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TNF related apoptosis-inducing ligand and its receptors in ocular tumors.

Abstract：

:Most of the ocular tumors have poor prognosis, and they remain a difficult problem in the area of ophthalmology. With the rapid development of molecular biology and immunologic techniques and the deep research on ocular tumor related genes, it becomes possible to diagnose and treat malignant tumors from the molecular level. The tumor necrosis factor related apoptosis-inducing ligand (TRAIL), a member of the tumor necrosis factor (TNF) super family, is a promising candidate, either alone or in combination with established cancer therapies, since it can initiate apoptosis through the activation of their death receptors. The ability of TRAIL to selectively induce apoptosis of transformed, virus-infected or tumor cells but not normal cells promotes the development of TRAIL-based cancer therapy. Here, we will review TRAIL and its receptors' structure, function, mechanism of action and application in ocular tumors therapy.

journal_name

Int J Ophthalmol

journal_title

International journal of ophthalmology

authors

Ning Q,Hou L,Meng M,Pan BR,Zhao XH

doi

10.3980/j.issn.2222-3959.2011.05.18

subject

Has Abstract

pub_date

2011-01-01 00:00:00

pages

552-7

issue

5

eissn

2222-3959

issn

2227-4898

pii

ijo-04-05-552

journal_volume

4

pub_type

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