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Emergence in Japan of an isolate of Klebsiella pneumoniae co-harbouring blaKPC-2 and rmtB.

Abstract：

OBJECTIVES:Here we describe a clinical isolate of Klebsiella pneumoniae ST11 harbouring both blaKPC-2 and rmtB genes in Japan. METHODS:A carbapenem- and aminoglycoside-resistant K. pneumoniae was isolated from an inpatient in Japan. Whole-genome sequencing (WGS) was performed using an Illumina next-generation sequencer. RESULTS:Minimum inhibitory concentrations (MICs) of meropenem and amikacin were ≥512μg/mL. WGS analysis revealed that the isolate harboured both blaKPC-2 and rmtB. The genetic environments of blaKPC-2 and rmtB consisted of IS6-orfA-orfB-IS481-blaKPC-2-ISKpn6-korC-orfC-orfD-rep-tnp-Tn3-IS6 and IS6-IS91-orfE-orfF-blaTEM-1-rmtB-orfG-IS6, respectively. These genetic environments are similar (>99% identity) to those of K. pneumoniae WCHKP040035 (accession no. CP028796) isolated in a Chinese hospital. The blaKPC-2 and rmtB genes were located on a 130-kb IncFII plasmid. CONCLUSIONS:This is the first report of a K. pneumoniae clinical isolate from Japan co-harbouring blaKPC-2 and rmtB on a 130-kb plasmid.

journal_name

J Glob Antimicrob Resist

journal_title

Journal of global antimicrobial resistance

authors

Uchida H,Tada T,Tohya M,Sugahara Y,Kato A,Miyairi I,Kirikae T

doi

10.1016/j.jgar.2018.11.026

subject

Has Abstract

pub_date

2019-06-01 00:00:00

pages

157-159

eissn

2213-7165

issn

2213-7173

pii

S2213-7165(18)30243-1

journal_volume

17

pub_type

杂志文章

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