Abstract:
:We present a new database, specifically devoted to ROS homeostasis regulated proteins. This database replaced our previous database, the PeroxiBase, which was focused only on various peroxidase families. The addition of 20 new protein families related with ROS homeostasis justifies the new name for this more complex and comprehensive database as RedoxiBase. Besides enlarging the focus of the database, new analysis tools and functionalities have been developed and integrated through the web interface, with which the users can now directly access to orthologous sequences and see the chromosomal localization of sequences when available. OrthoMCL tool, completed with a post-treatment process, provides precise predictions of orthologous gene groups for the sequences present in this database. In order to explore and analyse orthogroups results, taxonomic visualization of organisms containing sequence of a specific orthogroup as well as chromosomal distribution of the orthogroup with one or two organisms have been included.
journal_name
Redox Bioljournal_title
Redox biologyauthors
Savelli B,Li Q,Webber M,Jemmat AM,Robitaille A,Zamocky M,Mathé C,Dunand Cdoi
10.1016/j.redox.2019.101247subject
Has Abstractpub_date
2019-09-01 00:00:00pages
101247issn
2213-2317pii
S2213-2317(19)30580-4journal_volume
26pub_type
杂志文章相关文献
Redox Biology文献大全abstract::Microglia-mediated neuroinflammation plays a crucial role in the pathophysiological process of multiple neurological disorders such as ischemic stroke, yet lacks effective therapeutic agents. Previously, we discovered one novel synthetic compound, tanshinol borneol ester (DBZ), possesses anti-inflammatory and anti-ath...
journal_title:Redox biology
pub_type: 杂志文章
doi:10.1016/j.redox.2020.101644
更新日期:2020-09-01 00:00:00
abstract:OBJECTIVE:Cellular repressor of E1A-stimulated genes (CREG), a vasculoprotective molecule, is significantly downregulated in atherosclerotic vessels through unclear mechanisms. While epigenetic regulation is involved in atherosclerosis development, it is not known if the CREG gene is epigenetically regulated. The aim o...
journal_title:Redox biology
pub_type: 杂志文章
doi:10.1016/j.redox.2020.101444
更新日期:2020-05-01 00:00:00
abstract::Neurodegenerative diseases (NDD) such as Alzheimer's (AD) and Parkinson's disease (PD) are distinct clinical entities, however, the aggregation of key neuronal proteins, presumably leading to neuronal demise appears to represent a common mechanism. It has become evident, that advanced glycation end products (AGEs) tri...
journal_title:Redox biology
pub_type: 杂志文章
doi:10.1016/j.redox.2020.101546
更新日期:2020-07-01 00:00:00
abstract::In order to overcome intercellular variability and thereby effectively assess signal propagation in biological networks it is imperative to simultaneously quantify multiple biological observables in single living cells. While fluorescent biosensors have been the tool of choice to monitor the dynamics of protein intera...
journal_title:Redox biology
pub_type: 杂志文章
doi:10.1016/j.redox.2018.07.023
更新日期:2018-10-01 00:00:00
abstract::Adropin, a secretory signal peptide, has shown beneficial effects on improving glucose homeostasis and dyslipidemia. However, whether this peptide affects nonalcoholic steatohepatitis (NASH) has remained unclear. In this study, the serum adropin levels, liver injury and oxidative stress were measured in diet-induced N...
journal_title:Redox biology
pub_type: 杂志文章
doi:10.1016/j.redox.2018.101068
更新日期:2019-02-01 00:00:00
abstract::Electrophiles and reactive oxygen species (ROS) play a major role in modulating cellular defense mechanisms as well as physiological functions, and intracellular signaling. However, excessive ROS generation (endogenous and exogenous) can create a state of redox imbalance leading to cellular and tissue damage (Ma and H...
journal_title:Redox biology
pub_type: 杂志文章,评审
doi:10.1016/j.redox.2018.11.017
更新日期:2019-02-01 00:00:00
abstract::Hydroxytyrosol (HT) is a main phenolic component of olive oil. In this study, we investigated the safety and effects produced by HT purified (99.5%) from olive mill waste. HT was administered at a daily dosage of 45mg for 8 weeks to volunteers with mild hyperlipidemia (n=14). We measured markers of cardiovascular dise...
journal_title:Redox biology
pub_type: 临床试验,杂志文章
doi:10.1016/j.redox.2016.12.014
更新日期:2017-04-01 00:00:00
abstract::Fibrosis is one of the most prevalent features of age-related diseases like obesity, diabetes, non-alcoholic fatty liver disease, chronic kidney disease, or cardiomyopathy and affects millions of people in all countries. Although the understanding about the pathophysiology of fibrosis has improved a lot during the rec...
journal_title:Redox biology
pub_type: 杂志文章,评审
doi:10.1016/j.redox.2015.08.015
更新日期:2015-12-01 00:00:00
abstract::Necroptosis has been discovered as a new paradigm of cell death and may play a key role in heart disease and selenium (Se) deficiency. Hence, we detected the specific microRNA (miRNA) in response to Se-deficient heart using microRNAome analysis. For high-throughput sequencing using Se-deficient chicken cardiac tissue,...
journal_title:Redox biology
pub_type: 杂志文章
doi:10.1016/j.redox.2017.11.025
更新日期:2018-05-01 00:00:00
abstract::Cardiovascular disease is the leading cause of death and disability worldwide with increased oxidative stress and reduced NO bioavailability serving as key risk factors. For decades, elevation in protein abundance and enzymatic activity of xanthine oxidoreductase (XOR) under hypoxic/inflammatory conditions has been as...
journal_title:Redox biology
pub_type: 杂志文章
doi:10.1016/j.redox.2020.101447
更新日期:2020-07-01 00:00:00
abstract::There has been some dispute regarding reaction products formed at physiological peroxynitrite fluxes in the nanomolar range with phenolic molecules, when used to predict the behavior of protein-bound aromatic amino acids like tyrosine. Previous data showed that at nanomolar fluxes of peroxynitrite, nitration of these ...
journal_title:Redox biology
pub_type: 杂志文章
doi:10.1016/j.redox.2015.11.008
更新日期:2016-04-01 00:00:00
abstract::In the present study, we aimed to investigate the impact of permanent cystathionine-β-Synthase (CBS) gene knockdown in human telomerase reverse transcriptase (hTERT) immortalized human adipose-derived mesenchymal stem cells (ASC52telo) and in their capacity to differentiate into adipocytes. CBS gene KD in ASC52telo ce...
journal_title:Redox biology
pub_type: 杂志文章
doi:10.1016/j.redox.2020.101668
更新日期:2020-08-02 00:00:00
abstract::Isolated hepatocytes from young (4-6mo) and old (24-26mo) F344 rats were exposed to increasing concentrations of menadione, a vitamin K derivative and redox cycling agent, to determine whether the age-related decline in Nrf2-mediated detoxification defenses resulted in heightened susceptibility to xenobiotic insult. A...
journal_title:Redox biology
pub_type: 杂志文章
doi:10.1016/j.redox.2016.09.010
更新日期:2016-12-01 00:00:00
abstract::Hydrogen peroxide appears to be the key reactive oxygen species involved in redox signalling, but comparisons of the low concentrations of hydrogen peroxide that are calculated to exist within cells with those previously shown to activate common signalling events in vitro indicate that direct oxidation of key thiol gr...
journal_title:Redox biology
pub_type: 杂志文章,评审
doi:10.1016/j.redox.2020.101484
更新日期:2020-08-01 00:00:00
abstract::Activity-induced nitric oxide (NO) imbalance and "nitrosative stress" are proposed mechanisms of disrupted Ca(2+) homeostasis in atrophic skeletal muscle. We thus mapped S-nitrosylated (SNO) functional muscle proteins in healthy male subjects in a long-term bed rest study (BBR2-2 Study) without and with exercise as co...
journal_title:Redox biology
pub_type: 杂志文章
doi:10.1016/j.redox.2013.10.006
更新日期:2013-10-28 00:00:00
abstract:BACKGROUND:Obstructive Jaundice (OJ) is associated with a significant risk of developing acute renal failure (ARF). The involvement of oxidative stress in the development of cholestasis has been demonstrated in different experimental models. However, its role in the morbidity of human cholestasis is far to be elucidate...
journal_title:Redox biology
pub_type: 杂志文章
doi:10.1016/j.redox.2015.12.009
更新日期:2016-08-01 00:00:00
abstract::Mechanistic/mammalian target of rapamycin (mTOR) has emerged as a new potential therapeutic target for gastric cancer. Rapamycin and rapamycin analogs are undergoing clinical trials and have produced clinical responses in a subgroup of cancer patients. However, monotherapy with rapamycin at safe dosage fails to induce...
journal_title:Redox biology
pub_type: 杂志文章
doi:10.1016/j.redox.2016.09.006
更新日期:2016-12-01 00:00:00
abstract::Hydrogen peroxide (H2O2) modulates critical phosphorylation pathways in vascular endothelial cells, many of which affect endothelial nitric oxide synthase (eNOS) signal transduction. Both intracellular and extracellular sources of H2O2 have been implicated in eNOS regulation, yet the specific endothelial pathways rema...
journal_title:Redox biology
pub_type: 杂志文章
doi:10.1016/j.redox.2020.101605
更新日期:2020-09-01 00:00:00
abstract::Nitric oxide (NO) inhibits cell respiration reversibly and in competition with O2 through the inhibition of the mitochondrial cytochrome c oxidase (Complex IV). At concentrations lower than those required to inhibit respiration, endogenous NO enhances the reduction of the electron transport chain, thus enabling cells ...
journal_title:Redox biology
pub_type: 杂志文章
doi:10.1016/j.redox.2015.09.034
更新日期:2015-08-01 00:00:00
abstract::Glioblastoma (GBM) is the most common and most aggressive brain tumor, associated with high levels of reactive oxidative species (ROS) due to metabolic and signaling aberrations. High ROS levels are detrimental to cells, but it remains incompletely understood how cancer cells cope with the adverse effects. Here we sho...
journal_title:Redox biology
pub_type: 杂志文章
doi:10.1016/j.redox.2020.101578
更新日期:2020-07-01 00:00:00
abstract::Yeast Sir2 is an NAD-dependent histone deacetylase related to oxidative stress and aging. In a previous study, we showed that Sir2 is regulated by S-glutathionylation of key cysteine residues located at the catalytic domain. Mutation of these residues results in strains with increased resistance to disulfide stress. I...
journal_title:Redox biology
pub_type: 杂志文章
doi:10.1016/j.redox.2019.101229
更新日期:2019-06-01 00:00:00
abstract::Alterations in the NRF2/KEAP1 pathway result in the constitutive activation of NRF2, leading to the aberrant induction of antioxidant and detoxification enzymes, including NQO1. The NQO1 bioactivatable agent β-lapachone can target cells with high NQO1 expression but relies in the generation of reactive oxygen species ...
journal_title:Redox biology
pub_type: 杂志文章
doi:10.1016/j.redox.2020.101440
更新日期:2020-02-01 00:00:00
abstract::The inducible form of Heme Oxygenase-1 (HO-1), a major endoplasmic reticulum (ER) associated heme protein, is known to play important roles in protection against oxidative and chemical stress by degrading free heme released from degradation of heme proteins. In this study we show that induced expression of HO-1 by sub...
journal_title:Redox biology
pub_type: 杂志文章
doi:10.1016/j.redox.2013.07.004
更新日期:2013-07-23 00:00:00
abstract::Strenuous exercise is a potent stimulus to induce beneficial skeletal muscle adaptations, ranging from increased endurance due to mitochondrial biogenesis and angiogenesis, to increased strength from hypertrophy. While exercise is necessary to trigger and stimulate muscle adaptations, the post-exercise recovery period...
journal_title:Redox biology
pub_type: 杂志文章,评审
doi:10.1016/j.redox.2020.101480
更新日期:2020-08-01 00:00:00
abstract::We previously reported that the highly reactive cell-free heme (CFH) is increased in the plasma of patients with chronic lung injury and causes pulmonary edema in animal model of acute respiratory distress syndrome (ARDS) post inhalation of halogen gas. However, the mechanisms by which CFH causes pulmonary edema are u...
journal_title:Redox biology
pub_type: 杂志文章
doi:10.1016/j.redox.2020.101592
更新日期:2020-09-01 00:00:00
abstract:BACKGROUND:The oxidation of the methionine adenosyltransferase (MAT) by the combined impact of peroxides contaminating parenteral nutrition (PN) and oxidized redox potential of glutathione is suspected to explain its inhibition observed in animals. A modification of MAT activity is suspected to be at origin of the PN-a...
journal_title:Redox biology
pub_type: 杂志文章
doi:10.1016/j.redox.2015.12.003
更新日期:2016-08-01 00:00:00
abstract::Simvastatin reduces the blood concentration of cholesterol by inhibiting hydroxymethylglutaryl-coenzyme A reductase, the rate-limiting enzyme in cholesterol synthesis, and thereby reduces the risk of cardiovascular disease. In addition, simvastatin treatment leads to a reduction in fluxes in mitochondrial respiratory ...
journal_title:Redox biology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/j.redox.2016.05.007
更新日期:2016-10-01 00:00:00
abstract::Molecular level, mechanistic understanding of the roles of reactive oxygen species (ROS) in a variety of pathological conditions is hindered by the difficulties associated with determining the concentration of various ROS species. Here, we present an approach that converts fold-change in the signal from an intracellul...
journal_title:Redox biology
pub_type: 杂志文章
doi:10.1016/j.redox.2014.08.001
更新日期:2014-01-01 00:00:00
abstract::Autophagy is an important cell recycling program responsible for the clearance of damaged or long-lived proteins and organelles. Pharmacological modulators of this pathway have been extensively utilized in a wide range of basic research and pre-clinical studies. Bafilomycin A1 and chloroquine are commonly used compoun...
journal_title:Redox biology
pub_type: 杂志文章
doi:10.1016/j.redox.2016.11.004
更新日期:2017-04-01 00:00:00
abstract::Oxidative stress plays a major part in the pathogenesis of drug-induced liver injury. Yet, overcoming it with other xenobiotics impose additional risks. In this study, we consider the use of natural-occurring and purified Vitamin E analogs as hepatoprotective agents. Vitamin E is well-known for its intrinsic antioxida...
journal_title:Redox biology
pub_type: 杂志文章
doi:10.1016/j.redox.2015.01.013
更新日期:2015-01-01 00:00:00