Abstract:
BACKGROUND:Perioperative use of nonsteroidal anti-inflammatory drugs (NSAIDs) is known to reduce inflammatory response in relation to surgery. Inflammation may promote recurrence of cancer, thus inhibition by use of NSAIDs could reduce recurrence after surgery. OBJECTIVE:The aim of this study was to examine the association between perioperative use of NSAIDs and cancer recurrence, as well as disease-free survival (DFS) and mortality after colorectal cancer surgery. METHODS:This was a cohort study based on data from a prospective clinical database, electronic medical records, and nationwide registers, and included patients from six major colorectal centers in Denmark. The primary outcome was cancer recurrence, while secondary outcomes included 5-year mortality and DFS. RESULTS:Overall, 2308 patients undergoing colorectal cancer surgery between 1 January 2006 and 31 December 2009 were included. A total of 909 patients received at least 2 days of treatment with NSAIDs, of whom 702 (77.2%) received ibuprofen and 204 (22.4%) received diclofenac. Cox regression analysis adjusting for NSAIDs resulted in decreased recurrence risk (adjusted hazard ratio [HRadjusted] 0.84, 95% confidence interval [CI] 0.72-0.99; p = 0.042). Competing risk analysis confirmed the finding, with an HRadjusted of 0.76 (95% CI 0.60-0.97; p = 0.026). There was no significant effect on mortality or DFS. Sensitivity analysis of the effect of ibuprofen reported an HRadjusted of 0.83 (95% CI 0.70-1.00; p = 0.047). In restricted analyses of localized disease only (Union for International Cancer Control [UICC] I-II) and elective surgery only, no effect was found (localized: HRadjusted 0.81, 95% CI 0.62-1.06, p = 0.12; elective: HRadjusted 0.85, 95% CI 0.72-1.01, p = 0.063). CONCLUSIONS:Perioperative use of NSAIDs was associated with a reduced risk of cancer recurrence after resection for colorectal cancer. No effect on 5-year mortality or DFS was found.
journal_name
Ann Surg Oncoljournal_title
Annals of surgical oncologyauthors
Schack A,Fransgaard T,Klein MF,Gögenur Idoi
10.1245/s10434-019-07600-8subject
Has Abstractpub_date
2019-11-01 00:00:00pages
3826-3837issue
12eissn
1068-9265issn
1534-4681pii
10.1245/s10434-019-07600-8journal_volume
26pub_type
杂志文章abstract:PURPOSE:The goal of this study was to investigate clinical manifestations of lower extremity edema (LEE) after lymph node dissection in patients with primary endometrial cancer. METHODS:Women with primary endometrial cancer who underwent staging surgery between November 2001 and March 2011 were included in the study. ...
journal_title:Annals of surgical oncology
pub_type: 杂志文章
doi:10.1245/s10434-015-4613-1
更新日期:2016-01-01 00:00:00
abstract:BACKGROUND:The recent introduction of biological anticancer therapy has renewed the interest in functional imaging of tumor-associated angiogenesis (TAA) as a tool to monitor early therapy response. The present study evaluated imaging of TAA using P1227, a novel, small molecular magnetic resonance imaging (MRI) probe t...
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journal_title:Annals of surgical oncology
pub_type: 杂志文章,多中心研究
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更新日期:2008-12-01 00:00:00
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journal_title:Annals of surgical oncology
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pub_type: 杂志文章,随机对照试验
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更新日期:2014-06-01 00:00:00
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更新日期:2016-12-01 00:00:00
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journal_title:Annals of surgical oncology
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更新日期:2010-04-01 00:00:00
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journal_title:Annals of surgical oncology
pub_type: 杂志文章
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更新日期:1997-06-01 00:00:00
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journal_title:Annals of surgical oncology
pub_type: 杂志文章
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更新日期:2015-08-01 00:00:00
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journal_title:Annals of surgical oncology
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pub_type: 临床试验,杂志文章
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更新日期:2020-10-01 00:00:00
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journal_title:Annals of surgical oncology
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更新日期:2014-09-01 00:00:00
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更新日期:2016-09-01 00:00:00
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