Clinical and laboratory features of PCR-confirmed periocular tuberculosis in China.

Abstract:

:Experts lack knowledge of periocular tuberculosis (TB) in China. Nested polymerase chain reaction (PCR) shows advantages in diagnosis of extrapulmonary TB. Our study aims to explore the clinical and laboratory features of PCR-confirmed periocular TB. We retrospectively reviewed medical records of presumptive periocular TB and performed nested PCR test to confirm diagnosis. Nine cases were recruited. Clinical symptoms were chronic and insidious. Eight cases achieved favorable visual acuity, while one underwent enucleation due to fungal-TB panophthalmitis. Sensitivity of caseous necrosis, acid-fast bacilli (AFB) staining and interferon γ release assay (T-SPOT) test are 33.3%, 44.4% and 85.7% respectively. Low lymphocyte percentage (P=0.019) and high monocyte-lymphocyte ratio (P=0.042) positively correlate with AFB staining. Male gender (P=0.048) and Langhans giant cell (P=0.048) positively correlate with caseous necrosis. To conclude, traditional TB ancillary tests are not as sensitive as nested PCR technique. Several factors facilitate diagnosis including male gender, decreased lymphocytes, and typical Langhans giant cells.

journal_name

Int J Ophthalmol

authors

Ma RQ,Gan L,Bi YW,Yuan YF,Ren H,Qian J

doi

10.18240/ijo.2018.11.20

subject

Has Abstract

pub_date

2018-11-18 00:00:00

pages

1865-1869

issue

11

eissn

2222-3959

issn

2227-4898

pii

ijo-11-11-1865

journal_volume

11

pub_type

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