Reversal of acute effects of high dose morphine on lymphocyte activity by chlorisondamine.

Abstract:

:To explore the mechanisms mediating the effects of acute morphine on the immune system, effects of ganglionic blockade with chlorisondamine on acute high dose morphine-induced alterations in blood lymphocyte proliferation, white blood cell counts, spleen lymphocyte proliferation and splenic natural killer (NK) cell cytolytic activity were examined in male Sprague--Dawley rats. Two hours after morphine (30 mg/kg, s.c.) administration, blood lymphocyte proliferation (ConA) was decreased 85%; this effect was antagonized by chlorisondamine (5 mg/kg, i.p.). Notably, however, such morphine exposure did not significantly decrease splenic lymphocyte proliferation, although depression of NK cell activity was also evident and appeared to be chlorisondamine-sensitive. Immune effects of morphine 1 h after treatment were somewhat different. In this case, blood lymphocyte proliferation decreased and plasma levels of corticosterone increased, with ED(50) values of 2.2 and 7.8 mg/kg, respectively. Splenic lymphocyte proliferation and NK activity were also significantly depressed in the 1-h exposure paradigm, but only after administration of 30 mg/kg morphine. These results indicate that chlorisondamine blocks the effects of relatively high doses of morphine on blood lymphocyte activity and indicate that blood lymphocyte proliferation is more sensitive to effects of acute morphine exposure than splenic lymphocyte proliferation, NK cell cytolytic activity and activation of the HPA axis.

journal_name

Drug Alcohol Depend

authors

Mellon RD,Bayer BM

doi

10.1016/s0376-8716(00)00184-8

keywords:

subject

Has Abstract

pub_date

2001-04-01 00:00:00

pages

141-7

issue

2

eissn

0376-8716

issn

1879-0046

pii

S0376-8716(00)00184-8

journal_volume

62

pub_type

杂志文章
  • Mortality and cause of death in a cohort of people who had ever injected drugs in Glasgow: 1982-2012.

    abstract:BACKGROUND:To describe all-cause and cause-specific mortality in a cohort of people who had ever injected drugs (PWID) with a low prevalence of HIV over 20-30 years. METHODS:Using a retrospective study design, identifying data from a cohort of PWID recruited between 1982 and 1993 through in-patient drug treatment serv...

    journal_title:Drug and alcohol dependence

    pub_type: 杂志文章

    doi:10.1016/j.drugalcdep.2014.11.008

    authors: Nambiar D,Weir A,Aspinall EJ,Stoové M,Hutchinson S,Dietze P,Waugh L,Goldberg DJ

    更新日期:2015-02-01 00:00:00

  • Conditional probabilities of substance use disorders and associated risk factors: Progression from first use to use disorder on alcohol, cannabis, stimulants, sedatives and opioids.

    abstract:BACKGROUND:Relatively little is known about factors that may lead to the development of a substance use disorder (SUD), across a range of drug classes. This study aimed to identify factors that predict the likelihood of transition from use to SUD and the speed with which this may occur at the population level, with a f...

    journal_title:Drug and alcohol dependence

    pub_type: 杂志文章

    doi:10.1016/j.drugalcdep.2018.10.010

    authors: Marel C,Sunderland M,Mills KL,Slade T,Teesson M,Chapman C

    更新日期:2019-01-01 00:00:00

  • Gestational buprenorphine exposure: Effects on pregnancy, development, neonatal opioid withdrawal syndrome, and behavior in a translational rodent model.

    abstract:BACKGROUND:The opioid crisis has led to an increased number of pregnant opioid-dependent women receiving opioid-maintenance therapy (e.g. buprenorphine, BUP), but little is known about the consequences of gestational BUP exposure on pregnancy outcomes, maternal care, or offspring development. METHODS:Our translational...

    journal_title:Drug and alcohol dependence

    pub_type: 杂志文章

    doi:10.1016/j.drugalcdep.2019.107625

    authors: Wallin CM,Bowen SE,Roberge CL,Richardson LM,Brummelte S

    更新日期:2019-12-01 00:00:00

  • Early age at childhood parental incarceration and STI/HIV-related drug use and sex risk across the young adult lifecourse in the US: Heightened vulnerability of black and Hispanic youth.

    abstract:BACKGROUND:We measured associations between parental incarceration and STI/HIV-related drug use and sex risk, assessing differences by race, age at first parental incarceration, and potential mediators of the relationship. METHODS:We used Waves I (adolescence), III (young adulthood), and IV (adulthood) of the National...

    journal_title:Drug and alcohol dependence

    pub_type: 杂志文章

    doi:10.1016/j.drugalcdep.2017.11.006

    authors: Khan MR,Scheidell JD,Rosen DL,Geller A,Brotman LM

    更新日期:2018-02-01 00:00:00

  • Comparison of tobacco, alcohol and illegal drug usage among school students in three Pacific Island societies.

    abstract:BACKGROUND:Many Pacific Island countries are in social and epidemiological transition, but there are little population data about drug and alcohol usage among adolescents in this region. METHODS:Random samples of school students aged 11-17 years completed surveys in three populations: Pohnpei State in the Federated St...

    journal_title:Drug and alcohol dependence

    pub_type: 杂志文章

    doi:10.1016/j.drugalcdep.2006.08.030

    authors: Smith BJ,Phongsavan P,Bauman AE,Havea D,Chey T

    更新日期:2007-04-17 00:00:00

  • Association between buprenorphine/naloxone and high-dose opioid analgesic prescribing in Kentucky, 2012-2017.

    abstract:INTRODUCTION:Buprenorphine/naloxone treatment is a highly effective treatment for opioid use disorder decreasing illicit opioid use and both all-cause and opioid-involved overdose mortality. The purpose of this study was to investigate the relationships between buprenorphine/naloxone prescribing and high-dose opioid an...

    journal_title:Drug and alcohol dependence

    pub_type: 杂志文章

    doi:10.1016/j.drugalcdep.2019.107606

    authors: Luu H,Slavova S,Freeman PR,Lofwall M,Browning S,Slade E,Bush H

    更新日期:2019-12-01 00:00:00

  • The two-faceted nature of impulsivity in patients with borderline personality disorder and substance use disorder.

    abstract:BACKGROUND:Impulsivity, which has been the subject of extensive debate in psychiatric research, is a clinically important concept, especially with respect to Borderline Personality Disorder (BPD) and Substance Use Disorders (SUD). The current study aims to examine the presence of two aspects of impulsivity (self-report...

    journal_title:Drug and alcohol dependence

    pub_type: 杂志文章

    doi:10.1016/j.drugalcdep.2016.03.015

    authors: Maraz A,Andó B,Rigó P,Harmatta J,Takách G,Zalka Z,Boncz I,Lackó Z,Urbán R,van den Brink W,Demetrovics Z

    更新日期:2016-06-01 00:00:00

  • Potential undercounting of overdose deaths caused by specific drugs in vital statistics data: An analysis of Florida.

    abstract:INTRODUCTION:Due largely to ambiguous or incomplete information provided on death certificates, the widely cited Multiple Cause of Death (MCOD) data reported by the U.S. Centers for Disease Control and Prevention has been shown to undercount the number of fatal overdoses caused by specific drugs. However, the extent of...

    journal_title:Drug and alcohol dependence

    pub_type: 杂志文章

    doi:10.1016/j.drugalcdep.2019.107807

    authors: Quast TC

    更新日期:2020-02-01 00:00:00

  • Finding order in the DSM-IV nicotine dependence syndrome: a Rasch analysis.

    abstract::Little is known about the relative severity or typical sequence of Diagnostic and Statistical Manual (DSM-IV) symptoms of nicotine dependence. Using data from the National Comorbidity Study (NCS), the current study used a Rasch logistic item response model to assess the unidimensionality of the construct of nicotine d...

    journal_title:Drug and alcohol dependence

    pub_type: 杂志文章

    doi:10.1016/s0376-8716(03)00201-1

    authors: Strong DR,Kahler CW,Ramsey SE,Brown RA

    更新日期:2003-11-24 00:00:00

  • E-cigarette use frequency and motivations among current users in middle school.

    abstract:INTRODUCTION:The popularity of electronic cigarettes (e-cigarettes) has increased worldwide among youth, even in countries like Mexico that ban them. This study aimed to assess the correlates of e-cigarette use frequency among Mexican students who currently use ecigarettes, as well as to describe their reasons for use....

    journal_title:Drug and alcohol dependence

    pub_type: 杂志文章

    doi:10.1016/j.drugalcdep.2019.107585

    authors: Zavala-Arciniega L,Lozano P,Kollath-Cattano C,Gutierrez-Torres DS,Arillo-Santillán E,Barrientos-Gutiérrez I,Hardin JW,Thrasher JF

    更新日期:2019-11-01 00:00:00

  • Quitting smoking and change in alcohol consumption in the International Tobacco Control (ITC) Four Country Survey.

    abstract::Although frequent heavy drinking has been associated with decreased odds of quitting smoking, the extent to which smoking cessation is associated with decreased alcohol consumption is less clear. The present study examined over a 2-year period whether individuals who quit smoking for at least 6 months, compared to tho...

    journal_title:Drug and alcohol dependence

    pub_type: 杂志文章

    doi:10.1016/j.drugalcdep.2010.02.008

    authors: Kahler CW,Borland R,Hyland A,McKee SA,O'Connor RJ,Fong GT,Cummings KM

    更新日期:2010-07-01 00:00:00

  • Characteristics and circumstances of death related to new psychoactive stimulants and hallucinogens in Australia.

    abstract:BACKGROUND:New psychoactive stimulants and hallucinogens comprise a range of "designer drugs" that have risen to prominence in the 21st century. The study aimed to: 1. Determine the characteristics, and circumstances of death, of all recorded cases of new psychoactive stimulant and hallucinogen-related death in Austral...

    journal_title:Drug and alcohol dependence

    pub_type: 杂志文章

    doi:10.1016/j.drugalcdep.2019.107556

    authors: Darke S,Duflou J,Peacock A,Farrell M,Lappin J

    更新日期:2019-11-01 00:00:00

  • Is ecstasy a drug of dependence?

    abstract::This paper examines the evidence for an MDMA or "ecstasy" dependence syndrome. Animal evidence suggests that MDMA may be a less potent reinforcer than other drugs, but that it does have dependence potential. This suggests that (a) ecstasy dependence might be less likely than dependence upon other drugs; and (b) factor...

    journal_title:Drug and alcohol dependence

    pub_type: 杂志文章,评审

    doi:10.1016/j.drugalcdep.2009.09.009

    authors: Degenhardt L,Bruno R,Topp L

    更新日期:2010-02-01 00:00:00

  • Delivery of nicotine aerosol to mice via a modified electronic cigarette device.

    abstract:BACKGROUND:Although both men and women use e-cigarettes, most preclinical nicotine research has focused on its effects in male rodents following injection. The goals of the present study were to develop an effective e-cigarette nicotine delivery system, to compare results to those obtained after subcutaneous (s.c.) inj...

    journal_title:Drug and alcohol dependence

    pub_type: 杂志文章

    doi:10.1016/j.drugalcdep.2016.12.004

    authors: Lefever TW,Lee YO,Kovach AL,Silinski MA,Marusich JA,Thomas BF,Wiley JL

    更新日期:2017-03-01 00:00:00

  • Mindfulness-Oriented Recovery Enhancement reduces opioid craving among individuals with opioid use disorder and chronic pain in medication assisted treatment: Ecological momentary assessments from a stage 1 randomized controlled trial.

    abstract:BACKGROUND:Methadone maintenance therapy (MMT) is an efficacious form of medication assisted treatment for opioid use disorder (OUD), yet many individuals on MMT relapse. Chronic pain and deficits in positive affective response to natural rewards may result in dysphoria that fuels opioid craving and promotes relapse. A...

    journal_title:Drug and alcohol dependence

    pub_type: 杂志文章,随机对照试验

    doi:10.1016/j.drugalcdep.2019.07.007

    authors: Garland EL,Hanley AW,Kline A,Cooperman NA

    更新日期:2019-10-01 00:00:00

  • Reasons for using flavored liquids among electronic cigarette users: A concept mapping study.

    abstract:BACKGROUND:Electronic cigarettes (ECIGs) aerosolize liquids often containing flavorants for inhalation. Few studies have examined the role of flavors in ECIG use. This study's purpose was to examine reasons for flavored ECIG use using a mixed-method approach, concept mapping (CM). METHODS:Forty-six past 30-day adult E...

    journal_title:Drug and alcohol dependence

    pub_type: 杂志文章

    doi:10.1016/j.drugalcdep.2016.07.007

    authors: Soule EK,Lopez AA,Guy MC,Cobb CO

    更新日期:2016-09-01 00:00:00

  • Cannabis use during alcohol treatment is associated with alcohol-related problems one-year post-treatment.

    abstract:BACKGROUND:Prior research shows that cannabis use during treatment for Alcohol Use Disorders (AUD) is related to fewer abstinent days from alcohol, although only among those who use cannabis 1-2x/month. Here we extend prior research by assessing the relationship between the frequency of cannabis use during AUD treatmen...

    journal_title:Drug and alcohol dependence

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1016/j.drugalcdep.2018.08.020

    authors: Subbaraman MS,Metrik J,Patterson D,Stout RL

    更新日期:2018-12-01 00:00:00

  • Evaluation of nicotine patch adherence measurement using self-report and saliva cotinine among abstainers in a smoking cessation trial.

    abstract:BACKGROUND:Adherence to nicotine patches relates to cessation. This is the first study to examine the validity of self-reported nicotine patch adherence relative to saliva cotinine. METHODS:We used data from 198 clinical trial participants who received 11 weeks of nicotine patches, self-reported patch use, had saliva ...

    journal_title:Drug and alcohol dependence

    pub_type: 杂志文章

    doi:10.1016/j.drugalcdep.2020.107967

    authors: Schnoll R,Paul Wileyto E,Gross R,Hitsman B,Hawk LW Jr,Cinciripini P,George TP,Benowitz NL,Fen Lubitz S,Ashare R,Tyndale RF,Lerman C

    更新日期:2020-05-01 00:00:00

  • Capturing habitualness of drinking and smoking behavior in humans.

    abstract:BACKGROUND:Recent findings suggest that overreliance on habit may be common in individuals diagnosed with addiction. To advance our understanding of habit in clinical samples and from behavioral measures, this study examines the interrelations between self-reported habit index for smoking and drinking as well as behavi...

    journal_title:Drug and alcohol dependence

    pub_type: 杂志文章

    doi:10.1016/j.drugalcdep.2019.107738

    authors: Ray LA,Du H,Grodin E,Bujarski S,Meredith L,Ho D,Nieto S,Wassum K

    更新日期:2020-02-01 00:00:00

  • Response inhibition and fronto-striatal-thalamic circuit dysfunction in cocaine addiction.

    abstract:BACKGROUND:Many studies have investigated how cognitive control may be compromised in cocaine addiction. Here, we extend this literature by employing spatial Independent Component Analysis (ICA) to describe circuit dysfunction in relation to impairment in response inhibition in cocaine addiction. METHODS:Fifty-five co...

    journal_title:Drug and alcohol dependence

    pub_type: 杂志文章

    doi:10.1016/j.drugalcdep.2018.07.037

    authors: Wang W,Worhunsky PD,Zhang S,Le TM,Potenza MN,Li CR

    更新日期:2018-11-01 00:00:00

  • A tripartite of HIV-risk for African American women: the intersection of drug use, violence, and depression.

    abstract::The intersection of drug use, violence, and depression with HIV-risk among African American women is an under explored area of research. The current analyses examine whether particular sexual risk behaviors are associated with exposure to violence, depression or both among 420 African American out-of-treatment female ...

    journal_title:Drug and alcohol dependence

    pub_type: 杂志文章

    doi:10.1016/s0376-8716(02)00345-9

    authors: Johnson SD,Cunningham-Williams RM,Cottler LB

    更新日期:2003-05-21 00:00:00

  • Efficacy of the Community Reinforcement and Family Training for concerned significant others of treatment-refusing individuals with alcohol dependence: A randomized controlled trial.

    abstract:BACKGROUND:The Community Reinforcement and Family Training (CRAFT) is a promising approach for Concerned Significant Others (CSOs) of alcohol-dependent individuals (ADI) that aims to engage treatment-refusing patients in alcohol treatment and to improve CSO functioning. To date, only two randomized controlled trials (R...

    journal_title:Drug and alcohol dependence

    pub_type: 杂志文章,随机对照试验

    doi:10.1016/j.drugalcdep.2016.04.015

    authors: Bischof G,Iwen J,Freyer-Adam J,Rumpf HJ

    更新日期:2016-06-01 00:00:00

  • Dose related risk of motor vehicle crashes after cannabis use.

    abstract::The role of Delta(9)-tetrahydrocannabinol (THC) in driver impairment and motor vehicle crashes has traditionally been established in experimental and epidemiological studies. Experimental studies have repeatedly shown that THC impairs cognition, psychomotor function and actual driving performance in a dose related man...

    journal_title:Drug and alcohol dependence

    pub_type: 杂志文章,评审

    doi:10.1016/j.drugalcdep.2003.10.008

    authors: Ramaekers JG,Berghaus G,van Laar M,Drummer OH

    更新日期:2004-02-07 00:00:00

  • An exploratory randomized controlled trial of a novel high-school-based smoking cessation intervention for adolescent smokers using abstinence-contingent incentives and cognitive behavioral therapy.

    abstract:BACKGROUND:There are few effective smoking cessation interventions for adolescent smokers. We developed a novel intervention to motivate tobacco use behavior change by (1) enhancing desire to quit through the use of abstinence-contingent incentives (CM), (2) increasing cessation skills through the use of cognitive beha...

    journal_title:Drug and alcohol dependence

    pub_type: 杂志文章,随机对照试验

    doi:10.1016/j.drugalcdep.2013.03.002

    authors: Krishnan-Sarin S,Cavallo DA,Cooney JL,Schepis TS,Kong G,Liss TB,Liss AK,McMahon TJ,Nich C,Babuscio T,Rounsaville BJ,Carroll KM

    更新日期:2013-09-01 00:00:00

  • Effects of ethanol in vitro on some parameters of the immune response.

    abstract::The action of ethanol (ETH) on murine lymphocyte subpopulations and on human peripheral blood mononuclear cells (PBMC) stimulated in vitro by mitogens was studied. ETH caused a concentration-dependent decrease in DNA synthesis in the different murine cell types. ETH was more immunosuppressive for T lymphocytes than fo...

    journal_title:Drug and alcohol dependence

    pub_type: 杂志文章

    doi:10.1016/0376-8716(89)90061-6

    authors: Levallois C,Rouahi N,Balmes JL,Mani JC

    更新日期:1989-12-01 00:00:00

  • Impaired time perception and motor timing in stimulant-dependent subjects.

    abstract::Stimulant-dependent individuals (SDI) have abnormal brain metabolism and structural changes involving dopaminergic target areas important for the processing of time. These individuals are also more impulsive and impaired in working memory and attention. The current study tested whether SDI show altered temporal proces...

    journal_title:Drug and alcohol dependence

    pub_type: 杂志文章

    doi:10.1016/j.drugalcdep.2007.03.005

    authors: Wittmann M,Leland DS,Churan J,Paulus MP

    更新日期:2007-10-08 00:00:00

  • Substance use and homelessness among emergency department patients.

    abstract:BACKGROUND:Homelessness and substance use often coexist, resulting in high morbidity. Emergency department (ED) patients have disproportionate rates of both homelessness and substance use, yet little research has examined the overlap of these issues in the ED setting. We aimed to characterize alcohol and drug use in a ...

    journal_title:Drug and alcohol dependence

    pub_type: 杂志文章

    doi:10.1016/j.drugalcdep.2018.04.021

    authors: Doran KM,Rahai N,McCormack RP,Milian J,Shelley D,Rotrosen J,Gelberg L

    更新日期:2018-07-01 00:00:00

  • Perceived discrimination in addiction recovery: Assessing the prevalence, nature, and correlates using a novel measure in a U.S. National sample.

    abstract:BACKGROUND:Alcohol and other drug (AOD) problems are among the most stigmatized conditions globally diminishing help-seeking due to fear of discrimination. Discrimination is common also among people already in AOD recovery, but little is known about the prevalence and nature of perceived discrimination. Greater knowled...

    journal_title:Drug and alcohol dependence

    pub_type: 杂志文章

    doi:10.1016/j.drugalcdep.2019.107667

    authors: Vilsaint CL,Hoffman LA,Kelly JF

    更新日期:2020-01-01 00:00:00

  • The relative validity of a chronological drinking record.

    abstract::The results of chronological and a daily drinking record are compared. The chronological record was completed by interviewers who probed for information on all drinking episodes during the last week. The daily record covered only the last day and was completed by the respondent without interviewer assistance. Because ...

    journal_title:Drug and alcohol dependence

    pub_type: 杂志文章

    doi:10.1016/0376-8716(80)90018-6

    authors: Gerstel EK,Harford TC,Pautler CC

    更新日期:1980-12-01 00:00:00

  • Adaptive changes in the dopamine system produced by chronic ethanol feeding.

    abstract::The consumption of ethanol by mice resulted in an altered sensitivity of the brain dopamine systems to perturbations produced by agonists and antagonists. The results indicate that ethanol feeding and withdrawal produces a state in which the normal coupling between dopamine receptors and the effectors for these recept...

    journal_title:Drug and alcohol dependence

    pub_type: 杂志文章

    doi:10.1016/0376-8716(79)90007-3

    authors: Hoffman PL,Tabakoff B

    更新日期:1979-05-01 00:00:00