Simultaneous expression of two pathogenic genes in four Chinese patients affected with inherited retinal dystrophy.

abstract：:Diabetic retinopathy (DR) is one of the most common and challenging ocular complications of diabetes mellitus. As a chronic, progressive ocular disease that poses a serious threat to vision, DR has gradually become a leading cause of blindness worldwide. Emerging evidence points to an important role of endoplasmic ret...

journal_title：International journal of ophthalmology

authors： Kong DQ,Li L,Liu Y,Zheng GY

更新日期：2018-10-18 00:00:00

abstract：AIM:To evaluate the fractal feature of the retinal vasculature of normal eyes on a stereographic projected and montaged ultra-wide field (UWF) fluorescein angiography (FA). METHODS:Prospective, observational, cross-sectional study. Totally 59 eyes of 31 normal subjects were imaged using the Optos 200Tx. Images obtaine...

journal_title：International journal of ophthalmology

authors： Fan WY,Fleming A,Robertson G,Uji A,van Hemert J,Singer M,Sagong M,Ip M,Sadda SR

更新日期：2020-07-18 00:00:00

abstract：AIM:To determine whether intravitreal dexamethasone (DEX) implant induces posterior vitreous detachment or not. METHODS:We retrospectively reviewed 810 eyes of 405 patients who underwent intravitreal DEX implantation due to macular edema caused by diabetic and retinal venous occlusion in our clinic. The eyes having no...

journal_title：International journal of ophthalmology

authors： Alpay A

更新日期：2019-08-18 00:00:00

abstract：:Retinal diseases, including age-related macular degeneration (AMD) and diabetic retinopathy (DR) are the leading causes of blindness in adults over the age of 50 years in the US. While most of those conditions do not have a cure, currently available treatment options attempt to prevent further vision loss. For many op...

journal_title：International journal of ophthalmology

authors： Jiang S,Franco YL,Zhou Y,Chen J

更新日期：2018-06-18 00:00:00

abstract：AIM:To conduct a systematic review and quantitative Meta-analysis of the efficacy and safety of combined surgery for the eyes with coexisting cataract and open angle glaucoma. METHODS:We performed a systematic search of the related literature in the Cochrane Library, PubMed, EMBASE, Web of Science databases, CNKI, CBM...

journal_title：International journal of ophthalmology

authors： Jiang N,Zhao GQ,Lin J,Hu LT,Che CY,Wang Q,Xu Q,Li C,Zhang J

更新日期：2018-02-18 00:00:00

abstract：AIM:To provide statistical evidence for the use of antibiotics in ophthalmology by assessing the distribution and antibiotic sensitivity of bacterial isolates from ocular specimens with suspected microbial infections. METHODS:This study applied a retrospective analysis of 3690 bacterial isolates from ocular specimens,...

journal_title：International journal of ophthalmology

authors： Gao W,Xia T,Chen HB,Pan XJ,Huang YS,Wang X,Dong YL,Xie LX

更新日期：2020-01-18 00:00:00

abstract：AIM:To evaluate the clinical and optical outcomes after clear corneal incision cataract surgery (CICS) with three different incision sizes (1.8, 2.0 and 3.0 mm). METHODS:Eyes of 150 patients with age-related cataract scheduled for coaxial cataract surgery were randomized to three groups: 1.8, 2.0, or 3.0 mm CICS. Intr...

journal_title：International journal of ophthalmology

authors： Yu YB,Zhu YN,Wang W,Zhang YD,Yu YH,Yao K

更新日期：2016-03-18 00:00:00

abstract：AIM:To construct adenovirus vectors of lumican gene by gateway recombinant cloning technology to further understand the role of lumican gene in myopia. METHODS:Gateway recombinant cloning technology was used to construct adenovirus vectors. The wild-type (wt) and mutant (mut) forms of the lumican gene were synthesized...

journal_title：International journal of ophthalmology

authors： Wang GF,Qi B,Tu LL,Liu L,Yu GC,Zhong JX

更新日期：2016-09-18 00:00:00

abstract：:Experts lack knowledge of periocular tuberculosis (TB) in China. Nested polymerase chain reaction (PCR) shows advantages in diagnosis of extrapulmonary TB. Our study aims to explore the clinical and laboratory features of PCR-confirmed periocular TB. We retrospectively reviewed medical records of presumptive periocula...

journal_title：International journal of ophthalmology

authors： Ma RQ,Gan L,Bi YW,Yuan YF,Ren H,Qian J

更新日期：2018-11-18 00:00:00

abstract：AIM:To explore the roles of phospholipids and sphingolipids in the inflammatory process of uveitis. METHODS:Aqueous humor (AH) and the retina were obtained from endotoxin-induced uveitis (EIU) rats during the acute inflammation stage (24h after endotoxin injection). Lipids were extracted using a modified Bligh and Dye...

journal_title：International journal of ophthalmology

authors： Wang HY,Wang Y,Zhang Y,Wang J,Xiong SY,Sun Q

更新日期：2018-05-18 00:00:00

abstract：AIM:To construct functional human full-thickness corneal replacements. METHODS:Acellular porcine corneal matrix (APCM) was developed from porcine cornea by decellulariztion. The biomechanical properties of anterior-APCM (AAPCM) and posterior-APCM (PAPCM) were checked using uniaxial tensile testing. Human corneal cells...

journal_title：International journal of ophthalmology

authors： Zhang K,Ren XX,Li P,Pang KP,Wang H

更新日期：2019-03-18 00:00:00

abstract：AIM:To compare the efficacy and safety between laser therapy and anti-vascular endothelial growth factor (VEGF) agents intravitreal injection monotherapy in type-1 retinopathy of prematurity (ROP) and aggressive posterior retinopathy of prematurity (APROP). METHODS:A systematic literature search was performed in PubMe...

journal_title：International journal of ophthalmology

authors： Wang SD,Zhang GM,Shenzhen Screening for Retinopathy of Prematurity Cooperative Group.

更新日期：2020-05-18 00:00:00

abstract：AIM:To quantitatively evaluate the effect of the combined use of 577-nm subthreshold micropulse macular laser (SML) and multi-point mode pan retinal laser photocoagulation (PRP) on severe non-proliferative diabetic retinopathy (NPDR) with central-involved diabetic macular edema (CIDME) using optical coherence tomograph...

journal_title：International journal of ophthalmology

authors： Li ZJ,Xiao JH,Zeng P,Zeng R,Gao X,Zhang YC,Lan YQ

更新日期：2020-08-18 00:00:00

abstract：AIM:To determine the dominant predictive factors of postoperative visual recovery for patients with pituitary adenoma. METHODS:PubMed, Google Scholar, Web of Science and Cochrane Library were searched for relevant human studies, which investigated the prediction of the postoperative visual recovery of patients with pi...

journal_title：International journal of ophthalmology

authors： Sun M,Zhang ZQ,Ma CY,Chen SH,Chen XJ

更新日期：2017-11-18 00:00:00

abstract：AIM:To investigate the epidemiology and surgical outcomes of old canalicular laceration and analyze the variables impacting on the prognosis of reparation. METHODS:A retrospective review of all old canalicular laceration repairs from Jan. 1, 2008 to Dec. 30, 2015 was performed. Analyzed data included demographics, mec...

journal_title：International journal of ophthalmology

authors： Bai F,Tao H,Zhang Y,Wang P,Han C,Huang YF,Tao Y

更新日期：2017-06-18 00:00:00

abstract：AIM:To determine whether the PI3K/AKT/mTOR pathway is activated in proliferative vitreoretinopathy (PVR) in homo-sapiens. METHODS:The retina of controls and patients with PVR were collected and their levels of PI3K, phospho-AKT, phospho-mTOR, phospho-p70S6k and phospho-4EBP-1 were determined by Western blot. The cultu...

journal_title：International journal of ophthalmology

authors： Cai N,Dai SD,Liu NN,Liu LM,Zhao N,Chen L

更新日期：2012-01-01 00:00:00

abstract：AIM:To demonstrate local dry vitrectomy combined with segmental scleral buckling and viscoelastic tamponade for the treatment of partial rhegmatogenous retinal detachment (RRD) with local vitreous traction in patients at high-risk for proliferative vitreoretinopathy (PVR). METHODS:Eleven eyes of 11 patients were retro...

journal_title：International journal of ophthalmology

authors： Fei P,Jin HY,Zhang Q,Peng J,Li JK,Lyu J,Tian T,Lu ZP,Li J,Zhao PQ

更新日期：2020-11-18 00:00:00

abstract：AIM:To determine the epidemiological characteristics, clinical signs, laboratory findings, and outcomes in patients with corneal infection in Shandong peninsula of China. METHODS:The medical records of 578 inpatients (578 eyes) with corneal infection were reviewed retrospectively for demographic characteristics, risk ...

journal_title：International journal of ophthalmology

authors： Pan XJ,Jiang T,Zhu H,Liu PP,Zhou ZY,Mao AJ

更新日期：2016-01-18 00:00:00

abstract：AIM:To compare the safety and efficacy of phacoemulsification and small incision cataract surgery (SICS) in patients with uveitic cataract. METHODS:In a prospective, randomized multi-centric study, consecutive patients with uveitic cataract were randomized to receive phacoemulsification or manual SICS by either of two...

journal_title：International journal of ophthalmology

authors： Bhargava R,Kumar P,Sharma SK,Kumar M,Kaur A

更新日期：2015-10-18 00:00:00

abstract：AIM:To evaluate the efficacy of modified corneal ulcer debridement in superficial fungal keratitis unresponsive to medications. METHODS:A total of 209 patients (209 eyes) with fungal keratitis, involving no more than 50% of the stromal depth and not responding to antifungal agents for 2wk, were recruited in this retro...

journal_title：International journal of ophthalmology

authors： Wang JY,Wang DQ,Qi XL,Cheng J,Xie LX

更新日期：2018-02-18 00:00:00

abstract：AIM:To examine the association between the single nucleotide polymorphisms (SNPs) of matrix metalloprotease-9 (MMP-9) gene and primary angle-closure glaucoma (PACG) in a Chinese Han population. METHODS:DNA samples were extracted from peripheral-blood mononuclear cells of 214 PACG patients and 224 healthy controls. Gen...

journal_title：International journal of ophthalmology

authors： Gao XJ,Hou SP,Li PH

更新日期：2014-06-18 00:00:00

abstract：AIM:To determine the location of c-jun protein, dynamic changes in c-jun mRNA and protein expression, and ultrastructure characteristics in the rd mouse retina, following a single dose of brain-derived neurotrophic factor (BDNF) in a short period of time. METHODS:A single intravitreal injection of BDNF at two dosages ...

journal_title：International journal of ophthalmology

authors： Chen R,Yin XB,Peng CX,Li GL

更新日期：2012-01-01 00:00:00

abstract：AIM:To identify metastatic genes and miRNAs and to investigate the metastatic mechanism of uveal melanoma (UVM). METHODS:GSE27831, GSE39717, and GSE73652 gene expression profiles were downloaded from the Gene Expression Omnibus (GEO) database, and the limma R package was used to identify differentially expressed genes...

journal_title：International journal of ophthalmology

authors： Zhao DD,Zhao X,Li WT

更新日期：2020-07-18 00:00:00

abstract：AIM:To determine the effects of peripheral corneal thickness (PCT) on dynamic contour tonometry(DCT) and Goldmann applanation tonometry (GAT). METHODS:A cross-sectional study. We created a software which calculates the corneal contour (CC) as a function of the radius from the corneal apex to each pixel of the contour....

journal_title：International journal of ophthalmology

authors： Saenz-Frances F,Sanz-Pozo C,Borrego-Sanz L,Jañez L,Morales-Fernandez L,Martinez-de-la-Casa JM,Garcia-Sanchez J,Garcia-Feijoo J,Santos-Bueso E

更新日期：2017-10-18 00:00:00

abstract：AIM:To identify risk factors for an atherothrombotic event (ATE) among patients who were treated for diabetic macular edema (DME) with intravitreal bevacizumab injections. METHODS:This retrospective study enrolled all consecutive patients with DME who were treated by intravitreal bevacizumab from 2009 through 2016 in ...

journal_title：International journal of ophthalmology

authors： Tiosano A,Hadad A,Yanculovic N

更新日期：2020-09-18 00:00:00

abstract：AIM:To compare the clinical performance of two types of silicon hydrogel contact lenses used as bandage lenses after LASEK surgery. METHODS:A prospective, double-masked study was conducted on 42 eyes of 21 patients who received binocular LASEK surgeries. The interocular difference in spherical equivalent power was les...

journal_title：International journal of ophthalmology

authors： Qu XM,Dai JH,Jiang ZY,Qian YF

更新日期：2011-01-01 00:00:00

abstract：AIM:To investigate the relationship between C-reactive protein (CRP) and diabetic retinopathy (DR) in a cohort of Chinese patients with type 2 diabetes mellitus (T2DM). METHODS:Community-based observational cohort study. There were 1131 participants recruited from November 2009 to September 2011 in Desheng community i...

journal_title：International journal of ophthalmology

authors： Yang XF,Deng Y,Gu H,Lim A,Snellingen T,Liu XP,Wang NL,Domalpally A,Danis R,Liu NP

更新日期：2016-01-18 00:00:00

abstract：AIM:To explore the role of IgG4 serology in identifying common orbital lymphoproliferative disorders. METHODS:Eighty-one patients with orbital lymphoproliferative diseases were treated in the Department of Ocular Oncology, Beijing Tongren Hospital, Capital Medical University between September 2010 and December 2012. S...

journal_title：International journal of ophthalmology

authors： Li J,Ma JM,Ge X

更新日期：2016-02-18 00:00:00

abstract：AIM:To explore whether resveratrol (Res) can inhibit human retinal pigment epithelial cell (ARPE-19 cell) proliferation and migration, and to research the molecular mechanisms. METHODS:ARPE-19 cells were pretreated with various concentrations at 0, 50, 100, 150, 200 and 300 µmol/L of Res, and with 0 µmol/L Res as the ...

journal_title：International journal of ophthalmology

authors： Hao XN,Wang WJ,Chen J,Zhou Q,Qu YX,Liu XY,Xu W

更新日期：2016-12-18 00:00:00

abstract：AIM:To characterize the proliferative capacity of pterygial epithelium in different regions (head, neck and body) of pterygium and explore the function of transcription factor 4 (TCF4) in pterygium proliferation. METHODS:Thirty pterygium tissues and 10 normal conjunctival tissues were obtained from Zhongshan Ophthalmi...

journal_title：International journal of ophthalmology

authors： Nie C,Zhang XC,Xu SY,Quan YD,Tang ZX,Lu R

更新日期：2018-09-18 00:00:00