Abstract：
:Ulcerative colitis (UC), one of the two clinical subtypes of inflammatory bowel disease is perceived as a potential 'sleeping giant' in the Indian subcontinent. Clinical manifestation is overall believed to be the same across ethnic groups but overwhelming genetics from large European and fewer non-European studies have revealed shared as well as unique disease susceptibly signaturesbetween them, pointing to population specific differences at genomic and environmental levels. A systematic recount of the four major eras in UC genetics spanning earliest linkage analysis, cherry picked candidate gene association studies, unbiased genomewide association studies, their logical extension in trans-ethnic setting (Immunochip study), lastly whole exome sequencing efforts forrare variant burden; and lessons learnt thereof in context of genetically distinct Indian population was attempted in this review. Genetic heterogeneity manifesting at allelic/locus level across these approaches has been the consistent finding through the range of pan India studies. On the other hand, these salient findings also highlight the limitations of even the best of these genetic leadsfor prognostic/clinical application. The imminent need, therefore, for the UC research community to adopt newer approaches/tools with improved study design to (i) gain better insight into genetic/mechanistic basis of disease; (ii) identify biomarkers of immediate translational value; and (iii) develop new/alternate therapeutic options is emphasized at the end.
journal_name
J Genetjournal_title
Journal of geneticsauthors
Juyal G,Sood A,Midha V,Thelma BKsubject
Has Abstractpub_date
2018-12-01 00:00:00pages
1493-1507issue
5eissn
0022-1333issn
0973-7731journal_volume
97pub_type
杂志文章,评审abstract：:The parasitoid wasp Nasonia vitripennis reproduces by haplodiploidy; males are haploid and females are diploid. Sex determination in Nasonia is not governed by complementary alleles at one or more sex loci. As in most other insects, the sex-determining pathway consists of the basal switch doublesex that is sex-specifi...
journal_title：Journal of genetics
pub_type： 杂志文章
doi：10.1007/s12041-010-0045-7
更新日期：2010-09-01 00:00:00
abstract：:Low temperature stress is one of the major limiting factors affecting rice productivity in higher altitudes. DREB1A and DREB1B, are two transcription factors that have been reported to play key regulatory role in low temperature tolerance. In order to understand whether natural genetic variation in these two loci lead...
journal_title：Journal of genetics
pub_type： 杂志文章
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abstract：:miRNAs are important regulators of plant gene expression. There are few studies on the regulation of miRNAs in Lonicera edulis. We used high-throughput sequencing technology to analyse miRNAs in L. edulis, aiming to identify miRNAs and elucidate their function in L. edulis. In the present study, we employed the high-t...
journal_title：Journal of genetics
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abstract：:Migraine, a highly prevalent headache disorder, is regarded as a polygenic multifactorial disease. Single-nucleotide polymorphisms (SNPs) in the genes that involved in sex hormone metabolism may comprise risk for migraine, but the results of previous genetic association studies are conflicting. The aim of this study w...
journal_title：Journal of genetics
pub_type： 杂志文章
doi：10.1007/s12041-016-0625-2
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abstract：:Environmental stress has been suggested to be a major evolutionary force, both through inducing strong selection and because of its direct impact on developmental buffering processes that alter the evolvability of organisms. In particular, temperature has attracted much attention because of its importance as an ecolog...
journal_title：Journal of genetics
pub_type： 杂志文章
doi：10.1007/s12041-008-0063-x
更新日期：2008-12-01 00:00:00
abstract：:The six basic generations (two parents, F1, F2 and backcrosses) of 14 crosses developed from nine parents differing in fruits node-1 and fruit orientation were evaluated to decipher the genetics of three quantitative traits (average fruit weight, fruits plant-1 and green fruit yield plant-1) during the rainly season o...
journal_title：Journal of genetics
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abstract：:Metabolic syndrome (MetS) is an inflammatory disorder, in which various cytokines play important role in tilting balance towards disease state. Interleukin-10 (IL-10) is an important antiinflammatory cytokine, but its genetic polymorphisms and serum levels in Indian MetS subjects are unknown. Three IL-10 gene polymorp...
journal_title：Journal of genetics
pub_type： 杂志文章
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更新日期：2017-03-01 00:00:00
abstract：:Negative supercoiling stimulates transcription of many genes. In contrast, transcription of the genes coding for DNA gyrase is subject to a novel mechanism of autoregulation, wherein relaxation of the template DNA stimulates their transcription. Since DNA gyrase is the sole supercoiling activity in the eubacterial cel...
journal_title：Journal of genetics
pub_type： 杂志文章
doi：10.1007/BF02717907
更新日期：2001-12-01 00:00:00
abstract：:The deep divergence of mammalian groups 166 and 190 million years ago (MYA) provide genetic variation to explore the evolution of DNA sequence, gene arrangement and regulation of gene expression in mammals. With encouragement from the founder of the field, Mary Lyon, techniques in cytogenetics and molecular biology we...
journal_title：Journal of genetics
pub_type： 杂志文章,评审
doi：10.1007/s12041-015-0572-3
更新日期：2015-12-01 00:00:00
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journal_title：Journal of genetics
pub_type： 杂志文章
doi：10.1007/s12041-015-0576-z
更新日期：2015-12-01 00:00:00
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journal_title：Journal of genetics
pub_type： 杂志文章
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更新日期：2014-08-01 00:00:00
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journal_title：Journal of genetics
pub_type： 杂志文章
doi：10.1007/s12041-013-0299-y
更新日期：2013-12-01 00:00:00
abstract：:The best linear unbiased prediction (BLUP), derived from the linear mixed model (LMM), has been popularly used to estimate animal and plant breeding values (BVs) for a few decades. Conventional BLUP has a constraint that BVs are estimated from the assumed covariance among unknown BVs, namely conventional BLUP assumes ...
journal_title：Journal of genetics
pub_type： 杂志文章
doi：
更新日期：2020-01-01 00:00:00
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journal_title：Journal of genetics
pub_type： 杂志文章
doi：
更新日期：2019-12-01 00:00:00
abstract：:Sorghum downy mildew caused by Peronosclerospora sorghi is a major disease of maize and resistance is under the control of polygenes which necessitated identification of quantitative-trait loci (QTLs) for initiating marker-assisted introgression of resistant QTLs in elite susceptible inbred lines. In the present study...
journal_title：Journal of genetics
pub_type： 杂志文章
doi：10.1007/s12041-015-0590-1
更新日期：2015-12-01 00:00:00
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journal_title：Journal of genetics
pub_type： 杂志文章
doi：
更新日期：2018-09-01 00:00:00
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journal_title：Journal of genetics
pub_type： 杂志文章
doi：10.1007/s12041-016-0685-3
更新日期：2016-09-01 00:00:00
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journal_title：Journal of genetics
pub_type： 杂志文章
doi：10.1007/s12041-010-0058-2
更新日期：2010-12-01 00:00:00
abstract：:Autosomal recessive primary microcephaly is a rare genetic disorder that is characterized by reduced head circumference and a varying degree of intellectual disability. Genetic studies on consanguineous families with primary microcephaly have identified 15 (MCPH) causative genes that include MCPH1, WDR62, CDK5RAP2, CA...
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pub_type： 杂志文章
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更新日期：2017-06-01 00:00:00
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journal_title：Journal of genetics
pub_type： 杂志文章
doi：10.1007/s12041-013-0259-6
更新日期：2013-01-01 00:00:00
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journal_title：Journal of genetics
pub_type： 杂志文章,评审
doi：
更新日期：2018-07-01 00:00:00
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journal_title：Journal of genetics
pub_type： 杂志文章,评审
doi：
更新日期：2018-07-01 00:00:00
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journal_title：Journal of genetics
pub_type： 杂志文章
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更新日期：2019-03-01 00:00:00
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journal_title：Journal of genetics
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更新日期：2015-03-01 00:00:00
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journal_title：Journal of genetics
pub_type： 杂志文章
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更新日期：2017-12-01 00:00:00
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journal_title：Journal of genetics
pub_type： 杂志文章
doi：10.1007/s12041-007-0017-8
更新日期：2007-08-01 00:00:00
abstract：:Rattans, the spiny climbing palms of Arecaceae (Palmae) family exhibit high endemism to the biodiversity hot spots in India. Of the five rattan genera, Calamus is the only genus found in peninsular India with 15 of 21 species, endemic to the Western Ghats. The extensive utilization of rattans owing to their strength, ...
journal_title：Journal of genetics
pub_type： 杂志文章
doi：
更新日期：2019-11-01 00:00:00
abstract：:In 1929 the British biologist John Burdon Sanderson Haldane published a hypothesis on the origin of life on earth, which was one of the most emblematic of the interwar period. It was a scenario describing the progressive evolution of matter on the primitive earth and the emergence of life. Firstly, this paper presents...
journal_title：Journal of genetics
pub_type： 传,历史文章,杂志文章
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更新日期：2017-11-01 00:00:00
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journal_title：Journal of genetics
pub_type： 杂志文章
doi：10.1007/s12041-017-0756-0
更新日期：2017-06-01 00:00:00
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journal_title：Journal of genetics
pub_type： 杂志文章
doi：
更新日期：2018-12-01 00:00:00
