A novel assay to assess the effectiveness of antiangiogenic drugs in human breast cancer.

abstract：BACKGROUND:Heat shock protein 27 (hsp-27) is overexpressed in approximately 67% pure ductal carcinoma in situ (DCIS), in approximately 50% DCIS associated with invasive ductal carcinoma (IDC), and in approximately 25% IDC alone. If this decrease in hsp-27 expression has a role in the progression of malignancy in IDC, w...

journal_title：Annals of surgical oncology

authors： Storm FK,Mahvi DM,Gilchrist KW

更新日期：1996-11-01 00:00:00

abstract：: ...

journal_title：Annals of surgical oncology

authors：

更新日期：2019-02-01 00:00:00

abstract：INTRODUCTION:The National Comprehensive Cancer Network (NCCN) developed clinical practice guidelines for germline pathogenic variants in highly penetrant genes, such as TP53 and PTEN, and in moderately penetrant genes, such as CHEK2, ATM and PALB2. Whether the practice of radiographic surveillance of patients with path...

journal_title：Annals of surgical oncology

authors： Hudson L,Gower N,Lenarcic S,Trufan SJ,White RL Jr

更新日期：2020-07-01 00:00:00

abstract：BACKGROUND:Cholangiocarcinoma can be classified in intrahepatic cholangiocarcinoma (ICC) and perihilar cholangiocarcinoma (PCC). Moreover, PCC includes two different forms: extrahepatic (EH) PCC, which arises from the perihilar EH large ducts, and intrahepatic (IH) PCC, in which a significant liver mass invades the per...

journal_title：Annals of surgical oncology

authors： Ruzzenente A,Fassan M,Conci S,Simbolo M,Lawlor RT,Pedrazzani C,Capelli P,D'Onofrio M,Iacono C,Scarpa A,Guglielmi A

更新日期：2016-05-01 00:00:00

abstract：BACKGROUND:Abnormal phosphatase and tensin analog (PTEN) gene expression has been noted in neoplasms. The PTEN protein cleaves phosphate groups from cellular growth kinases, inhibiting tumor propagation. A downstream target of PTEN is AKT, a serine-threonine kinase that when activated inhibits apoptosis. We sought to d...

journal_title：Annals of surgical oncology

authors： Mohiuddin I,Cao X,Ozvaran MK,Zumstein L,Chada S,Smythe WR

更新日期：2002-04-01 00:00:00

abstract：PURPOSE:The goal of this study was to investigate clinical manifestations of lower extremity edema (LEE) after lymph node dissection in patients with primary endometrial cancer. METHODS:Women with primary endometrial cancer who underwent staging surgery between November 2001 and March 2011 were included in the study. ...

journal_title：Annals of surgical oncology

authors： Bae HS,Lim MC,Lee JS,Lee Y,Nam BH,Seo SS,Kang S,Chung SH,Kim JY,Park SY

更新日期：2016-01-01 00:00:00

abstract：:The purpose of this study was to clarify the outcome of the ratio between metastatic and examined lymph nodes (N ratio) in gastric cancer patients with < or =15 examined lymph nodes after D2 lymphadenectomy. A retrospective study was performed in 906 patients with gastric cancer who had undergone D2 resection. Patient...

journal_title：Annals of surgical oncology

authors： Xu DZ,Geng QR,Long ZJ,Zhan YQ,Li W,Zhou ZW,Chen YB,Sun XW,Chen G,Liu Q

更新日期：2009-02-01 00:00:00

abstract：BACKGROUND:Melphalan (L-PAM) hyperthermic isolated limb perfusion (HILP) is currently considered the standard treatment for patients with in-transit metastases from cutaneous melanoma. We here report on the results of L-PAM and low-dose tumor necrosis factor (TNF)alpha HILP in patients with bulky disease. METHODS:Twen...

journal_title：Annals of surgical oncology

authors： Rossi CR,Foletto M,Mocellin S,Pilati P,Lise M

更新日期：2004-02-01 00:00:00

abstract：BACKGROUND:Melanoma that involves the upper gastrointestinal (GI) tract is rare and studies relating to endoscopic and pathologic findings with clinical outcomes are lacking. We reviewed the gross and microscopic patterns of the upper GI tract in primary and metastatic melanoma, and examined their association with clin...

journal_title：Annals of surgical oncology

authors： Ahn JY,Hwang HS,Park YS,Kim HR,Jung HY,Kim JH,Lee SE,Kim MA

更新日期：2014-08-01 00:00:00

abstract：PURPOSE:Intraoperative margin assessment can reduce positive margins in patients undergoing breast-conserving surgery. However, reports on intraoperative margin assessment have described only the use of either imprint cytology or frozen section. This study was designed to elucidate the effect of intraoperative margin a...

journal_title：Annals of surgical oncology

authors： Tamanuki T,Namura M,Aoyagi T,Shimizu S,Suwa T,Matsuzaki H

更新日期：2020-08-19 00:00:00

abstract：BACKGROUND:Breast-conserving surgery (BCS) requires clear surgical margins to minimize local recurrence. We sought to identify groups of patients at higher risk of involved margins who might benefit from preoperative counselling and/or more generous excision at the first operation. METHODS:We reviewed demographic, cli...

journal_title：Annals of surgical oncology

authors： Kurniawan ED,Wong MH,Windle I,Rose A,Mou A,Buchanan M,Collins JP,Miller JA,Gruen RL,Mann GB

更新日期：2008-09-01 00:00:00

abstract：BACKGROUND:Oral health is associated with various diseases, including cancer. Tooth loss is a simple and objective index of oral health. OBJECTIVE:The purpose of this study was to investigate the association between preoperative tooth loss and esophageal cancer prognosis after esophagectomy. METHODS:This study includ...

journal_title：Annals of surgical oncology

authors： Miura S,Nakamura T,Hasegawa T,Miura Y,Takiguchi G,Urakawa N,Hasegawa H,Yamamoto M,Kanaji S,Matsuda Y,Yamashita K,Matsuda T,Oshikiri T,Suzuki S,Akashi M,Kakeji Y

更新日期：2020-03-01 00:00:00

abstract：BACKGROUND:The overall incidence of gastric cancer (GC) is higher in males than females. Specifically, signet ring cell carcinoma (SRC) is more frequently observed in younger female patients. However, limited information focused on sex-specific differences in GC has been reported. The aim of our study was to analyze cl...

journal_title：Annals of surgical oncology

authors： Kim HW,Kim JH,Lim BJ,Kim H,Kim H,Park JJ,Youn YH,Park H,Noh SH,Kim JW,Choi SH

更新日期：2016-12-01 00:00:00

abstract：BACKGROUND:In the Netherlands, a maximum waiting time from diagnosis to treatment (WT) of 5 weeks is recommended for curative cancer treatment. This study aimed to evaluate the association between WT and overall survival (OS) in patients undergoing gastrectomy for cancer. METHODS:This nationwide study included data fr...

journal_title：Annals of surgical oncology

authors： Brenkman HJF,Visser E,van Rossum PSN,Siesling S,van Hillegersberg R,Ruurda JP

更新日期：2017-07-01 00:00:00

abstract：BACKGROUND:Various patient, treatment, and pathologic factors have been associated with an increased risk of local recurrence (LR) following breast-conserving therapy (BCT) for ductal carcinoma in situ (DCIS). However, the strength and importance of individual factors has varied; whether combining factors improves pred...

journal_title：Annals of surgical oncology

authors： Collins LC,Achacoso N,Haque R,Nekhlyudov L,Quesenberry CP Jr,Schnitt SJ,Habel LA,Fletcher SW

更新日期：2015-12-01 00:00:00

abstract：BACKGROUND:Persistent post-mastectomy pain (PPMP) is a significant negative outcome occurring after breast surgery, and understanding which individual women are most at risk is essential to targeting of preventive efforts. The biopsychosocial model of pain suggests that factors from many domains may importantly modulat...

journal_title：Annals of surgical oncology

authors： Schreiber KL,Zinboonyahgoon N,Flowers KM,Hruschak V,Fields KG,Patton ME,Schwartz E,Azizoddin D,Soens M,King T,Partridge A,Pusic A,Golshan M,Edwards RR

更新日期：2021-01-15 00:00:00

abstract：BACKGROUND:Contralateral prophylactic mastectomy (CPM) is expected to add surgical morbidity but this incremental risk has not yet been defined. We sought to quantify the additional risks associated with CPM and determine how these risks influence the time to adjuvant therapy. METHODS:We identified women undergoing ma...

journal_title：Annals of surgical oncology

authors： Eck DL,Perdikis G,Rawal B,Bagaria S,McLaughlin SA

更新日期：2014-10-01 00:00:00

abstract：BACKGROUND:Recent data have demonstrated multiple benefits of intra- and postoperative fluid restriction in major abdominal surgery; however, data regarding the outcomes of fluid restriction in cytoreductive surgery and hyperthermic intraperitoneal chemoperfusion (CRS/HIPEC) are limited. This study evaluates the safety...

journal_title：Annals of surgical oncology

authors： Hendrix RJ,Damle A,Williams C,Harris A,Spanakis S,Lambert DH,Lambert LA

更新日期：2019-02-01 00:00:00

abstract：BACKGROUND:We investigated the relationship between pathologic T-stage and mesorectal metastases after preoperative chemoradiotherapy (CRT) for clinical stage II to III rectal carcinoma. METHODS:The records of consecutive patients with clinical stage II to III carcinoma of the mid or low rectum who underwent surgery a...

journal_title：Annals of surgical oncology

authors： Pucciarelli S,Capirci C,Emanuele U,Toppan P,Friso ML,Pennelli GM,Crepaldi G,Pasetto L,Nitti D,Lise M

更新日期：2005-02-01 00:00:00

abstract：BACKGROUND:Hereditary diffuse gastric cancer (HDGC) is an autosomal dominant cancer syndrome. Up to 30% of families with HDGC have mutations in the E-cadherin gene, CDH1. The role of prophylactic versus therapeutic gastrectomy for HDGC was studied prospectively. METHODS:Eighteen consecutive patients with CDH1 mutation...

journal_title：Annals of surgical oncology

authors： Chen Y,Kingham K,Ford JM,Rosing J,Van Dam J,Jeffrey RB,Longacre TA,Chun N,Kurian A,Norton JA

更新日期：2011-09-01 00:00:00

abstract：BACKGROUND:Breast cancer is increasingly detected during an early non-palpable stage. Together with pre-operative marking of the mass, intra-operative imaging provides invaluable clues. This study was designed to evaluate the usefulness of intra-operative sonography in the hands of the surgeon. METHODS:Between July 20...

journal_title：Annals of surgical oncology

authors： Haid A,Knauer M,Dunzinger S,Jasarevic Z,Köberle-Wührer R,Schuster A,Toeppker M,Haid B,Wenzl E,Offner F

更新日期：2007-11-01 00:00:00

abstract：BACKGROUND:Short-course radiotherapy with delayed surgery (SRT-delay) is still under clinical investigation for its efficacy in treating low rectal cancer (≤5 cm from the anal verge). This study was designed to assess the pattern of local recurrence and oncologic outcomes in T3 low rectal cancer treated with SRT-delay....

journal_title：Annals of surgical oncology

authors： Beppu N,Kimura F,Aihara T,Doi H,Tomita N,Yanagi H,Yamanaka N

更新日期：2017-01-01 00:00:00

abstract：BACKGROUND:Oncoplastic surgical techniques offer an option of breast conserving surgery for larger tumors with the use of glandular reshaping to prevent postoperative deformity. A technique for the excision of lower inner quadrant tumors via a V incision is described, the lower-inner quadrant-V (LIQ-V) mammoplasty, and...

journal_title：Annals of surgical oncology

authors： Clough KB,Oden S,Ihrai T,Massey E,Nos C,Sarfati I

更新日期：2013-11-01 00:00:00

abstract：BACKGROUND:mTHPC-mediated photodynamic therapy (PDT) is used for treatment of early head and neck squamous cell carcinoma. This study is a retrospective comparison of PDT with transoral surgery in the treatment of early primary squamous cell carcinoma of the oral cavity/oropharynx. METHODS:PDT data were retrieved from...

journal_title：Annals of surgical oncology

authors： de Visscher SA,Melchers LJ,Dijkstra PU,Karakullukcu B,Tan IB,Hopper C,Roodenburg JL,Witjes MJ

更新日期：2013-09-01 00:00:00

abstract：BACKGROUND:The utility of sentinel lymph node biopsy (SLNB) for desmoplastic melanoma (DM) is debated. We describe a large single-institution experience with SLNB for DM to determine clinicopathologic factors predictive of SLN metastasis. METHODS:Retrospective review identified 205 patients with DM who underwent SLNB ...

journal_title：Annals of surgical oncology

authors： Han D,Zager JS,Yu D,Zhao X,Walls B,Marzban SS,Rao NG,Sondak VK,Messina JL

更新日期：2013-07-01 00:00:00

abstract：BACKGROUND:Low-dose rate brachytherapy is a well-established adjuvant treatment for soft tissue sarcomas (STS). The experience with high-dose rate brachytherapy (HDR BT) in this indication is limited. The purpose of our study was to evaluate the viability of perioperative hyperfractionated HDR BT for STS. METHODS:Fort...

journal_title：Annals of surgical oncology

authors： Petera J,Soumarová R,Růzicková J,Neumanová R,Dusek L,Sirák I,Macingová Z,Paluska P,Kasaová L,Hodek M,Vosmik M

更新日期：2010-01-01 00:00:00

abstract：OBJECTIVE:We investigated the possible lobe-specific lymph node (LN) metastasis pattern of early-stage peripheral non-small cell lung cancers (NSCLC) and define the extent of lobe-specific LN dissection for them. METHODS:We retrospectively collected clinical data of patients undergoing lobectomy or segmentectomy with ...

journal_title：Annals of surgical oncology

authors： Deng HY,Zhou J,Wang RL,Jiang R,Zhu DX,Tang XJ,Zhou Q

更新日期：2020-02-01 00:00:00

abstract：BACKGROUND:The rising incidence of incidental thyroid carcinoma (ITC) detected during fluoro-2-deoxy-D: -glucose (FDG)-positron emission tomography (PET)/computed tomography (CT) scanning poses a challenge to clinicians. The present study aims to critically evaluate the clinicopathological characteristics of ITC detect...

journal_title：Annals of surgical oncology

authors： Law TT,Lang BH

更新日期：2011-02-01 00:00:00

abstract：BACKGROUND:Spleen-preserving laparoscopic distal pancreatectomy would be an ideal approach for benign and borderline malignant tumors in the distal pancreas.1 However, this procedure requires advanced surgical experience and technique because of the disadvantages of conventional laparoscopic surgery.2 METHODS:A 35-yea...

journal_title：Annals of surgical oncology

authors： Choi SH,Kang CM,Lee WJ,Chi HS

更新日期：2011-12-01 00:00:00

abstract：AIM:We evaluated preoperative serum carcinoembryonic antigen (CEA) as a prognostic factor for colorectal cancer and determined when surveillance of this marker was useful. METHODS:Serum CEA was measured preoperatively in 1,263 patients who underwent curative resection for colorectal cancer at 3-month intervals for the...

journal_title：Annals of surgical oncology

authors： Park IJ,Choi GS,Lim KH,Kang BM,Jun SH

更新日期：2009-11-01 00:00:00