Abstract:
OBJECTIVE:Although the olfactory receptor OR2AT4 was described as involved in epidermal renewal, there is no data about a cosmetic active ingredient activating this receptor. The aim of this research work was thus to identify a natural molecule binding to this receptor in order to stimulate keratinocyte migration. METHODS:For this purpose, natural molecules were extracted from Cocos nucifera flour. Then, efficacy of this natural extract was evaluated on keratinocyte migration in vitro. Molecules of the Cocos nucifera flour extract were then identified by UPLC-MS/MS. Molecular docking was finally conducted to investigate the potential interaction between identified molecules and the olfactory receptor OR2AT4. RESULTS:The Cocos nucifera flour extract significantly increased keratinocyte migration and results demonstrated that this effect was mediated by the olfactory receptor OR2AT4. Metabolomic analysis revealed two molecules, nonioside D and butyl 4-O-alpha-D-glucopyranosyl-beta-D-glucopyranoside, as significantly present in the Cocos nucifera flour extract compared to both Cocos nucifera oil and water. Finally, molecular docking revealed that butyl 4-O-alpha-D-glucopyranosyl-beta-D-glucopyranoside could interact with the extracellular domain 2 of the OR2AT4. CONCLUSION:This study highlighted for the first time a natural molecule, extracted from Cocos nucifera flour, able to interact with the olfactory receptor OR2AT4 and promote the keratinocyte migration and thus the epithelialization. OBJECTIF:Bien que le récepteur olfactif OR2AT4 a été décrit comme étant impliqué dans le renouvellement de l’épiderme, il n'y a à ce jour aucune donnée concernant un ingrédient actif cosmétique activant ce récepteur. Le but de cette étude est donc d'identifier une molécule naturelle capable de se fixer au récepteur OR2AT4 afin de stimuler la migration des kératinocytes. METHODE:L'efficacité de cet extrait naturel sur la migration des kératinocytes in vitro a ensuite été évaluée. Les molécules présentes dans l'extrait de farine de Cocos nucifera ont ensuite été identifées par UPLC-MS/MS. Enfin, des expérimentations de docking moléculaire ont été réalisées afin d'identifier une potentielle interaction entre les molécules précédemment identifiées et le récepteur olfactif OR2AT4. RESULTATS:L'extrait de farine de Cocos nucifera augmente significativement la migration des kératinocytes via l'activation du récepteur olfactif OR2AT4. Les analyses métabolomiques ont révélées deux molécules, le nonioside D et le butyl 4-O-alpha-D-glucopyranosyl-beta-D-glucopyranoside, comme étant significativement présentes dans l'extrait de farine de Cocos nucifera en comparaison avec l'huile et l'eau de coco. Enfin, le docking moléculaire révèle que le butyl 4-O-alpha-D-glucopyranosyl-beta-D-glucopyranoside, présent dans l'extrait de farine de Cocos nucifera peut interagir avec le domaine extracellulaire 2 du récepteur olfactif OR2AT4. CONCLUSION:Cette étude a identifié pour la première fois une molécule naturelle, extraite de la farine de Cocos nucifera, capable d'interagir avec le récepteur olfactif OR2AT4, afin de stimuler la migration kératinocytaire et ainsi favoriser le processus de ré-épithélialisation.
journal_name
Int J Cosmet Scijournal_title
International journal of cosmetic scienceauthors
Verzeaux L,Richer S,Viguier J,Gofflo S,Boudier D,Aymard E,Closs Bdoi
10.1111/ics.12526subject
Has Abstractpub_date
2019-04-01 00:00:00pages
194-199issue
2eissn
0142-5463issn
1468-2494journal_volume
41pub_type
杂志文章abstract::Synopsis The self-diffusion of salicylic acid has been monitored radiochemically through pigskins (whole and dermal) and human skins (whole, dermal and epidermal). The effects of pH, temperature and changing dimethyl formamide (DMF) concentration on the penetration of salicylic acid through the various skin membranes ...
journal_title:International journal of cosmetic science
pub_type: 杂志文章
doi:10.1111/j.1467-2494.1981.tb00292.x
更新日期:1981-12-01 00:00:00
abstract:BACKGROUND:The deposit and adherence of particulate matter (PM) from aerial pollution onto the surface of human hair is a poorly studied phenomenon. OBJECTIVES:(i) To reproduce in vitro the deposit of known PM on standardized hair swatches in a closed box, (ii) to compare in vitro data with those obtained under 'real-...
journal_title:International journal of cosmetic science
pub_type: 杂志文章
doi:10.1111/ics.12416
更新日期:2017-12-01 00:00:00
abstract::Synopsis This report utilizes a new procedure based on epidermal stripping to analyse unlabelled skin fatty acids. This technique was applied to the study of human dry skin treated with blackcurrant seed oil, an essential fatty acid rich lipid also containing gamma linolenic acid. In human dry skin the usual fatty aci...
journal_title:International journal of cosmetic science
pub_type: 杂志文章
doi:10.1111/j.1467-2494.1988.tb00014.x
更新日期:1988-08-01 00:00:00
abstract:OBJECTIVE:The aim of this work was to investigate an alternative hair-dyeing method with vegetable colourants as the tannins, as well as the impact of pre-treatment as the bleaching process. METHODS:Untreated, 1, 2 and 3 times bleached hair tresses that were dyed with tannins in combination with metal salts were chara...
journal_title:International journal of cosmetic science
pub_type: 杂志文章,评审
doi:10.1111/ics.12624
更新日期:2020-08-01 00:00:00
abstract::In recent years the importance of sphingolipids (cerebrosides, sphingomyelin, ceramides, sphingosine-1-phospate, etc.) in skin biology is receiving an increasing interest. Not only are ceramides essential for the barrier function of the skin, especially through their phytosphingosine, sphingosine and 6-hydroxysphingos...
journal_title:International journal of cosmetic science
pub_type: 杂志文章
doi:10.1111/j.1467-2494.2007.00394.x
更新日期:2007-08-01 00:00:00
abstract::Several treatments for skin whitening are available today, but few of them are completely adequate, especially owing to the carcinogenic potential attributed to classical drugs like hydroquinone, arbutin and kojic acid. To provide an alternative and safer technology for whitening, we developed two botanical compounds ...
journal_title:International journal of cosmetic science
pub_type: 杂志文章
doi:10.1111/j.1468-2494.2012.00736.x
更新日期:2012-10-01 00:00:00
abstract::Synopsis A rapid method has been developed in order to compare the photostability of several sunscreen agents incorporated in the same type of emulsion. Thin films of the different preparations were spread on quartz plates and irradiated with a solar simulator. Differences in energy distribution according to wavelengt...
journal_title:International journal of cosmetic science
pub_type: 杂志文章
doi:10.1111/j.1467-2494.1988.tb00002.x
更新日期:1988-04-01 00:00:00
abstract::In order to understand the skin benefits of emollient oil ingredients in topical skin moisturizers, one single highly popular in vivo method (corneometry), even when executed to perfection, does not suffice. A systematical exploration using a combination of bioengineering techniques shows how a previously unaccounted ...
journal_title:International journal of cosmetic science
pub_type: 杂志文章,评审
doi:10.1111/j.1468-2494.2012.00744.x
更新日期:2012-12-01 00:00:00
abstract:INTRODUCTION:We report on the preparation and efficacy of 10-hydroxystearic acid (HSA) that improves facial age spots and conspicuous pores. METHODS:The hydration of oleic acid into HSA was catalyzed by the oleate hydratase from Escherichia coli. Following treatment with HSA, collagen type I and type III was assessed ...
journal_title:International journal of cosmetic science
pub_type: 杂志文章
doi:10.1111/ics.12529
更新日期:2019-06-01 00:00:00
abstract::This paper examines the various methods that are available to the scientist working with natural materials to substantiate their efficacy. The methods discussed are: literature surveys, clinical trials, instrumental measurement, products with Pharmaceutical Licenses, comparison with other plants containing same active...
journal_title:International journal of cosmetic science
pub_type: 杂志文章
doi:10.1046/j.1467-2494.2000.00015.x
更新日期:2000-08-01 00:00:00
abstract::The aim of this study was to determine how worthwhile it would be to combine a newly developed topical slimming product with customized dietary habits not based on calorie restriction, so as to improve the cellulite appearance of the skin. At the beginning of the study, a nutritionist recorded the dietary habits of ea...
journal_title:International journal of cosmetic science
pub_type: 杂志文章,随机对照试验
doi:10.1111/j.1468-2494.2010.00630.x
更新日期:2011-08-01 00:00:00
abstract:OBJECTIVE:The present investigation is based on the formulation of water-in-oil (w/o) cream preparations of ascorbic acid (AA) at pH 4-6 using different emollients and humectants. METHODS:The preparations were stored in the dark at 30°C for a period of 3 months and were studied for their chemical and physical stabilit...
journal_title:International journal of cosmetic science
pub_type: 杂志文章
doi:10.1111/ics.12152
更新日期:2014-10-01 00:00:00
abstract:OBJECTIVE:The objective of this study was to clarify the effects of different body washing methods on skin texture. METHODS:Subjects were nine healthy women in their 20s. Skin on the inside of the forearms was washed every day for 4 weeks with protective washing (right forearm) and with non-protective washing (left fo...
journal_title:International journal of cosmetic science
pub_type: 杂志文章
doi:10.1111/ics.12114
更新日期:2014-04-01 00:00:00
abstract::Scars are well known to have a stratum corneum that is malfunctional. Increases in transepidermal water loss and decreases in stratum corneum capacitance and conductance have been reported. Occlusion therapy is a well-known route to improving the signs and symptoms of scarring. Until recently that has been assumed to ...
journal_title:International journal of cosmetic science
pub_type: 杂志文章
doi:10.1111/j.1468-2494.2012.751.x
更新日期:2012-09-23 00:00:00
abstract:OBJECTIVE:Facial attractiveness has been reported to be influenced by visual features such as facial shape and the colour and texture of the skin. However, no empirical studies have examined the effects of facial skin radiance on facial attractiveness. The present study investigated whether types of skin reflection (i....
journal_title:International journal of cosmetic science
pub_type: 杂志文章
doi:10.1111/ics.12673
更新日期:2020-11-20 00:00:00
abstract::Synopsis The principles on which stability tests are based are reviewed. The need to differentiate between product stability and product-container compatibility is emphasized. Recognition of this distinction is fundamental to the efficient organisation and execution of stability tests. Attention is also drawn to the d...
journal_title:International journal of cosmetic science
pub_type: 杂志文章
doi:10.1111/j.1467-2494.1985.tb00423.x
更新日期:1985-12-01 00:00:00
abstract:OBJECTIVE:Arbutin is an effective agent for the treatment of melanin disorders. Arbutin may be converted to hydroquinone under conditions of high temperature, ultraviolet (UV) radiation and dilute acid. The aim of the current study was to develop an analytical method to determine the levels of arbutin and hydroquinone ...
journal_title:International journal of cosmetic science
pub_type: 杂志文章
doi:10.1111/ics.12228
更新日期:2015-12-01 00:00:00
abstract::The phase diagrams were determined of lactic and isohexanoic hydroxy acids as well as salicylic acid with water, a non-ionic surfactant and a paraffinic oil to outline the influence of the hydroxy acids on the structure in a model for a skin lotion. The results showed the influence of the acid to be similar to that of...
journal_title:International journal of cosmetic science
pub_type: 杂志文章
doi:10.1111/j.1467-2494.2004.00212.x
更新日期:2004-06-01 00:00:00
abstract:BACKGROUND:Bromelain is a mixture of proteolytic enzymes found in various tissues of the pineapple plant (Ananas comosus) and other species of Bromeliaceae. Owing to its proteolytic activity, bromelain has been used in the food, medical, pharmaceutical and cosmetic industries, for its cell renewal, anti-ageing, whiteni...
journal_title:International journal of cosmetic science
pub_type: 杂志文章
doi:10.1111/ics.12308
更新日期:2016-10-01 00:00:00
abstract:OBJECTIVE:The objective of this work was to investigate the utility of a new in vitro SPF test method in blinded ring-testing, against new ISO acceptance criteria. METHODS:Twenty four blinded, commercial, emulsion-type, primary sunscreen products, covering the full range of labelled SPF in Europe (SPF6 - 50+), were te...
journal_title:International journal of cosmetic science
pub_type: 杂志文章
doi:10.1111/ics.12459
更新日期:2018-04-20 00:00:00
abstract::Nowadays, flavonoids are present in many cosmetic formulations, mainly in the form of plant extracts. The main reason of still increasing popularity of these substances is their beneficial biochemical activity. The main factor affecting activity of flavonoids in the skin is their skin penetration ability. The studies ...
journal_title:International journal of cosmetic science
pub_type: 杂志文章
doi:10.1046/j.1467-2494.2002.00166.x
更新日期:2002-12-01 00:00:00
abstract:OBJECTIVE:The aim of this study was to establish a comparative analysis of the chemical and enzymatic stability of α- and β-arbutins as potential sources of the substance of concern hydroquinone (HQ). The study was performed using an array of techniques including HPLC-PDA, nuclear magnetic resonance (NMR) and optical r...
journal_title:International journal of cosmetic science
pub_type: 杂志文章
doi:10.1111/ics.12275
更新日期:2016-04-01 00:00:00
abstract::Synopsis Glutathione (GSH) plays an important role in cellular protection during ageing. The hair plucking technique is a non-invasive method for the direct biochemical study of keratinocytes. Hair was taken from the suboccipital area of 63 volunteers (men and women whose ages ranged from 13 to 103 years). The results...
journal_title:International journal of cosmetic science
pub_type: 杂志文章
doi:10.1111/j.1467-2494.1991.tb00555.x
更新日期:1991-06-01 00:00:00
abstract::The color and odor of cosmetics have been shown to be crucial for affective states and able to influence autonomic responses. We report an original procedure to measure the effect on subjects of the color and odor of cosmetic products, and to quantify the correlation between objective (psychophysiological recording) a...
journal_title:International journal of cosmetic science
pub_type: 杂志文章
doi:10.1111/j.1467-2494.2003.00196.x
更新日期:2003-12-01 00:00:00
abstract::Sun exposure during leisure activity evokes fatigue. We employed the Advanced Trail Making Test (ATMT), a recently developed objective method of evaluating brain function performance used to measure mental fatigue, for objective determination of fatigue development caused by solar exposure to the human body. First, a ...
journal_title:International journal of cosmetic science
pub_type: 杂志文章
doi:10.1111/j.0142-5463.2004.00200.x
更新日期:2004-02-01 00:00:00
abstract::The causative substances for axillary osmidrosis, which are often found in apocrine sweat, are the decomposed/denatured products of short-chain fatty acid and other biological metabolite compounds produced by axillary-resident bacteria. Conventional underarm deodorants suppress the process of odour production mostly b...
journal_title:International journal of cosmetic science
pub_type: 杂志文章
doi:10.1111/j.1467-2494.2006.00322.x
更新日期:2006-08-01 00:00:00
abstract:OBJECTIVE:Quinoa (Chenopodium quinoa Willd.) is a seed crop rich in bioactive compounds including phytoecdysones (especially 20-hydroxyecdysone, 20HE), polyphenols, proteins and essential fatty acids. We previously reported a method to leach and concentrate quinoa bioactives into a complex phytochemical mixture termed ...
journal_title:International journal of cosmetic science
pub_type: 杂志文章
doi:10.1111/ics.12185
更新日期:2015-04-01 00:00:00
abstract::Good water-impermeable barrier function is vital for healthy skin. Abnormality of the barrier function is observed in a variety of skin diseases, such as atopic dermatitis, psoriasis and contact dermatitis. Moreover, repeated barrier disruption induces epidermal hyperplasia and inflammation. On the other hand, acceler...
journal_title:International journal of cosmetic science
pub_type: 杂志文章,评审
doi:10.1111/j.1468-2494.2008.00487.x
更新日期:2009-04-01 00:00:00
abstract::Reduction and prevention of health care-associated infections is a worldwide priority with emphasis on increasing hand hygiene compliance. Repetitive exposure to hand hygiene products and procedures is a significant factor in the development of occupational irritant hand dermatitis. Compliance has been difficult to ac...
journal_title:International journal of cosmetic science
pub_type: 杂志文章,评审
doi:10.1111/j.1468-2494.2012.00733.x
更新日期:2012-10-01 00:00:00
abstract:OBJECTIVE:Equol has been shown to improve skin health and regeneration, due to its antioxidative, phytoestrogenic and epigenetic characteristics. The effects of a topical intervention on skin structure, telomere length and epigenetic markers in skin cells were analysed. METHODS:Sixty-four participants were divided in ...
journal_title:International journal of cosmetic science
pub_type: 杂志文章,随机对照试验
doi:10.1111/ics.12408
更新日期:2017-10-01 00:00:00