Endoscopic and pathologic findings associated with clinical outcomes of melanoma in the upper gastrointestinal tract.


BACKGROUND:Melanoma that involves the upper gastrointestinal (GI) tract is rare and studies relating to endoscopic and pathologic findings with clinical outcomes are lacking. We reviewed the gross and microscopic patterns of the upper GI tract in primary and metastatic melanoma, and examined their association with clinical outcomes. METHODS:Twenty-nine cases of primary esophageal (n = 19) and metastatic gastric and/or duodenal melanoma (n = 10) that were detected during upper GI endoscopy between 1995 and 2011 were retrospectively analyzed. RESULTS:Three types of gross patterns were recognized-nodular pattern in 7 cases, mass-forming pattern in 18 cases, and flat pigmented pattern in 4 cases. In primary esophageal melanoma, 13 patients (68.4 %) underwent surgery and 9 received palliative therapy. Of all cases, 22 patients (75.9 %) died of disease progression; the median overall survival period was 12 months (interquartile range [IQR] 4.5-24.5 months), and from recognition of upper GI tract melanoma the median overall survival period was 9 months (IQR 3.5-17.0 months). In primary esophageal cases, skin melanoma stage better discriminated the patients with good prognosis than the esophageal cancer stage. The flat pigmented gross pattern proved to be a good prognostic factor in primary and metastatic GI tract melanomas (p = 0.016 and p = 0.046, respectively). CONCLUSIONS:Melanoma of the GI tract is a highly aggressive disease with a poor prognosis, both in primary and metastatic cases. However, in primary esophageal melanoma, careful inspection of the mucosa during endoscopic examination followed by surgical resection may result in extended survival.


Ann Surg Oncol


Ahn JY,Hwang HS,Park YS,Kim HR,Jung HY,Kim JH,Lee SE,Kim MA




Has Abstract


2014-08-01 00:00:00












  • Defining venous involvement in borderline resectable pancreatic cancer.

    abstract:BACKGROUND:Pancreatic adenocarcinoma impinging the portal and/or superior mesenteric vein (PV-SMV) is classified as borderline resectable, and preoperative chemoradiation is recommended to increase the margin-negative resection rate. There is no consensus about what degree of venous impingement constitutes borderline r...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章


    authors: Chun YS,Milestone BN,Watson JC,Cohen SJ,Burtness B,Engstrom PF,Haluszka O,Tokar JL,Hall MJ,Denlinger CS,Astsaturov I,Hoffman JP

    更新日期:2010-11-01 00:00:00

  • Utility of Chemoresponse Assay in Patients Undergoing Cytoreductive Surgery Plus Hyperthermic Intraperitoneal Chemotherapy.

    abstract:PURPOSE:Our aim was to evaluate the utility of in vitro drug sensitivity testing in patients with peritoneal surface malignancies undergoing cytoreductive surgery (CRS) plus hyperthermic intraperitoneal chemotherapy (HIPEC). METHODS:We found data for 27 patients who underwent CRS plus HIPEC from September 2009 to May ...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章


    authors: Bhagwandin S,Naffouje S,Salti G

    更新日期:2015-08-01 00:00:00

  • Factors predictive of nonsentinel lymph node involvement and clinical outcome in melanoma patients with metastatic sentinel lymph node.

    abstract:BACKGROUND:Identification of melanoma patients who need completion lymphadenectomy and adjuvant treatment after positive sentinel lymph node (SLN) biopsy would be a fundamental step forward toward personalized medicine. This study tested the hypothesis that the microscopic features of metastatic SLNs might predict not ...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章


    authors: Rossi CR,De Salvo GL,Bonandini E,Mocellin S,Foletto M,Pasquali S,Pilati P,Lise M,Nitti D,Rizzo E,Montesco MC

    更新日期:2008-04-01 00:00:00

  • Sentinel lymph node biopsy in pediatric and adolescent cutaneous melanoma patients.

    abstract:BACKGROUND:The rarity of melanoma in young patients, particularly pediatric ones, has to date precluded any valid comparisons being made between young patients and adults undergoing sentinel lymph node biopsy (SLNB) for intermediate thickness localized melanoma. The present study takes advantage of the large Sydney Mel...

    journal_title:Annals of surgical oncology

    pub_type: 临床试验,杂志文章


    authors: Howman-Giles R,Shaw HM,Scolyer RA,Murali R,Wilmott J,McCarthy SW,Uren RF,Thompson JF

    更新日期:2010-01-01 00:00:00

  • Aggressive management of peritoneal carcinomatosis from mucinous appendiceal neoplasms.

    abstract:BACKGROUND:Peritoneal carcinomatosis (PC) in the setting of mucinous appendiceal neoplasms is characterized by the intraperitoneal accumulation of mucinous ascites and mucin-secreting epithelial cells that leads to progressive compression of intra-abdominal organs, morbidity, and eventual death. We assessed postoperati...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章


    authors: Austin F,Mavanur A,Sathaiah M,Steel J,Lenzner D,Ramalingam L,Holtzman M,Ahrendt S,Pingpank J,Zeh HJ,Bartlett DL,Choudry HA

    更新日期:2012-05-01 00:00:00

  • Dickkopf-1 expression as a marker for predicting clinical outcome in esophageal squamous cell carcinoma.

    abstract:BACKGROUND AND OBJECTIVES:Dickkopf-1 (DKK1) is the inhibitor of the canonical Wnt signaling pathway, however it is highly transactivated in various cancers, suggesting the presence of unknown mechanism. Its implication in human esophageal squamous cell carcinoma (ESCC) has not been sufficiently investigated. PATIENTS ...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章


    authors: Makino T,Yamasaki M,Takemasa I,Takeno A,Nakamura Y,Miyata H,Takiguchi S,Fujiwara Y,Matsuura N,Mori M,Doki Y

    更新日期:2009-07-01 00:00:00

  • Evaluation of Lymph Node Staging Systems as Independent Prognosticators in Remnant Gastric Cancer Patients with an Insufficient Number of Harvested Lymph Nodes.

    abstract:BACKGROUND:The lymph node (LN) ratio (LNR) and the log odds of positive LNs (LODDS) have been proposed as sensitive prognosticators in patients with primary gastric cancer, especially in patients with an insufficient number of harvested LNs. We investigated the association of LNR and LODDS with survival in patients wit...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章


    authors: Kano K,Yamada T,Yamamoto K,Komori K,Watanabe H,Takahashi K,Maezawa Y,Fujikawa H,Numata M,Aoyama T,Tamagawa H,Cho H,Yukawa N,Yoshikawa T,Rino Y,Masuda M,Ogata T,Oshima T

    更新日期:2021-01-03 00:00:00

  • Incidental thyroid carcinoma by FDG-PET/CT: a study of clinicopathological characteristics.

    abstract:BACKGROUND:The rising incidence of incidental thyroid carcinoma (ITC) detected during fluoro-2-deoxy-D: -glucose (FDG)-positron emission tomography (PET)/computed tomography (CT) scanning poses a challenge to clinicians. The present study aims to critically evaluate the clinicopathological characteristics of ITC detect...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章


    authors: Law TT,Lang BH

    更新日期:2011-02-01 00:00:00

  • The ability of existing questionnaires to measure symptom change after paracentesis for symptomatic ascites.

    abstract:BACKGROUND:Symptomatic malignant ascites is a problem for patients with advanced intra-abdominal malignancy. Although the goal of paracentesis, the most common therapeutic intervention, is symptom palliation, the best method of assessing symptom improvement is unknown. The aim of this study was to assess the ability of...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章


    authors: Easson AM,Bezjak A,Ross S,Wright JG

    更新日期:2007-08-01 00:00:00

  • A comparison of clinical and pathologic assessments for the prediction of occult nipple involvement in nipple-sparing mastectomies.

    abstract:BACKGROUND:Nipple-sparing mastectomy (NSM) for both risk reduction and cancer is increasing. In the cancer setting, most studies suggest the use of both clinical and intraoperative biopsy criteria in patient selection. This study examines the use of both biopsy and clinical criteria in women undergoing total nipple-rem...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章


    authors: Stolier A,Stone JC,Moroz K,Hanemann CW,McNabb L,Jones SD,Lacey M

    更新日期:2013-01-01 00:00:00

  • Perioperative hyperfractionated high-dose rate brachytherapy for the treatment of soft tissue sarcomas: multicentric experience.

    abstract:BACKGROUND:Low-dose rate brachytherapy is a well-established adjuvant treatment for soft tissue sarcomas (STS). The experience with high-dose rate brachytherapy (HDR BT) in this indication is limited. The purpose of our study was to evaluate the viability of perioperative hyperfractionated HDR BT for STS. METHODS:Fort...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章,多中心研究


    authors: Petera J,Soumarová R,Růzicková J,Neumanová R,Dusek L,Sirák I,Macingová Z,Paluska P,Kasaová L,Hodek M,Vosmik M

    更新日期:2010-01-01 00:00:00

  • Low Lymph Node Retrieval After Preoperative Chemoradiation for Rectal Cancer is Associated with Improved Prognosis in Patients with a Good Tumor Response.

    abstract:PURPOSE:To examine the association between the number of lymph nodes retrieved and oncologic outcome after preoperative chemoradiation for rectal cancer according to tumor regression grade. METHODS:Patients with rectal cancer who underwent curative surgery between May 2004 and December 2012 were analyzed retrospective...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章


    authors: Kim HJ,Jo JS,Lee SY,Kim CH,Kim YJ,Kim HR

    更新日期:2015-01-01 00:00:00

  • Axillary Response in Patients Undergoing Neoadjuvant Endocrine Treatment for Node-Positive Breast Cancer: Systematic Literature Review and NCDB Analysis.

    abstract:BACKGROUND:Several studies have proven that neoadjuvant endocrine therapy (NET) has a similar beneficial therapeutic effect in estrogen-positive (ER+) breast cancer (BC) with improved breast conservation rate in patients undergoing NET versus neoadjuvant chemotherapy (NAC). The impact of axillary complete pathologic re...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章


    authors: Stafford A,Williams A,Edmiston K,Cocilovo C,Cohen R,Bruce S,Yoon-Flannery K,De La Cruz L

    更新日期:2020-11-01 00:00:00

  • Correlates of Refusal of Surgery in the Treatment of Non-metastatic Pancreatic Adenocarcinoma.

    abstract:BACKGROUND:Surgical resection is the most important therapeutic intervention for eligible patients with pancreatic cancer; however, a majority of patients never receive surgery for a variety of reasons, including patient refusal. Utilizing the National Cancer Database, we investigated the associated sociodemographic an...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章


    authors: Coffman A,Torgeson A,Lloyd S

    更新日期:2019-01-01 00:00:00

  • A look into the ductoscope: its role in pathologic nipple discharge.

    abstract:OBJECTIVE:Mammary ductoscopy allows direct visualization of the ductal system and a method for directed excision and pathologic diagnosis. We reviewed our experience with mammary ductoscopy in the evaluation of pathologic nipple discharge. METHODS:We reviewed all patients who underwent ductoscopy for pathologic nipple...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章


    authors: Fisher CS,Margenthaler JA

    更新日期:2011-10-01 00:00:00

  • Do Calcifications Seen on Mammography After Neoadjuvant Chemotherapy for Breast Cancer Always Need to Be Excised?

    abstract:BACKGROUND:This study aimed to determine the relationship between mammographic calcifications and magnetic resonance imaging (MRI) tumoral enhancement before and after neoadjuvant chemotherapy (NAC) and to assess the impact of these findings on surgical management. METHODS:This Institutional Review Board-approved, Hea...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章


    authors: Feliciano Y,Mamtani A,Morrow M,Stempel MM,Patil S,Jochelson MS

    更新日期:2017-06-01 00:00:00

  • Management of the axilla in women with breast cancer: current clinical practice and a new selective targeted approach.

    abstract:BACKGROUND:Axillary nodal status is the most important prognostic factor for patients with breast cancer. Clinical assessment and imaging modalities are not always reliable. Surgical removal and histopathological examination of axillary lymph nodes remain essential methods of staging the axilla. However, the optimal ma...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章,评审


    authors: Samphao S,Eremin JM,El-Sheemy M,Eremin O

    更新日期:2008-05-01 00:00:00

  • Re-excision rates of invasive ductal carcinoma with lobular features compared with invasive ductal carcinomas and invasive lobular carcinomas of the breast.

    abstract:BACKGROUND:Invasive ductal carcinoma (IDC) with lobular features (IDC-L) is not recognized as a subtype of breast cancer. We previously showed that IDC-L may be a variant of IDC with clinicopathological characteristics more similar to invasive lobular carcinoma (ILC). We sought to determine the re-excision rates of IDC...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章


    authors: Arps DP,Jorns JM,Zhao L,Bensenhaver J,Kleer CG,Pang JC

    更新日期:2014-12-01 00:00:00

  • Urinary pH Levels are Strongly Associated with Bladder Recurrence After Nephroureterectomy in Upper Tract Urothelial Carcinoma Patients with a Smoking History.

    abstract:PURPOSE:Aromatic amines, well-known bladder carcinogens, derived from cigarette smoke are activated by acidic urine. We herein determined whether urinary pH levels are associated with bladder recurrence in upper tract urothelial carcinoma patients with a positive smoking history. METHODS:A total of 256 upper tract uro...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章


    authors: Ide H,Kikuchi E,Hagiwara M,Hayakawa N,Hongo H,Miyajima A,Oya M

    更新日期:2016-12-01 00:00:00

  • Endoscopic therapy for Barrett's esophagus: a review of its emerging role in optimal diagnosis and endoluminal therapy.

    abstract::Barrett's esophagus (BE) is a premalignant lesion known to sequentially progress to esophageal adenocarcinoma. Management of BE has changed significantly over the last 5 years with the development of endoscopic resection and ablation, which has replaced esophagectomy as the treatment of choice in BE with high-grade dy...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章,评审


    authors: Dunki-Jacobs EM,Martin RC

    更新日期:2012-05-01 00:00:00

  • An aggressive approach to extrahepatic cholangiocarcinomas is warranted: margin status does not impact survival after resection.

    abstract:BACKGROUND:With cholangiocarcinoma, the only hope of a cure is resection. This study was undertaken to determine the impact of margin status, stage, tumor location, and adjuvant therapy on survival after resection of extrahepatic cholangiocarcinoma. METHODS:From 1985-2006, 91 patients underwent resections of cholangio...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章


    authors: Hernandez J,Cowgill SM,Al-Saadi S,Villadolid D,Ross S,Kraemer E,Shapiro M,Mullinax J,Cooper J,Goldin S,Zervos E,Rosemurgy A

    更新日期:2008-03-01 00:00:00

  • Prognostic and Predictive Value of the Peritoneal Cancer Index in Primary Advanced Epithelial Ovarian Cancer Patients After Complete Cytoreductive Surgery: Study of Tumor Bank Ovarian Cancer.

    abstract:PURPOSE:The peritoneal cancer index (PCI) is used to refer gastrointestinal malignancy patients to either palliative or curative management of their peritoneal carcinomatosis. The aim of this retrospective study was to evaluate the prognostic value of the PCI in patients with primary advanced epithelial ovarian cancer ...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章


    authors: Gasimli K,Braicu EI,Richter R,Chekerov R,Sehouli J

    更新日期:2015-08-01 00:00:00

  • Prognostic significance of c-erbB-2 and vascular endothelial growth factor in colorectal liver metastases.

    abstract:BACKGROUND:The prognostic value of c-erbB-2 and vascular endothelial growth factor (VEGF) expression in colorectal liver metastases (CLM) is unclear. The purpose of this study was to clarify the relationship of c-erbB-2 and VEGF with the clinicopathological parameters and the survival results in CLM. METHODS:For 44 pa...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章


    authors: Chen J,Li Q,Wang C,Wu J,Zhao G

    更新日期:2010-06-01 00:00:00

  • Higher expression of the heterogeneous nuclear ribonucleoprotein k in melanoma.

    abstract:BACKGROUND:The heterogeneous nuclear ribonucleoprotein (hnRNP) K is an essential RNA and DNA binding protein involved in gene expression and signal transduction. The role of hnRNP K in cancer is relatively understudied. However, several cellular functions strongly indicate that hnRNP K is involved in tumorigenesis. Onc...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章


    authors: Wen F,Shen A,Shanas R,Bhattacharyya A,Lian F,Hostetter G,Shi J

    更新日期:2010-10-01 00:00:00

  • p53 genotype predicts response to chemotherapy in patients with squamous cell carcinoma of the esophagus.

    abstract:BACKGROUND:Response to chemotherapy and anatomical spread are significant prognostic factors in patients with esophageal squamous cell carcinoma (ESCC) treated by chemotherapy then surgery. Predicting the response to chemotherapy would allow significant optimization of cancer treatment. METHODS:Genomic mutation and pr...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章


    authors: Yamasaki M,Miyata H,Fujiwara Y,Takiguchi S,Nakajima K,Nishida T,Yasuda T,Matsuyama J,Mori M,Doki Y

    更新日期:2010-02-01 00:00:00

  • Prognostic variables in invasive breast cancer: contribution of comedo versus noncomedo in situ component.

    abstract:BACKGROUND:Many invasive breast cancers are accompanied by a variety of noninvasive components. Histological distinctions have been made between these components, but to understand their importance, it is essential to examine their molecular biology. METHODS:Proliferative indices, oncoproteins, and steroid receptor ex...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章


    authors: Brower ST,Ahmed S,Tartter PI,Bleiweiss I,Amberson JB

    更新日期:1995-09-01 00:00:00

  • (18)F-FDG-PET/CT to select patients with peritoneal carcinomatosis for cytoreductive surgery and hyperthermic intraperitoneal chemotherapy.

    abstract:BACKGROUND:Cytoreductive surgery followed by hyperthermic intraperitoneal chemotherapy (HIPEC) is associated with significantly longer survival in patients with peritoneal carcinomatosis (PC). So far, no morphological imaging method has proven to accurately assess the intra-abdominal tumor spread. This study was design...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章


    authors: Pfannenberg C,Königsrainer I,Aschoff P,Oksüz MO,Zieker D,Beckert S,Symons S,Nieselt K,Glatzle J,Weyhern CV,Brücher BL,Claussen CD,Königsrainer A

    更新日期:2009-05-01 00:00:00

  • Intraoperative Ultrasound-Guided Lumpectomy Versus Mammographic Wire Localization for Breast Cancer Patients After Neoadjuvant Treatment.

    abstract:BACKGROUND:Intraoperative ultrasound (IOUS)-guided lumpectomy in early breast cancer has shown advantages over other techniques. However, the use of IOUS has been less explored after neoadjuvant treatment (NAT). This study aimed to compare IOUS- and wire localization (WL)-guided surgery in breast cancer patients after ...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章


    authors: Rubio IT,Esgueva-Colmenarejo A,Espinosa-Bravo M,Salazar JP,Miranda I,Peg V

    更新日期:2016-01-01 00:00:00

  • Comparison of hepatic resection and hepatic transplantation in the treatment of hepatocellular carcinoma among cirrhotic patients.

    abstract:BACKGROUND:The benefits of hepatic transplantation (HT) compared with hepatic resection (HR) in treating hepatocellular carcinoma (HCC) in patients with cirrhosis are controversial. The aim of this study was to compare the results of these therapeutic options. METHODS:The charts of all patients with cirrhosis who unde...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章


    authors: Shabahang M,Franceschi D,Yamashiki N,Reddy R,Pappas PA,Aviles K,Flores S,Chaparro A,Levi JU,Sleeman D,Tzakis AG,Kato T,Levi DM,Livingstone AS

    更新日期:2002-11-01 00:00:00

  • Cellular immunity delimits adenoviral gene therapy strategies for the treatment of neoplastic diseases.

    abstract:BACKGROUND:Adenoviral gene therapy is a promising new approach for the treatment of neoplastic diseases. To design rational clinical trials and distinguish the effects of therapeutic transgene expression from those caused by viral infection alone, the immune response to the vector must be understood. In these experimen...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章


    authors: DeMatteo RP,Yeh H,Friscia M,Caparrelli D,Burke C,Desai N,Chu G,Markmann JF,Raper SE,Barker CF

    更新日期:1999-01-01 00:00:00