当前位置： SCI文献检索 > NUCLEIC ACIDS RESEARCH期刊下所有文献 > Regulation of estrogen receptor alpha gene mediated by promoter B responsible for its enhanced expressionin human breast cancer.

Regulation of estrogen receptor alpha gene mediated by promoter B responsible for its enhanced expressionin human breast cancer.

Abstract：

:We have previously reported that transcription from a distal promoter (promoter B) of the estrogen receptor alpha (ERalpha) gene is responsible for the increased expression of ERalpha in human breast carcinomas. This paper first characterized the promoter B region in terms of transient transfection experiments with luciferase using MCF-7 cells. Gradual deletions from the 5'-end of promoter B resulted in a decrease in promoter activity corresponding to the deleted lengths; a deletion of 39 bp in a non-coding exon 1a, drastically diminished the activity, indicating existence of an important cis -element. Furthermore, electrophoretic mobility shift assay and subsequent mutational analysis indicated that this element containing nucleotide sequence CTGGAAAG forms a specific DNA-protein complex. This element was capable of transactivating a heterogeneous SV40 promoter in MCF-7 cells, confirming that the element is a transcriptional enhancer; the trans -acting factor binding to the element was named ERBF-1 (estrogen receptor promoter B associated factor-1). The ERBF-1 was exclusively expressed in those cells expressing ERalpha mRNA transcribed from promoter B. Our findings indicate that ERBF-1 plays an important role in the expression of the ERalpha gene transcribed from promoter B, which is selectively utilized in breast cancer.

journal_name

Nucleic Acids Res

journal_title

Nucleic acids research

authors

Tanimoto K,Eguchi H,Yoshida T,Hajiro-Nakanishi K,Hayashi S

doi

10.1093/nar/27.3.903

subject

Has Abstract

pub_date

1999-02-01 00:00:00

pages

903-9

issue

3

eissn

0305-1048

issn

1362-4962

pii

gkc168

journal_volume

27

pub_type

杂志文章

相关文献

NUCLEIC ACIDS RESEARCH文献大全
  • EBI metagenomics--a new resource for the analysis and archiving of metagenomic data.

    abstract：:Metagenomics is a relatively recently established but rapidly expanding field that uses high-throughput next-generation sequencing technologies to characterize the microbial communities inhabiting different ecosystems (including oceans, lakes, soil, tundra, plants and body sites). Metagenomics brings with it a number ...

    journal_title：Nucleic acids research

    pub_type： 杂志文章

    doi：10.1093/nar/gkt961

    authors： Hunter S,Corbett M,Denise H,Fraser M,Gonzalez-Beltran A,Hunter C,Jones P,Leinonen R,McAnulla C,Maguire E,Maslen J,Mitchell A,Nuka G,Oisel A,Pesseat S,Radhakrishnan R,Rocca-Serra P,Scheremetjew M,Sterk P,Vaughan D,

    更新日期：2014-01-01 00:00:00

  • An alternative protein factor which binds the internal promoter of Xenopus 5S ribosomal RNA genes.

    abstract：:In small oocytes of Xenopus species, two sets of 5S RNA genes, oocyte-type and somatic-type, are fully activated. The 5S RNA transcripts are temporarily stored, half in association with TFIIIA to form a 7S particle, the other half in association with tRNA and two proteins (p48 and p43) to form a 42S particle. It has b...

    journal_title：Nucleic acids research

    pub_type： 杂志文章

    doi：10.1093/nar/15.21.8679

    authors： Barrett P,Sommerville J

    更新日期：1987-11-11 00:00:00

  • SitEx: a computer system for analysis of projections of protein functional sites on eukaryotic genes.

    abstract：:Search of interrelationships between the structural-functional protein organization and exon structure of encoding gene provides insights into issues concerned with the function, origin and evolution of genes and proteins. The functions of proteins and their domains are defined mostly by functional sites. The relation...

    journal_title：Nucleic acids research

    pub_type： 杂志文章

    doi：10.1093/nar/gkr1187

    authors： Medvedeva I,Demenkov P,Kolchanov N,Ivanisenko V

    更新日期：2012-01-01 00:00:00

  • The CATH database: an extended protein family resource for structural and functional genomics.

    abstract：:The CATH database of protein domain structures (http://www.biochem.ucl.ac.uk/bsm/cath_new) currently contains 34 287 domain structures classified into 1383 superfamilies and 3285 sequence families. Each structural family is expanded with domain sequence relatives recruited from GenBank using a variety of efficient seq...

    journal_title：Nucleic acids research

    pub_type： 杂志文章

    doi：10.1093/nar/gkg062

    authors： Pearl FM,Bennett CF,Bray JE,Harrison AP,Martin N,Shepherd A,Sillitoe I,Thornton J,Orengo CA

    更新日期：2003-01-01 00:00:00

  • NGS-based identification and tracing of microsatellite instability from minute amounts DNA using inter-Alu-PCR.

    abstract：:Sensitive detection of microsatellite instability (MSI) in tissue or liquid biopsies using next generation sequencing (NGS) has growing prognostic and predictive applications in cancer. However, the complexities of NGS make it cumbersome as compared to established multiplex-PCR detection of MSI. We present a new appro...

    journal_title：Nucleic acids research

    pub_type： 杂志文章

    doi：10.1093/nar/gkaa1175

    authors： Yu F,Leong KW,Makrigiorgos A,Adalsteinsson VA,Ladas I,Ng K,Mamon H,Makrigiorgos GM

    更新日期：2020-12-08 00:00:00

  • Cell type-specific genomics of Drosophila neurons.

    abstract：:Many tools are available to analyse genomes but are often challenging to use in a cell type-specific context. We have developed a method similar to the isolation of nuclei tagged in a specific cell type (INTACT) technique [Deal,R.B. and Henikoff,S. (2010) A simple method for gene expression and chromatin profiling of ...

    journal_title：Nucleic acids research

    pub_type： 杂志文章

    doi：10.1093/nar/gks671

    authors： Henry GL,Davis FP,Picard S,Eddy SR

    更新日期：2012-10-01 00:00:00

  • Determination of base pairing in Escherichia coli and Bacillus stearothermophilus 5S RNAs by infrared spectroscopy.

    abstract：:The extent of base pairing in Escherichia coli and Bacillus stearothermophilus 5S RNAs was determined by infrared spectroscopy. From the infrared spectra taken at 20 degrees and 52 degrees C it is concluded that E. coli and B. stearothermophlius 5S RNAs possess a large number of base pairs (Table I). Comparison of our...

    journal_title：Nucleic acids research

    pub_type： 杂志文章

    doi：10.1093/nar/7.4.1043

    authors： Appel B,Erdmann VA,Stulz J,Ackerman T

    更新日期：1979-10-25 00:00:00

  • Identification of an snRNP-associated kinase activity that phosphorylates arginine/serine rich domains typical of splicing factors.

    abstract：:The U1 snRNP-specific 70K protein is one of the few snRNP proteins from higher eukaryotic cells that is phosphorylated in vivo (1,2). Immunoaffinity purified spliceosomal snRNPs (U1, U2, U5, and U4/U6) were tested for their ability to phosphorylate in vitro the U1-specific 70K protein. An snRNP-associated kinase activ...

    journal_title：Nucleic acids research

    pub_type： 杂志文章

    doi：10.1093/nar/21.12.2815

    authors： Woppmann A,Will CL,Kornstädt U,Zuo P,Manley JL,Lührmann R

    更新日期：1993-06-25 00:00:00

  • The sequence at the 3' terminus of mouse immunoglobulin secreted mu chain messenger RNA determined from cloned cDNA.

    abstract：:The 3' terminal nucleotide sequence of two clones containing DNA complementary to mu chain mRNA of IgM-secreting cells has been determined. The sequence shows a termination codon (UGA) adjacent to the terminal tyrosine codon for the secreted protein and a 3' non-coding region of at least 106 bases. The primary transla...

    journal_title：Nucleic acids research

    pub_type： 杂志文章

    doi：

    authors： Matthyssens G,Rabbitts TH

    更新日期：1980-02-25 00:00:00

  • Two-dimensional gel analysis of rolling circle replication in the presence and absence of bacteriophage T4 primase.

    abstract：:The rolling circle DNA replication structures generated by the in vitro phage T4 replication system were analyzed using two-dimensional agarose gels. Replication structures were generated in the presence or absence of T4 primase (gp61), permitting the analysis of replication forks with either duplex or single-stranded...

    journal_title：Nucleic acids research

    pub_type： 杂志文章

    doi：10.1093/nar/24.11.2166

    authors： Belanger KG,Mirzayan C,Kreuzer HE,Alberts BM,Kreuzer KN

    更新日期：1996-06-01 00:00:00

  • CNIT: a fast and accurate web tool for identifying protein-coding and long non-coding transcripts based on intrinsic sequence composition.

    abstract：:As more and more high-throughput data has been produced by next-generation sequencing, it is still a challenge to classify RNA transcripts into protein-coding or non-coding, especially for poorly annotated species. We upgraded our original coding potential calculator, CNCI (Coding-Non-Coding Index), to CNIT (Coding-No...

    journal_title：Nucleic acids research

    pub_type： 杂志文章

    doi：10.1093/nar/gkz400

    authors： Guo JC,Fang SS,Wu Y,Zhang JH,Chen Y,Liu J,Wu B,Wu JR,Li EM,Xu LY,Sun L,Zhao Y

    更新日期：2019-07-02 00:00:00

  • DNA polymerase I and a protein complex bind specifically to E. coli palindromic unit highly repetitive DNA: implications for bacterial chromosome organization.

    abstract：:Starting from a crude E. coli extract, two activities which specifically protect highly repetitive bacterial DNA sequences (called PU for Palindromic Unit or REP for Repetitive Extragenic Palindromic sequence) against a digestion with Exonuclease III have been purified. We show that one of these activities is due to t...

    journal_title：Nucleic acids research

    pub_type： 杂志文章

    doi：10.1093/nar/18.13.3941

    authors： Gilson E,Perrin D,Hofnung M

    更新日期：1990-07-11 00:00:00

  • Analytical approaches to RNA profiling data for the identification of genes enriched in specific cells.

    abstract：:We have recently developed a novel method for the affinity purification of the complete suite of translating mRNA from genetically labeled cell populations. This method permits comprehensive quantitative comparisons of the genes employed by each specific cell type. We provide a detailed description of tools for analys...

    journal_title：Nucleic acids research

    pub_type： 杂志文章

    doi：10.1093/nar/gkq130

    authors： Dougherty JD,Schmidt EF,Nakajima M,Heintz N

    更新日期：2010-07-01 00:00:00

  • The bacteriophage lambda O and P protein initiators promote the replication of single-stranded DNA.

    abstract：:A soluble enzyme system that specifically initiates lambda dv plasmid DNA replication at a bacteriophage lambda replication origin [Wold et al. (1982) Proc. Natl. Acad. Sci. USA 79, 6176-6180] is also capable of replicating the single-stranded circular chromosomes of phages M13 and phi X174 to a duplex form. This chai...

    journal_title：Nucleic acids research

    pub_type： 杂志文章

    doi：10.1093/nar/12.7.3069

    authors： LeBowitz JH,McMacken R

    更新日期：1984-04-11 00:00:00

  • The cell line A-to-I RNA editing catalogue.

    abstract：:Adenosine-to-inosine (A-to-I) RNA editing is a common post transcriptional modification. It has a critical role in protecting against false activation of innate immunity by endogenous double stranded RNAs and has been associated with various regulatory processes and diseases such as autoimmune and cardiovascular disea...

    journal_title：Nucleic acids research

    pub_type： 杂志文章

    doi：10.1093/nar/gkaa305

    authors： Schaffer AA,Kopel E,Hendel A,Picardi E,Levanon EY,Eisenberg E

    更新日期：2020-06-19 00:00:00

  • Characterization of multiple alternative RNAs resulting from antisense transcription of the PR264/SC35 splicing factor gene.

    abstract：:The PR264/SC35 splicing factor belongs to the family of SR proteins which function as essential and alternative splicing factors. Here, we report that the human PR264/SC35 locus is bidirectionally transcribed. Double in situ hybridization experiments have allowed simultaneous detection of sense and antisense RNA in hu...

    journal_title：Nucleic acids research

    pub_type： 杂志文章

    doi：10.1093/nar/25.22.4513

    authors： Sureau A,Soret J,Guyon C,Gaillard C,Dumon S,Keller M,Crisanti P,Perbal B

    更新日期：1997-11-15 00:00:00

  • Frequency and hydrogen bonding of nucleobase homopairs in small molecule crystals.

    abstract：:We used the high resolution and accuracy of the Cambridge Structural Database (CSD) to provide detailed information regarding base pairing interactions of selected nucleobases. We searched for base pairs in which nucleobases interact with each other through two or more hydrogen bonds and form more or less planar struc...

    journal_title：Nucleic acids research

    pub_type： 杂志文章

    doi：10.1093/nar/gkaa629

    authors： Cabaj MK,Dominiak PM

    更新日期：2020-09-04 00:00:00

  • MethBank 3.0: a database of DNA methylomes across a variety of species.

    abstract：:MethBank (http://bigd.big.ac.cn/methbank) is a database that integrates high-quality DNA methylomes across a variety of species and provides an interactive browser for visualization of methylation data. Here, we present an updated implementation of MethBank (version 3.0) by incorporating more DNA methylomes from multi...

    journal_title：Nucleic acids research

    pub_type： 杂志文章

    doi：10.1093/nar/gkx1139

    authors： Li R,Liang F,Li M,Zou D,Sun S,Zhao Y,Zhao W,Bao Y,Xiao J,Zhang Z

    更新日期：2018-01-04 00:00:00

  • The PRINTS protein fingerprint database in its fifth year.

    abstract：:PRINTS is a database of protein family 'fingerprints' offering a diagnostic resource for newly-determined sequences. By contrast with PROSITE, which uses single consensus expressions to characterise particular families, PRINTS exploits groups of motifs to build characteristic signatures. These signatures offer improve...

    journal_title：Nucleic acids research

    pub_type： 杂志文章

    doi：10.1093/nar/26.1.304

    authors： Attwood TK,Beck ME,Flower DR,Scordis P,Selley JN

    更新日期：1998-01-01 00:00:00

  • Importance in catalysis of a magnesium ion with very low affinity for a hammerhead ribozyme.

    abstract：:Available evidence suggests that Mg2+ ions are involved in reactions catalyzed by hammerhead ribozymes. However, the activity in the presence of exclusively monovalent ions led us to question whether divalent metal ions really function as catalysts when they are present. We investigated ribozyme activity in the presen...

    journal_title：Nucleic acids research

    pub_type： 杂志文章

    doi：10.1093/nar/gkh753

    authors： Inoue A,Takagi Y,Taira K

    更新日期：2004-08-09 00:00:00

  • The imprinted gene and parent-of-origin effect database.

    abstract：:The database of imprinted genes and parent-of-origin effects in animals (http://www.otago.ac.nz/IGC ) is a collation of genes and phenotypes for which parent-of-origin effects have been reported. The database currently includes over 220 entries, which describe over 40 imprinted genes in human, mouse and other animals....

    journal_title：Nucleic acids research

    pub_type： 杂志文章

    doi：10.1093/nar/29.1.275

    authors： Morison IM,Paton CJ,Cleverley SD

    更新日期：2001-01-01 00:00:00

  • BLAST2SRS, a web server for flexible retrieval of related protein sequences in the SWISS-PROT and SPTrEMBL databases.

    abstract：:SRS (Sequence Retrieval System) is a widely used keyword search engine for querying biological databases. BLAST2 is the most widely used tool to query databases by sequence similarity search. These tools allow users to retrieve sequences by shared keyword or by shared similarity, with many public web servers available...

    journal_title：Nucleic acids research

    pub_type： 杂志文章

    doi：10.1093/nar/gkg535

    authors： Bimpikis K,Budd A,Linding R,Gibson TJ

    更新日期：2003-07-01 00:00:00

  • Analysis of neonatal brain lacking ATRX or MeCP2 reveals changes in nucleosome density, CTCF binding and chromatin looping.

    abstract：:ATRX and MeCP2 belong to an expanding group of chromatin-associated proteins implicated in human neurodevelopmental disorders, although their gene-regulatory activities are not fully resolved. Loss of ATRX prevents full repression of an imprinted gene network in the postnatal brain and in this study we address the mec...

    journal_title：Nucleic acids research

    pub_type： 杂志文章

    doi：10.1093/nar/gku564

    authors： Kernohan KD,Vernimmen D,Gloor GB,Bérubé NG

    更新日期：2014-07-01 00:00:00

  • Participation of X47-fluorescamine modified E. coli tRNAs in in vitro protein biosynthesis.

    abstract：:The reaction of fluorescamine with primary amino groups of tRNAs was investigated. The reagent was attached under mild conditions to the 3'-end of tRNAPhe-C-C-A(3'NH) from yeast and to the minor nucleoside x in E. coli tRNAArg, tRNALys, tRNAMet, tRNAIle and tRNAPhe. The primary aliphatic amino groups of these tRNAs re...

    journal_title：Nucleic acids research

    pub_type： 杂志文章

    doi：10.1093/nar/5.12.4837

    authors： Sprinzl M,Faulhammer HG

    更新日期：1978-12-01 00:00:00

  • The nucleosome repeat length increases during erythropoiesis in the chick.

    abstract：:During erythropoiesis in the chick, the nucleosome repeat length increases from 190 base pairs to 212 base pairs. This increase is correlated with a dramatic increase in the concentration of the red cell specific histone H5 (from 0.2 molecules per nucleosome to 1 molecule per nucleosome) and with no change in the conc...

    journal_title：Nucleic acids research

    pub_type： 杂志文章

    doi：10.1093/nar/5.4.1179

    authors： Weintraub H

    更新日期：1978-04-01 00:00:00

  • Evolutionarily conserved proteins MnmE and GidA catalyze the formation of two methyluridine derivatives at tRNA wobble positions.

    abstract：:The wobble uridine of certain bacterial and mitochondrial tRNAs is modified, at position 5, through an unknown reaction pathway that utilizes the evolutionarily conserved MnmE and GidA proteins. The resulting modification (a methyluridine derivative) plays a critical role in decoding NNG/A codons and reading frame mai...

    journal_title：Nucleic acids research

    pub_type： 杂志文章

    doi：10.1093/nar/gkp762

    authors： Moukadiri I,Prado S,Piera J,Velázquez-Campoy A,Björk GR,Armengod ME

    更新日期：2009-11-01 00:00:00

  • PreCisIon: PREdiction of CIS-regulatory elements improved by gene's positION.

    abstract：:Conventional approaches to predict transcriptional regulatory interactions usually rely on the definition of a shared motif sequence on the target genes of a transcription factor (TF). These efforts have been frustrated by the limited availability and accuracy of TF binding site motifs, usually represented as position...

    journal_title：Nucleic acids research

    pub_type： 杂志文章

    doi：10.1093/nar/gks1286

    authors： Elati M,Nicolle R,Junier I,Fernández D,Fekih R,Font J,Képès F

    更新日期：2013-02-01 00:00:00

  • A novel C-T transition within the distal CCAAT motif of the G gamma-globin gene in the Japanese HPFH: implication of factor binding in elevated fetal globin expression.

    abstract：:Hereditary persistence of fetal hemoglobin (HPFH) is a condition characterized by the continued expression of the fetal globin gene in adulthood. Both deletional and nondeletional forms have been described. We studied one Japanese family with two different nondeletional forms of HPFH. Analysis of polymorphic restricti...

    journal_title：Nucleic acids research

    pub_type： 杂志文章

    doi：10.1093/nar/18.17.5245

    authors： Fucharoen S,Shimizu K,Fukumaki Y

    更新日期：1990-09-11 00:00:00

  • Argonaute binding within 3'-untranslated regions poorly predicts gene repression.

    abstract：:Despite two decades of study, the full scope of RNAi in mammalian cells has remained obscure. Here we combine: (i) Knockout of argonaute (AGO) variants; (ii) RNA sequencing analysis of gene expression changes and (iii) Enhanced Crosslinking Immunoprecipitation Sequencing (eCLIP-seq) using anti-AGO2 antibody to identif...

    journal_title：Nucleic acids research

    pub_type： 杂志文章

    doi：10.1093/nar/gkaa478

    authors： Chu Y,Kilikevicius A,Liu J,Johnson KC,Yokota S,Corey DR

    更新日期：2020-07-27 00:00:00

  • Each element of the Drosophila tRNAArg gene split promoter directs transcription in Xenopus oocytes.

    abstract：:The intragenic control regions of a eukaryotic tRNA gene have been examined by transcribing mutant forms of a Drosophila tRNAArg gene either by injection into the nucleus of Xenopus oocytes or in extracts prepared from isolated oocyte nuclei. These experiments demonstrate that the selection of the transcription initia...

    journal_title：Nucleic acids research

    pub_type： 杂志文章

    doi：10.1093/nar/11.24.8677

    authors： Sharp S,Dingermann T,Schaack J,Sharp JA,Burke DJ,DeRobertis EM,Söll D

    更新日期：1983-12-20 00:00:00