Association between leptin, obesity, hormonal interplay and male infertility.


:Male infertility is a major health problem worldwide. We investigated a possible association between leptin, obesity, hormonal interplay and male infertility. This cross-sectional study of 313 males (178 infertile and 135 fertile) was carried out in 2017. The subjects were categorised by body mass index (BMI) and body fat percentage (BF%) into normal weight, overweight and obese. Significantly higher levels of BMI and BF% (p-value < 0.001) and lower levels of FSH, LH, testosterone, and SHBG (p-value < 0.001) were found in infertile males. However, no significant difference was observed in leptin levels (p-value = 0.35). Leptin levels were significantly higher, and all the sex hormones were significantly lower (p-value < 0.001) in obese subjects, whereas according to BF% only leptin, FSH and SHBG were significantly different. Leptin showed a significant positive correlation with BMI and BF% (p < 0.001). A strong positive link to serum testosterone was found with age, FSH, and LH (p < 0.001) and a negative one with BMI and BF% (p < 0.001). In mutivariable anlaysis, after adjusting for the other covariates, a significant association between FSH and testosterone (p-value <0.001) was found. Serum leptin levels did not differ significantly in fertile and infertile groups, and no association was found with infertility. Furthermore, male obesity was found to be associated with infertility with the decrease in levels of sex hormones.






Amjad S,Baig M,Zahid N,Tariq S,Rehman R




Has Abstract


2019-02-01 00:00:00












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    pub_type: 杂志文章


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    pub_type: 临床试验,杂志文章,随机对照试验


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  • Andrological work-up of patients undergoing microsurgical epididymal sperm aspiration or testicular sperm extraction.

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    authors: Mukherjee M,Chattopadhyay S,Mathur PP

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  • Comparison of different mathematical models to assess seasonal variations in the longevity of DNA integrity of cooled-stored stallion sperm.

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    authors: Courot M

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    pub_type: 杂志文章


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    pub_type: 杂志文章


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    更新日期:2017-12-01 00:00:00

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    pub_type: 杂志文章


    authors: Berzin M,Bilgeri YR,Zanzinger A,Wing J,Kalk WJ,Mendelsohn D

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    pub_type: 杂志文章


    authors: Nada EA,El Taieb MA,Ibrahim HM,Al Saied AE

    更新日期:2015-09-01 00:00:00

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    pub_type: 杂志文章


    authors: Dolatkhah MA,Shokoohi M,Charvandeh S,Tvrda E,Shoorei H,Moghimian M,Alihemmati A

    更新日期:2020-12-01 00:00:00