Abstract：
:When a rat is on a limited fixed-time food schedule with full access to a running wheel (activity-based anorexia model, ABA), its activity level will increase hours prior to the feeding period. This activity, called food-anticipatory activity (FAA), is a hypothesized parallel to the hyperactivity symptom in human anorexia nervosa. To investigate in depth the characteristics of FAA, we retrospectively analyzed the level of FAA and activities during other periods in ABA rats. To our surprise, rats with the most body weight loss have the lowest level of FAA, which contradicts the previously established link between FAA and the severity of ABA symptoms. On the contrary, our study shows that postprandial activities are more directly related to weight loss. We conclude that FAA alone may not be sufficient to reflect model severity, and activities during other periods may be of potential value in studies using ABA model.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Wu H,van Kuyck K,Tambuyzer T,Luyten L,Aerts JM,Nuttin Bdoi
10.1038/srep03929subject
Has Abstractpub_date
2014-01-29 00:00:00pages
3929issn
2045-2322pii
srep03929journal_volume
4pub_type
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