Abstract：
:Because of its multifactorial nature, predicting the presence of cancer using a single biomarker is difficult. We aimed to establish a novel machine-learning model for predicting hepatocellular carcinoma (HCC) using real-world data obtained during clinical practice. To establish a predictive model, we developed a machine-learning framework which developed optimized classifiers and their respective hyperparameter, depending on the nature of the data, using a grid-search method. We applied the current framework to 539 and 1043 patients with and without HCC to develop a predictive model for the diagnosis of HCC. Using the optimal hyperparameter, gradient boosting provided the highest predictive accuracy for the presence of HCC (87.34%) and produced an area under the curve (AUC) of 0.940. Using cut-offs of 200 ng/mL for AFP, 40 mAu/mL for DCP, and 15% for AFP-L3, the accuracies of AFP, DCP, and AFP-L3 for predicting HCC were 70.67% (AUC, 0.766), 74.91% (AUC, 0.644), and 71.05% (AUC, 0.683), respectively. A novel predictive model using a machine-learning approach reduced the misclassification rate by about half compared with a single tumor marker. The framework used in the current study can be applied to various kinds of data, thus potentially become a translational mechanism between academic research and clinical practice.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Sato M,Morimoto K,Kajihara S,Tateishi R,Shiina S,Koike K,Yatomi Ydoi
10.1038/s41598-019-44022-8subject
Has Abstractpub_date
2019-05-30 00:00:00pages
7704issue
1issn
2045-2322pii
10.1038/s41598-019-44022-8journal_volume
9pub_type
杂志文章abstract：:The Batrachosauroididae are an enigmatic group of salamanders known from the Cretaceous and Tertiary of North America and Europe. In Europe, the family is known only by two species of the genus Palaeoproteus. The genus has limited distribution in Western and Central Europe. In the present paper, we describe a new spec...
journal_title：Scientific reports
pub_type： 历史文章,杂志文章
doi：10.1038/s41598-020-59255-1
更新日期：2020-02-17 00:00:00
abstract：:A major limitation for better understanding the role of the human gut virome in health and disease is the lack of validated methods that allow high throughput virome analysis. To overcome this, we evaluated the quantitative effect of homogenisation, centrifugation, filtration, chloroform treatment and random amplifica...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep16532
更新日期：2015-11-12 00:00:00
abstract：:Mind wandering (MW) refers to the disengagement of attention from the external environment and the generation of thoughts unrelated to the task at hand. It is a ubiquitous cognitive process resulting in lapses of attention. MW imposes a negative impact on attention-based task performance, but also has been associated ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-10616-3
更新日期：2017-08-31 00:00:00
abstract：:We have systematically investigated the influence of oxygen vacancy defects on the structural, electronic and magnetic properties of La(1-x)Sr(x)MnO3 (x = 1/3) film by means of ab initio calculations using bare GGA as well as GGA+U formalism, in the latter of which, the on-site Coulombic repulsion parameter U for Mn 3...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep22422
更新日期：2016-03-01 00:00:00
abstract：:The objective of this study was to investigate the associations between selenium exposure and cancer risk. We identified 69 studies and applied meta-analysis, meta-regression and dose-response analysis to obtain available evidence. The results indicated that high selenium exposure had a protective effect on cancer ris...
journal_title：Scientific reports
pub_type： 杂志文章,meta分析
doi：10.1038/srep19213
更新日期：2016-01-20 00:00:00
abstract：:A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has not been fixed in the paper. ...
journal_title：Scientific reports
pub_type： 已发布勘误
doi：10.1038/s41598-018-28707-0
更新日期：2018-08-07 00:00:00
abstract：:Gold nanoparticles have particular properties distinct from those of bulk gold crystals, and such nanoparticles are used in various applications in optics, catalysis, and drug delivery. Many reports on microbial synthesis of gold nanoparticles have appeared. However, the molecular details (reduction and dispersion) of...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep34626
更新日期：2016-10-11 00:00:00
abstract：:Harmaline (HAR), a natural occurrence β-carboline alkaloid, was isolated from the seeds of Peganum harmala and exhibited potent antitumor effect. In this study, the anti-gastric tumor effects of HAR were firstly investigated in vitro and in vivo. The results strongly showed that HAR could inhibit tumor cell proliferat...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep18613
更新日期：2015-12-18 00:00:00
abstract：:An infinite three dimensional (3D) crystal can be constructed by an infinite number of parallel 2D (hkl) crystal planes (CPs) coupled to each other. Based on lattice model Hamiltonian with the hopping between the nearest neighbor (1NN) CPs and all possible neighbor hoppings within each CP, we analytically prove that a...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep08679
更新日期：2015-03-02 00:00:00
abstract：:In this article a new spent catalyst sample preparation method was implemented for the purpose of molybdenum leaching in a single step. Further molybdenum and vanadium in the leach liquor were separated and their concentrations were enriched using the solvent extraction and stripping techniques. The impervious sulfur ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-58972-x
更新日期：2020-02-06 00:00:00
abstract：:Large-scale molecular epidemiologic studies of Plasmodium falciparum parasites have provided insights into parasite biology and transmission, can identify the spread of drug resistance, and are useful in assessing vaccine targets. The polyclonal nature infections in high transmission settings is problematic for tradit...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep41108
更新日期：2017-01-24 00:00:00
abstract：:A correction to this article has been published and is linked from the HTML version of this paper. The error has been fixed in the paper. ...
journal_title：Scientific reports
pub_type： 杂志文章,已发布勘误
doi：10.1038/s41598-017-16210-x
更新日期：2017-11-23 00:00:00
abstract：:High temperature stable selective emitters can significantly increase efficiency and radiative power in thermophotovoltaic (TPV) systems. However, optical properties of structured emitters reported so far degrade at temperatures approaching 1200 °C due to various degradation mechanisms. We have realized a 1D structure...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-43640-6
更新日期：2019-05-10 00:00:00
abstract：:Colors of crystals, pigments, metals, salt solutions and bioluminescence occur in nature due to the optical properties of electrons in atoms and molecules. However, colors can also result from interference effects on nanostructures. In contrast to artificial coloration, which are caused by well-defined regular structu...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-17914-w
更新日期：2017-12-15 00:00:00
abstract：:Highly invasive animal based test procedures for risk assessment such as the Draize eye test are under increasing criticism due to poor transferability for the human organism and animal-welfare concerns. However, besides all efforts, the Draize eye test is still not completely replaced by alternative animal-free metho...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-33118-2
更新日期：2018-10-09 00:00:00
abstract：:Genotyping-by-sequencing (GBS) or restriction-site associated DNA marker sequencing (RAD-seq) is a practical and cost-effective method for analysing large genomes from high diversity species. This method of sequencing, coupled with methylation-sensitive enzymes (often referred to as methylation-sensitive restriction e...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-19655-w
更新日期：2018-02-01 00:00:00
abstract：:In swine the upper reproductive tract undergoes early postnatal development, however little is known about the lower reproductive tract. Our objective was to measure cytology and proteome of vaginal swab samples taken on postnatal day (PND) 2 and 16 in gilts to determine if temporal changes occurred in cell and protei...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-49597-w
更新日期：2019-09-13 00:00:00
abstract：:This study investigates the effects of aircraft cabin pressure on intracranial pressure (ICP) elevation of a pneumocephalus patient. We propose an experimental setup that simulates the intracranial hydrodynamics of a pneumocephalus patient during flight. It consists of an acrylic box (skull), air-filled balloon [intra...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-70614-w
更新日期：2020-08-12 00:00:00
abstract：:We demonstrate a designed interaction between two isolated cell populations of Euglena gracilis and Chlamydomonas reinhardtii, separately confined in two 25-square micro-aquariums of lab-on-chip size. The interaction was realized by interlinking two identical optical feedback systems, which measured the cell distribut...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep24602
更新日期：2016-04-21 00:00:00
abstract：:Some studies have demonstrated interactions of AD-risk single nucleotide polymorphisms (SNPs) in non-APOE regions with APOE genotype. Nevertheless, no study reported interactions of expression quantitative trait locus (eQTL) for APOE with APOE genotype. In present study, we included 9286 unrelated AD patients and 8479...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-26398-1
更新日期：2018-05-23 00:00:00
abstract：:Reciprocity is frequently assumed to require complex cognitive abilities. Therefore, it has been argued that reciprocity may be restricted to animals that can meet these demands. Here, we provide evidence for the potential presence of direct reciprocity in teleost fishes. We demonstrate that in pairs of coral reef rab...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep14556
更新日期：2015-09-25 00:00:00
abstract：:A plasmonic Ag/TiO2 photocatalytic composite was designed by selecting Ag quantum dots (Ag QDs) to act as a surface plasmon resonance (SPR) photosensitizer for driving the visible-light driven photoelectrocatalytic hydrogen evolution. Vertically oriented hierarchical TiO2 nanotube arrays (H-TiO2-NTAs) with macroporous...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep10461
更新日期：2015-06-12 00:00:00
abstract：:Predation plays a central role in the lives of most organisms. Predators must find and subdue prey to survive and reproduce, whereas prey must avoid predators to do the same. The resultant antagonistic coevolution often leads to extreme adaptations in both parties. Few examples capture the imagination like a rapid str...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep40412
更新日期：2017-01-13 00:00:00
abstract：:While a large body of research has focused on the study of functional brain "connectivity", few investigators have focused on directionality of brain-brain interactions which, in spite of the mostly bidirectional anatomical substrates, cannot be assumed to be symmetrical. We employ a multivariate Granger Causality-bas...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-23996-x
更新日期：2018-04-03 00:00:00
abstract：:Symblepharon due to chemical burns affects ocular surface health, and there are currently no satisfactory treatments. To improve our understanding of symblepharon, an appropriate animal model is urgently needed. We established a rabbit model of superior conjunctival sac alkaline burn to evaluate symblepharon severity....
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-50286-x
更新日期：2019-09-25 00:00:00
abstract：:The accurate prediction of the impact of an amino acid substitution on the thermal stability of a protein is a central issue in protein science, and is of key relevance for the rational optimization of various bioprocesses that use enzymes in unusual conditions. Here we present one of the first computational tools to ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep23257
更新日期：2016-03-18 00:00:00
abstract：:DNA methylation-based biological age (DNAm age), as well as genome-wide average DNA methylation, have been reported to predict breast cancer risk. We aimed to investigate the associations between these DNA methylation-based risk factors and 18 conventional breast cancer risk factors for disease-free women. A sample of...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-51475-4
更新日期：2019-10-21 00:00:00
abstract：:In inflammatory bowel disease (IBD), compromised restitution of the epithelial barrier contributes to disease severity. Owing to the complexity in the pathogenesis of IBD, a variety of factors have been implicated in its progress. In this study, we report a functional interaction between macroautophagy and Corticotrop...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep23342
更新日期：2016-03-18 00:00:00
abstract：:Accurate and detailed knowledge of California's groundwater is of paramount importance for statewide water resources planning and management, and to sustain a multi-billion-dollar agriculture industry during prolonged droughts. In this study, we use water supply and demand information from California's Department of W...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-31210-1
更新日期：2018-08-27 00:00:00
abstract：:Advanced age is associated with a decline in cognitive function, likely caused by a combination of modifiable and non-modifiable factors such as genetics and lifestyle choices. Mounting evidence suggests that humanin and other mitochondrial derived peptides play a role in several age-related conditions including neuro...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-32616-7
更新日期：2018-09-21 00:00:00
