Abstract：
AIM:To investigate the ultrastructural pathogenesis of photodynamic therapy (PDT) for the experimental corneal neovascularization (CNV) by Hematoporphyrin Derivate (HPD) as photosensitizer and Argon laser as light source. METHODS:Experimental CNV models were induced in 7 white rabbits using alkali burn. Six weeks after models establishment, animals with CNV were injected with HPD intravenously, and 48 hours after the injection, 7 eyes were irradiated with argon laser (power 800mw, wavelength 514.5nm, spot diameter 200µm, exposure time 2ms). The irradiated CNV was observed by light microscopy and scanning electron microscopy. RESULTS:Histopathological study indicated that there was a striking decrease in the number of the CNV, vascular endothelium became degeneration and necrosis, some vessels were atrophy and attenuated, and vessels cavity were blocked by some thrombosis. No obvious abnormal histopathological findings were noted in surrounding tissues. CONCLUSION:The high precise action on CNV and minimal damage to surrounding tissues with PDT by HPD as photosensitizer suggested that PDT might be an effective and safe modality in the treatment of CNV.
journal_name
Int J Ophthalmoljournal_title
International journal of ophthalmologyauthors
Chen H,Zhang MC,Wang Z,Zhang Ydoi
10.3980/j.issn.2222-3959.2010.04.07subject
Has Abstractpub_date
2010-01-01 00:00:00pages
308-10issue
4eissn
2222-3959issn
2227-4898pii
ijo-03-04-308journal_volume
3pub_type
杂志文章abstract：AIM:To explore the correlation between several blood cell-associated inflammatory indices including mean platelet volume (MPV), platelet distribution width (PDW), neutrophil to lymphocyte ratio (NLR) and platelet-lymphocyte ratio (PLR), and the presence and severity of diabetic retinopathy (DR). METHODS:We searched fo...
journal_title：International journal of ophthalmology
pub_type： 杂志文章
doi：10.18240/ijo.2019.02.20
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journal_title：International journal of ophthalmology
pub_type： 杂志文章
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journal_title：International journal of ophthalmology
pub_type： 杂志文章
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journal_title：International journal of ophthalmology
pub_type： 杂志文章
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journal_title：International journal of ophthalmology
pub_type： 杂志文章
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journal_title：International journal of ophthalmology
pub_type： 杂志文章
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journal_title：International journal of ophthalmology
pub_type： 杂志文章
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journal_title：International journal of ophthalmology
pub_type： 杂志文章
doi：10.3980/j.issn.2222-3959.2011.03.22
更新日期：2011-01-01 00:00:00
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journal_title：International journal of ophthalmology
pub_type： 杂志文章,评审
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journal_title：International journal of ophthalmology
pub_type： 杂志文章
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更新日期：2011-01-01 00:00:00
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journal_title：International journal of ophthalmology
pub_type： 杂志文章
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pub_type： 杂志文章
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更新日期：2016-07-18 00:00:00
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journal_title：International journal of ophthalmology
pub_type： 杂志文章
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更新日期：2017-10-18 00:00:00
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journal_title：International journal of ophthalmology
pub_type： 杂志文章
doi：10.18240/ijo.2018.11.20
更新日期：2018-11-18 00:00:00
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journal_title：International journal of ophthalmology
pub_type： 杂志文章
doi：10.3980/j.issn.2222-3959.2015.01.12
更新日期：2015-02-18 00:00:00
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journal_title：International journal of ophthalmology
pub_type： 杂志文章
doi：10.3980/j.issn.2222-3959.2015.01.22
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abstract：:[This retracts the article DOI: 10.3980/j.issn.2222-3959.2015.01.27.]. ...
journal_title：International journal of ophthalmology
pub_type： 撤回出版物
doi：
更新日期：2017-07-18 00:00:00
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journal_title：International journal of ophthalmology
pub_type： 杂志文章
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journal_title：International journal of ophthalmology
pub_type： 杂志文章
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journal_title：International journal of ophthalmology
pub_type： 杂志文章
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更新日期：2016-05-18 00:00:00
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journal_title：International journal of ophthalmology
pub_type： 杂志文章
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更新日期：2020-06-18 00:00:00
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journal_title：International journal of ophthalmology
pub_type： 杂志文章
doi：10.18240/ijo.2016.01.19
更新日期：2016-01-18 00:00:00
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journal_title：International journal of ophthalmology
pub_type： 杂志文章,评审
doi：10.18240/ijo.2018.06.23
更新日期：2018-06-18 00:00:00
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journal_title：International journal of ophthalmology
pub_type： 杂志文章
doi：10.3980/j.issn.2222-3959.2010.04.17
更新日期：2010-01-01 00:00:00
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journal_title：International journal of ophthalmology
pub_type： 杂志文章
doi：10.3980/j.issn.2222-3959.2015.02.11
更新日期：2015-04-18 00:00:00
abstract：AIM:To evaluate clinical outcomes of unilateral implantation of a diffractive multifocal intraocular lens (IOL) in patients with contralateral monofocal IOL. METHODS:Twenty-two patients who already had implantation of a monofocal IOL in unilateral eye underwent implantation of a diffractive multifocal IOL in contralat...
journal_title：International journal of ophthalmology
pub_type： 杂志文章
doi：10.18240/ijo.2020.05.07
更新日期：2020-05-18 00:00:00
abstract：AIM:To evaluate the visual outcomes and patient satisfaction of two multifocal intraocular lens implantation patterns, with the decision between the two patterns being guided by the patients' choice of visual zones that best suited their lifestyle, or lifestyle zones. METHODS:This is a prospective non-randomized compa...
journal_title：International journal of ophthalmology
pub_type： 杂志文章
doi：10.3980/j.issn.2222-3959.2012.01.16
更新日期：2012-01-01 00:00:00
