当前位置： SCI文献检索 > INTERNATIONAL JOURNAL OF PHARMACEUTICS期刊下所有文献 > Powder bed 3D-printing of highly loaded drug delivery devices with hydroxypropyl cellulose as solid binder.

Powder bed 3D-printing of highly loaded drug delivery devices with hydroxypropyl cellulose as solid binder.

Abstract：

:3D-printing is a promising tool to pave the way to the widespread adaption of individualized medicine. Several printing techniques have been investigated and introduced to pharmaceutical research. Until now, only one 3D-printed medicine is approved on the US market. The medicine is manufactured via drop-on-powder deposition, which uses inkjet printing to jet a liquid binder on a powder bed to create 3D objects. However, inkjet processes are prone to nozzle clogging when binders or active pharmaceutical ingredients (APIs) are included in the printing ink. This renders the formulation development of the ink the most challenging step. In this study, different hydroxypropyl cellulose (HPC) grades were investigated as solid binders in the powder formulation on a commercially available DoP printer. The printed ink only consisted of a water/ethanol mixture. Formulations containing 70% caffeine as model API were developed and tablets printed. It was found that the friability of the tablets greatly depends on the particle size of the employed binder, whereas disintegration time and dissolution properties mainly depend on the viscosity of the employed binders. Higher viscous binders led to slower disintegration and dissolution whereas lower viscous binders led to faster disintegration and dissolution. The study demonstrates that HPC is a suitable solid binder for DoP printing and that 3D-DoP printing can be used to print robust dosage forms.

journal_name

Int J Pharm

journal_title

International journal of pharmaceutics

authors

Infanger S,Haemmerli A,Iliev S,Baier A,Stoyanov E,Quodbach J

doi

10.1016/j.ijpharm.2018.11.048

subject

Has Abstract

pub_date

2019-01-30 00:00:00

pages

198-206

eissn

0378-5173

issn

1873-3476

pii

S0378-5173(18)30872-X

journal_volume

555

pub_type

杂志文章

相关文献

INTERNATIONAL JOURNAL OF PHARMACEUTICS文献大全
  • Inhalable liposomal formulation for vasoactive intestinal peptide.

    abstract：:Inhalation of vasoactive intestinal peptide (VIP) was suggested as promising treatment option of various lung diseases like asthma and pulmonary hypertension. However, the medical use of peptides is limited by their short half-life due to rapid enzymatic degradation in the airways. For that reason, we recently develop...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2008.01.046

    authors： Hajos F,Stark B,Hensler S,Prassl R,Mosgoeller W

    更新日期：2008-06-05 00:00:00

  • Microprocessor controlled transdermal drug delivery.

    abstract：:Transdermal drug delivery via iontophoresis is reviewed with special focus on the delivery of lidocaine for local anesthesia and fentanyl for patient controlled acute therapy such as postoperative pain. The role of the microprocessor controller in achieving dosimetry, alternating/reverse polarity, pre-programmed, and ...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章,评审

    doi：10.1016/j.ijpharm.2006.03.053

    authors： Subramony JA,Sharma A,Phipps JB

    更新日期：2006-07-06 00:00:00

  • Continuous monitoring of API content, API distribution and crushing strength after tableting via near-infrared chemical imaging.

    abstract：:Near-infrared chemical imaging (NIR-CI) with high-speed cameras based on the push-broom acquisition principle is a rapidly-evolving and can be used for a variety of purposes, from classification (and sorting) of products to mapping spatial distribution of materials. The present study examined if NIR-CI is suitable for...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2016.12.003

    authors： Wahl PR,Pucher I,Scheibelhofer O,Kerschhaggl M,Sacher S,Khinast JG

    更新日期：2017-02-25 00:00:00

  • Enhanced oral bioavailability of docetaxel in rats by four consecutive days of pre-treatment with curcumin.

    abstract：:As with many other anti-cancer agents, docetaxel is a substrate for ATP-binding cassette transporters such as P-glycoprotein and its metabolism is mainly catalysed by CYP3A. In order to improve the oral bioavailability of docetaxel, a component of turmeric, curcumin, which can down-regulate the intestinal P-glycoprote...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2010.08.015

    authors： Yan YD,Kim DH,Sung JH,Yong CS,Choi HG

    更新日期：2010-10-31 00:00:00

  • Anticancer effect of X-Ray triggered methotrexate conjugated albumin coated bismuth sulfide nanoparticles on SW480 colon cancer cell line.

    abstract：:The application of nanoparticles (NPs) as radio-sensitizers and carriers has opened up a new horizon to overcome the limitations of chemo and radiotherapy. In this study, bovine serum albumin-coated Bi2S3 NPs (Bi2S3@BSA NPs) were synthesized and evaluated in terms of their ability to be used as a radio-sensitizer and ...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2020.119320

    authors： Faghfoori MH,Nosrati H,Rezaeejam H,Charmi J,Kaboli S,Johari B,Danafar H

    更新日期：2020-05-30 00:00:00

  • Dynamic swelling behavior of gamma-radiation induced polyelectrolyte poly(AAm-co-CA) hydrogels in urea solutions.

    abstract：:The aim of this study was to investigate the equilibrium swelling properties in urea solutions of gamma-radiation induced polyelectrolyte copolymeric hydrogels consisting of acrylamide (AAm) and crotonic acid (CA). Poly(acrylamide-co-crotonic acid), poly(AAm-co-CA) hydrogels containing different amounts of CA were obt...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2005.05.026

    authors： Karadağ E,Uzüm OB,Saraydin D,Güven O

    更新日期：2005-09-14 00:00:00

  • A single-layer film coating for colon-targeted oral delivery.

    abstract：:Most pH-sensitive polymer coating studies for potential colonic delivery systems apply multiple layers to protect the active agent from degradation and early release in the stomach and small intestine. This study designed a single-coat pH-sensitive layer for colon-specific delivery with a potential biopolymer, namely,...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2019.01.066

    authors： Nguyen MNU,Tran PHL,Tran TTD

    更新日期：2019-03-25 00:00:00

  • Continuous direct compression as manufacturing platform for sustained release tablets.

    abstract：:This study presents a framework for process and product development on a continuous direct compression manufacturing platform. A challenging sustained release formulation with high content of a poorly flowing low density drug was selected. Two HPMC grades were evaluated as matrix former: standard Methocel CR and direc...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2017.01.010

    authors： Van Snick B,Holman J,Cunningham C,Kumar A,Vercruysse J,De Beer T,Remon JP,Vervaet C

    更新日期：2017-03-15 00:00:00

  • Surface activity of a non-micelle forming compound containing a surface-active impurity.

    abstract：PURPOSE:The purpose of this study is to characterize the surface activity of a water-soluble compound and its ability to form aggregates/micelles. METHODS:Aqueous solutions of the compound were prepared at various concentrations. Surface tension was determined using drop volume and Wilhelmy plate methods. Moreover, co...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2006.10.034

    authors： Al-Maaieh A,Aburub A

    更新日期：2007-04-04 00:00:00

  • Enhancement effect of resveratrol on the intestinal absorption of bestatin by regulating PEPT1, MDR1 and MRP2 in vivo and in vitro.

    abstract：:The purpose of present study was to assess the enhancing effect of resveratrol (Res) on the absorption of bestatin and clarify the related molecular mechanism. Res facilitated bestatin absorption by down-regulating both protein and gene levels of multidrug resistance 1 (Mdr1) and Multidrug resistance-associated protei...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2015.09.042

    authors： Jia Y,Liu Z,Huo X,Wang C,Meng Q,Liu Q,Sun H,Sun P,Yang X,Shu X,Liu K

    更新日期：2015-11-10 00:00:00

  • Effect of binders on the release rates of direct molded verapamil tablets using twin-screw extruder in melt granulation.

    abstract：:Conventional manufacturing of pharmaceutical tablets often involves single processes such as blending, granulation, milling and direct compression. A process that minimizes and incorporates all these in a single continuous step is desirable. The concept of omitting milling step followed by direct-molding of tablets ut...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2013.12.053

    authors： Tan DC,Chin WW,Tan EH,Hong S,Gu W,Gokhale R

    更新日期：2014-03-10 00:00:00

  • Liposome-like nanocapsules of dual drug-tailed betaine for cancer therapy.

    abstract：:A novel dual drug-tailed betaine conjugate amphiphile has been firstly synthesized in which the polar headgroup is derived from glycine betaine and the hydrophobic tails are chlorambucil molecules. The newly prepared conjugate undergoes self-assembly to form stable liposome-like nanocapsules as an effective carrier wi...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2015.08.006

    authors： Fang S,Niu Y,Zhang W,Zhang Y,Yu L,Zhang Y,Li X

    更新日期：2015-09-30 00:00:00

  • Amino acid based amphiphilic copolymer micelles as carriers of non-steroidal anti-inflammatory drugs: solubilization, in vitro release and biological evaluation.

    abstract：:Three novel amino acid based anionic amphiphilic copolymers poly(sodium N-acryloyl-l-valinate-co-alkylacrylamide) (where, alkyl=octyl and dodecyl) with either 9 or 16 mol% hydrophobic substitution were synthesized. These hydrophobically modified polyelectrolytes (HMPs), above a critical concentration, self-assemble in...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2011.01.041

    authors： Dutta P,Dey J,Perumal V,Mandal M

    更新日期：2011-04-04 00:00:00

  • New amphotericin B-gamma cyclodextrin formulation for topical use with synergistic activity against diverse fungal species and Leishmania spp.

    abstract：:Amphotericin B (AmB) has a broad antifungal and leishmanicidal activity with low incidence of clinical resistance. Its parenteral administration has high risk of nephrotoxicity that limits its use. In order to treat cutaneous infections, AmB topical administration is a safer therapy because of the low systemic absorpt...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2014.07.004

    authors： Ruiz HK,Serrano DR,Dea-Ayuela MA,Bilbao-Ramos PE,Bolás-Fernández F,Torrado JJ,Molero G

    更新日期：2014-10-01 00:00:00

  • Solid-state compatibility studies using a high-throughput and automated forced degradation system.

    abstract：:As the number of pharmaceutical candidate compounds increases, so does the need for development workflow that is capable of handling more compounds in shorter times. In this paper, the establishment of a high-throughput automated powder compatibility testing system is reported. The integrated robotic system automatica...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2007.12.002

    authors： Wakasawa T,Sano K,Hirakura Y,Toyo'oka T,Kitamura S

    更新日期：2008-05-01 00:00:00

  • Inertial sizing of aerosol inhaled from two dry powder inhalers with realistic breath patterns versus constant flow rates.

    abstract：:A procedure is developed that allows particles inhaled with realistic breath patterns to be sized by cascade impaction at a constant flow rate. This procedure is then used to examine the difference between particle sizes obtained with constant flow rate (step profile) versus actual-subject breath patterns for two dry ...

    journal_title：International journal of pharmaceutics

    pub_type： 临床试验,杂志文章

    doi：10.1016/s0378-5173(00)00569-x

    authors： Finlay WH,Gehmlich MG

    更新日期：2000-12-04 00:00:00

  • Ondansetron buccal administration for paediatric use: A comparison between films and wafers.

    abstract：:The objective of this study was the development of different solid formulations, such as wafers and films, for buccal administration of ondansetron, a selective and potent antagonist of 5-hydroxytryptamine 3 receptors used in children for the treatment of nausea and vomiting. Wafers and films have been prepared drying...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2020.119228

    authors： Giordani B,Abruzzo A,Prata C,Nicoletta FP,Dalena F,Cerchiara T,Luppi B,Bigucci F

    更新日期：2020-04-30 00:00:00

  • Physicochemical characterisation of liposomes with encapsulated local anaesthetics.

    abstract：:Local anaesthetics may be added to intravenous o/w emulsions of propofol to reduce the initial pain of injection. Due to incompatibility problems of the emulsion on the addition of a local anaesthetic solution, prior encapsulation of the drug within liposomes is suggested. The liposomes were prepared with the sonicati...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2004.01.015

    authors： Müller M,Mackeben S,Müller-Goymann CC

    更新日期：2004-04-15 00:00:00

  • Ascorbyl-dipalmitate-stabilised nanoemulsions as a potential localised treatment of inflammatory bowel diseases.

    abstract：:Current efforts on inflammatory bowel diseases (IBD) treatment are focused on strategies for localised drug delivery at the intestinal mucosa. Despite the potential of curcumin (CC) for IBD treatment, its low solubility and stability limit its application. Thus, the design of nanocarriers that focus CC delivery at the...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2020.119533

    authors： Plaza-Oliver M,Beloqui A,Santander-Ortega MJ,Castro-Vázquez L,Rodríguez-Robledo V,Arroyo-Jiménez MM,Préat V,Lozano MV

    更新日期：2020-08-30 00:00:00

  • Cathepsin K inhibitor-polymer conjugates: potential drugs for the treatment of osteoporosis and rheumatoid arthritis.

    abstract：:The role of the newly discovered cysteine protease, cathepsin K, in osteoporosis and rheumatoid arthritis is reviewed. The current development of cathepsin K inhibitors and their targeted delivery using synthetic polymer carriers are discussed. Future challenges and possible strategies to improve these delivery system...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章,评审

    doi：10.1016/j.ijpharm.2003.03.003

    authors： Wang D,Li W,Pechar M,Kopecková P,Brömme D,Kopecek J

    更新日期：2004-06-11 00:00:00

  • Squalene-based nanoparticles for the targeting of atherosclerotic lesions.

    abstract：:Native low-density lipoproteins (LDL) naturally accumulate at atherosclerotic lesions and are thought to be among the main drivers of atherosclerosis progression. Numerous nanoparticular systems making use of recombinant lipoproteins have been developed for targeting atherosclerotic plaque. These innovative formulatio...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2020.119282

    authors： Brusini R,Dormont F,Cailleau C,Nicolas V,Peramo A,Varna M,Couvreur P

    更新日期：2020-05-15 00:00:00

  • Cosolvency approach for assessing the solubility of drugs in poly(vinylpyrrolidone).

    abstract：:The log-linear cosolvency model was applied for estimating the solubility of four drugs: ritonavir, griseofulvin, itraconazole and ketoconazole in poly(vinylpyrrolidone) (PVP). Cosolvent mixtures consisted of PVP mixed in different proportions with N-ethylpyrrolidone, which served as the monomeric analogue of the repe...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2015.08.016

    authors： Chen X,Fadda HM,Aburub A,Mishra D,Pinal R

    更新日期：2015-10-15 00:00:00

  • Development of a new approach to investigating the drug transfer from colloidal carrier systems applying lipid nanosuspension-containing alginate microbeads as acceptor.

    abstract：:As a new approach to analyzing the release behavior of lipophilic drugs from colloidal carriers, solid trimyristin nanoparticles were incorporated into differently sized (34-1363 μm) calcium alginate hydrogel microbeads to serve as acceptor in release studies. The microbeads were prepared by electrostatic droplet gene...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2015.03.082

    authors： Strasdat B,Bunjes H

    更新日期：2015-07-15 00:00:00

  • Production of dry-state ketoprofen-encapsulated PMMA NPs by coupling micromixer-assisted nanoprecipitation and spray drying.

    abstract：:We present a two-step process to produce dry-state Ketoprofen-loaded poly(methyl methacrylate) nanoparticles (NPs) with controllable size and tunable drug release profile. A colloidal suspension of drug-loaded nanoparticles was first obtained from a nanoprecipitation process and then transferred into a commercial spra...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2018.12.031

    authors： Ding S,Serra CA,Anton N,Yu W,Vandamme TF

    更新日期：2019-03-10 00:00:00

  • In vitro and in vivo evaluation of Pluronic F127-based ocular delivery system for timolol maleate.

    abstract：:The purpose of this study was to develop Pluronic F127 (PF127) based formulations of timolol maleate (TM) aimed at enhancing its ocular bioavailability. The effect of isotonicity agents and PF127 concentrations on the rheological properties of the prepared formulations was examined. In an attempt to reduce the concent...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/s0378-5173(02)00234-x

    authors： El-Kamel AH

    更新日期：2002-07-08 00:00:00

  • A preliminary study for the development and optimization by experimental design of an in vitro method for prediction of drug buccal absorption.

    abstract：:The work was aimed at developing an in vitro method able to provide rapid and reliable evaluation of drug absorption through buccal mucosa. Absorption simulator apparatus endowed with an artificial membrane was purposely developed by experimental design. The apparent permeation coefficient (Papp) through excised porci...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2018.06.032

    authors： Mura P,Orlandini S,Cirri M,Maestrelli F,Mennini N,Casella G,Furlanetto S

    更新日期：2018-08-25 00:00:00

  • Evaluation of a newly developed HPMC ophthalmic insert with sustained release properties as a carrier for thermolabile therapeutics.

    abstract：:A novel drug delivery system (DDS) with sustained release properties was developed to allow ocular protein delivery. The DDS developed is aimed at overcoming stability issues during preparation such as denaturation of proteins caused by shear forces applied or due to elevated temperatures and air entrapment potentiall...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2015.01.042

    authors： Everaert A,Broeckx G,Fransen E,Ludwig A,Kiekens F,Weyenberg W

    更新日期：2015-03-15 00:00:00

  • Preparation of poly(DL-lactide-co-glycolide) nanoparticles by modified spontaneous emulsification solvent diffusion method.

    abstract：PURPOSE:The objectives of this study were to establish a new preparation method for poly(DL-lactide-co-glycolide) (PLGA) nanoparticles by modifying the spontaneous emulsification solvent diffusion (SESD) method and to elucidate the mechanism of nanoparticle formation on the basis of the phase separation principle of PL...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/s0378-5173(99)00187-8

    authors： Murakami H,Kobayashi M,Takeuchi H,Kawashima Y

    更新日期：1999-10-05 00:00:00

  • Assessing the physical-chemical properties and stability of dapivirine-loaded polymeric nanoparticles.

    abstract：:Nanocarriers may provide interesting delivery platforms for microbicide drugs and their characterization should be addressed early in development. Differently surface-engineered dapivirine-loaded, poly(epsilon-caprolactone) (PCL)-based nanoparticles (NPs) were obtained by nanoprecipitation using polyethylene oxide (PE...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2013.08.049

    authors： das Neves J,Amiji M,Bahia MF,Sarmento B

    更新日期：2013-11-18 00:00:00

  • The effect of a P123 template in mesopores of mesocellular foam on the controlled-release of venlafaxine.

    abstract：:A series of mesocellular foams (MCFs)-based mesoporous silica nanospheres (DH-MCF-P123-n, (n=12, 2, 0.5)) were synthesized as controlled-release deliveries for a typical antidepressant drug, venlafaxine. The foams were 3-(2,3-dihydroxypropoxyl)propyl-grafted and the P123 template partially preserved. We studied the re...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2011.12.048

    authors： Tang J,Bian Z,Hu J,Xu S,Liu H

    更新日期：2012-03-15 00:00:00