Abstract：
:The deep divergence of mammalian groups 166 and 190 million years ago (MYA) provide genetic variation to explore the evolution of DNA sequence, gene arrangement and regulation of gene expression in mammals. With encouragement from the founder of the field, Mary Lyon, techniques in cytogenetics and molecular biology were progressively adapted to characterize the sex chromosomes of kangaroos and other marsupials, platypus and echidna-and weird rodent species. Comparative gene mapping reveals the process of sex chromosome evolution from their inception 190 MYA (they are autosomal in platypus) to their inevitable end (the Y has disappeared in two rodent lineages). Our X and Y are relatively young, getting their start with the evolution of the sex-determining SRY gene, which triggered progressive degradation of the Y chromosome. Even more recently, sex chromosomes of placental mammals fused with an autosomal region which now makes up most of the Y. Exploration of gene activity patterns over four decades showed that dosage compensation via X-chromosome inactivation is unique to therian mammals, and that this whole chromosome control process is different in marsupials and absent in monotremes and reptiles, and birds. These differences can be exploited to deduce how mammalian sex chromosomes and epigenetic silencing evolved.
journal_name
J Genetjournal_title
Journal of geneticsauthors
Graves JAdoi
10.1007/s12041-015-0572-3subject
Has Abstractpub_date
2015-12-01 00:00:00pages
567-74issue
4eissn
0022-1333issn
0973-7731journal_volume
94pub_type
杂志文章,评审abstract：:Ulcerative colitis (UC), one of the two clinical subtypes of inflammatory bowel disease is perceived as a potential 'sleeping giant' in the Indian subcontinent. Clinical manifestation is overall believed to be the same across ethnic groups but overwhelming genetics from large European and fewer non-European studies ha...
journal_title：Journal of genetics
pub_type： 杂志文章,评审
doi：
更新日期：2018-12-01 00:00:00
abstract：:The parasitoid wasp Nasonia vitripennis reproduces by haplodiploidy; males are haploid and females are diploid. Sex determination in Nasonia is not governed by complementary alleles at one or more sex loci. As in most other insects, the sex-determining pathway consists of the basal switch doublesex that is sex-specifi...
journal_title：Journal of genetics
pub_type： 杂志文章
doi：10.1007/s12041-010-0045-7
更新日期：2010-09-01 00:00:00
abstract：:Mucuna pruriens is a well-recognized agricultural and horticultural crop with important medicinal use. However, antinutritional factors in seed and adverse morphological characters have negatively affected its cultivation. To elucidate the genetic control of agronomic traits, an intraspecific genetic linkage map of In...
journal_title：Journal of genetics
pub_type： 杂志文章
doi：10.1007/s12041-015-0602-1
更新日期：2016-03-01 00:00:00
abstract：:Recurrent spontaneous abortions (RSA) is defined as three or more consecutive pregnancy losses before 20 weeks of gestation. Various causes of RSA have been identified, still 50% cases remain unexplained after evaluation. One of the causes of unexplained recurrent spontaneous abortions (URSA) is supposed to be the dis...
journal_title：Journal of genetics
pub_type： 杂志文章
doi：
更新日期：2018-06-01 00:00:00
abstract：:Eucalyptus is an important short rotation pulpy woody plant, grown widely in the tropics. Recently, many genomic programmes are underway leading to the accumulation of voluminous genomic and expressed sequence tag sequences in public databases. These sequences can be utilized for analysis of simple sequence repeats (S...
journal_title：Journal of genetics
pub_type： 杂志文章
doi：10.1007/s12041-008-0003-9
更新日期：2008-04-01 00:00:00
abstract：:Although it is known that hormones, growth factors and integrin promote hepatocyte proliferation in liver regeneration (LR) through ERK1/2 signalling pathway, reports about regulating processes of its intracellular paths in hepatocytes of LR are limited. This study aims at exploring which paths of ERK1/2 signalling pa...
journal_title：Journal of genetics
pub_type： 杂志文章
doi：
更新日期：2011-12-01 00:00:00
abstract：:Complete diallel crosses with five parents of common wheat (Triticum aestivum L.) were conducted to analyse inheritance of 17 amino acid contents by using the genetic model including seed, cytoplasmic, maternal and environment interaction effects on quantitative traits of seeds in cereal crops. The results showed that...
journal_title：Journal of genetics
pub_type： 杂志文章
doi：10.1007/s12041-014-0408-6
更新日期：2014-08-01 00:00:00
abstract：:The evolutionary dynamics of the tetra-nucleotide microsatellite locus Spl-106 were investigated at the repeat and flanking sequences in 137 individuals of 15 Acipenseriform species, giving 93 homologous sequences, which were detected in 11 out of 15 species. Twenty-three haplotypes of flanking sequences and three dis...
journal_title：Journal of genetics
pub_type： 杂志文章
doi：10.1007/s12041-011-0055-0
更新日期：2011-08-01 00:00:00
abstract：:In Catharanthus roseus, three morphological cum salt-tolerant chemically induced mutants of Mendelian inheritance and their wild-type parent cv Nirmal were characterized for overall cytosine methylation at DNA repeats, expression of 119 protein coding and seven miRNA-coding genes and 50 quantitative traits. The mutant...
journal_title：Journal of genetics
pub_type： 杂志文章
doi：10.1007/s12041-013-0271-x
更新日期：2013-12-01 00:00:00
abstract：:Cupressus gigantea and C. torulosa are ecologically and economically important endemic species of the conifer family Cupressaceae on the Qinghai-Tibetan plateau. C. gigantea was previously classified as a subspecies of C. torulosa because of their similar morphological characteristics and close distribution. In this s...
journal_title：Journal of genetics
pub_type： 杂志文章
doi：
更新日期：2019-03-01 00:00:00
abstract：:The development of the DNA theory of inheritance culminated in the publication of the molecular structure of DNA 60 years ago. This paper describes this development, beginning with the discovery of DNA as a chemical substance by Friedrich Miescher in 1869, followed by its basic chemical analysis and demonstration of i...
journal_title：Journal of genetics
pub_type： 历史文章,杂志文章,评审
doi：10.1007/s12041-014-0337-4
更新日期：2014-04-01 00:00:00
abstract：:Glutathione transferases (GSTs; EC 2.5.1.18) play important roles in stress tolerance and metabolic detoxification in plants.In higher plants, studies on GSTs have focussed largely on agricultural plants. There is restricted information about molecular characterization of GSTs in gymnosperms. To date, only tau class G...
journal_title：Journal of genetics
pub_type： 杂志文章
doi：10.1007/s12041-015-0538-5
更新日期：2015-09-01 00:00:00
abstract：:The ad-8 gene of Neurospora crassa, in addition to being used for the study of purine biology, has been extensively studied as a model for gene structure, mutagenesis and intralocus recombination. Because of this there is an extensive collection of well-characterized N. crassa ad-8 mutants in the Fungal Genetics Stock...
journal_title：Journal of genetics
pub_type： 杂志文章
doi：10.1007/s12041-012-0175-1
更新日期：2012-08-01 00:00:00
abstract：:We studied nucleotide sequence variation at the gene coding for dopa decarboxylase (Ddc) in seven populations of Drosophila melanogaster. Strength and pattern of linkage disequilibrium are somewhat distinct in the extensively sampled Spanish and Raleigh populations. In the Spanish population, a few sites are in strong...
journal_title：Journal of genetics
pub_type： 杂志文章
doi：10.1007/s12041-007-0017-8
更新日期：2007-08-01 00:00:00
abstract：:miRNAs are important regulators of plant gene expression. There are few studies on the regulation of miRNAs in Lonicera edulis. We used high-throughput sequencing technology to analyse miRNAs in L. edulis, aiming to identify miRNAs and elucidate their function in L. edulis. In the present study, we employed the high-t...
journal_title：Journal of genetics
pub_type： 杂志文章
doi：
更新日期：2020-01-01 00:00:00
abstract：:SOX proteins constitute a large family of diverse, well-conserved transcription factors present in vertebrates and invertebrates, and also implicated in control of many developmental processes. Our objectives have been to identify Sox14 gene of goat (Capra hircus), cow (Bos taurus) and rat (Rattus norvegicus), and to ...
journal_title：Journal of genetics
pub_type： 杂志文章
doi：10.1007/s12041-009-0003-4
更新日期：2009-04-01 00:00:00
abstract：:Migraine, a highly prevalent headache disorder, is regarded as a polygenic multifactorial disease. Single-nucleotide polymorphisms (SNPs) in the genes that involved in sex hormone metabolism may comprise risk for migraine, but the results of previous genetic association studies are conflicting. The aim of this study w...
journal_title：Journal of genetics
pub_type： 杂志文章
doi：10.1007/s12041-016-0625-2
更新日期：2016-03-01 00:00:00
abstract：:Angiogenesis is the formation of new blood vessels from pre-existing vasculature. Pathologic angiogenesis in the eye can lead to severe visual impairment. In our review, we discuss the roles of both pro-angiogenic and anti-angiogenic molecular players in corneal angiogenesis, proliferative diabetic retinopathy, exudat...
journal_title：Journal of genetics
pub_type： 杂志文章,评审
doi：10.1007/s12041-009-0068-0
更新日期：2009-12-01 00:00:00
abstract：:Molecular characterization of 23 cytogenetically confirmed XY females was attempted by screening coding regions of SRY and androgen receptor (AR) genes. Five of the index cases showed sequence variations in various exons of the AR gene: a deletion (n.1911delG) and substitutions n.1761G>A and n.1317C>T in exon 1; n.351...
journal_title：Journal of genetics
pub_type： 杂志文章
doi：10.1007/s12041-016-0716-0
更新日期：2016-12-01 00:00:00
abstract：:Allohexaploid wheat was derived from interspecific hybridization, followed by spontaneous chromosome doubling. Newly synthesized hexaploid wheat by crossing Triticum turgidum and Aegilops tauschii provides a classical model to understand the mechanisms of allohexaploidization in wheat. However, immediate chromosome le...
journal_title：Journal of genetics
pub_type： 杂志文章
doi：10.1007/s12041-016-0704-4
更新日期：2016-12-01 00:00:00
abstract：:The endangered medicinal plant Glehnia littoralis is one of the important natural source of furanocoumarin, which has been used as mucolytic, antitussive, antitumour and antibacterial. However, the genetic information of furanocoumarin biosynthesis in G. littoralis is scarce at present. The objective of this study was...
journal_title：Journal of genetics
pub_type： 杂志文章
doi：
更新日期：2020-01-01 00:00:00
abstract：:More than 100 mutations have been reported till date in the rhodopsin gene in patients with retinitis pigmentosa. The present study was undertaken to detect the reported rhodopsin gene point mutations in Indian retinitis pigmentosa patients. We looked for presence or absence of codon 345 and 347 mutations in exon 5 of...
journal_title：Journal of genetics
pub_type： 杂志文章
doi：10.1007/BF02728336
更新日期：2001-08-01 00:00:00
abstract：:Neurodegenerative diseases such as Alzheimer's disease, Parkinson's disease, and amyotrophic lateral sclerosis are pressing health concerns in modern societies for which effective therapies are still lacking. Recent high-throughput genomic technologies have enabled genome-scale, multidimensional investigations to faci...
journal_title：Journal of genetics
pub_type： 杂志文章,评审
doi：
更新日期：2018-07-01 00:00:00
abstract：:The hepatic lipase plays a central role in the lipid metabolism, catalyzing the hydrolysis of phospholipids, monoglycerides, diglycerides, and triglycerides, and acyl-CoA. It is also implied in the conversion of very low-density lipoprotein and intermediate density lipoprotein to low density lipoproteins. As a consequ...
journal_title：Journal of genetics
pub_type： 杂志文章
doi：
更新日期：2020-03-01 00:00:00
abstract：:Central Himalayan region of India encompasses varied ecological habitats ranging from near tropics to the mid-elevation forests dominated by cool-temperate taxa. In past, we have reported several new records and novel species from Uttarakhand state of India. Here, we assessed genetic variations in three mitochondrial ...
journal_title：Journal of genetics
pub_type： 杂志文章
doi：10.1007/s12041-016-0646-x
更新日期：2016-06-01 00:00:00
abstract：:Cottonseed contains 16% seed oil and 23% seed protein by weight. High levels of palmitic acid provides a degree of stability to the oil, while the presence of bound gossypol in proteins considerably changes their properties, including their biological value. This study uses genetic principles to identify genomic regio...
journal_title：Journal of genetics
pub_type： 杂志文章
doi：10.1007/s12041-015-0489-x
更新日期：2015-03-01 00:00:00
abstract：:We present evidence for coexistence of three different Drosophila species by rescheduling their life history traits in a natural population using the same resource, at the same time and same place. D. ananassae has faster larval development time (DT) and faster DT(egg-fly) than other two species thus utilizing the res...
journal_title：Journal of genetics
pub_type： 杂志文章
doi：10.1007/BF02715798
更新日期：2005-12-01 00:00:00
abstract：:Lhx9 is an LIM (named for the first three proteins in which the domain was found, Lin-11, Isl1 and Mec-3) homeodomain protein involved in development and differentiation of the gonad. In this study, we isolated the full-length Lhx9 and Lhx9α from Andrias davidianus, detected the tissue distribution and analysed the me...
journal_title：Journal of genetics
pub_type： 杂志文章
doi：10.1007/s12041-016-0685-3
更新日期：2016-09-01 00:00:00
abstract：:A rapid decline in temperature poses a major challenge for poikilothermic fish, as their entire metabolism depends on ambient temperature. The gene expression of rainbow trout Oncorhynchus mykiss having undergone such a cold shock (0◦C) was compared to a control (5◦C) in a microarray and quantitative real-time PCR bas...
journal_title：Journal of genetics
pub_type： 杂志文章
doi：10.1007/s12041-017-0811-x
更新日期：2017-09-01 00:00:00
abstract：:Genomics research in recent years, especially the human ENCODE project, have made great strides in understanding the genomic and epigenomic structure and organization of humans. These advances promise a new era of precision medicine, through a better understanding of the genomic correlates of human physiology and prom...
journal_title：Journal of genetics
pub_type： 杂志文章
doi：10.1007/s12041-013-0313-4
更新日期：2013-12-01 00:00:00
