Abstract：
:Functional imaging has become an important tool in oncology because it not only provides information about the size and localization of the tumour, but also about the pathophysiological features of the tumoural cells. One of the characteristic features of some tumour types is that their fast growth leads to deficient intratumoral vascularization, which results in low oxygen availability. To overcome this lack of oxygen, tumoural cells activate the neoangiogenic program by upregulating the transcription factor HIF-1α. Herein we report a non-invasive in vitro detection method of hypoxia using designed fluorescent peptide probes based on the oxygen-dependent degradation domain of HIF-1α. The fluorescent probe retains the oxygen-sensing capability of HIF-1α, so that it is stabilized under hypoxia and readily degraded by the proteasome under normoxia, thus providing direct information of the cellular oxygen availability.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Iglesias P,Penas C,Barral-Cagiao L,Pazos E,Costoya JAdoi
10.1038/s41598-019-43618-4subject
Has Abstractpub_date
2019-05-08 00:00:00pages
7117issue
1issn
2045-2322pii
10.1038/s41598-019-43618-4journal_volume
9pub_type
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