Abstract:
:The dermal striated muscle panniculus carnosus (PC), prevalent in lower mammals with remnants in humans, is highly regenerative, and whose function is purported to be linked to defence and shivering thermogenesis. Given the heterogeneity of responses of different muscles to disease, we set out to characterize the PC in wild-type and muscular dystrophic mdx mice. The mouse PC contained mainly fast-twitch type IIB myofibers showing body wide distribution. The PC exemplified heterogeneity in myofiber sizes and a prevalence of central nucleated fibres (CNFs), hallmarks of regeneration, in wild-type and mdx muscles, which increased with age. PC myofibers were hypertrophic in mdx compared to wild-type mice. Sexual dimorphism was apparent with a two-fold increase in CNFs in PC from male versus female mdx mice. To evaluate myogenic potential, PC muscle progenitors were isolated from 8-week old wild-type and mdx mice, grown and differentiated for 7-days. Myogenic profiling of PC-derived myocytes suggested that male mdx satellite cells (SCs) were more myogenic than female counterparts, independent of SC density in PC muscles. Muscle regenerative differences in the PC were associated with alterations in expression of calcium handling regulatory proteins. These studies highlight unique aspects of the PC muscle and its potential as a model to study mechanisms of striated muscle regeneration in health and disease.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Bahri OA,Naldaiz-Gastesi N,Kennedy DC,Wheatley AM,Izeta A,McCullagh KJAdoi
10.1038/s41598-019-52071-2subject
Has Abstractpub_date
2019-11-04 00:00:00pages
15964issue
1issn
2045-2322pii
10.1038/s41598-019-52071-2journal_volume
9pub_type
杂志文章abstract::The stress distribution around endosseous implants is an important determinant of the surgical success. However, no method developed so far to determine the implant stability is sensitive to the loading conditions of the bone-implant interface (BII). The objective of this study is to investigate whether a quantitative...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-50665-4
更新日期:2019-10-02 00:00:00
abstract::Bursaphelenchus xylophilus is a quarantined migratory endoparasite known to cause severe economic losses in pine forest ecosystems. The study presents the nematicidal effects of halogenated indoles on B. xylophilus and their action mechanisms. 5-Iodoindole and abamectin (positive control) at low concentration (10 µg/m...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-07074-2
更新日期:2017-07-28 00:00:00
abstract::Drug-resistant bacteria represent a significant global threat. Given the dearth of new antibiotics, host-directed therapies (HDTs) are especially desirable. As IFN-gamma (IFNγ) plays a central role in host resistance to intracellular bacteria, including Mycobacterium tuberculosis, we searched for small molecules to au...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep24409
更新日期:2016-04-18 00:00:00
abstract::Head and neck squamous cell carcinoma (HNSCC) development is a multistage process includes the normal, dysplasia and squamous cell carcinoma (SCC) stages. Recently, increasing evidence has suggested that the tumor microenvironment (TME) is an integral part of malignant transformation. Exploring certain key node genes ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep20208
更新日期:2016-02-01 00:00:00
abstract::The 28,000-year-old remains of a woolly mammoth, named 'Yuka', were found in Siberian permafrost. Here we recovered the less-damaged nucleus-like structures from the remains and visualised their dynamics in living mouse oocytes after nuclear transfer. Proteomic analyses demonstrated the presence of nuclear components ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-40546-1
更新日期:2019-03-11 00:00:00
abstract::Non-alcoholic steatohepatitis (NASH) is a progressive form of non-alcoholic fatty liver disease (NAFLD) that may lead to liver cirrhosis or hepatocellular carcinoma. Here, we examined the diagnostic utility of tri-antennary tri-sialylated mono-fucosylated glycan of alpha-1 antitrypsin (AAT-A3F), a non-invasive glycobi...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-56947-1
更新日期:2020-01-15 00:00:00
abstract::A wide network of interconnected areas was previously found in neuroimaging studies involving normal as well as pathological subjects; however literature seems to suffer from a lack of investigation in glucose metabolism behaviour under olfactory condition. Thus, the present work describe for the first time a pure olf...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep05146
更新日期:2014-06-03 00:00:00
abstract::The accident at the Fukushima Daiichi nuclear power plant caused serious radiocesium ((137)Cs) contamination of forest ecosystems located in mountainous and hilly regions with steep terrain. To understand topographic effects on the redistribution and accumulation of (137)Cs on forest floor, we investigated the distrib...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep06853
更新日期:2014-10-31 00:00:00
abstract::FMS-like tyrosine kinase 3 (FLT3) is a key driver of acute myeloid leukemia (AML). Several tyrosine kinase inhibitors (TKIs) targeting FLT3 have been evaluated clinically, but their effects are limited when used in monotherapy due to the emergence of drug-resistance. Thus, a better understanding of drug-resistance pat...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-54901-9
更新日期:2019-12-09 00:00:00
abstract::Cry1A insecticidal toxins bind sequentially to different larval gut proteins facilitating oligomerization, membrane insertion and pore formation. Cry1Ac interaction with cadherin triggers oligomerization. However, a mutation in an ABC transporter gene (ABCC2) is linked to Cry1Ac resistance in Plutella xylostella. Cry1...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-02545-y
更新日期:2017-05-24 00:00:00
abstract::This paper proposes a novel approach to sulfur removal by adding zinc during the digestion process. The effects of zinc dosage on the concentrations of different valence sulfur in sodium aluminate solution were investigated at length to find that high-valence sulfur (S2O32-, SO32-, SO42-) concentration in sodium alumi...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-17499-4
更新日期:2017-12-07 00:00:00
abstract::Emerging evidence indicates the existence of a new class of cancer genes that act as "signal linkers" coordinating oncogenic signals between mutated and differentially expressed genes. While frequently mutated oncogenes and differentially expressed genes, which we term Class I cancer genes, are readily detected by mos...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-07481-5
更新日期:2017-08-01 00:00:00
abstract::Vascular endothelial growth factor (VEGF) and placental growth factor (PlGF) plays a crucial role in breakdown of the blood-retinal barrier due to hyperpermeability in diabetic retinopathy (DR). However, the distinct signaling driven by VEGF and PlGF in the pathogenesis of DR remains unclear. In this study, we investi...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-51603-0
更新日期:2019-10-25 00:00:00
abstract::Reverse transcription quantitative real-time polymerase chain reaction (RT-qPCR) is an accurate and fast method to measure gene expression. Reproducibility of the analyses is the main limitation of RT-qPCR experiments. Galaxy is an open, web-based, genomic workbench for a reproducible, transparent, and accessible scie...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-53155-9
更新日期:2019-11-26 00:00:00
abstract::Floral transition is influenced by environmental factors such as light and temperature. Plants are capable of integrating photoperiod and ambient temperature signaling into their developmental program. Despite extensive investigations on individual genetic pathways, little is known about the molecular components that ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep12071
更新日期:2015-07-10 00:00:00
abstract::The growing interest in engineered tumor models prompted us to devise a method for the non-invasive assessment of such models. Here, we report on bioluminescence imaging (BLI) for the assessment of engineered tumor models in the fertilized chicken egg, i.e, chick chorioallantoic membrane (CAM) assay. One prostate canc...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-04572-1
更新日期:2017-07-10 00:00:00
abstract::Heteroplasmy is the existence of more than one mitochondrial DNA (mtDNA) variant within a cell. The evolutionary mechanisms of heteroplasmy are not fully understood, despite being a very common phenomenon. Here we combined heteroplasmy measurements using high throughput sequencing on green turtles (Chelonia mydas) wit...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-56918-6
更新日期:2020-01-14 00:00:00
abstract::Angiopoietin-like protein 8 (ANGPTL8) has a role in lipid metabolism, beta-cell proliferation and diabetes progression, however, the association between different variants in the ANGPTL8 gene and metabolic syndrome (MetS) components has not been studied widely especially in Arab ethnic groups. In this study, the assoc...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-63850-7
更新日期:2020-04-21 00:00:00
abstract::Changes in river channel erosion or deposition affect the geomorphic evolution, aquatic ecosystems, and river regulation strategies. Fluvial processes are determined by the flow, sediment and boundary conditions, and it has long been expected that increasing sediment supply will induce aggradation. Here, based on thor...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep37108
更新日期:2016-11-18 00:00:00
abstract::The Malay people are an important ethnic composition in Southeast Asia, but their genetic make-up and population structure remain poorly studied. Here we conducted a genome-wide study of four geographical Malay populations: Peninsular Malaysian Malay (PMM), Singaporean Malay (SGM), Indonesian Malay (IDM) and Sri Lanka...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep14375
更新日期:2015-09-23 00:00:00
abstract::In contrast to annual plants, in perennial plants, the shoot apical meristem (SAM) can undergo seasonal transitions between dormancy and activity; understanding this transition is crucial for understanding growth in perennial plants. However, little is known about the molecular mechanisms of SAM development in trees. ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep19938
更新日期:2016-02-02 00:00:00
abstract::Disturbances in calcium metabolism are common in individuals with chronic kidney disease (CKD), but whether they are associated with subsequent kidney function decline is less clear. In a CKD 3-5 cohort of 15,755 adult citizens of Stockholm with creatinine tests taken during 2006-2011 and concurrent calcium testing at...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-23500-5
更新日期:2018-03-26 00:00:00
abstract::In cloud water, microorganisms are exposed to very strong stresses especially related to the presence of reactive oxygen species including H2O2 and radicals, which are the driving force of cloud chemistry. In order to understand how the bacterium Pseudomonas graminis isolated from cloud water respond to this oxidative...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-49319-2
更新日期:2019-09-05 00:00:00
abstract::The Sansha Yongle Blue Hole (SYBH) is the deepest blue hole found anywhere to date. Study of the SYBH can provide insight into the interactions between hole wall morphology and many geological/hydrological mechanisms. A comprehensive investigation of the SYBH was carried out for the first time in 2017 using a professi...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-35220-x
更新日期:2018-11-20 00:00:00
abstract::13C-labeled glucose combined with chromatography and mass spectrometry enables us to decipher the percentage of lactate generated from various metabolic pathways. We showed that lactate derived from glycolysis, pentose phosphate pathway, Krebs cycle, and other sources accounted for 82-90%, 6.0-11%, 0.67-1.8% and 1.5-7...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-08277-3
更新日期:2017-08-16 00:00:00
abstract::Kabuki Syndrome (KS) is a rare disorder characterized by distinctive facial features, short stature, skeletal abnormalities, and neurodevelopmental deficits. Previously, we showed that loss of function of RAP1A, a RAF1 regulator, can activate the RAS/MAPK pathway and cause KS, an observation recapitulated in other gen...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-28709-y
更新日期:2018-07-17 00:00:00
abstract::Tobacco hairy root (HR) cultures, which have been widely used for the heterologous production of target compounds, have an innate capacity to bioconvert exogenous t-resveratrol (t-R) into t-piceatannol (t-Pn) and t-pterostilbene (t-Pt). We established genetically engineered HR carrying the gene encoding stilbene synth...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-18330-w
更新日期:2017-12-21 00:00:00
abstract::We investigate the steerability of two-qubit Bell-diagonal states under projective measurements by the steering party. In the simplest nontrivial scenario of two projective measurements, we solve this problem completely by virtue of the connection between the steering problem and the joint-measurement problem. A neces...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep22025
更新日期:2016-02-25 00:00:00
abstract::Micronutrients are essential for survival and growth for all the organisms including pathogens. In this manuscript, we report that zinc (Zn) chelator N,N,N',N'-tetrakis(2-pyridinylmethyl)-1,2-ethylenediamine (TPEN) affects growth and viability of intracellular pathogen Leishmania donovani (LD) by a concentration and t...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-10041-6
更新日期:2017-09-05 00:00:00
abstract::We present a density functional theory (DFT) for steady-state nonequilibrium quantum systems such as molecular junctions under a finite bias. Based on the steady-state nonequilibrium statistics that maps nonequilibrium to an effective equilibrium, we show that ground-state DFT (GS-DFT) is not applicable in this case a...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep15386
更新日期:2015-10-16 00:00:00