The association of adjusted Global AntiphosPholipid Syndrome Score (aGAPSS) with cardiovascular disease in subjects with antiphospholipid antibodies.


BACKGROUND AND AIMS:Cardiovascular disease (CVD), including coronary artery disease and stroke/peripheral artery disease, is less commonly reported than venous thromboembolism in subjects with antiphospholipid antibodies (aPLs) and little is known about the association of CVD with adjusted Global AntiphosPholipid Syndrome Score (aGAPSS). METHODS:Consecutive aPLs subjects were enrolled to assess the association of CVD with aGAPSS. Moreover, additional risk factors of CVD were identified by means of multivariate analysis to design an aGAPSS specific for CVD (aGAPSSCVD). RESULTS:A total of 192 aPLs subjects (34 males, 158 females, mean age 49.84 ± 12.0 years) were enrolled. CVD was reported in 52 subjects (27.1%), 26 episodes of coronary artery disease and 26 stroke/peripheral artery disease. The prevalence of CVD increased for increasing aGAPSS ranging from 20.5% in the lowest aGAPSS category, up to 37.9% in the highest category (p = 0.027). ROC analysis showed that aGAPSS detected 63.0% of CVD and was associated with OR for CVD of 2.52 (95%CI: 1.24-5.10, p = 0.010). When including obesity, diabetes and smoking habit in the score, we found that aGAPSSCVD detected 71.4% of CVD (72.4% for early-CVD and 69.0% for CVD after 50 years) with an OR for CVD of 4.68 (95%CI: 2.31-9.51, p < 0.001). CONCLUSIONS:The aGAPSSCVD, obtained after adding obesity, smoking habit and diabetes to the standard aGAPSS, showed a higher detection rate of CVD in aPLs subjects, particularly of early-CVD. These results need to be validated in ad hoc designed prospective studies.






Di Minno MND,Scalera A,Tufano A,Ambrosino P,Bettiol A,Silvestri E,Emmi G,Prisco D




Has Abstract


2018-11-01 00:00:00












  • Rice bran oil lowers serum total and low density lipoprotein cholesterol and apo B levels in nonhuman primates.

    abstract::The hypolipidemic response of rice bran oil (RBO) was investigated in nonhuman primates fed semi-purified diets containing blends of oils which included RBO at 0-35% Kcals as dietary fat. The studies demonstrated the following: (a) the degree of reduction of serum total cholesterol (TC) and low density lipoprotein cho...


    pub_type: 杂志文章


    authors: Nicolosi RJ,Ausman LM,Hegsted DM

    更新日期:1991-06-01 00:00:00

  • Roles of Sp1 and protein kinase C in regulation of human serum paraoxonase 1 (PON1) gene transcription in HepG2 cells.

    abstract::Human serum paraoxonase 1 (PON1) is associated with high-density lipoprotein, and inhibits oxidative modification of low-density lipoprotein in vitro. Therefore, PON1 is supposed to protect against atherosclerosis in vivo. In this study, we investigated the direct effect of Sp1 on PON1 transcription in HepG2 cells usi...


    pub_type: 杂志文章


    authors: Osaki F,Ikeda Y,Suehiro T,Ota K,Tsuzura S,Arii K,Kumon Y,Hashimoto K

    更新日期:2004-10-01 00:00:00

  • Binding and degradation of heavy and light subfractions of low density lipoprotein by cultured fibroblasts and macrophages.

    abstract::The heavy and light subfractions of low density lipoprotein (LDL) were bound to the same extent and with the same affinity by the LDL receptors of cultured human fibroblasts, both when assayed at 4 degrees C and when assayed at 37 degrees C. They were also degraded similarly by the low affinity, LDL-receptor-mediated ...


    pub_type: 杂志文章


    authors: Knight BL,Thompson GR,Soutar AK

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  • Lipid peroxidation of circulating low density lipoproteins with age, smoking and in peripheral vascular disease.

    abstract::In this study, lipid peroxides in plasma and the low density lipoprotein (LDL) fraction and plasma concentrations of vitamin E, lipids and lipoproteins were measured in 22 smokers (mean age 35 years), 26 non-smoking patients with peripheral vascular disease (PVD), mean age 66 years), and 23 younger (ages < or = 55 yea...


    pub_type: 杂志文章


    authors: Sanderson KJ,van Rij AM,Wade CR,Sutherland WH

    更新日期:1995-11-01 00:00:00

  • Maternal smoking in pregnancy is associated with cholesterol development in the offspring: A 27-years follow-up study.

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    pub_type: 杂志文章


    authors: Jaddoe VWV,de Ridder MAJ,van den Elzen APM,Hofman A,Uiterwaal CSPM,Witteman JCM

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  • Inability of plasma high-density lipoproteins to inhibit cell adhesion molecule expression in human coronary artery endothelial cells.

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    pub_type: 杂志文章


    authors: Stannard AK,Khan S,Graham A,Owen JS,Allen SP

    更新日期:2001-01-01 00:00:00

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    pub_type: 杂志文章,随机对照试验


    authors: Lunder M,Janić M,Habjan S,Sabovič M

    更新日期:2011-04-01 00:00:00

  • Endothelial function and arterial stiffness indexes in subjects with acute ischemic stroke: Relationship with TOAST subtype.

    abstract:BACKGROUND AND AIMS:Only one study has examined endothelial function in subjects with acute ischemic stroke and no study has yet assessed arterial stiffness and reactive hyperemia peripheral arterial tonometry (RH-PAT) in ischemic stroke and its clinical subtypes. Our study aimed to evaluate arterial stiffness and endo...


    pub_type: 杂志文章


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  • On the mechanism for PPAR agonists to enhance ABCA1 gene expression.

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    pub_type: 杂志文章


    authors: Ogata M,Tsujita M,Hossain MA,Akita N,Gonzalez FJ,Staels B,Suzuki S,Fukutomi T,Kimura G,Yokoyama S

    更新日期:2009-08-01 00:00:00

  • Type 1 diabetes increases retention of low-density lipoprotein in the atherosclerosis-prone area of the murine aorta.

    abstract:BACKGROUND AND AIMS:Individuals with type 1 diabetes mellitus are at high risk of developing atherosclerotic cardiovascular disease, but the underlying mechanisms by which type 1 diabetes accelerates atherosclerosis remain unknown. Increased retention of low-density lipoprotein (LDL) in atherosclerosis-prone sites of t...


    pub_type: 杂志文章


    authors: Hagensen MK,Mortensen MB,Kjolby M,Stillits NL,Steffensen LB,Bentzon JF

    更新日期:2017-08-01 00:00:00

  • Cholesterol and public policy.

    abstract::Cholesterol lowering in both primary and secondary prevention has been clearly demonstrated to lower coronary morbidity and, in secondary prevention, to lower coronary mortality as well. Putative dangers of cholesterol lowering remain unproven. Population studies linking low cholesterol to noncoronary mortalities do n...


    pub_type: 杂志文章


    authors: LaRosa JC

    更新日期:1994-08-01 00:00:00

  • Histamine promotes the differentiation of macrophages from CD11b+ myeloid cells and formation of foam cells through a Stat6-dependent pathway.

    abstract:BACKGROUND AND AIMS:The enzyme histidine decarboxylase (Hdc), which generates histamine, is highly expressed in CD11b+Gr-1+ myeloid cells that play a critical role in infection, inflammation and tumorigenesis. The aim of this study was to explore the role of Hdc-expressing CD11b+ myeloid cells or histamine in atherogen...


    pub_type: 杂志文章


    authors: Xu L,Cheng D,Huang Z,Ding S,Zhang W,Tan H,Shi H,Chen R,Zou Y,Wang TC,Yang X,Ge J

    更新日期:2017-08-01 00:00:00

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    pub_type: 杂志文章


    authors: Saito H,Salmon JA,Moncada S

    更新日期:1986-08-01 00:00:00

  • Rapid screening for specific mutations in patients with a clinical diagnosis of familial hypercholesterolaemia.

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    pub_type: 杂志文章


    authors: Talmud P,Tybjaerg-Hansen A,Bhatnagar D,Mbewu A,Miller JP,Durrington P,Humphries S

    更新日期:1991-08-01 00:00:00

  • Usefulness of lipoprotein ratios in assessing carotid atherosclerosis in Japanese type 2 diabetic patients.

    abstract:OBJECTIVE:It is indicated that total/HDL cholesterol and LDL/HDL cholesterol ratios have more predictive power for cardiovascular disease compared to classic lipid parameters. However, there have been few reports about the usefulness of these indices for the assessment of early stage atherosclerosis in Japanese type 2 ...


    pub_type: 杂志文章


    authors: Katakami N,Kaneto H,Osonoi T,Saitou M,Takahara M,Sakamoto F,Yamamoto K,Yasuda T,Matsuoka TA,Matsuhisa M,Yamasaki Y,Shimomura I

    更新日期:2011-02-01 00:00:00

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    pub_type: 杂志文章


    authors: Roemmich JN,Feda DM,Seelbinder AM,Lambiase MJ,Kala GK,Dorn J

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    pub_type: 临床试验,杂志文章


    authors: Korhonen T,Savolainen MJ,Kesäniemi YA

    更新日期:1999-09-01 00:00:00

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    pub_type: 杂志文章


    authors: Leroy A,Vu-Dac N,Theret N,Pio F,Fruchart JC

    更新日期:1989-09-01 00:00:00

  • Imbalanced gp130 signalling in ApoE-deficient mice protects against atherosclerosis.

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    pub_type: 杂志文章


    authors: Jones GW,McLeod L,Kennedy CL,Bozinovski S,Najdovska M,Jenkins BJ

    更新日期:2015-02-01 00:00:00

  • The influence of lifestyle modification on carotid artery intima-media thickness in a suburban Japanese population.

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    pub_type: 杂志文章


    authors: Okada K,Maeda N,Tatsukawa M,Shimizu C,Sawayama Y,Hayashi J

    更新日期:2004-04-01 00:00:00

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    pub_type: 杂志文章


    authors: Chung GE,Lee JH,Lee H,Kim MK,Yim JY,Choi SY,Kim YJ,Yoon JH,Kim D

    更新日期:2018-05-01 00:00:00

  • Hematoporphyrin binding to cultured aortic smooth muscle cells from spontaneously atherosclerotic turkey.

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  • A novel oxidized low-density lipoprotein marker, serum amyloid A-LDL, is associated with obesity and the metabolic syndrome.

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    authors: Kotani K,Satoh N,Kato Y,Araki R,Koyama K,Okajima T,Tanabe M,Oishi M,Yamakage H,Yamada K,Hattori M,Shimatsu A,Japan Obesity and Metabolic Syndrome Study Group.

    更新日期:2009-06-01 00:00:00

  • Abnormalities of blood rheology in familial hypercholesterolaemia: effects of treatment.

    abstract::Whole blood and plasma viscosity, red cell aggregability and deformability, and plasma fibrinogen have been compared between 20 patients with heterozygous familial hypercholesterolaemia (FH), without clinical arterial disease, and 20 age- and sex-matched controls. Plasma fibrinogen was elevated in FH, associated with ...


    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验


    authors: Jay RH,Rampling MW,Betteridge DJ

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    pub_type: 杂志文章


    authors: Orekhov AN,Andreeva ER,Mikhailova IA,Gordon D

    更新日期:1998-07-01 00:00:00

  • Altered relation of the renin-aldosterone system and vasoactive peptides in type 2 diabetes: The KORA F4 study.

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    authors: Then C,Rottenkolber M,Lechner A,Meisinger C,Heier M,Koenig W,Peters A,Rathmann W,Bidlingmaier M,Reincke M,Seissler J

    更新日期:2016-09-01 00:00:00

  • High-density lipoprotein particle concentration and subclinical atherosclerosis of the carotid arteries in Japanese men.

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    pub_type: 杂志文章


    authors: Zaid M,Fujiyoshi A,Miura K,Abbott RD,Okamura T,Takashima N,Torii S,Saito Y,Hisamatsu T,Miyagawa N,Ohkubo T,Kadota A,Sekikawa A,Maegawa H,Nakamura Y,Mitsunami K,Ueshima H,SESSA Research group.

    更新日期:2015-04-01 00:00:00

  • Detection of atherosclerotic cardiovascular disease influences the perceived need for aggressive lipid management.

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    pub_type: 杂志文章


    authors: Mancini GBJ,Gupta M,Tsigoulis M,Cannon CP,Genest J,Ray KK,Santos RD,Watts GF,Raggi P

    更新日期:2017-08-01 00:00:00

  • Inflammation modulates human HDL composition and function in vivo.

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    pub_type: 杂志文章


    authors: de la Llera Moya M,McGillicuddy FC,Hinkle CC,Byrne M,Joshi MR,Nguyen V,Tabita-Martinez J,Wolfe ML,Badellino K,Pruscino L,Mehta NN,Asztalos BF,Reilly MP

    更新日期:2012-06-01 00:00:00

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    pub_type: 杂志文章


    authors: Aluganti Narasimhulu C,Selvarajan K,Brown M,Parthasarathy S

    更新日期:2014-09-01 00:00:00