Abstract：
:Overweight and stress are both related to brain structural abnormalities. The allostatic load model states that frequent disruption of homeostasis is inherently linked to oxidative stress and inflammatory responses that in turn can damage the brain. However, the effects of the allostatic load on the central nervous system remain largely unknown. The current study aimed to assess the relationship between the allostatic load and the composition of whole-brain white matter tracts in overweight subjects. Additionally, we have also tested for grey matter changes regarding allostatic load increase. Thirty-one overweight-to-obese adults and 21 lean controls participated in the study. Our results showed that overweight participants presented higher allostatic load indexes. Such increases correlated with lower fractional anisotropy in the inferior fronto-occipital fasciculi and the right anterior corona radiata, as well as with grey matter reductions in the left precentral gyrus, the left lateral occipital gyrus, and the right pars opercularis. These results suggest that an otherwise healthy overweight status is linked to long-term biological changes potentially harmful to the brain.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Ottino-González J,Jurado MA,García-García I,Segura B,Marqués-Iturria I,Sender-Palacios MJ,Tor E,Prats-Soteras X,Caldú X,Junqué C,Pasternak O,Garolera Mdoi
10.1038/s41598-018-34219-8subject
Has Abstractpub_date
2018-10-26 00:00:00pages
15898issue
1issn
2045-2322pii
10.1038/s41598-018-34219-8journal_volume
8pub_type
杂志文章abstract：:The limits of mammography have led to an increasing interest on possible alternatives such as the breast Computed Tomography (bCT). The common goal of all X-ray imaging techniques is to achieve the optimal contrast resolution, measured through the Contrast to Noise Ratio (CNR), while minimizing the radiological risks,...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-49351-2
更新日期：2019-09-11 00:00:00
abstract：:Poor oral health is not only associated with diabetes and cardiovascular disease but adverse pregnancy outcomes. However the influence of dental caries on pregnancy is unknown. The aim of this study was to evaluate the association between dental caries and adverse pregnancy outcomes and the effect of treatment for den...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-62306-2
更新日期：2020-03-24 00:00:00
abstract：:Hierarchical classification (HC) stratifies and classifies data from broad classes into more specific classes. Unlike commonly used data classification strategies, this enables the probabilistic prediction of unknown classes at different levels, minimizing the burden of incomplete databases. Despite these advantages, ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-14092-7
更新日期：2017-11-03 00:00:00
abstract：:Systemic lipopolysaccharide (LPS) is implicated in increasing mortality in patients with alcoholic hepatitis but the underlying mechanisms are not well characterised. The objective of this study was to characterise neutrophil function, LPS and cytokine concentrations within the splanchnic circulation of alcoholic cirr...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep40157
更新日期：2017-01-04 00:00:00
abstract：:Footprint evidence of human-megafauna interactions remains extremely rare in the archaeological and palaeontological records. Recent work suggests ancient playa environments may hold such evidence, though the prints may not be visible. These so-called "ghost tracks" comprise a rich archive of biomechanical and behavio...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-52996-8
更新日期：2019-11-11 00:00:00
abstract：:Overexposure to intense noise can destroy the synapses between auditory nerve fibers and their hair cell targets without destroying the hair cells themselves. In adult mice, this synaptopathy is immediate and largely irreversible, whereas, in guinea pigs, counts of immunostained synaptic puncta can recover with increa...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-76553-w
更新日期：2020-11-17 00:00:00
abstract：:Surface enhanced Raman scattering (SERS) is generally and widely used to enhance the vibrational fingerprint of molecules located at the vicinity of noble metal nanoparticles. In this work, SERS is originally used to enhance the own vibrational density of states (VDOS) of nude and isolated gold nanoparticles. This off...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep39164
更新日期：2016-12-16 00:00:00
abstract：:Methicillin-resistant Staphylococcus aureus (MRSA), are the most frequent cause of sepsis, which urgently demanding new drugs for treating infection. Two homologous insect CSαβ peptides-DLP2 and DLP4 from Hermetia illucens were firstly expressed in Pichia pastoris, with the yields of 873.5 and 801.3 mg/l, respectively...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-10839-4
更新日期：2017-09-21 00:00:00
abstract：:Machine learning is a well-known approach for virtual screening. Recently, deep learning, a machine learning algorithm in artificial neural networks, has been applied to the advancement of precision medicine and drug discovery. In this study, we performed comparative studies between deep neural networks (DNN) and othe...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-73681-1
更新日期：2020-10-08 00:00:00
abstract：:To manage health conditions of farmed fish and other living creatures, a simple method to measure bioelectric signals of the creatures in seawater is expected. A novel method to measure bioelectric signals by utilizing the conductivity of seawater surrounding the entire body of a fish is proposed. As for the proposed ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-73485-3
更新日期：2020-10-01 00:00:00
abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...
journal_title：Scientific reports
pub_type： 已发布勘误
doi：10.1038/s41598-020-60470-z
更新日期：2020-03-10 00:00:00
abstract：:Chronic hepatitis B virus (HBV) infection is a major global health burden. Functional exhaustion and numerical reduction of HBV-specific cytotoxic T lymphocytes (CTLs) in the liver and peripheral blood limit anti-HBV CTL activity in patients with chronic HBV infection (CHB). However, the ongoing anti-HBV CD8(+) T cell...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep12159
更新日期：2015-07-22 00:00:00
abstract：:The controlled preparation of Au nanoparticles (NPs) in the size range of 6 to 22 nm is explored in this study. The Au NPs were prepared by the reduction of tetrachloroauric acid using maltose in the presence of nonionic surfactant Tween 80 at various concentrations to control the size of the resulting Au NPs. With in...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-22976-5
更新日期：2018-03-15 00:00:00
abstract：:Peatlands perform important ecosystem functions, such as carbon storage and nutrient retention, which are affected, among other factors, by vegetation and peat decomposition. The availability of silicon (Si) in peatlands differs strongly, ranging from <1 to >25 mg L-1. Since decomposition of organic material was recen...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-09130-3
更新日期：2017-08-18 00:00:00
abstract：:Risk of malaria in infants can be influenced by prenatal factors. In this study, the potential for placental parasitemia at delivery in predicting susceptibility of infants to Plasmodium falciparum (Pf) infections was evaluated. Seventy-two newborns of mothers who were placental malaria negative (PM-) and of mothers w...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-18574-6
更新日期：2018-01-09 00:00:00
abstract：:The aim was to investigate the ability of self-assembling Peptide P11-4 Matrix (SAPM) to remineralize artificial initial caries lesions compared to the use of fluoride varnish. Volunteers were recruited for this randomised, cross-over in situ trial. Bovine specimens, half including orthodontic brackets, were recessed ...
journal_title：Scientific reports
pub_type： 杂志文章,随机对照试验
doi：10.1038/s41598-018-36536-4
更新日期：2019-01-22 00:00:00
abstract：:To hear out a conversation against other talkers listeners overcome energetic and informational masking. Largely attributed to top-down processes, information masking has also been demonstrated using unintelligible speech and amplitude-modulated maskers suggesting bottom-up processes. We examined the role of speech-li...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep08662
更新日期：2015-03-02 00:00:00
abstract：:Maonan nationality is a relatively conservative and isolated minority in China. Little is known about the association of the Slit-Robo Rho GTPase activating protein 2 gene (SRGAP2) single nucleotide polymorphisms (SNPs) and serum lipid levels in the Chinese populations. This study was performed to clarify the associat...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-10950-6
更新日期：2017-09-14 00:00:00
abstract：:Abscisic acid (ABA) is a phytohormone that is necessary for stress adaptation. Recent studies have reported that attenuated levels of ABA improved grain yield and seedling growth under low temperature in cereals. To improve plant growth under low temperature, we attempted to generate ABA-insensitive transgenic rice by...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-30866-z
更新日期：2018-08-17 00:00:00
abstract：:Under specific reaction conditions, levansucrase from Bacillus subtilis (SacB) catalyzes the synthesis of a low molecular weight levan through the non-processive elongation of a great number of intermediates. To deepen understanding of the polymer elongation mechanism, we conducted a meticulous examination of the fruc...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-32872-7
更新日期：2018-10-09 00:00:00
abstract：:We report measurements of the thermal conductance of a structure made from commercial Acrylonitrile Butadiene Styrene (ABS) modules, known as LEGO® blocks, in the temperature range from 70 mK to 1.8 K. A power law for the sample's thermal conductivity κ = (8.7 ± 0.3) × 10-5 T 1.75±0.02 WK-1 m-1 was determined. We conc...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-55616-7
更新日期：2019-12-23 00:00:00
abstract：:We report on the magnetic field control of a bipolar resistive switching in Ag/TiO2/FTO based resistive random access memory device through I-V characteristics. Essentially, in the presence of magnetic field and in the low resistance state, an abrupt change in the resistance of the device demands higher voltage, hinti...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-17607-4
更新日期：2017-12-08 00:00:00
abstract：:E. coli is the main causative agent of mastitis in dairy cows, but the mechanism of molecular regulation underlying the occurrence and development of mastitis has not yet been fully elucidated. In this study, an E. coli-induced mastitis model was created and RNASeq technology was used to measure the miRNA expression p...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-30518-2
更新日期：2018-08-23 00:00:00
abstract：:The transforming growth factor beta (TGFβ) related signaling is one of the most important signaling pathways regulating early developmental events. Smad2 and Smad3 are structurally similar and it is mostly considered that they are equally important in mediating TGFβ signals. Here, we show that Smad3 is an insensitive ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep21602
更新日期：2016-02-24 00:00:00
abstract：:This manuscript presents a detailed characterization of active control of bow shock waves via leading edge injection, including subsonic coolant ejection and the appearance of Coanda effects. The flow phenomena occurring at steady and pulsating flow injection regimes were analyzed using steady and unsteady two-dimensi...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-79048-w
更新日期：2020-12-14 00:00:00
abstract：:Myocardial ischemia culminates in ATP production impairment, ionic derangement and cell death. The provision of metabolic substrates during reperfusion significantly increases heart tolerance to ischemia by improving mitochondrial performance. Under normoxia, glutamate contributes to myocardial energy balance as subst...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-13478-x
更新日期：2017-10-12 00:00:00
abstract：:Multiple predatory insect lineages have developed a raptorial lifestyle by which they strike and hold prey using modified forelegs armed with spine-like structures and other integumentary specialisations. However, how structures enabling the raptorial function evolved in insects remains largely hypothetical or inferre...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-49398-1
更新日期：2019-09-13 00:00:00
abstract：:Pneumocystis jirovecii pneumonia (PJP) is a potentially life-threatening infection that occurs in immunocompromised patients. The aim of this study was to evaluate risk factors for PJP in kidney transplantation recipients. We conducted a retrospective analysis of patient data from 500 consecutive kidney transplants pe...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-01818-w
更新日期：2017-05-08 00:00:00
abstract：:Around 350 million tonnes of plastics are annually produced worldwide. A remarkable percentage of these products is dispersed in the environment, finally reaching and dispersed in the marine environment. Recent field surveys detected microplastics' concentrations in the Mediterranean Sea. The most commonly polymers fo...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-74543-6
更新日期：2020-11-16 00:00:00
abstract：:Large (>10 kb) palindromic sequences are enriched on mammalian sex chromosomes. In mice, these palindromes harbor gene families (≥2 gene copies) expressed exclusively in post-meiotic testicular germ cells, a time when most single-copy sex-linked genes are transcriptionally repressed. This observation led to the hypoth...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-27360-x
更新日期：2018-06-12 00:00:00
