Abstract：
:Compared to solid tumors, the role of PD-L1 in hematological malignancies is less explored, and the knowledge in this area is mostly limited to lymphomas. However, several studies indicated that PD-L1 is also overexpressed in myeloid malignancies. Successful treatment of the acute myeloid leukemia (AML) is likely associated with elimination of the residual disease by the immune system, and possible involvement of PD-L1 in this process remains to be elucidated. We analyzed PD-L1 expression on AML primary cells by flow cytometry and, in parallel, transcript levels were determined for the transcription variants v1 and v2. The ratio of v1/v2 cDNA correlated with the surface protein amount, and high v1/v2 levels were associated with worse overall survival (p = 0.0045). The prognostic impact of PD-L1 was limited to AML with mutated nucleophosmin and concomitant internal tandem duplications in the FLT3 gene (p less than 0.0001 for this particular AML subgroup).
journal_name
Int J Mol Scijournal_title
International journal of molecular sciencesauthors
Brodská B,Otevřelová P,Šálek C,Fuchs O,Gašová Z,Kuželová Kdoi
10.3390/ijms20112823subject
Has Abstractpub_date
2019-06-10 00:00:00issue
11issn
1422-0067pii
ijms20112823journal_volume
20pub_type
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