Abstract：
AIM:To explore the roles of phospholipids and sphingolipids in the inflammatory process of uveitis. METHODS:Aqueous humor (AH) and the retina were obtained from endotoxin-induced uveitis (EIU) rats during the acute inflammation stage (24h after endotoxin injection). Lipids were extracted using a modified Bligh and Dyer method and subjected to mass spectrometric identification using class-specific lipid standards and ratiometric quantification. Relative intensity analysis was performed to evaluate the amount change of common lipids between the EIU and control groups. RESULTS:Unique lipid species encompassing all five phospholipid classes were found in both control and the EIU AH and retina. Commensurate with the significantly increased level of lysophospholipids in the EIU AH and retina, we found that the ratio of lysophospholipids to total phospholipids was significantly increased too. We also detected a significant increase in 18:0 lysophosphatidylcholine levels in the EIU group (fold change =6.4 in AH and 3.8 in retina). Cer240, Cer241, and SM240 levels remarkably increased in the EIU AH. Enhanced C12 ceramide-1-phosphate (C12 C-1-P), C16 C-1-P, C24 C-1-P, and upregulated Cer160, Cer240, SM120, and SM240 were found in EIU retina. C-1-P was believed to restore homeostasis by inhibiting nuclear factor kappa B (NF-κB) activation. However, we still found elevated NF-κB levels in the EIU retina. CONCLUSION:A variety of lipids might have played a critical role in EIU inflammation. Exogenous topical application of these protective lipids or inhibition of these pro-inflammatory lipids may be useful therapeutic strategies for the resolution of EIU.
journal_name
Int J Ophthalmoljournal_title
International journal of ophthalmologyauthors
Wang HY,Wang Y,Zhang Y,Wang J,Xiong SY,Sun Qdoi
10.18240/ijo.2018.05.05subject
Has Abstractpub_date
2018-05-18 00:00:00pages
736-746issue
5eissn
2222-3959issn
2227-4898pii
ijo-11-05-736journal_volume
11pub_type
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journal_title：International journal of ophthalmology
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journal_title：International journal of ophthalmology
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journal_title：International journal of ophthalmology
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journal_title：International journal of ophthalmology
pub_type： 杂志文章
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journal_title：International journal of ophthalmology
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doi：10.18240/ijo.2019.03.01
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journal_title：International journal of ophthalmology
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journal_title：International journal of ophthalmology
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