Abstract：
AIM:To assess the biosafety of a poly(acrylamide-co-sodium acrylate) hydrogel (PAH) as a 3D-printed intraocular lens (IOL) material. METHODS:The biosafety of PAH was first evaluated in vitro using human lens epithelial cells (LECs) and the ARPE19 cell line, and a cell counting kit-8 (CCK-8) assay was performed to investigate alterations in cell proliferation. A thin film of PAH and a conventional IOL were intraocularly implanted into the eyes of New Zealand white rabbits respectively, and a sham surgery served as control group. The anterior segment photographs, intraocular pressure (IOP), blood parameters and electroretinograms (ERG) were recorded. Inflammatory cytokines in the aqueous humor, such as TNFα and IL-8, were examined by ELISA. Cell apoptosis of the retina was investigated by TUNEL assay, and macroPAHge activation was detected by immunostaining. RESULTS:PAH did not slow cell proliferation when cocultured with human LECs or ARPE19 cells. The implantation of a thin film of a 3D-printed IOL composed of PAH did not affect the IOP, blood parameters, ERG or optical structure in any of the three experimental groups (n=3 for each). Both TNFα and IL-8 in the aqueous humor of PAH group were transiently elevated 1wk post-operation and recovered to normal levels at 1 and 3mo post-operation. Iba1+ macroPAHges in the anterior chamber angle in PAH group were increased markedly compared to those of the control group; however, there was no significant difference compared to those in the IOL group. CONCLUSION:PAH is a safe material for 3D printing of personal IOLs that hold great potential for future clinical applications.
journal_name
Int J Ophthalmoljournal_title
International journal of ophthalmologyauthors
Li JW,Li YJ,Hu XS,Gong Y,Xu BB,Xu HW,Yin ZQdoi
10.18240/ijo.2020.10.03subject
Has Abstractpub_date
2020-10-18 00:00:00pages
1521-1530issue
10eissn
2222-3959issn
2227-4898pii
ijo-13-10-1521journal_volume
13pub_type
杂志文章abstract：:Valsalva retinopathy was described as a particular form of retinopathy, pre-retinal and subinternal limiting membrane haemorrhages in nature that rarely may break through and become subhyloid or intravitreal, secondary to a sudden increase in intrathoracic pressure. We reported a new way that Nd:YAG laser for ILM hyal...
journal_title：International journal of ophthalmology
pub_type： 杂志文章
doi：10.3980/j.issn.2222-3959.2013.02.25
更新日期：2013-04-18 00:00:00
abstract：AIM:To evaluate the safety and efficacy of intravitreal etanercept in the inhibiting of proliferative vitreoretinopathy (PVR) in a model of penetrating ocular injury. METHODS:Penetrating ocular injury on the retina of rabbit was induced, which was subsequently treated using 0.1 mL of sterile water or 0.1 mL of 12.5 mg...
journal_title：International journal of ophthalmology
pub_type： 杂志文章
doi：10.18240/ijo.2019.05.06
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journal_title：International journal of ophthalmology
pub_type： 杂志文章
doi：10.3980/j.issn.2222-3959.2013.05.06
更新日期：2013-10-18 00:00:00
abstract：AIM:To investigate the association of Manganese superoxide dismutase (MnSOD) Val16Ala polymorphism with diabetic retinopathy (DR). METHODS:PubMed, Embase, China National Knowledge Infrastructure, and Wanfang databases were searched. The pooled odds ratios (ORs) and 95% confidence intervals (CIs) were calculated to eva...
journal_title：International journal of ophthalmology
pub_type： 杂志文章
doi：10.18240/ijo.2017.04.22
更新日期：2017-04-18 00:00:00
abstract：:To revise the peer-reviewed literature on geometric properties of the scleral-conjunctival structure in order to define their clinical relevance and the potential relationship between their changes and myopia development or progression. A bibliographic search focused on the study of the geometry of conjunctiva and/or ...
journal_title：International journal of ophthalmology
pub_type： 杂志文章,评审
doi：10.18240/ijo.2020.09.22
更新日期：2020-09-18 00:00:00
abstract：:Retinoblastoma (RB) is the most common intraocular cancer of infancy and childhood. This cancer is initiated by mutation on RB1, the tumor suppressor gene that is responsible for the regulation of both cell cycle and gnome stability in retinal cells. Patients with a constitutional mutation on RB1 can be inherited. RB ...
journal_title：International journal of ophthalmology
pub_type： 杂志文章
doi：10.3980/j.issn.2222-3959.2013.03.26
更新日期：2013-06-18 00:00:00
abstract：AIM:To evaluate the impact of 4 different intraocular lenses (IOLs) on posterior capsule opacification (PCO) by comparing the neodymium: yttrium-aluminum-garnet (Nd:YAG) laser capsulotomy rates. METHODS:This retrospective study included 4970 eyes of 4013 cataract patients who underwent phacoemulsification and IOL impl...
journal_title：International journal of ophthalmology
pub_type： 杂志文章
doi：10.3980/j.issn.2222-3959.2015.01.22
更新日期：2015-02-18 00:00:00
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journal_title：International journal of ophthalmology
pub_type： 杂志文章
doi：10.3980/j.issn.2222-3959.2011.04.06
更新日期：2011-01-01 00:00:00
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journal_title：International journal of ophthalmology
pub_type： 杂志文章
doi：10.3980/j.issn.2222-3959.2012.03.03
更新日期：2012-01-01 00:00:00
abstract：AIM:To report the abnormal type of the orbital liposarcoma-dedifferentiated subtype in a patient. METHODS:A case report. RESULTS:A 23 years old Chinese woman with a recurrence of right-sided proptosis was evaluated. Ocular examination revealed proptosis of the right eye with chemosis, hyperemia and limitation of eye ...
journal_title：International journal of ophthalmology
pub_type： 杂志文章
doi：10.3980/j.issn.2222-3959.2011.04.26
更新日期：2011-01-01 00:00:00
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journal_title：International journal of ophthalmology
pub_type： 杂志文章
doi：10.18240/ijo.2018.04.03
更新日期：2018-04-18 00:00:00
abstract：:[This retracts the article DOI: 10.3980/j.issn.2222-3959.2015.01.27.]. ...
journal_title：International journal of ophthalmology
pub_type： 撤回出版物
doi：
更新日期：2017-07-18 00:00:00
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journal_title：International journal of ophthalmology
pub_type： 杂志文章
doi：10.18240/ijo.2016.04.15
更新日期：2016-04-18 00:00:00
abstract：AIM:To evaluate the measurements of anterior segment parameters using three different non-contact optical devices in keratoconus patients. METHODS:A hundred and one eyes of 55 keratoconus patients were enrolled in this study. The mean age was 26.2±8.9 years. The inclusion criteria were keratoconus stage I to III accor...
journal_title：International journal of ophthalmology
pub_type： 杂志文章
doi：10.3980/j.issn.2222-3959.2013.04.21
更新日期：2013-08-18 00:00:00
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journal_title：International journal of ophthalmology
pub_type： 杂志文章
doi：10.18240/ijo.2018.03.26
更新日期：2018-03-18 00:00:00
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journal_title：International journal of ophthalmology
pub_type： 杂志文章
doi：10.18240/ijo.2016.05.16
更新日期：2016-05-18 00:00:00
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journal_title：International journal of ophthalmology
pub_type： 杂志文章
doi：10.18240/ijo.2020.02.04
更新日期：2020-02-18 00:00:00
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journal_title：International journal of ophthalmology
pub_type： 杂志文章
doi：10.18240/ijo.2016.08.11
更新日期：2016-08-18 00:00:00
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journal_title：International journal of ophthalmology
pub_type： 杂志文章
doi：10.3980/j.issn.2222-3959.2015.04.06
更新日期：2015-08-18 00:00:00
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journal_title：International journal of ophthalmology
pub_type： 杂志文章
doi：10.3980/j.issn.2222-3959.2013.01.19
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journal_title：International journal of ophthalmology
pub_type： 杂志文章
doi：10.18240/ijo.2020.08.22
更新日期：2020-08-18 00:00:00
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journal_title：International journal of ophthalmology
pub_type： 杂志文章
doi：10.18240/ijo.2019.04.19
更新日期：2019-04-18 00:00:00
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journal_title：International journal of ophthalmology
pub_type： 杂志文章
doi：10.18240/ijo.2019.06.10
更新日期：2019-06-18 00:00:00
abstract：AIM:To determine the dominant predictive factors of postoperative visual recovery for patients with pituitary adenoma. METHODS:PubMed, Google Scholar, Web of Science and Cochrane Library were searched for relevant human studies, which investigated the prediction of the postoperative visual recovery of patients with pi...
journal_title：International journal of ophthalmology
pub_type： 杂志文章
doi：10.18240/ijo.2017.11.17
更新日期：2017-11-18 00:00:00
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journal_title：International journal of ophthalmology
pub_type： 杂志文章
doi：10.18240/ijo.2016.12.14
更新日期：2016-12-18 00:00:00
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journal_title：International journal of ophthalmology
pub_type： 杂志文章
doi：10.3980/j.issn.2222-3959.2015.03.04
更新日期：2015-06-18 00:00:00
abstract：AIM:To investigate the impact of non-Descemet stripping endothelial keratoplasty (non-DSEK) on graft rejection rate, and its overall procedural effectiveness in patients. METHODS:Non-DSEK was performed on 65 eyes of 64 patients, and the procedural outcomes, including rejection episodes, failure and dislocation of the ...
journal_title：International journal of ophthalmology
pub_type： 杂志文章
doi：10.18240/ijo.2017.02.07
更新日期：2017-02-18 00:00:00
abstract：AIM:To explore the effect of saturated hydrogen saline on blue light-induced retinal damage in rats. METHODS:The retinal damage of rats was induced by blue light exposure for 6 hours and examined 8 hours, 16 hours and 24 hours after the exposure. One hundred female Sprague-Dawley rats were randomly divided into four g...
journal_title：International journal of ophthalmology
pub_type： 杂志文章
doi：10.3980/j.issn.2222-3959.2012.02.07
更新日期：2012-01-01 00:00:00
abstract：AIM:To describe and compare the corneal endothelial cell density and morphology in young, low and moderate myopic Chinese adults in Malaysian Chinese population. METHODS:Non-contact specular microscopy (Topcon SP3000P, Tokyo, Japan) was performed in low (n=78; 21.22±1.51 years) and moderate (n=78; 21.82±1.40 years) my...
journal_title：International journal of ophthalmology
pub_type： 杂志文章
doi：10.3980/j.issn.2222-3959.2013.04.11
更新日期：2013-08-18 00:00:00
abstract：AIM:To observe and characterize imaging features of macular and optic disc areas in less than 60-year-old patients with early primary open angle glaucoma (POAG) by optical coherence tomography (OCT) and optical coherence tomography angiography (OCTA), and to evaluate the diagnostic value of OCT and OCTA. METHODS:Total...
journal_title：International journal of ophthalmology
pub_type： 杂志文章
doi：10.18240/ijo.2020.12.11
更新日期：2020-12-18 00:00:00
