Abstract：
:Long noncoding RNA (lncRNA) H19, a well-known oncogenic lncRNA, is overexpressed in various cancers. Several studies have investigated the association between polymorphisms in lncRNA H19 and the risk of various cancer types; however, the findings were inconsistent. In this study, we performed a meta-analysis to identify the precise association between H19 polymorphisms and cancer risk. Appropriate studies were retrieved from searching Web of Science, PubMed, Scopus, and Google scholar databases, updated 25 November 2018. The pooled odds ratios (ORs with 95% confidence intervals (CIs) were calculated to estimate the strength of the association between H19 polymorphisms and cancer risk. Our findings revealed that the H19-rs217727 C>T polymorphism is significantly associated with an increased risk of overall cancer in homozygous codominant (OR=1.28, 95% CI=1.04-1.57, P =0.020, TT vs CC), dominant (OR=1.20, 95% CI=1.04-1.37, P =0.010, CT+TT vs CC), recessive (OR=1.21, 95% CI=1.00-1.46, P =0.048, TT vs CT+CC), and allele (OR=1.16, 95% CI=1.05-1.28, P =0.003, T vs C) genetic models. No significant correlations were observed between H19: rs2839698 G>A, rs2107425 C>T, rs2735971 C>T, rs3024270 G>C, rs3741219 T>C, rs2839701 C>G, rs2735469 C>T, rs17658052 G>A, and rs3741216 T>A polymorphisms and overall cancer risk. Stratified analysis by cancer type proposed that the rs217727 variant is associated with increased risk of oral squamous cell carcinoma (OSCC) and lung cancer, whereas the rs2839698 variant is associated with increased risk of gastrointestinal cancer. Taken together, these findings support an association between H19 rs217727, and rs2839698 polymorphisms and cancer susceptibility. Larger and well-designed studies are necessary to further confirm these findings in detail.
journal_name
J Genetjournal_title
Journal of geneticsauthors
Hashemi M,Moazeni-Roodi A,Sarabandi S,Karami S,Ghavami Ssubject
Has Abstractpub_date
2019-09-01 00:00:00eissn
0022-1333issn
0973-7731journal_volume
98pub_type
杂志文章,meta分析,评审abstract：:Rattans, the spiny climbing palms of Arecaceae (Palmae) family exhibit high endemism to the biodiversity hot spots in India. Of the five rattan genera, Calamus is the only genus found in peninsular India with 15 of 21 species, endemic to the Western Ghats. The extensive utilization of rattans owing to their strength, ...
journal_title：Journal of genetics
pub_type： 杂志文章
doi：
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journal_title：Journal of genetics
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pub_type： 杂志文章
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journal_title：Journal of genetics
pub_type： 杂志文章,评审
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pub_type： 杂志文章
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journal_title：Journal of genetics
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更新日期：2019-09-01 00:00:00
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journal_title：Journal of genetics
pub_type： 杂志文章,评审
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更新日期：2017-07-01 00:00:00
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doi：10.1007/s12041-013-0313-4
更新日期：2013-12-01 00:00:00
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更新日期：2019-03-01 00:00:00
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pub_type： 杂志文章
doi：10.1007/s12041-017-0756-0
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pub_type： 杂志文章
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