 杂志文章
doi：10.1016/j.drugalcdep.2014.11.008
更新日期：2015-02-01 00:00:00
abstract：OBJECTIVE:To assess the state of peer-reviewed literature surrounding uptake and adherence of antiretroviral therapy (ART) among HIV-positive women who use drugs (WWUD). METHODS:Consistent with PRISMA-ScR guidelines, we conducted a scoping literature review on ART uptake and adherence among WWUD, searching PubMed, Emb...
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pub_type： 杂志文章,评审
doi：10.1016/j.drugalcdep.2020.108218
更新日期：2020-10-01 00:00:00
