Abstract：
:Processing the meaning of action language correlates with somatotopic activity in premotor cortex (PMC). A previous neurostimulation study supported a causal contribution of PMC activity to action verb understanding, but the direction of the effect was unexpected: inhibiting PMC made participants respond faster to action verbs. Here we investigated the effects of PMC excitation and inhibition on action verb understanding using tDCS. Right-handed participants received tDCS stimulation with the anodal electrode (presumed to be excitatory) and cathodal electrode (presumed to be inhibitory) placed over left and right PMC, respectively, or with the reverse configuration. After completing the stimulation protocol, participants made lexical decisions on unimanual action verbs (e.g., throw) and abstract verbs (e.g., think). tDCS configuration selectively affected how accurately participants responded to unimanual action verbs. When the anode was positioned over left PMC we observed a relative impairment in performance for right-hand responses (i.e. the hand with which these participants typically perform unimanual actions). By contrast, when the cathode was positioned over left PMC we observed a relative improvement. tDCS configuration did not differentially affect responses to abstract verbs. These complementary effects of excitatory and inhibitory tDCS clarify the functional role of premotor hand areas in understanding action language.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Gijssels T,Ivry RB,Casasanto Ddoi
10.1038/s41598-018-29600-6subject
Has Abstractpub_date
2018-07-30 00:00:00pages
11452issue
1issn
2045-2322pii
10.1038/s41598-018-29600-6journal_volume
8pub_type
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