Abstract：
:Modic change (MC) is considered an independent risk factor for low back pain (LBP) but its aetiology remains unclear. In this cross-sectional, large-scale population-based study we sought to characterise associations between endplate defect (ED) and MC in a population sample of broad age range. The study population consisted of 831 twin volunteers (including 4155 discs and 8310 endplates) from TwinsUK. Lumbar T2-weighted MR images were coded for ED and MC. Total endplate (TEP) score was calculated at each intervertebral disc while receiver operating curves (ROC) were calculated to define critical endplate values predictive of MC. MC was detected in 32.1% of the subjects, with a significantly higher prevalence at lower lumbar levels (3.5% at L1/2-L3/4 vs. 15.9% at L4/5-L5/S1, p < 0.001). TEP score was strongly and independently associated with MC at each lumbar level (risk estimates from 1.49 to 2.44; all p ≤ 0.001) after adjustment for age, sex, BMI and twin pairing. ROC analysis showed a TEP score cut-off of 6 above which there was a significantly higher prevalence of MC. In conclusion, ED were strongly associated with MC at every lumbar level. These findings support the hypothesis that endplate defect is a major initiating factor for the cascade of events that may include disc degeneration (DD) and MC.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Määttä JH,Rade M,Freidin MB,Airaksinen O,Karppinen J,Williams FMKdoi
10.1038/s41598-018-34933-3subject
Has Abstractpub_date
2018-11-09 00:00:00pages
16630issue
1issn
2045-2322pii
10.1038/s41598-018-34933-3journal_volume
8pub_type
杂志文章abstract：:At ambient pressure, the hydrogen bond in materials such as ice, hydrates, and hydrous minerals that compose the Earth and icy planets generally takes an asymmetric O-H···O configuration. Pressure significantly affects this configuration, and it is predicted to become symmetric, such that the hydrogen is centered betw...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-33598-2
更新日期：2018-10-19 00:00:00
abstract：:Retrotransposons can represent half of eukaryotic genomes. Retrotransposon dysregulation destabilizes genomes and has been linked to various human diseases. Emerging regulators of retromobility include RNA-DNA hybrid-containing structures known as R-loops. Accumulation of these structures at the transposons of yeast 1...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-73018-y
更新日期：2020-09-29 00:00:00
abstract：:Large-area, pinhole-free CH3NH3PbI3 perovskite thin films were successfully fabricated on 5 cm × 5 cm flexible indium tin oxide coated polyethylene naphthalate (ITO-PEN) substrates through a sequential evaporation/spin-coating deposition method in this research. The influence of the rate-controlled evaporation of PbI2...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-18970-y
更新日期：2018-01-11 00:00:00
abstract：:Nutrient resorption processes in the plants infected by pathogen remain poorly understood. Huanglongbing (HLB) is a destructive disease of citrus. HLB-pathogen 'Candidatus Liberibacter asiaticus' grows specifically in the phloem of hosts and may cause problems in the plant vascular system after infection. Therefore, i...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep14675
更新日期：2015-09-30 00:00:00
abstract：:Detection of antihypertensive drugs in biological samples is an important tool to assess the adherence of hypertensive patients. Urine and serum/plasma screenings based on qualitative results may lead to misinterpretations regarding drugs with a prolonged detectability. The aim of the present study was to develop a me...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-52164-y
更新日期：2019-10-30 00:00:00
abstract：:Circular Dichroism data are often decomposed into their constituent spectra to quantify the secondary structure of peptides or proteins but the estimation of the secondary structure content fails when light scattering leads to spectral distortion. If peptide-induced liposome self-association occurs, subtracting contro...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep39450
更新日期：2016-12-22 00:00:00
abstract：:Galectin-3 is a biomarker of fibrosis, inflammation and oxidative stress, and its role in heart remodelling and exercise intolerance has not been conclusively proven in heart failure (HF) patients with reduced ejection fraction (rEF). We prospectively assessed 67 consecutive patients with symptomatic HF and left ventr...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-73634-8
更新日期：2020-10-07 00:00:00
abstract：:Amorphous silicon oxycarbide (SiOC) is of great technological interest. However, its atomic-level structure is not well understood. Using density functional theory calculations, we show that the clustering tendency of C atoms in SiOC is extremely sensitive to hydrogen (H): without H, the C-C interaction is attractive,...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep13051
更新日期：2015-08-13 00:00:00
abstract：:The Raman spectral features from spinal cord tissue sections of transgenic, ALS model mice and non-transgenic mice were compared using 457 nm excitation line, profiting from the favourable signal intensity obtained in the molecular fingerprint region at this wavelength. Transverse sections from four SOD1G93A mice at 7...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-31469-4
更新日期：2018-08-30 00:00:00
abstract：:Global climate change (GCC) can negatively affect freshwater ecosystems. However, the degree to which freshwater populations can acclimate to long-term warming and the underlying molecular mechanisms are not yet fully understood. We used the cooling water discharge (CWD) area of a power plant as a model for long-term ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep39476
更新日期：2016-12-20 00:00:00
abstract：:A fluorimetric Hg2+ test strip has been developed using a lotus-inspired fabrication method for suppressing the "coffee stains" toward the uniform distribution of probe materials through creating a hydrophobic drying pattern for fast solvent evaporation. The test strips were first loaded with the model probes of fluor...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep36494
更新日期：2016-11-04 00:00:00
abstract：:Aberrant immune responses characterize autoimmune disorders like Rheumatoid Arthritis (RA) wherein lymphocytes are recognized as key players. Role of CD8+ T cells in RA has been less defined however we found that these cells are activated in RA patients with increased expression of cytolytic granules and inflammatory ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-01033-7
更新日期：2017-04-19 00:00:00
abstract：:Wurtzite solid solutions between GaN and ZnO highlight an intriguing paradigm for water splitting into hydrogen and oxygen using solar energy. However, large composition discrepancy often occurs inside the compound owing to the volatile nature of Zn, thereby prescribing rigorous terms on synthetic conditions. Here we ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep19060
更新日期：2016-01-12 00:00:00
abstract：:Uric acid (UA) has been proposed as an important risk factor for cardiovascular and renal morbidity. We conducted an interventional trial to assess effects of altered salt intake on plasma and urine UA levels and the relationship between UA levels and salt sensitivity in humans. Ninety subjects (18-65 years old) were ...
journal_title：Scientific reports
pub_type： 临床试验,杂志文章
doi：10.1038/s41598-018-20048-2
更新日期：2018-01-23 00:00:00
abstract：:Vertical hot electron transistors incorporating atomically-thin 2D materials, such as graphene or MoS2, in the base region have been proposed and demonstrated in the development of electronic and optoelectronic applications. To the best of our knowledge, all previous 2D material-base hot electron transistors only cons...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep32503
更新日期：2016-09-01 00:00:00
abstract：:Because of the critical role of transportation in modern times, one of the most successful application areas of statistical physics of complex networks is the study of traffic dynamics. However, the vast majority of works treat transportation networks as an isolated system, which is inconsistent with the fact that man...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep19059
更新日期：2016-01-21 00:00:00
abstract：:We study the electronic structure and lattice dynamics in the ferromagnet MnBi using first-principles calculations and a tight-binding model. The band structure around the Fermi level is dominated by Bi-p states which are the primary contributors to the magnetic anisotropy energy in the low temperature structure. A ti...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep07222
更新日期：2014-11-27 00:00:00
abstract：:Friction is a major inhibitor in almost every mechanical system. Enlightened by the Leidenfrost effect - a droplet can be levitated by its own vapor layer on a sufficiently hot surface - we demonstrate for the first time that a small cart can also be levitated by Leidenfrost vapor. The levitated cart can carry certain...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep00797
更新日期：2012-01-01 00:00:00
abstract：:The use of engineered viral strains such as gene therapy vectors and oncolytic viruses (OV) to selectively destroy cancer cells is poised to make a major impact in the clinic and revolutionize cancer therapy. In particular, several studies have shown that OV therapy is safe and well tolerated in humans and can infect ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep26786
更新日期：2016-05-26 00:00:00
abstract：:Rheumatoid arthritis (RA) is an autoimmune disease characterized by progressive immune-mediated joint deterioration. Current treatments are not antigen specific and are associated with various adverse. We have previously demonstrated that tolerogenic dendritic cells (Tol-DC) are potent antigen-specific immune regulato...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep43188
更新日期：2017-02-23 00:00:00
abstract：:Chronic consumption of excess ethanol increases the risk of colorectal cancer. The pathogenesis of ethanol-related colorectal cancer (ER-CRC) is thought to be partly mediated by gut microbes. Specifically, bacteria in the colon and rectum convert ethanol to acetaldehyde (AcH), which is carcinogenic. However, the effec...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep27923
更新日期：2016-06-13 00:00:00
abstract：:No study to date has prospectively evaluated the association between pre-diagnostic cruciferous vegetables intake and lung cancer survival among women. This analysis included 547 incident lung cancer cases identified from the Shanghai Women's Health Study (SWHS) during the follow-up period of 1997-2011. Dietary intake...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep10306
更新日期：2015-05-19 00:00:00
abstract：:The Asian citrus psyllid (ACP; Diaphorina citri) is the vector of Candidatus Liberibacter asiaticus (CLas) that is associated with the devastating Huanglongbing (HLB; citrus greening disease). This pest of Asian origin has spread into the Americas and more recently into a few countries in East Africa. During recent su...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-66380-4
更新日期：2020-06-10 00:00:00
abstract：:The fluorination of p-type metal phthalocyanines produces n-type semiconductors, allowing the design of organic electronic circuits that contain inexpensive heterojunctions made from chemically and thermally stable p- and n-type organic semiconductors. For the evaluation of close to intrinsic transport properties, hig...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep07573
更新日期：2014-12-19 00:00:00
abstract：:A 63-day feeding trial was conducted in northern snakehead to observe the effects of a dietary soybean meal substitution on the microbiota community, morphology and inflammatory cytokine gene expression in the intestine. Four isonitrogenous and isoenergetic diets containing increasing levels of soybean meal were used ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-18430-7
更新日期：2018-01-08 00:00:00
abstract：:Neoadjuvant systemic treatment is increasingly being integrated in the standard treatment of pancreatic ductal adenocarcinoma (PDAC) patients to improve oncological outcomes. Current available imaging techniques remain unreliable in assessing response to therapies, as they cannot distinguish between (vital) tumor tiss...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-73242-6
更新日期：2020-10-01 00:00:00
abstract：:Proton-sensing ovarian cancer G-protein coupled receptor (OGR1) plays an important role in pH homeostasis. Acidosis occurs at sites of intestinal inflammation and can induce endoplasmic reticulum (ER) stress and the unfolded protein response (UPR), an evolutionary mechanism that enables cells to cope with stressful co...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-57657-9
更新日期：2020-01-29 00:00:00
abstract：:Despite the increasing number of studies conducted recently to evaluate the association between HPV infections and the risk of prostate cancer, the results remain inconclusive. Furthermore, the prevalence and distribution of overall and individual HPV types worldwide in prostate cancer has not been reported until now....
journal_title：Scientific reports
pub_type： 杂志文章,meta分析
doi：10.1038/srep14667
更新日期：2015-10-06 00:00:00
abstract：:Measurement-based quantum computing is one of the most promising quantum computing models. Although various universal resource states have been proposed so far, it was open whether only two Pauli bases are enough for both of universal measurement-based quantum computing and its verification. In this paper, we construc...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-49968-3
更新日期：2019-09-19 00:00:00
abstract：:A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has been fixed in the paper. ...
journal_title：Scientific reports
pub_type： 已发布勘误
doi：10.1038/s41598-018-35439-8
更新日期：2018-11-22 00:00:00
