Abstract：
:In view of well-documented association of hyperhomocysteinaemia with a wide spectrum of diseases and higher incidence of vitamin deficiencies in Indians, we proposed a mathematical model to forecast the role of demographic and genetic variables in influencing homocysteinemetabolism and investigated the influence of life style modulations in controlling homocysteine levels. Total plasma homocysteine levels were measured in fasting samples using reverse phase HPLC. Multiple linear regression (MLR) and neuro-fuzzy models were developed. The MLR model explained 64% variability in homocysteine, while the neurofuzzy model showed higher accuracy in predicting homocysteine with a mean absolute error of 0.00002 μmol/L. Methylene tetrahydrofolate reductase (MTHFR) C677T, 5-methyltetrahydrofolate homocysteine methyltransferase (MTR) A2756G and 5- methyltetrahydrofolate homocysteine methyltransferase reductase (MTRR) A66G were shown to be positively associatiated with homocysteine, while nonvegetarian diet, serine hydroxymethyltransferase 1 (SHMT1) C1420T and TYMS 5'-UTR 28 bp tandem repeat exhibited negative association with homocysteine. The protective role of SHMT1 C1420T was attributed to more H-bonding interactions in the mutant modelled compared to the wild type, as shown through in silico analysis. To conclude, polymorphisms in genes regulating remethylation of homocysteine strongly influence homocysteine levels. The restoration of one-carbon homeostasis by SHMT1 C1420T or increased flux of folate towards remethylation due to TYMS 5'-UTR 28 bp tandem repeat or nonvegetarian diet can lower homocysteine levels.
journal_name
J Genetjournal_title
Journal of geneticsauthors
Naushad SM,Rama Devi AR,Nivetha S,Lakshmitha G,Stanley AB,Hussain T,Kutala VKdoi
10.1007/s12041-017-0856-xsubject
Has Abstractpub_date
2017-12-01 00:00:00pages
919-926issue
6eissn
0022-1333issn
0973-7731journal_volume
96pub_type
杂志文章abstract：:Rattans, the spiny climbing palms of Arecaceae (Palmae) family exhibit high endemism to the biodiversity hot spots in India. Of the five rattan genera, Calamus is the only genus found in peninsular India with 15 of 21 species, endemic to the Western Ghats. The extensive utilization of rattans owing to their strength, ...
journal_title：Journal of genetics
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journal_title：Journal of genetics
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abstract：:Ellis-van Creveld syndrome is an autosomal recessive skeletal dysplasia primarily characterized by the features such as disproportionate dwarfism, short ribs, short limbs, dysplastic nails, cardiovascular malformations, post-axial polydactyly (PAP) (bilateral) of hands and feet. EVC/EVC2 located in head-to-head arrang...
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journal_title：Journal of genetics
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journal_title：Journal of genetics
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更新日期：2014-08-01 00:00:00
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journal_title：Journal of genetics
pub_type： 杂志文章
doi：10.1007/s12041-012-0175-1
更新日期：2012-08-01 00:00:00
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更新日期：2011-04-01 00:00:00
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journal_title：Journal of genetics
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更新日期：2005-12-01 00:00:00
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journal_title：Journal of genetics
pub_type： 杂志文章
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更新日期：2016-03-01 00:00:00
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doi：
更新日期：2020-01-01 00:00:00
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doi：10.1007/s12041-017-0762-2
更新日期：2017-06-01 00:00:00
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journal_title：Journal of genetics
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更新日期：2016-12-01 00:00:00
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journal_title：Journal of genetics
pub_type： 杂志文章
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更新日期：2008-04-01 00:00:00
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journal_title：Journal of genetics
pub_type： 杂志文章
doi：10.1007/s12041-010-0058-2
更新日期：2010-12-01 00:00:00
abstract：:ABC (ATP-binding cassette) transporters are members of a large superfamily of proteins that utilize ATP hydrolysis to translocate a wide range of substrates across biological membranes. In general, members of C subfamily (ABCC) are structurally characterized by an additional (N-terminal) transmembrane domain (TMD0). P...
journal_title：Journal of genetics
pub_type： 杂志文章
doi：10.1007/s12041-014-0327-6
更新日期：2014-04-01 00:00:00
abstract：:In this study, primer pairs of 15 microsatellite markers associated with sex determination of tilapia were selected and amplified in Wami tilapia, Oreochromis urolepis hornorum. While one marker, UNH168, on linkage group 3 (LG3) was associated (P <0.001) with the phenotypic sex in the experimental population, nine gen...
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pub_type： 杂志文章
doi：10.1007/s12041-016-0653-y
更新日期：2016-06-01 00:00:00
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更新日期：2008-12-01 00:00:00
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pub_type： 杂志文章,多中心研究
doi：
更新日期：2018-03-01 00:00:00
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更新日期：2006-12-01 00:00:00
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abstract：:Neurodegenerative diseases such as Alzheimer's disease, Parkinson's disease, and amyotrophic lateral sclerosis are pressing health concerns in modern societies for which effective therapies are still lacking. Recent high-throughput genomic technologies have enabled genome-scale, multidimensional investigations to faci...
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更新日期：2018-07-01 00:00:00
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