Abstract:
:We investigated how the organization of functional brain networks was related to cognitive reserve (CR) during a memory task in healthy aging. We obtained the magnetoencephalographic functional networks of 20 elders with a high or low CR level to analyse the differences at network features. We reported a negative correlation between synchronization of the whole network and CR, and observed differences both at the node and at the network level in: the average shortest path and the network outreach. Individuals with high CR required functional networks with lower links to successfully carry out the memory task. These results may indicate that those individuals with low CR level exhibited a dual pattern of compensation and network impairment, since their functioning was more energetically costly to perform the task as the high CR group. Additionally, we evaluated how the dynamical properties of the different brain regions were correlated to the network parameters obtaining that entropy was positively correlated with the strength and clustering coefficient, while complexity behaved conversely. Consequently, highly connected nodes of the functional networks showed a more stochastic and less complex signal. We consider that network approach may be a relevant tool to better understand brain functioning in aging.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Martínez JH,López ME,Ariza P,Chavez M,Pineda-Pardo JA,López-Sanz D,Gil P,Maestú F,Buldú JMdoi
10.1038/s41598-018-28747-6subject
Has Abstractpub_date
2018-07-12 00:00:00pages
10525issue
1issn
2045-2322pii
10.1038/s41598-018-28747-6journal_volume
8pub_type
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