Abstract：
:Amphibian secretion is an important source of bioactive molecules that naturally protect the skin against noxious microorganisms. Collectively called antimicrobial peptides (AMPs), these molecules have a wide spectrum of action, targeting viruses, bacteria and fungi. Like many membrane and secreted proteins, AMPs have cleavable signal sequences that mediate and translocate the nascent polypeptide chains into the endoplasmic reticulum. Although it is accepted that the signal peptides (SPs) are simple and interchangeable, there is neither sequence nor structure that is conserved among all gene families. They derived from a common ancestor but developed different traits as they adapt to distinct environmental pressures. The aim of this study was to provide anoverview of the diversity of SPs of the frog, taking into account reported cDNA sequences and the evolutionary relationship among them. We analysed more than 2000 records that reported the relative abundance, diversity and evolutionary divergence based on the peptide signals of frog AMPs. We conclude that the physical properties of the sequence are more important than the specific peptidesin AMP SPs. Since there is significant overlapping among related genera, differences in secretion from different peptide types should be regulated by additional levels, such as posttranscriptional modifications or 5-UTR sequences.
journal_name
J Genetjournal_title
Journal of geneticsauthors
Pérez LO,Cancelarich NL,Aguilar S,Basso NG,Marani MMsubject
Has Abstractpub_date
2018-12-01 00:00:00pages
1205-1212issue
5eissn
0022-1333issn
0973-7731journal_volume
97pub_type
杂志文章abstract：:Environmental stress has been suggested to be a major evolutionary force, both through inducing strong selection and because of its direct impact on developmental buffering processes that alter the evolvability of organisms. In particular, temperature has attracted much attention because of its importance as an ecolog...
journal_title：Journal of genetics
pub_type： 杂志文章
doi：10.1007/s12041-008-0063-x
更新日期：2008-12-01 00:00:00
abstract：:Lhx9 is an LIM (named for the first three proteins in which the domain was found, Lin-11, Isl1 and Mec-3) homeodomain protein involved in development and differentiation of the gonad. In this study, we isolated the full-length Lhx9 and Lhx9α from Andrias davidianus, detected the tissue distribution and analysed the me...
journal_title：Journal of genetics
pub_type： 杂志文章
doi：10.1007/s12041-016-0685-3
更新日期：2016-09-01 00:00:00
abstract：:This study aimed to investigate whether the genetic variants of CRTC1, BARX1, FOXP1 and FOXF1 are associated with the development of oesophageal adenocarcinoma (OA) in Chinese population. A total of 744 OA patients and 1138 controls were included in this study. Here we genotyped four SNPs, rs10419226 of CRTC1, rs11789...
journal_title：Journal of genetics
pub_type： 杂志文章,多中心研究
doi：
更新日期：2018-03-01 00:00:00
abstract：:Primary osteoarthritis (OA) is a leading cause of disability in developed countries. Currently no satisfactory treatment to stop disease progression exists. Recent studies suggest that activation of the transcription factor peroxisome proliferator-activated receptor gamma (PPARγ) is an interesting therapeutic target f...
journal_title：Journal of genetics
pub_type： 杂志文章
doi：10.1007/s12041-014-0444-2
更新日期：2014-12-01 00:00:00
abstract：:Metabolic syndrome (MetS) is an inflammatory disorder, in which various cytokines play important role in tilting balance towards disease state. Interleukin-10 (IL-10) is an important antiinflammatory cytokine, but its genetic polymorphisms and serum levels in Indian MetS subjects are unknown. Three IL-10 gene polymorp...
journal_title：Journal of genetics
pub_type： 杂志文章
doi：10.1007/s12041-016-0738-7
更新日期：2017-03-01 00:00:00
abstract：:Panicle traits are the most important agronomic characters which directly relate to yield in rice. Panicle length (PL) being one of the major components of rice panicle structure is controlled by quantitative trait loci (QTLs). In our research, conducted at Research Farm of SKUAST-J, crosses of parental lines K343 and...
journal_title：Journal of genetics
pub_type： 杂志文章
doi：
更新日期：2019-06-01 00:00:00
abstract：:Glutathione transferases (GSTs; EC 2.5.1.18) play important roles in stress tolerance and metabolic detoxification in plants.In higher plants, studies on GSTs have focussed largely on agricultural plants. There is restricted information about molecular characterization of GSTs in gymnosperms. To date, only tau class G...
journal_title：Journal of genetics
pub_type： 杂志文章
doi：10.1007/s12041-015-0538-5
更新日期：2015-09-01 00:00:00
abstract：:In this study, primer pairs of 15 microsatellite markers associated with sex determination of tilapia were selected and amplified in Wami tilapia, Oreochromis urolepis hornorum. While one marker, UNH168, on linkage group 3 (LG3) was associated (P <0.001) with the phenotypic sex in the experimental population, nine gen...
journal_title：Journal of genetics
pub_type： 杂志文章
doi：10.1007/s12041-016-0653-y
更新日期：2016-06-01 00:00:00
abstract：:To understand the phylogenetic position of Bostrychus sinensis in Eleotridae and the phylogenetic relationships of the family, we determined the nucleotide sequence of the mitochondrial (mt) genome of Bostrychus sinensis. It is the first complete mitochondrial genome sequence of Bostrychus genus. The entire mtDNA sequ...
journal_title：Journal of genetics
pub_type： 杂志文章
doi：10.1007/s12041-013-0259-6
更新日期：2013-01-01 00:00:00
abstract：:Somatic embryos (SE) of habanero pepper (Capsicum chinense Jacq.) represent persistent deformations in the shoot apical meristem (SAM), which inhibits their capacity to form organs and subsequently plants. In dicotyledonous plants, SAM is formed in the apex, between cotyledons and it plays a central role in postembryo...
journal_title：Journal of genetics
pub_type： 杂志文章
doi：
更新日期：2019-09-01 00:00:00
abstract：:The aetiology of developmental dyslexia (DD) is complex; although candidate genes have been suggested, the molecular mechanism and risk factors remain unknown. The KIAA0319 gene is functionally related to neuronal migration and axon growth, and several studies have examined associations between KIAA0319 polymorphisms ...
journal_title：Journal of genetics
pub_type： 杂志文章,meta分析
doi：
更新日期：2019-06-01 00:00:00
abstract：:The six basic generations (two parents, F1, F2 and backcrosses) of 14 crosses developed from nine parents differing in fruits node-1 and fruit orientation were evaluated to decipher the genetics of three quantitative traits (average fruit weight, fruits plant-1 and green fruit yield plant-1) during the rainly season o...
journal_title：Journal of genetics
pub_type： 杂志文章
doi：
更新日期：2019-09-01 00:00:00
abstract：:Ellis-van Creveld syndrome is an autosomal recessive skeletal dysplasia primarily characterized by the features such as disproportionate dwarfism, short ribs, short limbs, dysplastic nails, cardiovascular malformations, post-axial polydactyly (PAP) (bilateral) of hands and feet. EVC/EVC2 located in head-to-head arrang...
journal_title：Journal of genetics
pub_type： 杂志文章
doi：10.1007/s12041-017-0868-6
更新日期：2017-12-01 00:00:00
abstract：:We have analysed the evolution of ERG28/C14orf1, a gene coding for a protein involved in sterol biosynthesis. While primary sequence of the protein is well conserved in all organisms able to synthesize sterols de novo, strong divergence is noticed in insects, which are cholesterol auxotrophs. In spite of this virtual ...
journal_title：Journal of genetics
pub_type： 杂志文章
doi：10.1007/BF02811414
更新日期：2001-04-01 00:00:00
abstract：:Ulcerative colitis (UC), one of the two clinical subtypes of inflammatory bowel disease is perceived as a potential 'sleeping giant' in the Indian subcontinent. Clinical manifestation is overall believed to be the same across ethnic groups but overwhelming genetics from large European and fewer non-European studies ha...
journal_title：Journal of genetics
pub_type： 杂志文章,评审
doi：
更新日期：2018-12-01 00:00:00
abstract：:Low temperature stress is one of the major limiting factors affecting rice productivity in higher altitudes. DREB1A and DREB1B, are two transcription factors that have been reported to play key regulatory role in low temperature tolerance. In order to understand whether natural genetic variation in these two loci lead...
journal_title：Journal of genetics
pub_type： 杂志文章
doi：10.1007/s12041-015-0507-z
更新日期：2015-06-01 00:00:00
abstract：:The parasitoid wasp Nasonia vitripennis reproduces by haplodiploidy; males are haploid and females are diploid. Sex determination in Nasonia is not governed by complementary alleles at one or more sex loci. As in most other insects, the sex-determining pathway consists of the basal switch doublesex that is sex-specifi...
journal_title：Journal of genetics
pub_type： 杂志文章
doi：10.1007/s12041-010-0045-7
更新日期：2010-09-01 00:00:00
abstract：:Neurodegenerative diseases constitute a large proportion of disorders in elderly, majority being sporadic in occurrence with ∼5-10% familial. A strong genetic component underlies the Mendelian forms but nongenetic factors together with genetic vulnerability contributes to the complex sporadic forms. Several gene disco...
journal_title：Journal of genetics
pub_type： 杂志文章,评审
doi：
更新日期：2018-07-01 00:00:00
abstract：:Some members of hairy/Enhancer-of-split-related gene (HES) family have important effects on axial mesoderm segmentation and the establishment and maintenance of the somite fringe. In fishes, the her6 gene, a member of the HES family, is the homologue of hes1 in mammals and chicken. In this study, the her6 gene and its...
journal_title：Journal of genetics
pub_type： 杂志文章
doi：10.1007/BF02935327
更新日期：2006-12-01 00:00:00
abstract：:The hepatic lipase plays a central role in the lipid metabolism, catalyzing the hydrolysis of phospholipids, monoglycerides, diglycerides, and triglycerides, and acyl-CoA. It is also implied in the conversion of very low-density lipoprotein and intermediate density lipoprotein to low density lipoproteins. As a consequ...
journal_title：Journal of genetics
pub_type： 杂志文章
doi：
更新日期：2020-03-01 00:00:00
abstract：:Chronic periodontitis (CP) is the common form of inflammatory oral disease. Matrix metalloproteinases (MMPs) play a pivotal role in the progression of CP by degrading gingival tissue and its remodelling. Here, we conducted a case-control study to investigate a possible association of single-nucleotide polymorphism of ...
journal_title：Journal of genetics
pub_type： 杂志文章
doi：
更新日期：2019-03-01 00:00:00
abstract：:Long noncoding RNA (lncRNA) H19, a well-known oncogenic lncRNA, is overexpressed in various cancers. Several studies have investigated the association between polymorphisms in lncRNA H19 and the risk of various cancer types; however, the findings were inconsistent. In this study, we performed a meta-analysis to identi...
journal_title：Journal of genetics
pub_type： 杂志文章,meta分析,评审
doi：
更新日期：2019-09-01 00:00:00
abstract：:IQSEC2 is an X-linked gene highly expressed at the excitatory synapses where it plays a crucial role in α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor trafficking and synaptic plasticity. To date, several males and females with severe to profound intellectual disability have been reported harbouring fra...
journal_title：Journal of genetics
pub_type： 杂志文章
doi：
更新日期：2020-01-01 00:00:00
abstract：:Genomics research in recent years, especially the human ENCODE project, have made great strides in understanding the genomic and epigenomic structure and organization of humans. These advances promise a new era of precision medicine, through a better understanding of the genomic correlates of human physiology and prom...
journal_title：Journal of genetics
pub_type： 杂志文章
doi：10.1007/s12041-013-0313-4
更新日期：2013-12-01 00:00:00
abstract：:Proline and glutamine-rich wheat seed endosperm proteins are collectively referred to as prolamins. They are comprised of HMW-GSs, LMW-GSs and gliadins. HMW-GSs are major determinants of gluten elasticity and LMW-GSs considerably affect dough extensibility and maximum dough resistance. The inheritance of glutenin subu...
journal_title：Journal of genetics
pub_type： 杂志文章
doi：10.1007/s12041-010-0025-y
更新日期：2010-08-01 00:00:00
abstract：:A rapid decline in temperature poses a major challenge for poikilothermic fish, as their entire metabolism depends on ambient temperature. The gene expression of rainbow trout Oncorhynchus mykiss having undergone such a cold shock (0◦C) was compared to a control (5◦C) in a microarray and quantitative real-time PCR bas...
journal_title：Journal of genetics
pub_type： 杂志文章
doi：10.1007/s12041-017-0811-x
更新日期：2017-09-01 00:00:00
abstract：:Nodal-related protein (ndr2) is amember of the transforming growth factor type β superfamily of factors and is required for ventral midline patterning of the embryonic central nervous system in zebrafish. In humans, mutations in the gene encoding nodal cause holoprosencephaly and heterotaxy. Mutations in the ndr2 gene...
journal_title：Journal of genetics
pub_type： 杂志文章
doi：
更新日期：2018-12-01 00:00:00
abstract：:In Catharanthus roseus, three morphological cum salt-tolerant chemically induced mutants of Mendelian inheritance and their wild-type parent cv Nirmal were characterized for overall cytosine methylation at DNA repeats, expression of 119 protein coding and seven miRNA-coding genes and 50 quantitative traits. The mutant...
journal_title：Journal of genetics
pub_type： 杂志文章
doi：10.1007/s12041-013-0271-x
更新日期：2013-12-01 00:00:00
abstract：:In 1929 the British biologist John Burdon Sanderson Haldane published a hypothesis on the origin of life on earth, which was one of the most emblematic of the interwar period. It was a scenario describing the progressive evolution of matter on the primitive earth and the emergence of life. Firstly, this paper presents...
journal_title：Journal of genetics
pub_type： 传,历史文章,杂志文章
doi：10.1007/s12041-017-0831-6
更新日期：2017-11-01 00:00:00
abstract：:We describe a newborn female with a de novo duplication of chromosomes 2q31.2 and 2q37.3, and a de novo monosomy 9p24.3. The clinical findings of this patient include congenital heart defects, dysmorphic facial features, hypotonia, feeding difficulties and microcephaly. Ultrasonographic prenatal findings were negative...
journal_title：Journal of genetics
pub_type： 杂志文章
doi：
更新日期：2018-03-01 00:00:00
