Abstract:
OBJECTIVES:The rapid spread of multidrug-resistant (MDR) Acinetobacter baumannii poses a substantial threat for morbidity and mortality worldwide. In particular, carbapenem-resistant A. baumannii has caused a severe challenge to human health. Here we reported the draft genome sequence of A. baumannii S131434, an OXA-23, OXA-66, ADC-25 and TEM-1D co-producing strain recovered from a patient with neonatal pneumonia in China and belonging to the globally disseminated sequence type 195 (ST195) of clonal complex 92 (CC92). METHODS:Genomic DNA was sequenced using an Illumina HiSeq platform and the reads were de novo assembled into contigs using CLC Genomics Workbench. The assembled contigs were annotated and bioinformatics analysis was performed. RESULTS:The genome comprised a circular chromosome of 3898344bp. The presence of the blaOXA-23, blaOXA-66, blaADC-25 and blaTEM-1D genes was detected. In addition, genes conferring resistance to aminoglycosides, macrolides and tetracycline were also identified. Antimicrobial susceptibility testing revealed that the isolate was resistant to all of the tested antibiotics except for polymyxin B, piperacillin/sulbactam and trimethoprim/sulfamethoxazole. CONCLUSION:To our knowledge, this is the first report of a clinical A. baumannii ST195 (CC92) isolate producing OXA-23, OXA-66, ADC-25 and TEM-1D in southern China. This draft genome will facilitate further our understanding of the antimicrobial resistance and pathogenic mechanisms in this strain and provides valuable information regarding the colonisation and adaptation of MDR pathogens.
journal_name
J Glob Antimicrob Resistjournal_title
Journal of global antimicrobial resistanceauthors
Lv W,Zhang X,Hou M,Han D,Li Y,Xiong Wdoi
10.1016/j.jgar.2018.11.008subject
Has Abstractpub_date
2019-03-01 00:00:00pages
1-3eissn
2213-7165issn
2213-7173pii
S2213-7165(18)30224-8journal_volume
16pub_type
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journal_title:Journal of global antimicrobial resistance
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journal_title:Journal of global antimicrobial resistance
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journal_title:Journal of global antimicrobial resistance
pub_type: 杂志文章,评审
doi:10.1016/j.jgar.2020.04.010
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doi:10.1016/j.jgar.2017.12.007
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journal_title:Journal of global antimicrobial resistance
pub_type: 杂志文章,评审
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journal_title:Journal of global antimicrobial resistance
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journal_title:Journal of global antimicrobial resistance
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doi:10.1016/j.jgar.2016.10.005
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journal_title:Journal of global antimicrobial resistance
pub_type: 杂志文章
doi:10.1016/j.jgar.2017.04.008
更新日期:2017-09-01 00:00:00
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journal_title:Journal of global antimicrobial resistance
pub_type: 杂志文章
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journal_title:Journal of global antimicrobial resistance
pub_type: 杂志文章
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journal_title:Journal of global antimicrobial resistance
pub_type: 杂志文章
doi:10.1016/j.jgar.2020.03.011
更新日期:2020-09-01 00:00:00
abstract:OBJECTIVES:Numerous previous publications on the detection of bacterial isolates harbouring the mcr-1 gene from animals and humans strongly suggest an underlying route of transmission of colistin resistance via the food chain. The aim of this study was to investigate the presence of colistin-resistant (Col-R) bacteria ...
journal_title:Journal of global antimicrobial resistance
pub_type: 杂志文章
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更新日期:2019-03-01 00:00:00
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journal_title:Journal of global antimicrobial resistance
pub_type: 杂志文章
doi:10.1016/j.jgar.2016.12.015
更新日期:2017-06-01 00:00:00