Abstract：
AIM:To evaluate the role of intravitreal ranubizumab (IVR) in the treatment of familial exudative vitreoretinopathy (FEVR) of stage 2 or greater either as primary or an ajunct to conventional treatments. METHODS:Retrospective, non-controlled clinical study. Thirty patients (37 eyes) diagnosed with FEVR were enrolled. Twenty patients (66.67%) were male and 10 patients (33.33%) were female. Age ranged from 0.4 to 35 years old (median 3y). IVR was used either as primary or as a combined therapy according to the retinal neovasuclar activities. The follow up ranged from 1 to 57mo with mean 16.73±15.73 (median 11)mo. The treatment effect of retinal neovasuclar activites were recorded as well as the ocular and systemic side effects. RESULTS:Among 30 patients (37 eyes), 10 eyes received single IVR, 1 eye received 2 injections. Three eyes were treated with IVR and simutanous laser photocoagulation. Laser indirect ophthalmoscopy (LIO) was applied in 5 eyes 1mo after the primary IVR. Seven eyes were treated surgically following the primary IVR due to persistent retinal neovasuclar activities and retinal traction. IVR was used as combined treatment with vitrectomy in 11 eyes. Retinal neovascular regression was notified 1mo following the primary IVR in all eyes. Neither systemic nor ocular complications were recorded. CONCLUSION:IVR may be an effective modality in the treatment of FEVR either as primary or as an ajunct to the conventional therapies. The long term effect and safty of IVR still need further research.
journal_name
Int J Ophthalmoljournal_title
International journal of ophthalmologyauthors
Lu YZ,Deng GD,Liu JH,Yan Hdoi
10.18240/ijo.2018.06.13subject
Has Abstractpub_date
2018-06-18 00:00:00pages
976-980issue
6eissn
2222-3959issn
2227-4898pii
ijo-11-06-976journal_volume
11pub_type
杂志文章abstract：AIM:To evaluate the clinical effect and complications of two different filling materials (aerocyst urethral catheter and expansion sponges) applying in external dacryocystorhinostomy (EXT-DCR) and compare their advantages and disadvantages. METHODS:A retrospective study was made in the period from April, 1 2000 to Apr...
journal_title：International journal of ophthalmology
pub_type： 杂志文章
doi：10.3980/j.issn.2222-3959.2011.05.08
更新日期：2011-01-01 00:00:00
abstract：:Experts lack knowledge of periocular tuberculosis (TB) in China. Nested polymerase chain reaction (PCR) shows advantages in diagnosis of extrapulmonary TB. Our study aims to explore the clinical and laboratory features of PCR-confirmed periocular TB. We retrospectively reviewed medical records of presumptive periocula...
journal_title：International journal of ophthalmology
pub_type： 杂志文章
doi：10.18240/ijo.2018.11.20
更新日期：2018-11-18 00:00:00
abstract：:Most of the ocular tumors have poor prognosis, and they remain a difficult problem in the area of ophthalmology. With the rapid development of molecular biology and immunologic techniques and the deep research on ocular tumor related genes, it becomes possible to diagnose and treat malignant tumors from the molecular ...
journal_title：International journal of ophthalmology
pub_type： 杂志文章
doi：10.3980/j.issn.2222-3959.2011.05.18
更新日期：2011-01-01 00:00:00
abstract：AIM:To quantify the changes in the lens profile with accommodation in different age groups. METHODS:The Pentacam HR system was used to obtain the images of the anterior eye segment from 23 young and 15 presbyopic emmetropic subjects in unaccommodated (with an accommodation stimulus of 0.0D) and accommodated (with an a...
journal_title：International journal of ophthalmology
pub_type： 杂志文章
doi：10.3980/j.issn.2222-3959.2011.06.07
更新日期：2011-01-01 00:00:00
abstract：AIM:To conduct a comparative study of effectiveness of silicone hydrogel contact lens and hydrogel contact lens, which are used in patients after laser-assisted subepithelial keratomileusis (LASEK). METHODS:Sixty-three patients (121 eyes) with a spherical equivalent ≤-5.0 D were chosen after undergoing LASEK in 2012 a...
journal_title：International journal of ophthalmology
pub_type： 杂志文章
doi：10.3980/j.issn.2222-3959.2015.06.09
更新日期：2015-12-18 00:00:00
abstract：AIM:To investigate the healing process after severe corneal epithelial damage in rats treated with mesenchymal stem cells (MSCs) cultured with or without keratinocyte growth factor (KGF-2) and autologous serum (AS) on amniotic membrane (AM). Many patients are blind and devastated by severe ocular surface diseases due t...
journal_title：International journal of ophthalmology
pub_type： 杂志文章
doi：10.3980/j.issn.2222-3959.2014.02.05
更新日期：2014-04-18 00:00:00
abstract：AIM:To study the imaging characteristics of lacrimal punctum lesion with optical coherence tomography (OCT), and provide imaging basis for the diagnosis and treatment of lacrimal punctum diseases. METHODS:A total of 25 patients (28 eyes) with epiphora and lacrimal puncta lesions were enrolled. Lacrimal puncta lesions ...
journal_title：International journal of ophthalmology
pub_type： 杂志文章
doi：10.18240/ijo.2020.06.07
更新日期：2020-06-18 00:00:00
abstract：:We evaluated thirteen eyes of twelve patients diagnosed clinically and serologically with Toxocara optic neuropathy. Eleven patients had unilateral involvement and one patient had bilateral optic neuropathy. Eight patients (66.7%) had a possible infection source to Toxocara. Six patients (50%) had painless acute optic...
journal_title：International journal of ophthalmology
pub_type： 杂志文章
doi：10.18240/ijo.2018.03.26
更新日期：2018-03-18 00:00:00
abstract：:Myopia is a significant public health problem and its prevalence is increasing over time and genetic factors in disease development are important. The prevalence and incidence of myopia within sampled population often varies with age, country, sex, race, ethnicity, occupation, environment, and other factors. Myopia gr...
journal_title：International journal of ophthalmology
pub_type： 杂志文章
doi：10.3980/j.issn.2222-3959.2011.06.17
更新日期：2011-01-01 00:00:00
abstract：:We report a case of syndromic gingival fibromatosis with notable ocular lesions, bilateral congenital cataracts, esotropia, and high myopia of a 21-year-old male patient from China. The patient was diagnosed with gingival fibromatosis based on his massive gingival overgrowth and histological findings that were consist...
journal_title：International journal of ophthalmology
pub_type： 杂志文章
doi：10.3980/j.issn.2222-3959.2014.03.32
更新日期：2014-06-18 00:00:00
abstract：AIM:To investigate the impact of non-Descemet stripping endothelial keratoplasty (non-DSEK) on graft rejection rate, and its overall procedural effectiveness in patients. METHODS:Non-DSEK was performed on 65 eyes of 64 patients, and the procedural outcomes, including rejection episodes, failure and dislocation of the ...
journal_title：International journal of ophthalmology
pub_type： 杂志文章
doi：10.18240/ijo.2017.02.07
更新日期：2017-02-18 00:00:00
abstract：AIM:To investigate the ultrastructural pathogenesis of photodynamic therapy (PDT) for the experimental corneal neovascularization (CNV) by Hematoporphyrin Derivate (HPD) as photosensitizer and Argon laser as light source. METHODS:Experimental CNV models were induced in 7 white rabbits using alkali burn. Six weeks afte...
journal_title：International journal of ophthalmology
pub_type： 杂志文章
doi：10.3980/j.issn.2222-3959.2010.04.07
更新日期：2010-01-01 00:00:00
abstract：AIM:To evaluate the real-life clinical outcomes of intravitreal injection of conbercept combined rescue therapy for polypoidal choroidal vasculopathy (PCV). METHODS:This was an open label, single center, and interventional study. All enrolled patients were treated initially with three consecutive monthly intravitreal ...
journal_title：International journal of ophthalmology
pub_type： 杂志文章
doi：10.18240/ijo.2019.01.08
更新日期：2019-01-18 00:00:00
abstract：AIM:To compare conventional slow equilibrium cooling and directional freezing (DF) by gauze package for cryopreservation of human umbilical vein endothelial cells (HUVECs). METHODS:HUVECs were randomly assigned to conventional freezing (CF) and DF by gauze package group. The two groups of HUVECs were incubated with a ...
journal_title：International journal of ophthalmology
pub_type： 杂志文章
doi：10.3980/j.issn.2222-3959.2014.05.05
更新日期：2014-10-18 00:00:00
abstract：AIM:To evaluate the measurements of anterior segment parameters using three different non-contact optical devices in keratoconus patients. METHODS:A hundred and one eyes of 55 keratoconus patients were enrolled in this study. The mean age was 26.2±8.9 years. The inclusion criteria were keratoconus stage I to III accor...
journal_title：International journal of ophthalmology
pub_type： 杂志文章
doi：10.3980/j.issn.2222-3959.2013.04.21
更新日期：2013-08-18 00:00:00
abstract：AIM:To evaluate clinical outcomes of unilateral implantation of a diffractive multifocal intraocular lens (IOL) in patients with contralateral monofocal IOL. METHODS:Twenty-two patients who already had implantation of a monofocal IOL in unilateral eye underwent implantation of a diffractive multifocal IOL in contralat...
journal_title：International journal of ophthalmology
pub_type： 杂志文章
doi：10.18240/ijo.2020.05.07
更新日期：2020-05-18 00:00:00
abstract：AIM:To assess the refractive status, anterior chamber depth (ACD) and axial length (AL) of patients with primary angle-closure disease (PACD). METHODS:Retrospective cohort. Data was collected from charts of all PACD patients treated from April 2013 to December 2015. Analysis was done on 137 patient charts with complet...
journal_title：International journal of ophthalmology
pub_type： 杂志文章
doi：10.18240/ijo.2017.08.10
更新日期：2017-08-18 00:00:00
abstract：AIM:To determine whether intravitreal dexamethasone (DEX) implant induces posterior vitreous detachment or not. METHODS:We retrospectively reviewed 810 eyes of 405 patients who underwent intravitreal DEX implantation due to macular edema caused by diabetic and retinal venous occlusion in our clinic. The eyes having no...
journal_title：International journal of ophthalmology
pub_type： 杂志文章
doi：10.18240/ijo.2019.08.10
更新日期：2019-08-18 00:00:00
abstract：AIM:To explore the correlation between several blood cell-associated inflammatory indices including mean platelet volume (MPV), platelet distribution width (PDW), neutrophil to lymphocyte ratio (NLR) and platelet-lymphocyte ratio (PLR), and the presence and severity of diabetic retinopathy (DR). METHODS:We searched fo...
journal_title：International journal of ophthalmology
pub_type： 杂志文章
doi：10.18240/ijo.2019.02.20
更新日期：2019-02-18 00:00:00
abstract：AIM:To analyze the lab diagnosis and etiology of infectious endophthalmitis. METHODS:The medical and microbial records of 36 patients diagnosed with infectious endophthalmitis and 8 patients diagnosed with intraocular lens (IOL)-related inflammation between Nov. 1999 and Dec. 2009 were retrospectively reviewed for lab...
journal_title：International journal of ophthalmology
pub_type： 杂志文章
doi：10.3980/j.issn.2222-3959.2011.01.23
更新日期：2011-01-01 00:00:00
abstract：AIM:To investigate the cross-talk between oxidative stress and the epidermal growth factor receptor (EGFR)/AKT signaling pathway in retinal pigment epithelial (RPE) cells. METHODS:Human RPE cell lines (ARPE-19 cell) were treated with different doses of epidermal growth factor (EGF) and hydrogen peroxide (H2O2). Cell v...
journal_title：International journal of ophthalmology
pub_type： 杂志文章
doi：10.18240/ijo.2017.04.02
更新日期：2017-04-18 00:00:00
abstract：AIM:To identify the genetic defects in a Chinese family with achromatopsia. METHODS:A 2.5-year-old boy, who displayed nystagmus, photophobia, and hyperopia since early infancy, was clinically evaluated. To further confirm and localize the causative mutations in this family, targeted region capture and next-generation ...
journal_title：International journal of ophthalmology
pub_type： 杂志文章
doi：10.3980/j.issn.2222-3959.2015.05.10
更新日期：2015-10-18 00:00:00
abstract：AIM:To compare the changes in corneal biomechanics measured by ocular response analyzer (ORA) after 2.2-mm microincision cataract surgery and 3.0-mm standard coaxial phacoemulsification. METHODS:The prospective nonrandomized study comprised eyes with cataract that had 2.2-mm coaxial microincision or 3.0-mm standard in...
journal_title：International journal of ophthalmology
pub_type： 杂志文章
doi：10.18240/ijo.2016.02.08
更新日期：2016-02-18 00:00:00
abstract：AIM:To investigate mitochondrial factors associated with Leber hereditary optic neuropathy (LHON) through complete sequencing and analysis of the mitochondrial genome of Chinese patients with this disease. METHODS:Two unrelated southern Chinese families with LHON and 10 matched healthy controls were recruited, and the...
journal_title：International journal of ophthalmology
pub_type： 杂志文章
doi：10.3980/j.issn.2222-3959.2012.01.06
更新日期：2012-01-01 00:00:00
abstract：:To revise the peer-reviewed literature on geometric properties of the scleral-conjunctival structure in order to define their clinical relevance and the potential relationship between their changes and myopia development or progression. A bibliographic search focused on the study of the geometry of conjunctiva and/or ...
journal_title：International journal of ophthalmology
pub_type： 杂志文章,评审
doi：10.18240/ijo.2020.09.22
更新日期：2020-09-18 00:00:00
abstract：AIM:To evaluate chorioretinal responses to intravitreal aflibercept injection (IAI) in patients with acute central serous chorioretinopathy (CSC). METHODS:Seventy-one eyes from 71 patients with symptomatic CSC for less than six months were included. Thirty-five eyes received a single IAI and 36 eyes were observed with...
journal_title：International journal of ophthalmology
pub_type： 杂志文章
doi：10.18240/ijo.2019.12.08
更新日期：2019-12-18 00:00:00
abstract：AIM:To explore the role of IgG4 serology in identifying common orbital lymphoproliferative disorders. METHODS:Eighty-one patients with orbital lymphoproliferative diseases were treated in the Department of Ocular Oncology, Beijing Tongren Hospital, Capital Medical University between September 2010 and December 2012. S...
journal_title：International journal of ophthalmology
pub_type： 杂志文章
doi：10.18240/ijo.2016.02.18
更新日期：2016-02-18 00:00:00
abstract：AIM:To investigate the role of heparanase-1 in laser-induced choroidal neovascularization (CNV). METHODS:Experimental CNV was induced by krypton laser photocoagulation in 15 male Brown Norway rats. Fundus fluorescein angiography and histopathological examination were performed in observing the CNV development. The exp...
journal_title：International journal of ophthalmology
pub_type： 杂志文章
doi：10.3980/j.issn.2222-3959.2013.02.04
更新日期：2013-04-18 00:00:00
abstract：AIM:To explore the roles of phospholipids and sphingolipids in the inflammatory process of uveitis. METHODS:Aqueous humor (AH) and the retina were obtained from endotoxin-induced uveitis (EIU) rats during the acute inflammation stage (24h after endotoxin injection). Lipids were extracted using a modified Bligh and Dye...
journal_title：International journal of ophthalmology
pub_type： 杂志文章
doi：10.18240/ijo.2018.05.05
更新日期：2018-05-18 00:00:00
abstract：AIM:To investigate the relationship between C-reactive protein (CRP) and diabetic retinopathy (DR) in a cohort of Chinese patients with type 2 diabetes mellitus (T2DM). METHODS:Community-based observational cohort study. There were 1131 participants recruited from November 2009 to September 2011 in Desheng community i...
journal_title：International journal of ophthalmology
pub_type： 杂志文章
doi：10.18240/ijo.2016.01.19
更新日期：2016-01-18 00:00:00
