Activation of transcription by two factors that bind promoter and enhancer sequences of the human metallothionein gene and SV40.

abstract：:A 7-A resolution map of the purple membrane has been obtained by electron microscopy of tilted, unstained specimens. The protein in the membrane contains seven, closely packed, alpha-helical segments which extend roughly perpendicular to the plane of the membrane for most of its width. Lipid bilayer regions fill the s...

journal_title：Nature

authors： Henderson R,Unwin PN

更新日期：1975-09-04 00:00:00

abstract：:Comprehensive protein protein interaction maps promise to reveal many aspects of the complex regulatory network underlying cellular function. Recently, large-scale approaches have predicted many new protein interactions in yeast. To measure their accuracy and potential as well as to identify biases, strengths and weak...

journal_title：Nature

authors： von Mering C,Krause R,Snel B,Cornell M,Oliver SG,Fields S,Bork P

更新日期：2002-05-23 00:00:00

abstract：:Millions of years before we began to manipulate the flow of light using synthetic structures, biological systems were using nanometre-scale architectures to produce striking optical effects. An astonishing variety of natural photonic structures exists: a species of Brittlestar uses photonic elements composed of calcit...

journal_title：Nature

authors： Vukusic P,Sambles JR

更新日期：2003-08-14 00:00:00

abstract：:Deuterostomes are a remarkably diverse super-phylum, including not only the chordates (to which we belong) but groups as disparate as the echinoderms and the hemichordates. The phylogeny of deuterostomes is now achieving some degree of stability, especially on account of new molecular data, but this leaves as conjectu...

journal_title：Nature

authors： Shu DG,Morris SC,Han J,Zhang ZF,Liu JN

更新日期：2004-07-22 00:00:00

abstract：:The alpha-helix defined in 1951 by Pauling et al. on the basis of model building and X-ray fibre diffraction data has 3.65 residues per turn (n) achieved with planar peptides, torsion angles of phi = -48 degrees and psi = -57 degrees and hydrogen bonds which are close to linear. Although X-ray analyses of proteins hav...

journal_title：Nature

authors： Blundell T,Barlow D,Borkakoti N,Thornton J

更新日期：1983-11-17 00:00:00

abstract：:The proteins encoded by the ras oncogene are thought to trigger expression of the transformed phenotype in some types of cancer cells. In human cells, the ras protein family consists of several members including normal (proto-oncogene) and mutant (oncogene) forms. In general, the proto-oncogene forms are thought to be...

journal_title：Nature

authors： Feramisco JR,Clark R,Wong G,Arnheim N,Milley R,McCormick F

更新日期：1985-04-18 00:00:00

abstract：:In the originally published version of this Article, the sequenced axolotl strain (the homozygous white mutant) was denoted as 'D/D' rather than 'd/d' in Fig. 1a and the accompanying legend, the main text and the Methods section. The original Article has been corrected online. ...

journal_title：Nature

authors： Nowoshilow S,Schloissnig S,Fei JF,Dahl A,Pang AWC,Pippel M,Winkler S,Hastie AR,Young G,Roscito JG,Falcon F,Knapp D,Powell S,Cruz A,Cao H,Habermann B,Hiller M,Tanaka EM,Myers EW

更新日期：2018-07-01 00:00:00

abstract：:Copper, zinc superoxide dismutase (SOD) catalyses the very rapid two-step dismutation of the toxic superoxide radical (O-2) to molecular oxygen and hydrogen peroxide through the alternate reduction and oxidation of the active-site copper. We report here that after refitting and further refinement of the previous 2 A s...

journal_title：Nature

authors： Tainer JA,Getzoff ED,Richardson JS,Richardson DC

更新日期：1983-11-17 00:00:00

abstract：:Retinoic-acid-inducible gene-I (RIG-I; also called DDX58) is a cytosolic viral RNA receptor that interacts with MAVS (also called VISA, IPS-1 or Cardif) to induce type I interferon-mediated host protective innate immunity against viral infection. Furthermore, members of the tripartite motif (TRIM) protein family, whic...

journal_title：Nature

authors： Gack MU,Shin YC,Joo CH,Urano T,Liang C,Sun L,Takeuchi O,Akira S,Chen Z,Inoue S,Jung JU

更新日期：2007-04-19 00:00:00

abstract：:Osteoclasts are the only somatic cells with bone-resorbing capacity and, as such, they have a critical role not only in normal bone homeostasis (called 'bone remodelling') but also in the pathogenesis of bone destructive disorders such as rheumatoid arthritis and osteoporosis. A major focus of research in the field ha...

journal_title：Nature

authors： Ishii M,Egen JG,Klauschen F,Meier-Schellersheim M,Saeki Y,Vacher J,Proia RL,Germain RN

更新日期：2009-03-26 00:00:00

abstract：:Most mitochondrial proteins are synthesized on cytoplasmic ribosomes and imported into mitochondria. The imported proteins are directed to one of four submitochondrial compartments--the outer mitochondrial membrane, the inner mitochondrial membrane, the intramembraneous space, or the matrix--where the protein then fun...

journal_title：Nature

authors： Bose HS,Lingappa VR,Miller WL

更新日期：2002-05-02 00:00:00

abstract：:The dominant forcing factors for past large-scale changes in vegetation are widely debated. Changes in the distribution of C4 plants--adapted to warm, dry conditions and low atmospheric CO2 concentrations--have been attributed to marked changes in environmental conditions, but the relative impacts of changes in aridit...

journal_title：Nature

authors： Schefuss E,Schouten S,Jansen JH,Sinninghe Damsté JS

更新日期：2003-03-27 00:00:00

abstract：:Mammalian cells proteolytically release (shed) the extracellular domains of many cell-surface proteins. Modification of the cell surface in this way can alter the cell's responsiveness to its environment and release potent soluble regulatory factors. The release of soluble tumour-necrosis factor-alpha (TNF-alpha) from...

journal_title：Nature

authors： Black RA,Rauch CT,Kozlosky CJ,Peschon JJ,Slack JL,Wolfson MF,Castner BJ,Stocking KL,Reddy P,Srinivasan S,Nelson N,Boiani N,Schooley KA,Gerhart M,Davis R,Fitzner JN,Johnson RS,Paxton RJ,March CJ,Cerretti DP

更新日期：1997-02-20 00:00:00

abstract：:Cognitive ethology focuses on the study of animals under natural conditions to reveal ecologically adapted modes of learning. But biologists can more easily study what an animal learns than how it learns. For example, honeybees take repeated 'orientation' flights before becoming foragers at about three weeks of age. T...

journal_title：Nature

authors： Capaldi EA,Smith AD,Osborne JL,Fahrbach SE,Farris SM,Reynolds DR,Edwards AS,Martin A,Robinson GE,Poppy GM,Riley JR

更新日期：2000-02-03 00:00:00

abstract：:Hyperpolarization-activated cation channels of the HCN gene family contribute to spontaneous rhythmic activity in both heart and brain. All four family members contain both a core transmembrane segment domain, homologous to the S1-S6 regions of voltage-gated K+ channels, and a carboxy-terminal 120 amino-acid cyclic nu...

journal_title：Nature

authors： Wainger BJ,DeGennaro M,Santoro B,Siegelbaum SA,Tibbs GR

更新日期：2001-06-14 00:00:00

abstract：:The ability of the immune system to eliminate and shape the immunogenicity of tumours defines the process of cancer immunoediting1. Immunotherapies such as those that target immune checkpoint molecules can be used to augment immune-mediated elimination of tumours and have resulted in durable responses in patients with...

journal_title：Nature

authors： Alspach E,Lussier DM,Miceli AP,Kizhvatov I,DuPage M,Luoma AM,Meng W,Lichti CF,Esaulova E,Vomund AN,Runci D,Ward JP,Gubin MM,Medrano RFV,Arthur CD,White JM,Sheehan KCF,Chen A,Wucherpfennig KW,Jacks T,Unanue ER,Ar

更新日期：2019-10-01 00:00:00

abstract：:About one-third of the carbon dioxide (CO(2)) released into the atmosphere as a result of human activity has been absorbed by the oceans, where it partitions into the constituent ions of carbonic acid. This leads to ocean acidification, one of the major threats to marine ecosystems and particularly to calcifying organ...

journal_title：Nature

authors： Beaufort L,Probert I,de Garidel-Thoron T,Bendif EM,Ruiz-Pino D,Metzl N,Goyet C,Buchet N,Coupel P,Grelaud M,Rost B,Rickaby RE,de Vargas C

更新日期：2011-08-03 00:00:00

abstract：:Exploiters (parasites and predators) are thought to play a significant role in diversification, and ultimately speciation, of their hosts or prey. Exploiters may drive sympatric (within-population) diversification if there are a variety of exploiter-resistance strategies or fitness costs associated with exploiter resi...

journal_title：Nature

authors： Buckling A,Rainey PB

更新日期：2002-12-05 00:00:00

abstract：:Two approaches to the antibody-directed targeting of toxic or cytolytic activity and augmentation of cellular immune responses have been explored for tumour immunotherapy, but so far success has been limited. Obstacles facing immunotherapy are the limited accessibility of antibodies or antibody conjugates to solid tum...

journal_title：Nature

authors： Chen SY,Yang AG,Chen JD,Kute T,King CR,Collier J,Cong Y,Yao C,Huang XF

更新日期：1997-01-02 00:00:00

abstract：:The nucleus of mammalian cells displays a distinct spatial segregation of active euchromatic and inactive heterochromatic regions of the genome1,2. In conventional nuclei, microscopy shows that euchromatin is localized in the nuclear interior and heterochromatin at the nuclear periphery1,2. Genome-wide chromosome conf...

journal_title：Nature

authors： Falk M,Feodorova Y,Naumova N,Imakaev M,Lajoie BR,Leonhardt H,Joffe B,Dekker J,Fudenberg G,Solovei I,Mirny LA

更新日期：2019-06-01 00:00:00

abstract：:Four incorrect figure citations in this Letter have been corrected online. ...

journal_title：Nature

authors： Leo N,Carolus V,White JS,Kenzelmann M,Hudl M,Tolédano P,Honda T,Kimura T,Ivanov SA,Weil M,Lottermoser T,Meier D,Fiebig M

更新日期：2018-11-01 00:00:00

abstract：:A three-dimensional image of tubulin protofilaments, reconstructed to 20 A resolution from electron micrographs of negatively stained zinc-induced sheets, has been used to generate an improved model for microtubule substructure. This model has been used to phase a reconstructed image from X-ray amplitudes, which is co...

journal_title：Nature

authors： Amos LA,Baker TS

更新日期：1979-06-14 00:00:00

abstract：:HIV has advanced from high-risk groups such as intravenous drug users to some in the general population, according to comprehensive new data from the south of China. What needs to be done to halt its spread? ...

journal_title：Nature

authors： Lu L,Jia M,Ma Y,Yang L,Chen Z,Ho DD,Jiang Y,Zhang L

更新日期：2008-10-02 00:00:00

abstract：:Recognition of self-antigen-derived epitopes presented by major histocompatibility complex class II (MHC II) molecules on thymic epithelial cells (TECs) is critical for the generation of a functional and self-tolerant CD4 T-cell repertoire. Whereas haematopoietic antigen-presenting cells generate MHC-II-peptide comple...

journal_title：Nature

authors： Nedjic J,Aichinger M,Emmerich J,Mizushima N,Klein L

更新日期：2008-09-18 00:00:00

abstract：:The Pacific oyster Crassostrea gigas belongs to one of the most species-rich but genomically poorly explored phyla, the Mollusca. Here we report the sequencing and assembly of the oyster genome using short reads and a fosmid-pooling strategy, along with transcriptomes of development and stress response and the proteom...

journal_title：Nature

authors： Zhang G,Fang X,Guo X,Li L,Luo R,Xu F,Yang P,Zhang L,Wang X,Qi H,Xiong Z,Que H,Xie Y,Holland PW,Paps J,Zhu Y,Wu F,Chen Y,Wang J,Peng C,Meng J,Yang L,Liu J,Wen B,Zhang N,Huang Z,Zhu Q,Feng Y,Mount A

更新日期：2012-10-04 00:00:00

abstract：:Microtubule-based ATPases of the kinesin superfamily provide the motile force for many animated features of living cells. Kinesin motors differ in their direction of movement along microtubules. Kinesin and ncd, a kinesin-related motor involved in formation and maintenance of mitotic and meiotic spindles, move in oppo...

journal_title：Nature

authors： Sablin EP,Kull FJ,Cooke R,Vale RD,Fletterick RJ

更新日期：1996-04-11 00:00:00

abstract：: ...

journal_title：Nature

authors： Jia H

更新日期：2018-11-01 00:00:00

abstract：:The actin cytoskeleton is regulated by GTP-hydrolysing proteins, the Rho GTPases, which act as molecular switches in diverse signal-transduction processes. Various bacterial toxins can inactivate Rho GTPases by ADP-ribosylation or glucosylation. Previous research has identified Rho proteins as putative targets for Esc...

journal_title：Nature

authors： Schmidt G,Sehr P,Wilm M,Selzer J,Mann M,Aktories K

更新日期：1997-06-12 00:00:00

abstract：:In the pseudogap state of the high-transition-temperature (high-T(c)) copper oxide superconductors, angle-resolved photoemission (ARPES) measurements have seen Fermi arcs-that is, open-ended gapless sections in the large Fermi surface-rather than a closed loop expected of an ordinary metal. This is all the more puzzli...

journal_title：Nature

authors： Meng J,Liu G,Zhang W,Zhao L,Liu H,Jia X,Mu D,Liu S,Dong X,Zhang J,Lu W,Wang G,Zhou Y,Zhu Y,Wang X,Xu Z,Chen C,Zhou XJ

更新日期：2009-11-19 00:00:00

abstract：:Very large collisions in the asteroid belt could lead temporarily to a substantial increase in the rate of impacts of meteorites on Earth. Orbital simulations predict that fragments from such events may arrive considerably faster than the typical transit times of meteorites falling today, because in some large impacts...

journal_title：Nature

authors： Heck PR,Schmitz B,Baur H,Halliday AN,Wieler R

更新日期：2004-07-15 00:00:00