Abstract：
:In 1929 the British biologist John Burdon Sanderson Haldane published a hypothesis on the origin of life on earth, which was one of the most emblematic of the interwar period. It was a scenario describing the progressive evolution of matter on the primitive earth and the emergence of life. Firstly, this paper presents the main ideas put forward by Haldane in this famous text. The second part makes comparisons between Haldane and Alexander Ivanovitch Oparin's ideas regarding the origins of life (1924). These two theories, apparently very similar, presented distinct conclusions. The third part focusses on Haldane's reflections on the emergence of life during the 1950s and 1960s, and shows how they were linked to the recent developments of prebiotic chemistry and molecular biology.
journal_name
J Genetjournal_title
Journal of geneticsauthors
Tirard Sdoi
10.1007/s12041-017-0831-6subject
Has Abstractpub_date
2017-11-01 00:00:00pages
735-739issue
5eissn
0022-1333issn
0973-7731journal_volume
96pub_type
传,历史文章,杂志文章abstract：:Neurodegenerative diseases constitute a large proportion of disorders in elderly, majority being sporadic in occurrence with ∼5-10% familial. A strong genetic component underlies the Mendelian forms but nongenetic factors together with genetic vulnerability contributes to the complex sporadic forms. Several gene disco...
journal_title：Journal of genetics
pub_type： 杂志文章,评审
doi：
更新日期：2018-07-01 00:00:00
abstract：:Complete diallel crosses with five parents of common wheat (Triticum aestivum L.) were conducted to analyse inheritance of 17 amino acid contents by using the genetic model including seed, cytoplasmic, maternal and environment interaction effects on quantitative traits of seeds in cereal crops. The results showed that...
journal_title：Journal of genetics
pub_type： 杂志文章
doi：10.1007/s12041-014-0408-6
更新日期：2014-08-01 00:00:00
abstract：:The Drosophila simulans Lhr rescues lethal hybrids from the cross of D. melanogaster and D. simulans. We describe here, the phenotypes of Lhr dependent rescue hybrids and demonstrate the effects of Lhr on functional morphology of the salivary chromosomes in the hybrids. Our results reveal that the phenotypes of the 'L...
journal_title：Journal of genetics
pub_type： 杂志文章
doi：10.1007/s12041-007-0028-5
更新日期：2007-12-01 00:00:00
abstract：:Equal transmission of the two alleles at a locus from a heterozygote parent to the offspring is rarely violated. Beside the differential embryonic mortality, nondisjunction and gene conversion that are rather irregular forms of transmission-ratio distortion (TRD), there are two major forms of departure from Mendelian ...
journal_title：Journal of genetics
pub_type： 杂志文章
doi：10.1007/s12041-008-0019-1
更新日期：2008-08-01 00:00:00
abstract：:Ellis-van Creveld syndrome is an autosomal recessive skeletal dysplasia primarily characterized by the features such as disproportionate dwarfism, short ribs, short limbs, dysplastic nails, cardiovascular malformations, post-axial polydactyly (PAP) (bilateral) of hands and feet. EVC/EVC2 located in head-to-head arrang...
journal_title：Journal of genetics
pub_type： 杂志文章
doi：10.1007/s12041-017-0868-6
更新日期：2017-12-01 00:00:00
abstract：:In this study, primer pairs of 15 microsatellite markers associated with sex determination of tilapia were selected and amplified in Wami tilapia, Oreochromis urolepis hornorum. While one marker, UNH168, on linkage group 3 (LG3) was associated (P <0.001) with the phenotypic sex in the experimental population, nine gen...
journal_title：Journal of genetics
pub_type： 杂志文章
doi：10.1007/s12041-016-0653-y
更新日期：2016-06-01 00:00:00
abstract：:Long noncoding RNA (lncRNA) H19, a well-known oncogenic lncRNA, is overexpressed in various cancers. Several studies have investigated the association between polymorphisms in lncRNA H19 and the risk of various cancer types; however, the findings were inconsistent. In this study, we performed a meta-analysis to identi...
journal_title：Journal of genetics
pub_type： 杂志文章,meta分析,评审
doi：
更新日期：2019-09-01 00:00:00
abstract：:The aetiology of developmental dyslexia (DD) is complex; although candidate genes have been suggested, the molecular mechanism and risk factors remain unknown. The KIAA0319 gene is functionally related to neuronal migration and axon growth, and several studies have examined associations between KIAA0319 polymorphisms ...
journal_title：Journal of genetics
pub_type： 杂志文章,meta分析
doi：
更新日期：2019-06-01 00:00:00
abstract：:The present study aimed to identify the alternatively spliced isoforms of pig MEF2A gene and to determine theirmRNA expression patterns. Four alternatively spliced isoforms of pig MEF2A gene (i.e. MEF2A1, MEF2A2, MEF2A3 and MEF2A4) were cloned according to the results of transcriptome sequencing. The fifth to eighth e...
journal_title：Journal of genetics
pub_type： 杂志文章
doi：
更新日期：2018-09-01 00:00:00
abstract：:Amphibian secretion is an important source of bioactive molecules that naturally protect the skin against noxious microorganisms. Collectively called antimicrobial peptides (AMPs), these molecules have a wide spectrum of action, targeting viruses, bacteria and fungi. Like many membrane and secreted proteins, AMPs have...
journal_title：Journal of genetics
pub_type： 杂志文章
doi：
更新日期：2018-12-01 00:00:00
abstract：:Nodal-related protein (ndr2) is amember of the transforming growth factor type β superfamily of factors and is required for ventral midline patterning of the embryonic central nervous system in zebrafish. In humans, mutations in the gene encoding nodal cause holoprosencephaly and heterotaxy. Mutations in the ndr2 gene...
journal_title：Journal of genetics
pub_type： 杂志文章
doi：
更新日期：2018-12-01 00:00:00
abstract：:The evolutionary dynamics of the tetra-nucleotide microsatellite locus Spl-106 were investigated at the repeat and flanking sequences in 137 individuals of 15 Acipenseriform species, giving 93 homologous sequences, which were detected in 11 out of 15 species. Twenty-three haplotypes of flanking sequences and three dis...
journal_title：Journal of genetics
pub_type： 杂志文章
doi：10.1007/s12041-011-0055-0
更新日期：2011-08-01 00:00:00
abstract：:In view of well-documented association of hyperhomocysteinaemia with a wide spectrum of diseases and higher incidence of vitamin deficiencies in Indians, we proposed a mathematical model to forecast the role of demographic and genetic variables in influencing homocysteinemetabolism and investigated the influence of li...
journal_title：Journal of genetics
pub_type： 杂志文章
doi：10.1007/s12041-017-0856-x
更新日期：2017-12-01 00:00:00
abstract：:Rattans, the spiny climbing palms of Arecaceae (Palmae) family exhibit high endemism to the biodiversity hot spots in India. Of the five rattan genera, Calamus is the only genus found in peninsular India with 15 of 21 species, endemic to the Western Ghats. The extensive utilization of rattans owing to their strength, ...
journal_title：Journal of genetics
pub_type： 杂志文章
doi：
更新日期：2019-11-01 00:00:00
abstract：:Expressed sequence tags (ESTs) provide researchers with a quick and inexpensive route for discovering new genes, data on gene expression and regulation, and also provide genic markers that help in constructing genome maps. Cacao is an important perennial crop of humid tropics. Cacao EST sequences, as available in the ...
journal_title：Journal of genetics
pub_type： 杂志文章
doi：10.1007/s12041-009-0030-1
更新日期：2009-08-01 00:00:00
abstract：:Somatic embryos (SE) of habanero pepper (Capsicum chinense Jacq.) represent persistent deformations in the shoot apical meristem (SAM), which inhibits their capacity to form organs and subsequently plants. In dicotyledonous plants, SAM is formed in the apex, between cotyledons and it plays a central role in postembryo...
journal_title：Journal of genetics
pub_type： 杂志文章
doi：
更新日期：2019-09-01 00:00:00
abstract：:The prevalence of genetic variants associated to cutaneous melanoma (CM) has never been determined within Cypriot melanomas. This study evaluates the frequency of variants in cyclin-dependent kinase inhibitor 2A (CDKN2A) and melanocortin-1 receptor (MC1R) in 32 patients diagnosed with CM. Other characteristics and ris...
journal_title：Journal of genetics
pub_type： 杂志文章
doi：10.1007/s12041-017-0742-6
更新日期：2017-03-01 00:00:00
abstract：:It is not clear whether matK evolves under Darwinian selection. In this study, the gymnosperm Taxaceae, Cephalotaxaceae and Pinaceae were used to illustrate the physicochemical evolution, molecular adaptation and evolutionary dynamics of gene divergence in matKs. matK sequences were amplified from 27 Taxaceae and 12 C...
journal_title：Journal of genetics
pub_type： 杂志文章
doi：10.1007/s12041-010-0014-1
更新日期：2010-04-01 00:00:00
abstract：:Genomics research in recent years, especially the human ENCODE project, have made great strides in understanding the genomic and epigenomic structure and organization of humans. These advances promise a new era of precision medicine, through a better understanding of the genomic correlates of human physiology and prom...
journal_title：Journal of genetics
pub_type： 杂志文章
doi：10.1007/s12041-013-0313-4
更新日期：2013-12-01 00:00:00
abstract：:Here, we describe a rapid, efficient and noncomplicated method for extracting poultry genomic DNA. This simple method obtains excellent qualities of molecular biology grade DNA in a matter of only about 15 min. A straightforward protocol is followed in this extraction procedure, in which, when the blood cells are plac...
journal_title：Journal of genetics
pub_type： 杂志文章
doi：
更新日期：2018-08-24 00:00:00
abstract：:IQSEC2 is an X-linked gene highly expressed at the excitatory synapses where it plays a crucial role in α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor trafficking and synaptic plasticity. To date, several males and females with severe to profound intellectual disability have been reported harbouring fra...
journal_title：Journal of genetics
pub_type： 杂志文章
doi：
更新日期：2020-01-01 00:00:00
abstract：:The endangered medicinal plant Glehnia littoralis is one of the important natural source of furanocoumarin, which has been used as mucolytic, antitussive, antitumour and antibacterial. However, the genetic information of furanocoumarin biosynthesis in G. littoralis is scarce at present. The objective of this study was...
journal_title：Journal of genetics
pub_type： 杂志文章
doi：
更新日期：2020-01-01 00:00:00
abstract：:Neurodegenerative diseases such as Alzheimer's disease, Parkinson's disease, and amyotrophic lateral sclerosis are pressing health concerns in modern societies for which effective therapies are still lacking. Recent high-throughput genomic technologies have enabled genome-scale, multidimensional investigations to faci...
journal_title：Journal of genetics
pub_type： 杂志文章,评审
doi：
更新日期：2018-07-01 00:00:00
abstract：:We report a genetic diversity study of Kherigarh cattle, a utility draught-purpose breed of India, currently declining at a startling rate, by use of microsatellite markers recommended by the Food and Agriculture Organization. Microsatellite genotypes were derived, and allelic and genotypic frequencies, heterozygositi...
journal_title：Journal of genetics
pub_type： 杂志文章
doi：10.1007/BF02729017
更新日期：2006-08-01 00:00:00
abstract：:Cottonseed contains 16% seed oil and 23% seed protein by weight. High levels of palmitic acid provides a degree of stability to the oil, while the presence of bound gossypol in proteins considerably changes their properties, including their biological value. This study uses genetic principles to identify genomic regio...
journal_title：Journal of genetics
pub_type： 杂志文章
doi：10.1007/s12041-015-0489-x
更新日期：2015-03-01 00:00:00
abstract：:Chronic periodontitis (CP) is the common form of inflammatory oral disease. Matrix metalloproteinases (MMPs) play a pivotal role in the progression of CP by degrading gingival tissue and its remodelling. Here, we conducted a case-control study to investigate a possible association of single-nucleotide polymorphism of ...
journal_title：Journal of genetics
pub_type： 杂志文章
doi：
更新日期：2019-03-01 00:00:00
abstract：:Esterases are known to play essential role inmetabolism, reproductive physiology and behaviour of Drosophila. Esterases are highly polymorphic enzymes in Drosophila, but the polymorphism of these enzymes is not well studied in Drosophila ananassae. Recent studies on esterase polymorphism in D. ananassae revealed that ...
journal_title：Journal of genetics
pub_type： 杂志文章
doi：10.1007/s12041-017-0814-7
更新日期：2017-09-01 00:00:00
abstract：:Multiple experimental evolution studies on Drosophila melanogaster in the 1980s and 1990s indicated that enhanced competitive ability evolved primarily through increased larval tolerance to nitrogenous wastes and increased larval feeding and foraging rate, at the cost of efficiency of food conversion to biomass, and t...
journal_title：Journal of genetics
pub_type： 杂志文章
doi：10.1007/s12041-016-0656-8
更新日期：2016-09-01 00:00:00
abstract：:Primary osteoarthritis (OA) is a leading cause of disability in developed countries. Currently no satisfactory treatment to stop disease progression exists. Recent studies suggest that activation of the transcription factor peroxisome proliferator-activated receptor gamma (PPARγ) is an interesting therapeutic target f...
journal_title：Journal of genetics
pub_type： 杂志文章
doi：10.1007/s12041-014-0444-2
更新日期：2014-12-01 00:00:00
abstract：:Genomewide association study (GWAS) is an efficient tool for the detection of SNPs and candidate genes in quantitative traits. Growth rate is an important trait for increasing the meat production in sheep. A total of 96 Baluchi sheep were genotyped using Illumina Ovine SNP50 BeadChip to run a GWAS for an average daily...
journal_title：Journal of genetics
pub_type： 杂志文章
doi：
更新日期：2018-06-01 00:00:00
