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Virulence and antimicrobial resistance of Staphylococcus aureus isolated from bloodstream infections and pneumonia in Southern Poland.

Abstract：

OBJECTIVES:Staphylococcus aureus remains the most important cause of infections in hospitals and long-term care facilities. The aim of this study was to analyse the resistance, virulence, and epidemiological and genetic relationships of S. aureus from bloodstream infections (BSIs) and pneumonia from patients in Southern Poland. METHODS:All strains were tested for antimicrobial susceptibility using the disk diffusion method. Etest was also performed for vancomycin, teicoplanin, tigecycline, oxacillin, cefoxitin and penicillin. PCR amplification was used to detect selected virulence genes. The genetic similarity of methicillin-resistant S. aureus (MRSA) isolates was determined by spa typing and pulsed-field gel electrophoresis (PFGE). Using the BURP algorithm and the Ridom SpaServer database, spa types were clustered into different clonal complexes (spa-CCs). RESULTS AND CONCLUSIONS:MRSA strains were observed at a prevalence of 26.7%, but 88.6% of hospital-acquired infections were MRSA, with no difference between BSIs and pneumonia. The highest resistance was observed to erythromycin and tobramycin. None of the strains were resistant to linezolid, glycopeptides or tigecycline. The strains had no significant virulence factors and the number of virulence genes present did not correlate with the degree of drug resistance. PFGE typing showed relatively high diversity of strains. The majority of isolates belonged to spa type t003 (CC5).

journal_name

J Glob Antimicrob Resist

journal_title

Journal of global antimicrobial resistance

authors

Pomorska-Wesołowska M,Chmielarczyk A,Chlebowicz M,Ziółkowski G,Szczypta A,Natkaniec J,Romaniszyn D,Pobiega M,Dzikowska M,Krawczyk L,Kozioł J,Wójkowska-Mach J

doi

10.1016/j.jgar.2017.07.009

subject

Has Abstract

pub_date

2017-12-01 00:00:00

pages

100-104

eissn

2213-7165

issn

2213-7173

pii

S2213-7165(17)30137-6

journal_volume

11

pub_type

杂志文章

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