Research Trends of Macrophage Polarization: A Bibliometric Analysis.

Abstract:

Background:Macrophage polarization is involved in the development of many diseases such as obesity, diabetes, and cancer. This study aimed to understand the trends and hotspots of macrophage polarization research. Methods:We searched through the Web of Science Core Collection database to obtain original articles in this research domain. CiteSpace, HistCite, and VOSviewer software were used to facilitate the analysis and visualization of scientific productivity and emerging trends. Results:The survey included 3064 articles, and the annual number of publications exhibited an exponential increase. These articles have received a total of 74,801 citations, and the number of annual citations grew from 68 to 18,074 in a decade. Research on macrophage polarization was performed in 76 countries, and the USA ranked first in terms of research output by contributing 1129 (36.8%) articles. The USA also had the highest H-index, total citations, and highly cited article number. PLOS One, Journal of Immunology, and Scientific Reports were the three journals that published the most articles. Interdisciplinary research areas involving macrophage polarization, such as biomaterials, cancer, and diabetes, were identified by journal citation analysis. The top 20 most productive institutions were located mainly in the USA, France, and China, and top authors originated mainly from the USA and Italy. Tumor biology, obesity, and infection were research hotspots and may be promising in the next few years. Conclusions:This study provides a comprehensive analysis that delineates the scientific productivity, collaboration, and research hotspots of macrophage polarization research. :巨噬细胞极化研究趋势的文献计量学分析摘要背景:巨噬细胞极化参与许多疾病的发生发展过程,例如肥胖、糖尿病和癌症。本研究旨在理解巨噬细胞极化的研究趋势和研究热点。 方法:我们检索了科学网核心合集(WoSCC)数据库以获得本研究领域的原创性文献,使用软件Citespace,Histcite和VOSviewer对该领域的科学产出及研究趋势进行分析,并将其可视化。 结果:本研究共纳入3064篇文献,年文献发表量呈指数增长趋势。这些文献共被引用74801次,在最近10年内,年度被引次数从68次增长至18074次。共有76个国家参与了巨噬细胞极化的相关研究,美国以1129篇文献(占总数的36.8%)占据了国家科研产出榜的首位。美国发表的文献也拥有最高的H指数,总被引次数和高被引文献数。PLOS One, Journal of Immunology 和 Scientific Reports是该领域内发表文献数量最多的三份杂志。通过对杂志间相互引用状况进行分析,我们发现了与巨噬细胞极化相关的多个跨学科研究领域,例如生物材料、肿瘤和糖尿病。发文量最多的20家科研机构主要位于美国、法国和中国,被引次数最多的作者主要来自美国和意大利。肿瘤、肥胖和感染是巨噬细胞极化相关的研究热点,在未来数年中可能值得关注。 结论:本研究提供了一份综合性分析,以描述巨噬细胞极化研究的科学产出,研究合作和研究热点。.

journal_name

Chin Med J (Engl)

journal_title

Chinese medical journal

authors

Gao H,Huang FY,Wang ZP

doi

10.4103/0366-6999.247215

subject

Has Abstract

pub_date

2018-12-20 00:00:00

pages

2968-2975

issue

24

eissn

0366-6999

issn

2542-5641

pii

ChinMedJ_2018_131_24_2968_247215

journal_volume

131

pub_type

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