The association of adjusted Global AntiphosPholipid Syndrome Score (aGAPSS) with cardiovascular disease in subjects with antiphospholipid antibodies.


BACKGROUND AND AIMS:Cardiovascular disease (CVD), including coronary artery disease and stroke/peripheral artery disease, is less commonly reported than venous thromboembolism in subjects with antiphospholipid antibodies (aPLs) and little is known about the association of CVD with adjusted Global AntiphosPholipid Syndrome Score (aGAPSS). METHODS:Consecutive aPLs subjects were enrolled to assess the association of CVD with aGAPSS. Moreover, additional risk factors of CVD were identified by means of multivariate analysis to design an aGAPSS specific for CVD (aGAPSSCVD). RESULTS:A total of 192 aPLs subjects (34 males, 158 females, mean age 49.84 ± 12.0 years) were enrolled. CVD was reported in 52 subjects (27.1%), 26 episodes of coronary artery disease and 26 stroke/peripheral artery disease. The prevalence of CVD increased for increasing aGAPSS ranging from 20.5% in the lowest aGAPSS category, up to 37.9% in the highest category (p = 0.027). ROC analysis showed that aGAPSS detected 63.0% of CVD and was associated with OR for CVD of 2.52 (95%CI: 1.24-5.10, p = 0.010). When including obesity, diabetes and smoking habit in the score, we found that aGAPSSCVD detected 71.4% of CVD (72.4% for early-CVD and 69.0% for CVD after 50 years) with an OR for CVD of 4.68 (95%CI: 2.31-9.51, p < 0.001). CONCLUSIONS:The aGAPSSCVD, obtained after adding obesity, smoking habit and diabetes to the standard aGAPSS, showed a higher detection rate of CVD in aPLs subjects, particularly of early-CVD. These results need to be validated in ad hoc designed prospective studies.






Di Minno MND,Scalera A,Tufano A,Ambrosino P,Bettiol A,Silvestri E,Emmi G,Prisco D




Has Abstract


2018-11-01 00:00:00












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    authors: Kervinen K,Savolainen MJ,Salokannel J,Hynninen A,Heikkinen J,Ehnholm C,Koistinen MJ,Kesäniemi YA

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    authors: Vilne B,Skogsberg J,Foroughi Asl H,Talukdar HA,Kessler T,Björkegren JLM,Schunkert H

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    pub_type: 杂志文章


    authors: Görög P

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    更新日期:1999-06-01 00:00:00

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    authors: Srivastava RA

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    authors: Nawa T,Nawa MT,Adachi MT,Uchimura I,Shimokawa R,Fujisawa K,Tanaka A,Numano F,Kitajima S

    更新日期:2002-04-01 00:00:00

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    authors: Wartiovaara U,Perola M,Mikkola H,Tötterman K,Savolainen V,Penttilä A,Grant PJ,Tikkanen MJ,Vartiainen E,Karhunen PJ,Peltonen L,Palotie A

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    authors: Pawlak K,Domaniewski T,Mysliwiec M,Pawlak D

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    pub_type: 杂志文章


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    pub_type: 杂志文章


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