Bacillus subtilis cell diameter is determined by the opposing actions of two distinct cell wall synthetic systems.

abstract：:Aichi virus (AiV), an unusual and poorly characterized picornavirus, classified in the genus Kobuvirus, can cause severe gastroenteritis and deaths in children below the age of five years, especially in developing countries1,2. The seroprevalence of AiV is approximately 60% in children under the age of ten years and r...

journal_title：Nature microbiology

authors： Zhu L,Wang X,Ren J,Kotecha A,Walter TS,Yuan S,Yamashita T,Tuthill TJ,Fry EE,Rao Z,Stuart DI

更新日期：2016-09-05 00:00:00

abstract：:Here, we developed hCK, a Madin-Darby canine kidney (MDCK) cell line that expresses high levels of human influenza virus receptors and low levels of avian virus receptors. hCK cells supported human A/H3N2 influenza virus isolation and growth much more effectively than conventional MDCK or human virus receptor-overexpr...

journal_title：Nature microbiology

authors： Takada K,Kawakami C,Fan S,Chiba S,Zhong G,Gu C,Shimizu K,Takasaki S,Sakai-Tagawa Y,Lopes TJS,Dutta J,Khan Z,Kriti D,van Bakel H,Yamada S,Watanabe T,Imai M,Kawaoka Y

更新日期：2019-08-01 00:00:00

abstract：:The microbial environment influences animal physiology. However, the underlying molecular mechanisms of such functional interactions are largely undefined. Previously, we showed that during chronic undernutrition, strains of Lactobacillus plantarum, a major commensal partner of Drosophila, promote host juvenile growth...

journal_title：Nature microbiology

authors： Matos RC,Schwarzer M,Gervais H,Courtin P,Joncour P,Gillet B,Ma D,Bulteau AL,Martino ME,Hughes S,Chapot-Chartier MP,Leulier F

更新日期：2017-12-01 00:00:00

abstract：: ...

journal_title：Nature microbiology

authors： Francetic O

更新日期：2018-11-01 00:00:00

abstract：:Crimean-Congo haemorrhagic fever (CCHF) is the most medically significant tick-borne disease, being widespread in the Middle East, Asia, Africa and parts of Europe 1 . Increasing case numbers, westerly movement and broadly ranging case fatality rates substantiate the concern of CCHF as a public health threat. Ixodid t...

journal_title：Nature microbiology

authors： Haddock E,Feldmann F,Hawman DW,Zivcec M,Hanley PW,Saturday G,Scott DP,Thomas T,Korva M,Avšič-Županc T,Safronetz D,Feldmann H

更新日期：2018-05-01 00:00:00

abstract：:Primary sclerosing cholangitis (PSC) is a chronic inflammatory liver disease and its frequent complication with ulcerative colitis highlights the pathogenic role of epithelial barrier dysfunction. Intestinal barrier dysfunction has been implicated in the pathogenesis of PSC, yet its underlying mechanism remains unknow...

journal_title：Nature microbiology

authors： Nakamoto N,Sasaki N,Aoki R,Miyamoto K,Suda W,Teratani T,Suzuki T,Koda Y,Chu PS,Taniki N,Yamaguchi A,Kanamori M,Kamada N,Hattori M,Ashida H,Sakamoto M,Atarashi K,Narushima S,Yoshimura A,Honda K,Sato T,Kanai T

更新日期：2019-03-01 00:00:00

abstract：:Many insects, including mosquitoes, planthoppers, aphids and leafhoppers, are the hosts of bacterial symbionts and the vectors for transmitting viral pathogens1-3. In general, symbiotic bacteria can indirectly affect viral transmission by enhancing immunity and resistance to viruses in insects3-5. Whether symbiotic ba...

journal_title：Nature microbiology

authors： Jia D,Mao Q,Chen Y,Liu Y,Chen Q,Wu W,Zhang X,Chen H,Li Y,Wei T

更新日期：2017-03-06 00:00:00

abstract：:Enterovirus 71 (EV71) is a common cause of hand, foot and mouth disease-a disease endemic especially in the Asia-Pacific region1. Scavenger receptor class B member 2 (SCARB2) is the major receptor of EV71, as well as several other enteroviruses responsible for hand, foot and mouth disease, and plays a key role in cell...

journal_title：Nature microbiology

authors： Zhou D,Zhao Y,Kotecha A,Fry EE,Kelly JT,Wang X,Rao Z,Rowlands DJ,Ren J,Stuart DI

更新日期：2019-03-01 00:00:00

abstract：:Clostridium difficile infection (CDI) is mediated by two major exotoxins, toxin A (TcdA) and toxin B (TcdB), that damage the colonic epithelial barrier and induce inflammatory responses. The function of the colonic vascular barrier during CDI has been relatively understudied. Here we report increased colonic vascular ...

journal_title：Nature microbiology

authors： Huang J,Kelly CP,Bakirtzi K,Villafuerte Gálvez JA,Lyras D,Mileto SJ,Larcombe S,Xu H,Yang X,Shields KS,Zhu W,Zhang Y,Goldsmith JD,Patel IJ,Hansen J,Huang M,Yla-Herttuala S,Moss AC,Paredes-Sabja D,Pothoulakis C,Shah

更新日期：2019-02-01 00:00:00

abstract：:Outbreaks of viral infections are a global health burden. Although type I interferon (IFN-I) exerts broad-spectrum antiviral effects, its antiviral efficacy in host cells is largely restricted by viruses. How the antiviral efficacy of IFN-I can be improved remains to be explored. Here, we identified the ADP-ribosyltra...

journal_title：Nature microbiology

authors： Guo T,Zuo Y,Qian L,Liu J,Yuan Y,Xu K,Miao Y,Feng Q,Chen X,Jin L,Zhang L,Dong C,Xiong S,Zheng H

更新日期：2019-11-01 00:00:00

abstract：:Coenzymes are vital for cellular metabolism and act on the full spectrum of enzymatic reactions. Intrinsic chemical reactivity, enzyme promiscuity and high flux through their catalytic cycles make coenzymes prone to damage. To counteract such compromising factors and ensure stable levels of functional coenzymes, cells...

journal_title：Nature microbiology

authors： Hartl J,Kiefer P,Meyer F,Vorholt JA

更新日期：2017-05-15 00:00:00

abstract：:Competition among microorganisms is a key determinant of successful host colonization and persistence. For Streptococcus pneumoniae, lower than predicted rates of co-colonizing strains suggest a competitive advantage for resident bacteria over newcomers. In light of evolutionary theory, we hypothesized that S. pneumon...

journal_title：Nature microbiology

authors： Shen P,Lees JA,Bee GCW,Brown SP,Weiser JN

更新日期：2019-01-01 00:00:00

abstract：:We describe Idionectes vortex gen. nov., sp. nov., a unicellular microeukaryote that swims by continuous inversion of its surface, similar to a vortex ring. This previously unreported mode of motility approximates a hypothetical concept called the 'toroidal swimmer', in which a doughnut-shaped object rotates around it...

journal_title：Nature microbiology

authors： Hess S,Eme L,Roger AJ,Simpson AGB

更新日期：2019-10-01 00:00:00

abstract：:Surface ocean waters are dominated by planktonic bacterial lineages with highly reduced genomes. The best examples are the cyanobacterial genus Prochlorococcus, the alphaproteobacterial clade SAR11 and the gammaproteobacterial clade SAR86, which together represent over 50% of the cells in surface oceans. Several studi...

journal_title：Nature microbiology

authors： Luo H,Huang Y,Stepanauskas R,Tang J

更新日期：2017-06-12 00:00:00

abstract：:Tigecycline is one of the last-resort antibiotics to treat complicated infections caused by both multidrug-resistant Gram-negative and Gram-positive bacteria1. Tigecycline resistance has sporadically occurred in recent years, primarily due to chromosome-encoding mechanisms, such as overexpression of efflux pumps and r...

journal_title：Nature microbiology

authors： Sun J,Chen C,Cui CY,Zhang Y,Liu X,Cui ZH,Ma XY,Feng Y,Fang LX,Lian XL,Zhang RM,Tang YZ,Zhang KX,Liu HM,Zhuang ZH,Zhou SD,Lv JN,Du H,Huang B,Yu FY,Mathema B,Kreiswirth BN,Liao XP,Chen L,Liu YH

更新日期：2019-09-01 00:00:00

abstract：:The original version of this Letter has been modified in the abstract and main text to better reflect the distribution of Neu5Ac sialoglycans in humans. Additionally, co-author Lingquan Deng's present address has been further clarified. ...

journal_title：Nature microbiology

authors： Gao X,Deng L,Stack G,Yu H,Chen X,Naito-Matsui Y,Varki A,Galán JE

更新日期：2017-12-01 00:00:00

abstract：:In most Gram-negative pathogens, the hydrolysis of UDP-2,3-diacylglucosamine to generate lipid X in lipid A biosynthesis is catalysed by the membrane-associated enzyme LpxH. We report the crystal structure of LpxH in complex with its product, lipid X, unveiling a unique insertion lid above the conserved architecture o...

journal_title：Nature microbiology

authors： Cho J,Lee CJ,Zhao J,Young HE,Zhou P

更新日期：2016-08-15 00:00:00

abstract：:Dimethylsulfoniopropionate (DMSP) is one of the Earth's most abundant organosulfur molecules, a signalling molecule1, a key nutrient for marine microorganisms2,3 and the major precursor for gaseous dimethyl sulfide (DMS). DMS, another infochemical in signalling pathways4, is important in global sulfur cycling2 and aff...

journal_title：Nature microbiology

authors： Curson AR,Liu J,Bermejo Martínez A,Green RT,Chan Y,Carrión O,Williams BT,Zhang SH,Yang GP,Bulman Page PC,Zhang XH,Todd JD

更新日期：2017-02-13 00:00:00

abstract：:Bacterial toxin-antitoxin systems (TASs) are thought to respond to various stresses, often inducing growth-arrested (persistent) sub-populations of cells whose housekeeping functions are inhibited. Many such TASs induce this effect through the translation-dependent RNA cleavage (RNase) activity of their toxins, which ...

journal_title：Nature microbiology

authors： Kirkpatrick CL,Martins D,Redder P,Frandi A,Mignolet J,Chapalay JB,Chambon M,Turcatti G,Viollier PH

更新日期：2016-02-22 00:00:00

abstract：:The temporal dynamics of phytoplankton growth and activity have large impacts on fluxes of matter and energy, yet obtaining in situ metabolic measurements of sufficient resolution for even dominant microorganisms remains a considerable challenge. We performed Lagrangian diel sampling with synoptic measurements of popu...

journal_title：Nature microbiology

authors： Wilson ST,Aylward FO,Ribalet F,Barone B,Casey JR,Connell PE,Eppley JM,Ferrón S,Fitzsimmons JN,Hayes CT,Romano AE,Turk-Kubo KA,Vislova A,Armbrust EV,Caron DA,Church MJ,Zehr JP,Karl DM,DeLong EF

更新日期：2017-07-31 00:00:00

abstract：:Cellular adhesion mediates many important plant-microbe interactions. In the devastating blast fungus Magnaporthe oryzae1, powerful glycoprotein-rich mucilage adhesives2 cement melanized and pressurized dome-shaped infection cells-appressoria-to host rice leaf surfaces. Enormous internal turgor pressure is directed on...

journal_title：Nature microbiology

authors： Rocha RO,Elowsky C,Pham NTT,Wilson RA

更新日期：2020-12-01 00:00:00

abstract：:Bacteria have evolved diverse mechanisms to fend off predation by bacteriophages. We previously identified the Dnd system, which uses DndABCDE to insert sulfur into the DNA backbone as a double-stranded phosphorothioate (PT) modification, and DndFGH, a restriction component. Here, we describe an unusual SspABCD-SspE P...

journal_title：Nature microbiology

authors： Xiong X,Wu G,Wei Y,Liu L,Zhang Y,Su R,Jiang X,Li M,Gao H,Tian X,Zhang Y,Hu L,Chen S,Tang Y,Jiang S,Huang R,Li Z,Wang Y,Deng Z,Wang J,Dedon PC,Chen S,Wang L

更新日期：2020-07-01 00:00:00

abstract：:Single-cell RNA sequencing has revealed extensive cellular heterogeneity within many organisms, but few methods have been developed for microbial clonal populations. The yeast genome displays unusually dense transcript spacing, with interleaved and overlapping transcription from both strands, resulting in a minuscule ...

journal_title：Nature microbiology

authors： Nadal-Ribelles M,Islam S,Wei W,Latorre P,Nguyen M,de Nadal E,Posas F,Steinmetz LM

更新日期：2019-04-01 00:00:00

abstract：:In the version of this Article originally published, author Carolina Falcón Garcia's name was coded wrongly, resulting in it being incorrect when exported to citation databases. This has now been corrected, though no visible changes will be apparent. ...

journal_title：Nature microbiology

authors： Dragoš A,Martin M,Garcia CF,Kricks L,Pausch P,Heimerl T,Bálint B,Maróti G,Bange G,López D,Lieleg O,Kovács ÁT

更新日期：2019-02-01 00:00:00

abstract：:Host factors that silence provirus transcription in CD4+ memory T cells help HIV-1 escape eradication by the host immune system and by antiviral drugs1. These same factors, however, must be overcome for HIV-1 to propagate. Here we show that Vpx and Vpr encoded by diverse primate immunodeficiency viruses activate provi...

journal_title：Nature microbiology

authors： Yurkovetskiy L,Guney MH,Kim K,Goh SL,McCauley S,Dauphin A,Diehl WE,Luban J

更新日期：2018-12-01 00:00:00

abstract：:Human onchocerciasis is a serious neglected tropical disease caused by the filarial nematode Onchocerca volvulus that can lead to blindness and chronic disability. Control of the disease relies largely on mass administration of a single drug, and the development of new drugs and vaccines depends on a better knowledge ...

journal_title：Nature microbiology

authors： Cotton JA,Bennuru S,Grote A,Harsha B,Tracey A,Beech R,Doyle SR,Dunn M,Hotopp JC,Holroyd N,Kikuchi T,Lambert O,Mhashilkar A,Mutowo P,Nursimulu N,Ribeiro JM,Rogers MB,Stanley E,Swapna LS,Tsai IJ,Unnasch TR,Voronin

更新日期：2016-11-21 00:00:00

abstract：:Many animal viruses are enveloped in a lipid bilayer taken up from cellular membranes. Because viral surface proteins bind to these membranes to initiate infection, we hypothesized that free virions may also be capable of interacting with the envelopes of other virions extracellularly. Here, we demonstrate this hypoth...

journal_title：Nature microbiology

authors： Cuevas JM,Durán-Moreno M,Sanjuán R

更新日期：2017-05-22 00:00:00

abstract：:Autophagy and interferon (IFN)-mediated innate immunity are critical antiviral defence mechanisms, and recent evidence indicated that tripartite motif (TRIM) proteins are important regulators of both processes. Although the role of TRIM proteins in modulating antiviral cytokine responses has been well established, muc...

journal_title：Nature microbiology

authors： Sparrer KMJ,Gableske S,Zurenski MA,Parker ZM,Full F,Baumgart GJ,Kato J,Pacheco-Rodriguez G,Liang C,Pornillos O,Moss J,Vaughan M,Gack MU

更新日期：2017-11-01 00:00:00

abstract：:The core properties of microbial genomes, including GC content and genome size, are known to vary widely among different bacteria and archaea 1,2 . Several hypotheses have been proposed to explain this genomic variability, but the fundamental drivers that shape bacterial and archaeal genomic properties remain uncertai...

journal_title：Nature microbiology

authors： Mende DR,Bryant JA,Aylward FO,Eppley JM,Nielsen T,Karl DM,DeLong EF

更新日期：2017-10-01 00:00:00

abstract：:Legionella pneumophila, the causative bacterium for Legionnaires' disease, hijacks host membrane trafficking for the maturation of the Legionella-containing vacuole (LCV). The LCV membrane mainly contains PtdIns4P, which is important for anchoring many secreted Legionella effectors onto the LCV. Here, we identify a cr...

journal_title：Nature microbiology

authors： Dong N,Niu M,Hu L,Yao Q,Zhou R,Shao F

更新日期：2016-12-12 00:00:00