Abstract:
:We report the complete DNA sequence of the short repeat region in the genome of herpes simplex virus type 1, as 6633 base pairs of composition 79.5% G+C. This contains immediate early gene 3, encoding the IE175 protein, an important transcriptional activator of later virus genes. The IE175 coding region was identified as a 3894 base sequence of 81.5% G+C DNA. The base composition of this gene is thus the most extreme yet determined, and the IE175 predicted amino acid composition is correspondingly biased, most notably with an alanine content of 20.9%. Functionally important regions of the IE175 polypeptide were tentatively identified by comparison with the sequence of the homologous protein from varicella-zoster virus and from locations of ts mutations, and were correlated with properties of the amino acid sequence. Aspects of the evolution of such an extreme composition DNA sequence were discussed.
journal_name
Nucleic Acids Resjournal_title
Nucleic acids researchauthors
McGeoch DJ,Dolan A,Donald S,Brauer DHdoi
10.1093/nar/14.4.1727subject
Has Abstractpub_date
1986-02-25 00:00:00pages
1727-45issue
4eissn
0305-1048issn
1362-4962journal_volume
14pub_type
杂志文章abstract::We present the sequences of five additional human U2 pseudogenes which are very similar to the U2.13 pseudogene reported previously [Van Arsdell et al. (1981) Cell 26, 11-17]. All six U2 pseudogenes preserve the 5' end of the mature U2 snRNA sequence, and all six are flanked by nearly perfect direct repeats that diffe...
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journal_title:Nucleic acids research
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journal_title:Nucleic acids research
pub_type: 杂志文章
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journal_title:Nucleic acids research
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更新日期:2012-04-01 00:00:00
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journal_title:Nucleic acids research
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更新日期:2004-03-22 00:00:00
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journal_title:Nucleic acids research
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更新日期:1993-08-11 00:00:00
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更新日期:2017-07-03 00:00:00
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更新日期:2003-08-15 00:00:00
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更新日期:2012-05-01 00:00:00
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journal_title:Nucleic acids research
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更新日期:2013-06-01 00:00:00
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更新日期:2016-12-15 00:00:00
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journal_title:Nucleic acids research
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