Abstract：
:Chronic periodontitis (CP) is the common form of inflammatory oral disease. Matrix metalloproteinases (MMPs) play a pivotal role in the progression of CP by degrading gingival tissue and its remodelling. Here, we conducted a case-control study to investigate a possible association of single-nucleotide polymorphism of MMP genes and their interaction with CP in the Indian population. A total of 357 DNA samples of venous blood was isolated, of which 157 were identified as CP patients and 200 were healthy individuals. Genotyping of six MMP genes (MMP1, MMP3, MMP7, MMP8, MMP12 and MMP13) was done using polymerase chain reaction following Sanger's method of sequencing. Statistical analyses were performed by SPSS v16.0, R package (SNPassoc). Gene-gene interactions were evaluated by MDR 3.0.2. The frequency of 6A allele of MMP3 -11715A-6A gene polymorphisms (36%) and G allele of MMP8 +17G-C gene polymorphisms (34%) were higher in the CP population compared with the healthy population (19% and 24%, respectively). A significant association of T allele of MMP8 -799C-T gene promoter polymorphism was found with CP (OR = 2.95, 95%CI = 2.16 - 4.04, P < 0.0001). Genotypic frequency of MMP12 -82A-G polymorphism is associated with CP risk while its allelic distribution is not (OR = 1.32, 95%CI = 0.93 - 1.88, P = 0.129). Gene-gene interactions show the best cross validation consistency model, i.e. MMP1 -519A-G X MMP7 -181A-G X MMP8 -799C-T polymorphismswith a value of 9/10. This gene-gene interaction shows that the significant association of MMP8 -799C-T polymorphism with CP increased susceptibility. Allelic distribution of MMP8+17G-C and MMP3-11715A-6A polymorphisms revealed their protective role towards decreased risk of CP. MMP1 -519A-G and MMP7 -181A-G polymorphisms show combinatorial synergistic effect on CP risk.
journal_name
J Genetjournal_title
Journal of geneticsauthors
Majumder P,Ghosh S,Dey SKsubject
Has Abstractpub_date
2019-03-01 00:00:00eissn
0022-1333issn
0973-7731journal_volume
98pub_type
杂志文章abstract：:The deep divergence of mammalian groups 166 and 190 million years ago (MYA) provide genetic variation to explore the evolution of DNA sequence, gene arrangement and regulation of gene expression in mammals. With encouragement from the founder of the field, Mary Lyon, techniques in cytogenetics and molecular biology we...
journal_title：Journal of genetics
pub_type： 杂志文章,评审
doi：10.1007/s12041-015-0572-3
更新日期：2015-12-01 00:00:00
abstract：:Negative supercoiling stimulates transcription of many genes. In contrast, transcription of the genes coding for DNA gyrase is subject to a novel mechanism of autoregulation, wherein relaxation of the template DNA stimulates their transcription. Since DNA gyrase is the sole supercoiling activity in the eubacterial cel...
journal_title：Journal of genetics
pub_type： 杂志文章
doi：10.1007/BF02717907
更新日期：2001-12-01 00:00:00
abstract：:Cupressus gigantea and C. torulosa are ecologically and economically important endemic species of the conifer family Cupressaceae on the Qinghai-Tibetan plateau. C. gigantea was previously classified as a subspecies of C. torulosa because of their similar morphological characteristics and close distribution. In this s...
journal_title：Journal of genetics
pub_type： 杂志文章
doi：
更新日期：2019-03-01 00:00:00
abstract：:Environmental stress has been suggested to be a major evolutionary force, both through inducing strong selection and because of its direct impact on developmental buffering processes that alter the evolvability of organisms. In particular, temperature has attracted much attention because of its importance as an ecolog...
journal_title：Journal of genetics
pub_type： 杂志文章
doi：10.1007/s12041-008-0063-x
更新日期：2008-12-01 00:00:00
abstract：:Mucuna pruriens is a well-recognized agricultural and horticultural crop with important medicinal use. However, antinutritional factors in seed and adverse morphological characters have negatively affected its cultivation. To elucidate the genetic control of agronomic traits, an intraspecific genetic linkage map of In...
journal_title：Journal of genetics
pub_type： 杂志文章
doi：10.1007/s12041-015-0602-1
更新日期：2016-03-01 00:00:00
abstract：:Proline and glutamine-rich wheat seed endosperm proteins are collectively referred to as prolamins. They are comprised of HMW-GSs, LMW-GSs and gliadins. HMW-GSs are major determinants of gluten elasticity and LMW-GSs considerably affect dough extensibility and maximum dough resistance. The inheritance of glutenin subu...
journal_title：Journal of genetics
pub_type： 杂志文章
doi：10.1007/s12041-010-0025-y
更新日期：2010-08-01 00:00:00
abstract：:Both cowpea and yard-long bean belong to Vigna unguiculata ssp. unguiculata but have diverged through human induced evolution in sub-Saharan Africa and Asia, respectively. To map the quantitative trait loci (QTLs) for yield associated traits and derive new lines that may combine the attributes of both types, we develo...
journal_title：Journal of genetics
pub_type： 杂志文章
doi：
更新日期：2020-01-01 00:00:00
abstract：:Ulcerative colitis (UC), one of the two clinical subtypes of inflammatory bowel disease is perceived as a potential 'sleeping giant' in the Indian subcontinent. Clinical manifestation is overall believed to be the same across ethnic groups but overwhelming genetics from large European and fewer non-European studies ha...
journal_title：Journal of genetics
pub_type： 杂志文章,评审
doi：
更新日期：2018-12-01 00:00:00
abstract：:Low temperature stress is one of the major limiting factors affecting rice productivity in higher altitudes. DREB1A and DREB1B, are two transcription factors that have been reported to play key regulatory role in low temperature tolerance. In order to understand whether natural genetic variation in these two loci lead...
journal_title：Journal of genetics
pub_type： 杂志文章
doi：10.1007/s12041-015-0507-z
更新日期：2015-06-01 00:00:00
abstract：:We studied nucleotide sequence variation at the gene coding for dopa decarboxylase (Ddc) in seven populations of Drosophila melanogaster. Strength and pattern of linkage disequilibrium are somewhat distinct in the extensively sampled Spanish and Raleigh populations. In the Spanish population, a few sites are in strong...
journal_title：Journal of genetics
pub_type： 杂志文章
doi：10.1007/s12041-007-0017-8
更新日期：2007-08-01 00:00:00
abstract：:The endangered medicinal plant Glehnia littoralis is one of the important natural source of furanocoumarin, which has been used as mucolytic, antitussive, antitumour and antibacterial. However, the genetic information of furanocoumarin biosynthesis in G. littoralis is scarce at present. The objective of this study was...
journal_title：Journal of genetics
pub_type： 杂志文章
doi：
更新日期：2020-01-01 00:00:00
abstract：:The parasitoid wasp Nasonia vitripennis reproduces by haplodiploidy; males are haploid and females are diploid. Sex determination in Nasonia is not governed by complementary alleles at one or more sex loci. As in most other insects, the sex-determining pathway consists of the basal switch doublesex that is sex-specifi...
journal_title：Journal of genetics
pub_type： 杂志文章
doi：10.1007/s12041-010-0045-7
更新日期：2010-09-01 00:00:00
abstract：:Migraine, a highly prevalent headache disorder, is regarded as a polygenic multifactorial disease. Single-nucleotide polymorphisms (SNPs) in the genes that involved in sex hormone metabolism may comprise risk for migraine, but the results of previous genetic association studies are conflicting. The aim of this study w...
journal_title：Journal of genetics
pub_type： 杂志文章
doi：10.1007/s12041-016-0625-2
更新日期：2016-03-01 00:00:00
abstract：:Oil palm (Elaeis guineensis Jacq.) is a perennial vegetable and a high oil-yielding crop (4-6 t/ha). There is a large scope for increasing the oil yield by selecting elite planting material for breeding programme in germplasm evaluation, characterization and utilization. In the present study, a diverse range of 150 oi...
journal_title：Journal of genetics
pub_type： 杂志文章
doi：
更新日期：2020-01-01 00:00:00
abstract：:Gene coexpression patterns can reveal gene collections with functional consistency. This study systematically constructs regulatory networks for pituitary tumours by integrating gene coexpression, transcriptional and posttranscriptional regulation. Through network analysis, we elaborate the incidence mechanism of pitu...
journal_title：Journal of genetics
pub_type： 杂志文章
doi：10.1007/s12041-013-0299-y
更新日期：2013-12-01 00:00:00
abstract：:Autosomal recessive primary microcephaly is a rare genetic disorder that is characterized by reduced head circumference and a varying degree of intellectual disability. Genetic studies on consanguineous families with primary microcephaly have identified 15 (MCPH) causative genes that include MCPH1, WDR62, CDK5RAP2, CA...
journal_title：Journal of genetics
pub_type： 杂志文章
doi：10.1007/s12041-017-0759-x
更新日期：2017-06-01 00:00:00
abstract：:Garcinia gummi-gutta (L.) Roxb. (Clusiaceae) is an endemic, semidomesticated, fruit-yielding tree species distributed in the Western Ghats of India and Sri Lanka. Various bioactive phytochemicals, such as garcinol, benzophenones and xanthones are isolated from G. gummi-gutta and have shown antibacterial, antiviral and...
journal_title：Journal of genetics
pub_type： 杂志文章
doi：10.1007/s12041-017-0756-0
更新日期：2017-06-01 00:00:00
abstract：:The best linear unbiased prediction (BLUP), derived from the linear mixed model (LMM), has been popularly used to estimate animal and plant breeding values (BVs) for a few decades. Conventional BLUP has a constraint that BVs are estimated from the assumed covariance among unknown BVs, namely conventional BLUP assumes ...
journal_title：Journal of genetics
pub_type： 杂志文章
doi：
更新日期：2020-01-01 00:00:00
abstract：:In view of well-documented association of hyperhomocysteinaemia with a wide spectrum of diseases and higher incidence of vitamin deficiencies in Indians, we proposed a mathematical model to forecast the role of demographic and genetic variables in influencing homocysteinemetabolism and investigated the influence of li...
journal_title：Journal of genetics
pub_type： 杂志文章
doi：10.1007/s12041-017-0856-x
更新日期：2017-12-01 00:00:00
abstract：:We have investigated nucleotide polymorphism at the beta-esterase gene cluster including the Est-6 gene and psiEst-6 putative pseudogene in four samples of Drosophila melanogaster derived from natural populations of southern Africa (Zimbabwe), Europe (Spain), North America (USA: California), and South America (Venezue...
journal_title：Journal of genetics
pub_type： 杂志文章
doi：10.1007/BF02715813
更新日期：2003-12-01 00:00:00
abstract：:The aetiology of developmental dyslexia (DD) is complex; although candidate genes have been suggested, the molecular mechanism and risk factors remain unknown. The KIAA0319 gene is functionally related to neuronal migration and axon growth, and several studies have examined associations between KIAA0319 polymorphisms ...
journal_title：Journal of genetics
pub_type： 杂志文章,meta分析
doi：
更新日期：2019-06-01 00:00:00
abstract：:Ellis-van Creveld syndrome is an autosomal recessive skeletal dysplasia primarily characterized by the features such as disproportionate dwarfism, short ribs, short limbs, dysplastic nails, cardiovascular malformations, post-axial polydactyly (PAP) (bilateral) of hands and feet. EVC/EVC2 located in head-to-head arrang...
journal_title：Journal of genetics
pub_type： 杂志文章
doi：10.1007/s12041-017-0868-6
更新日期：2017-12-01 00:00:00
abstract：:Eucalyptus is an important short rotation pulpy woody plant, grown widely in the tropics. Recently, many genomic programmes are underway leading to the accumulation of voluminous genomic and expressed sequence tag sequences in public databases. These sequences can be utilized for analysis of simple sequence repeats (S...
journal_title：Journal of genetics
pub_type： 杂志文章
doi：10.1007/s12041-008-0003-9
更新日期：2008-04-01 00:00:00
abstract：:We report a genetic diversity study of Kherigarh cattle, a utility draught-purpose breed of India, currently declining at a startling rate, by use of microsatellite markers recommended by the Food and Agriculture Organization. Microsatellite genotypes were derived, and allelic and genotypic frequencies, heterozygositi...
journal_title：Journal of genetics
pub_type： 杂志文章
doi：10.1007/BF02729017
更新日期：2006-08-01 00:00:00
abstract：:Angiogenesis is the formation of new blood vessels from pre-existing vasculature. Pathologic angiogenesis in the eye can lead to severe visual impairment. In our review, we discuss the roles of both pro-angiogenic and anti-angiogenic molecular players in corneal angiogenesis, proliferative diabetic retinopathy, exudat...
journal_title：Journal of genetics
pub_type： 杂志文章,评审
doi：10.1007/s12041-009-0068-0
更新日期：2009-12-01 00:00:00
abstract：:Amphibian secretion is an important source of bioactive molecules that naturally protect the skin against noxious microorganisms. Collectively called antimicrobial peptides (AMPs), these molecules have a wide spectrum of action, targeting viruses, bacteria and fungi. Like many membrane and secreted proteins, AMPs have...
journal_title：Journal of genetics
pub_type： 杂志文章
doi：
更新日期：2018-12-01 00:00:00
abstract：:We present evidence for coexistence of three different Drosophila species by rescheduling their life history traits in a natural population using the same resource, at the same time and same place. D. ananassae has faster larval development time (DT) and faster DT(egg-fly) than other two species thus utilizing the res...
journal_title：Journal of genetics
pub_type： 杂志文章
doi：10.1007/BF02715798
更新日期：2005-12-01 00:00:00
abstract：:Glutathione transferases (GSTs; EC 2.5.1.18) play important roles in stress tolerance and metabolic detoxification in plants.In higher plants, studies on GSTs have focussed largely on agricultural plants. There is restricted information about molecular characterization of GSTs in gymnosperms. To date, only tau class G...
journal_title：Journal of genetics
pub_type： 杂志文章
doi：10.1007/s12041-015-0538-5
更新日期：2015-09-01 00:00:00
abstract：:miRNAs are important regulators of plant gene expression. There are few studies on the regulation of miRNAs in Lonicera edulis. We used high-throughput sequencing technology to analyse miRNAs in L. edulis, aiming to identify miRNAs and elucidate their function in L. edulis. In the present study, we employed the high-t...
journal_title：Journal of genetics
pub_type： 杂志文章
doi：
更新日期：2020-01-01 00:00:00
abstract：:The ad-8 gene of Neurospora crassa, in addition to being used for the study of purine biology, has been extensively studied as a model for gene structure, mutagenesis and intralocus recombination. Because of this there is an extensive collection of well-characterized N. crassa ad-8 mutants in the Fungal Genetics Stock...
journal_title：Journal of genetics
pub_type： 杂志文章
doi：10.1007/s12041-012-0175-1
更新日期：2012-08-01 00:00:00
