Abstract:
:Pneumonia due to Gram-negative bacteria is associated with high mortality. Acinetobacter baumannii is a Gram-negative bacterium that is associated with hospital-acquired and ventilator-associated pneumonia. Bacteria have been described to release outer membrane vesicles (OMVs) that are capable of mediating systemic inflammation. The mechanism by which A. baumannii OMVs mediate inflammation is not fully defined. We sought to investigate the roles that Toll-like receptors (TLRs) play in A. baumannii OMV-mediated pulmonary inflammation. We isolated OMVs from A. baumannii cultures and intranasally introduced the OMVs into mice. Intranasal introduction of A. baumannii OMVs mediated pulmonary inflammation, which is associated with neutrophil recruitment and weight loss. In addition, A. baumannii OMVs increased the release of several chemokines and cytokines in the mouse lungs. The proinflammatory responses were partially inhibited in TLR2- and TLR4-deficient mice compared to those of wild-type mice. This study highlights the important roles of TLRs in A. baumannii OMV-induced pulmonary inflammation in vivo.
journal_name
Infect Immunjournal_title
Infection and immunityauthors
Marion CR,Lee J,Sharma L,Park KS,Lee C,Liu W,Liu P,Feng J,Gho YS,Dela Cruz CSdoi
10.1128/IAI.00243-19subject
Has Abstractpub_date
2019-08-21 00:00:00issue
9eissn
0019-9567issn
1098-5522pii
IAI.00243-19journal_volume
87pub_type
杂志文章abstract::The amino acid sequence of heat-stable enterotoxin produced by enterotoxigenic Escherichia coli 18D has been revised. Amino acids originally assigned to positions 11 and 18, i.e., Tyr and Asn, respectively, were found to occupy positions 18 and 11, respectively. Thus all heat-stable enterotoxins composed of 18 amino a...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.47.3.834-836.1985
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journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.64.3.913-918.1996
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journal_title:Infection and immunity
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doi:10.1128/IAI.6.4.438-443.1972
更新日期:1972-10-01 00:00:00
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journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.61.9.3583-3589.1993
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journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.62.2.371-376.1994
更新日期:1994-02-01 00:00:00
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journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.23.3.829-837.1979
更新日期:1979-03-01 00:00:00
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journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.61.6.2334-2339.1993
更新日期:1993-06-01 00:00:00
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journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.11.3.603-606.1975
更新日期:1975-03-01 00:00:00
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journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.60.4.1589-1597.1992
更新日期:1992-04-01 00:00:00
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journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.41.3.1380-1382.1983
更新日期:1983-09-01 00:00:00
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journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/iai.71.9.4891-4900.2003
更新日期:2003-09-01 00:00:00
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journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.73.8.4777-4786.2005
更新日期:2005-08-01 00:00:00
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journal_title:Infection and immunity
pub_type: 杂志文章
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更新日期:2010-11-01 00:00:00
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journal_title:Infection and immunity
pub_type: 杂志文章
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更新日期:2009-02-01 00:00:00
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journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.59.8.2609-2614.1991
更新日期:1991-08-01 00:00:00
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journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.69.10.6193-6200.2001
更新日期:2001-10-01 00:00:00
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journal_title:Infection and immunity
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doi:10.1128/IAI.51.2.507-513.1986
更新日期:1986-02-01 00:00:00
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journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.65.6.2254-2259.1997
更新日期:1997-06-01 00:00:00
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journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.4.5.660-661.1971
更新日期:1971-11-01 00:00:00
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journal_title:Infection and immunity
pub_type: 杂志文章
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更新日期:1982-10-01 00:00:00
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journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.64.6.2220-2224.1996
更新日期:1996-06-01 00:00:00
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journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.02572-14
更新日期:2015-03-01 00:00:00
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journal_title:Infection and immunity
pub_type: 杂志文章
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更新日期:2014-03-01 00:00:00
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journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.69.5.3110-3119.2001
更新日期:2001-05-01 00:00:00
abstract::Trypanosoma cruzi is a protozoan parasite that can initiate mucosal infection after conjunctival exposure. The anatomical route of T. cruzi invasion and spread after conjunctival parasite contamination remains poorly characterized. In the present work we have identified the sites of initial invasion and replication af...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.00319-06
更新日期:2006-10-01 00:00:00
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journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.10.4.742-746.1974
更新日期:1974-10-01 00:00:00
abstract::Erysipelothrix rhusiopathiae is a primary pathogen of swine and turkeys and sporadic cause of disease in a variety of other hosts, including humans. A genomic library of the highly virulent strain of E. rhusiopathiae E1-6P was constructed in the expression-cloning vector lambda gt11 and screened with serum from a pig ...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.58.9.3116-3121.1990
更新日期:1990-09-01 00:00:00
abstract::Both interleukin-17A (IL-17A) and IL-17F are proinflammatory cytokines that have an important role in intestinal homeostasis via receptor signaling. These cytokines have been characterized in chickens, but very little is known about their receptors and their functional activity. We provide here the first description o...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.02141-14
更新日期:2014-09-01 00:00:00
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journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.62.4.1437-1443.1994
更新日期:1994-04-01 00:00:00