Abstract：
:We report a genetic diversity study of Kherigarh cattle, a utility draught-purpose breed of India, currently declining at a startling rate, by use of microsatellite markers recommended by the Food and Agriculture Organization. Microsatellite genotypes were derived, and allelic and genotypic frequencies, heterozygosities and gene diversity were estimated. A total of 131 alleles were distinguished by the 21 microsatellite markers used. All the microsatellites were highly polymorphic, with mean (+/- s.e.) allelic number of 6.24 +/- 1.7, ranging 4-10 per locus. The observed heterozygosity in the population ranged between 0.261 and 0.809, with mean (+/- s.e.) of 0.574 +/- 0.131, indicating considerable genetic variation in this population. Genetic bottleneck hypotheses were also explored. Our data suggest that the Kherigarh breed has not experienced a genetic bottleneck in the recent past.
journal_name
J Genetjournal_title
Journal of geneticsauthors
Pandey AK,Sharma R,Singh Y,Prakash BB,Ahlawat SPdoi
10.1007/BF02729017subject
Has Abstractpub_date
2006-08-01 00:00:00pages
117-22issue
2eissn
0022-1333issn
0973-7731journal_volume
85pub_type
杂志文章abstract：:Elevated levels of interleukin-1 (IL-1) have been shown to amplify the inflammatory response against periodontopathogenic bacteria.In humans,polymorphisms in the IL1A and IL1B genes are the most well-studied genetic polymorphisms associated with periodontal disease (PD). In contrast to human, there is a lack of knowle...
journal_title：Journal of genetics
pub_type： 杂志文章
doi：10.1007/s12041-015-0576-z
更新日期：2015-12-01 00:00:00
abstract：:More than 100 mutations have been reported till date in the rhodopsin gene in patients with retinitis pigmentosa. The present study was undertaken to detect the reported rhodopsin gene point mutations in Indian retinitis pigmentosa patients. We looked for presence or absence of codon 345 and 347 mutations in exon 5 of...
journal_title：Journal of genetics
pub_type： 杂志文章
doi：10.1007/BF02728336
更新日期：2001-08-01 00:00:00
abstract：:This study aimed to investigate whether the genetic variants of CRTC1, BARX1, FOXP1 and FOXF1 are associated with the development of oesophageal adenocarcinoma (OA) in Chinese population. A total of 744 OA patients and 1138 controls were included in this study. Here we genotyped four SNPs, rs10419226 of CRTC1, rs11789...
journal_title：Journal of genetics
pub_type： 杂志文章,多中心研究
doi：
更新日期：2018-03-01 00:00:00
abstract：:Long noncoding RNA (lncRNA) H19, a well-known oncogenic lncRNA, is overexpressed in various cancers. Several studies have investigated the association between polymorphisms in lncRNA H19 and the risk of various cancer types; however, the findings were inconsistent. In this study, we performed a meta-analysis to identi...
journal_title：Journal of genetics
pub_type： 杂志文章,meta分析,评审
doi：
更新日期：2019-09-01 00:00:00
abstract：:Ulcerative colitis (UC), one of the two clinical subtypes of inflammatory bowel disease is perceived as a potential 'sleeping giant' in the Indian subcontinent. Clinical manifestation is overall believed to be the same across ethnic groups but overwhelming genetics from large European and fewer non-European studies ha...
journal_title：Journal of genetics
pub_type： 杂志文章,评审
doi：
更新日期：2018-12-01 00:00:00
abstract：:An A --> G single nucleotide polymorphism (SNP) at nucleotide 153,104 in the retinoblastoma susceptibility locus (RB1) at 13q14 was previously reported to be present only in Asians. In this study, we determined the distribution of this SNP in normal Southeast Asian populations (Chinese, Malay, Javanese, Thai, Filipino...
journal_title：Journal of genetics
pub_type： 杂志文章
doi：10.1007/BF02715879
更新日期：2003-04-01 00:00:00
abstract：:The endangered medicinal plant Glehnia littoralis is one of the important natural source of furanocoumarin, which has been used as mucolytic, antitussive, antitumour and antibacterial. However, the genetic information of furanocoumarin biosynthesis in G. littoralis is scarce at present. The objective of this study was...
journal_title：Journal of genetics
pub_type： 杂志文章
doi：
更新日期：2020-01-01 00:00:00
abstract：:The evolutionary dynamics of the tetra-nucleotide microsatellite locus Spl-106 were investigated at the repeat and flanking sequences in 137 individuals of 15 Acipenseriform species, giving 93 homologous sequences, which were detected in 11 out of 15 species. Twenty-three haplotypes of flanking sequences and three dis...
journal_title：Journal of genetics
pub_type： 杂志文章
doi：10.1007/s12041-011-0055-0
更新日期：2011-08-01 00:00:00
abstract：:We studied nucleotide sequence variation at the gene coding for dopa decarboxylase (Ddc) in seven populations of Drosophila melanogaster. Strength and pattern of linkage disequilibrium are somewhat distinct in the extensively sampled Spanish and Raleigh populations. In the Spanish population, a few sites are in strong...
journal_title：Journal of genetics
pub_type： 杂志文章
doi：10.1007/s12041-007-0017-8
更新日期：2007-08-01 00:00:00
abstract：:Sorghum downy mildew caused by Peronosclerospora sorghi is a major disease of maize and resistance is under the control of polygenes which necessitated identification of quantitative-trait loci (QTLs) for initiating marker-assisted introgression of resistant QTLs in elite susceptible inbred lines. In the present study...
journal_title：Journal of genetics
pub_type： 杂志文章
doi：10.1007/s12041-015-0590-1
更新日期：2015-12-01 00:00:00
abstract：:Circadian rhythms and sleep are two separate but intimately related processes. Circadian rhythms are generated through the precisely controlled, cyclic expression of a number of genes designated clock genes. Genetic variability in these genes has been associated with a number of phenotypic differences in circadian as ...
journal_title：Journal of genetics
pub_type： 杂志文章,评审
doi：10.1007/s12041-008-0074-7
更新日期：2008-12-01 00:00:00
abstract：:Neurodegenerative diseases such as Alzheimer's disease, Parkinson's disease, and amyotrophic lateral sclerosis are pressing health concerns in modern societies for which effective therapies are still lacking. Recent high-throughput genomic technologies have enabled genome-scale, multidimensional investigations to faci...
journal_title：Journal of genetics
pub_type： 杂志文章,评审
doi：
更新日期：2018-07-01 00:00:00
abstract：:Here, we describe a rapid, efficient and noncomplicated method for extracting poultry genomic DNA. This simple method obtains excellent qualities of molecular biology grade DNA in a matter of only about 15 min. A straightforward protocol is followed in this extraction procedure, in which, when the blood cells are plac...
journal_title：Journal of genetics
pub_type： 杂志文章
doi：
更新日期：2018-08-24 00:00:00
abstract：:Migraine, a highly prevalent headache disorder, is regarded as a polygenic multifactorial disease. Single-nucleotide polymorphisms (SNPs) in the genes that involved in sex hormone metabolism may comprise risk for migraine, but the results of previous genetic association studies are conflicting. The aim of this study w...
journal_title：Journal of genetics
pub_type： 杂志文章
doi：10.1007/s12041-016-0625-2
更新日期：2016-03-01 00:00:00
abstract：:The six basic generations (two parents, F1, F2 and backcrosses) of 14 crosses developed from nine parents differing in fruits node-1 and fruit orientation were evaluated to decipher the genetics of three quantitative traits (average fruit weight, fruits plant-1 and green fruit yield plant-1) during the rainly season o...
journal_title：Journal of genetics
pub_type： 杂志文章
doi：
更新日期：2019-09-01 00:00:00
abstract：:Neurodegenerative diseases constitute a large proportion of disorders in elderly, majority being sporadic in occurrence with ∼5-10% familial. A strong genetic component underlies the Mendelian forms but nongenetic factors together with genetic vulnerability contributes to the complex sporadic forms. Several gene disco...
journal_title：Journal of genetics
pub_type： 杂志文章,评审
doi：
更新日期：2018-07-01 00:00:00
abstract：:Negative supercoiling stimulates transcription of many genes. In contrast, transcription of the genes coding for DNA gyrase is subject to a novel mechanism of autoregulation, wherein relaxation of the template DNA stimulates their transcription. Since DNA gyrase is the sole supercoiling activity in the eubacterial cel...
journal_title：Journal of genetics
pub_type： 杂志文章
doi：10.1007/BF02717907
更新日期：2001-12-01 00:00:00
abstract：:The ad-8 gene of Neurospora crassa, in addition to being used for the study of purine biology, has been extensively studied as a model for gene structure, mutagenesis and intralocus recombination. Because of this there is an extensive collection of well-characterized N. crassa ad-8 mutants in the Fungal Genetics Stock...
journal_title：Journal of genetics
pub_type： 杂志文章
doi：10.1007/s12041-012-0175-1
更新日期：2012-08-01 00:00:00
abstract：:In view of well-documented association of hyperhomocysteinaemia with a wide spectrum of diseases and higher incidence of vitamin deficiencies in Indians, we proposed a mathematical model to forecast the role of demographic and genetic variables in influencing homocysteinemetabolism and investigated the influence of li...
journal_title：Journal of genetics
pub_type： 杂志文章
doi：10.1007/s12041-017-0856-x
更新日期：2017-12-01 00:00:00
abstract：:Low temperature stress is one of the major limiting factors affecting rice productivity in higher altitudes. DREB1A and DREB1B, are two transcription factors that have been reported to play key regulatory role in low temperature tolerance. In order to understand whether natural genetic variation in these two loci lead...
journal_title：Journal of genetics
pub_type： 杂志文章
doi：10.1007/s12041-015-0507-z
更新日期：2015-06-01 00:00:00
abstract：:It is a key challenge to conduct reproducibility in genetic research, especially association studies in obesity. While susceptibility of a single-nucleotide polymorphism (SNP), rs9939609, in the fat mass and obesity-associated (FTO) gene to obesity has been reported in various populations, data from Asians is less con...
journal_title：Journal of genetics
pub_type： 杂志文章
doi：10.1007/s12041-016-0671-9
更新日期：2016-09-01 00:00:00
abstract：:Garcinia gummi-gutta (L.) Roxb. (Clusiaceae) is an endemic, semidomesticated, fruit-yielding tree species distributed in the Western Ghats of India and Sri Lanka. Various bioactive phytochemicals, such as garcinol, benzophenones and xanthones are isolated from G. gummi-gutta and have shown antibacterial, antiviral and...
journal_title：Journal of genetics
pub_type： 杂志文章
doi：10.1007/s12041-017-0756-0
更新日期：2017-06-01 00:00:00
abstract：:We have analysed the evolution of ERG28/C14orf1, a gene coding for a protein involved in sterol biosynthesis. While primary sequence of the protein is well conserved in all organisms able to synthesize sterols de novo, strong divergence is noticed in insects, which are cholesterol auxotrophs. In spite of this virtual ...
journal_title：Journal of genetics
pub_type： 杂志文章
doi：10.1007/BF02811414
更新日期：2001-04-01 00:00:00
abstract：:The deep divergence of mammalian groups 166 and 190 million years ago (MYA) provide genetic variation to explore the evolution of DNA sequence, gene arrangement and regulation of gene expression in mammals. With encouragement from the founder of the field, Mary Lyon, techniques in cytogenetics and molecular biology we...
journal_title：Journal of genetics
pub_type： 杂志文章,评审
doi：10.1007/s12041-015-0572-3
更新日期：2015-12-01 00:00:00
abstract：:A rapid decline in temperature poses a major challenge for poikilothermic fish, as their entire metabolism depends on ambient temperature. The gene expression of rainbow trout Oncorhynchus mykiss having undergone such a cold shock (0◦C) was compared to a control (5◦C) in a microarray and quantitative real-time PCR bas...
journal_title：Journal of genetics
pub_type： 杂志文章
doi：10.1007/s12041-017-0811-x
更新日期：2017-09-01 00:00:00
abstract：:In Catharanthus roseus, three morphological cum salt-tolerant chemically induced mutants of Mendelian inheritance and their wild-type parent cv Nirmal were characterized for overall cytosine methylation at DNA repeats, expression of 119 protein coding and seven miRNA-coding genes and 50 quantitative traits. The mutant...
journal_title：Journal of genetics
pub_type： 杂志文章
doi：10.1007/s12041-013-0271-x
更新日期：2013-12-01 00:00:00
abstract：:The prevalence of genetic variants associated to cutaneous melanoma (CM) has never been determined within Cypriot melanomas. This study evaluates the frequency of variants in cyclin-dependent kinase inhibitor 2A (CDKN2A) and melanocortin-1 receptor (MC1R) in 32 patients diagnosed with CM. Other characteristics and ris...
journal_title：Journal of genetics
pub_type： 杂志文章
doi：10.1007/s12041-017-0742-6
更新日期：2017-03-01 00:00:00
abstract：:Angiogenesis is the formation of new blood vessels from pre-existing vasculature. Pathologic angiogenesis in the eye can lead to severe visual impairment. In our review, we discuss the roles of both pro-angiogenic and anti-angiogenic molecular players in corneal angiogenesis, proliferative diabetic retinopathy, exudat...
journal_title：Journal of genetics
pub_type： 杂志文章,评审
doi：10.1007/s12041-009-0068-0
更新日期：2009-12-01 00:00:00
abstract：:IQSEC2 is an X-linked gene highly expressed at the excitatory synapses where it plays a crucial role in α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor trafficking and synaptic plasticity. To date, several males and females with severe to profound intellectual disability have been reported harbouring fra...
journal_title：Journal of genetics
pub_type： 杂志文章
doi：
更新日期：2020-01-01 00:00:00
abstract：:Esterases are known to play essential role inmetabolism, reproductive physiology and behaviour of Drosophila. Esterases are highly polymorphic enzymes in Drosophila, but the polymorphism of these enzymes is not well studied in Drosophila ananassae. Recent studies on esterase polymorphism in D. ananassae revealed that ...
journal_title：Journal of genetics
pub_type： 杂志文章
doi：10.1007/s12041-017-0814-7
更新日期：2017-09-01 00:00:00
