Abstract:
BACKGROUND:Whole-body MRI is used for staging paediatric Hodgkin lymphoma, commonly using size thresholds, which fail to detect disease in normal-size lymph nodes. OBJECTIVE:To investigate quantitative whole-body MRI metrics for nodal characterisation. MATERIALS AND METHODS:Thirty-seven children with Hodgkin lymphoma underwent 1.5-tesla (T) whole-body MRI using short tau inversion recovery (STIR) half-Fourier-acquisition single-shot turbo-spin-echo and diffusion-weighted imaging (DWI). 18Flourine-2-fluoro-2-deoxyglucose (FDG) positron emission tomography (PET)/CT was acquired as the reference standard. Two independent readers assessed 11 nodal sites. The readers measured short-axis-diameter, apparent diffusion coefficient, (ADC) and normalised T2-signal intensity of the largest lymph node at each site. We used receiver operating characteristics (ROC)/area-under-the-curve (AUC) analysis for each MRI metric and derived sensitivity and specificity for nodes with short-axis diameter ≥10 mm. Sub-analysis of sensitivity and specificity was performed with application of ADC cut-off values (<0.77, <1.15 and <1.79×10-3 mm2 s-1) to 5- to 9-mm nodes. RESULTS:ROC/AUC values for reader 1/reader 2 were 0.80/0.80 and 0.81/0.81 for short-axis-diameter measured using DWI and STIR half-Fourier-acquisition single-shot turbo spin echo, respectively; 0.67/0.72 for normalised T2 signal intensity and 0.74/0.67 for ADC. Sensitivity and specificity for a short-axis diameter ≥10 mm were 84.2% and 66.7% for Reader 1 and 82.9% and 68.9% for Reader 2. Applying a short-axis-diameter ≥10-mm threshold followed by ADC cut-offs to normal-size 5- to 9-mm nodes resulted in sensitivity and specificity for Reader 1 of 88.8% and 60%, 92.1% and 56.7%, and 100% and 16.7%; and for Reader 2, 86.1% and 67.2%, 95.3% and 65.6%, and 100% and 19.7%; and ADC thresholds of <0.77, <1.15, and <1.79×10-3 mm2 s-1, respectively. CONCLUSION:Nodal size measurement provides the best single classifier for nodal disease status in paediatric Hodgkin lymphoma. Combined short-axis diameter and ADC thresholds marginally improve sensitivity and drop specificity compared with size classification alone.
journal_name
Pediatr Radioljournal_title
Pediatric radiologyauthors
Latifoltojar A,Humphries PD,Menezes LJ,Haroon A,Daw S,Shankar A,Punwani Sdoi
10.1007/s00247-019-04463-9subject
Has Abstractpub_date
2019-09-01 00:00:00pages
1285-1298issue
10eissn
0301-0449issn
1432-1998pii
10.1007/s00247-019-04463-9journal_volume
49pub_type
杂志文章abstract::Pyloric atresia is an uncommon congenital gastric outlet obstruction, accounting for only 1% of gastrointestinal atresias. Up to 55% of cases have associated anomalies, the most common of which is epidermolysis bullosa. Fetal MRI findings of the epidermolysis bullosa-pyloric atresia association have not been previousl...
journal_title:Pediatric radiology
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doi:10.1007/s00247-013-2737-7
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journal_title:Pediatric radiology
pub_type: 杂志文章
doi:10.1007/BF02386822
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abstract::Juvenile granulosa cell tumor of the testis is a distinct form of sex cord-stromal tumor of neonates and infants [1]. This tumor comprises a significant percentage of testicular tumors in baby boys. We present a patient who had preoperative imaging studies. ...
journal_title:Pediatric radiology
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journal_title:Pediatric radiology
pub_type: 临床试验,杂志文章
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journal_title:Pediatric radiology
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journal_title:Pediatric radiology
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journal_title:Pediatric radiology
pub_type: 杂志文章,评审
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journal_title:Pediatric radiology
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abstract:BACKGROUND:High-signal T2-weighted bone marrow changes can be found in both bone marrow edema and hematopoietic marrow and are often seen on pediatric MR images of the feet and ankle. OBJECTIVE:To evaluate whether high-signal T2 changes of the bone marrow seen on pediatric MRI of feet and ankles represent residual hem...
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journal_title:Pediatric radiology
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更新日期:2009-08-01 00:00:00
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pub_type: 杂志文章,已发布勘误
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更新日期:2018-12-01 00:00:00
abstract:: ...
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journal_title:Pediatric radiology
pub_type: 杂志文章
doi:10.1007/BF02014983
更新日期:1993-01-01 00:00:00
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journal_title:Pediatric radiology
pub_type: 杂志文章,评审
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更新日期:2014-07-01 00:00:00
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journal_title:Pediatric radiology
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更新日期:1983-01-01 00:00:00
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journal_title:Pediatric radiology
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journal_title:Pediatric radiology
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更新日期:2010-12-01 00:00:00