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Broccoli sprouts juice prevents lens protein aggregation in streptozotocin-induced diabetic rat.

Abstract：

AIM:To investigate the effect of broccoli sprouts juice in preventing lens protein aggregation in diabetic rat model. METHODS:Totally 25 male Wistar rats were divided into negative control group, diabetic group without juice treatment as positive control and diabetic group given broccoli sprouts juice 0.25, 0.5 and 1 g/d for 28d. Diabetic rat model was obtained by administering a single dose streptozotocin 65 mg/kg intraperitoneal. At the end of the study, all rats were examined for fasting blood sugar level (FBS), visual cataract score using slit lamp biomicroscope and lens αB-crystallin expression using Western blot method. Statistical analysis was performed using one way ANOVA with post hoc test, correlation test, and simple linear regression. RESULTS:Positive control group had the highest cataract score and lens aggregated αB-crystallin expression. Broccoli sprout juice dose of 1 g/d group had the mildest cataract score, as well as the expression of lens aggregated αB-crystallin compared to treatments groups 1 and 2, opposite to lens native αB-crystallin expression. The broccoli sprout juice groups gave a significant decrease in cataract score, and also in lens aggregated αB-crystallin expression in diabetic rat models (P<0.05). CONCLUSION:Broccoli sprout juice has a significant effect in preventing lens protein aggregation in diabetic rat model. The higher dose gives better visual cataract scores, lower lens aggregated αB-crystallin expression and higher lens native αB-crystallin expression.

journal_name

Int J Ophthalmol

journal_title

International journal of ophthalmology

authors

Puspitasari A,Handayani N

doi

10.18240/ijo.2019.09.02

subject

Has Abstract

pub_date

2019-09-18 00:00:00

pages

1380-1385

issue

9

eissn

2222-3959

issn

2227-4898

pii

ijo-12-09-1380

journal_volume

12

pub_type

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